KEGG   PATHWAY: nvs04151
Entry
nvs04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Neogale vison (American mink)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
nvs04151  PI3K-Akt signaling pathway
nvs04151

Other DBs
GO: 0043491
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889097  FGF20; fibroblast growth factor 20 [KO:K04358]
122889210  FGF5; fibroblast growth factor 5 [KO:K04358]
122889250  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122889261  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
122889330  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122889362  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
122889423  AREG; amphiregulin [KO:K09782]
122889430  SPP1; osteopontin isoform X1 [KO:K06250]
122889433  [KO:K06253]
122889469  TLR2; toll-like receptor 2 [KO:K10159]
122889497  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122889649  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122889741  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
122889792  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122889837  [KO:K16197]
122889856  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122889876  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122889883  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122889886  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122889911  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122890020  VEGFC; vascular endothelial growth factor C [KO:K05449]
122890038  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
122890087  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122890130  IL2; interleukin-2 [KO:K05429]
122890259  [KO:K16339] [EC:3.1.2.2]
122890262  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
122890516  EREG; proepiregulin [KO:K09784]
122890558  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
122890843  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
122891090  HSP90B1; endoplasmin [KO:K09487]
122891223  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
122891238  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
122891302  NTF3; neurotrophin-3 [KO:K04356]
122891322  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
122891465  ITGA8; integrin alpha-8 [KO:K06584]
122891486  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122891646  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
122891679  [KO:K04382] [EC:3.1.3.16]
122891702  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122891725  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122891729  [KO:K04736]
122891785  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122891855  COL2A1; collagen alpha-1(II) chain [KO:K19719]
122891883  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122891954  FGF6; fibroblast growth factor 6 [KO:K04358]
122892012  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
122892137  ITGB7; integrin beta-7 [KO:K06590]
122892167  FGF23; fibroblast growth factor 23 [KO:K22428]
122892168  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
122892356  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
122892370  VWF; von Willebrand factor [KO:K03900]
122892380  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
122892381  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122892401  ITGB1; integrin beta-1 [KO:K05719]
122892405  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122892446  KRAS; GTPase KRas isoform X1 [KO:K07827]
122892537  KITLG; kit ligand isoform X1 [KO:K05461]
122892551  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
122892610  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
122892628  ITGA5; integrin alpha-5 [KO:K06484]
122892906  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
122892921  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
122892946  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
122892965  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122893035  PGF; placenta growth factor isoform X1 [KO:K16859]
122893048  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122893272  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122893363  ITGA11; integrin alpha-11 [KO:K06587]
122893443  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
122893729  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
122893946  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
122894083  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
122894098  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
122894100  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
122894113  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122894134  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122894172  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122894202  THBS1; thrombospondin-1 [KO:K16857]
122894205  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
122894274  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122894367  ITGA2; integrin alpha-2 [KO:K06481]
122894384  ITGA1; integrin alpha-1 [KO:K06480]
122894598  GHR; growth hormone receptor [KO:K05080]
122894750  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122895046  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
122895287  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
122895342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122895383  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
122895413  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
122895420  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
122895434  PRLR; prolactin receptor [KO:K05081]
122895593  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
122895703  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
122895813  CD19; B-lymphocyte antigen CD19 [KO:K06465]
122895932  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122895963  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122896086  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
122896129  TSC2; tuberin isoform X1 [KO:K07207]
122896140  YWHAG; 14-3-3 protein gamma [KO:K16198]
122896293  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
122896347  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
122896393  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
122896452  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
122897084  MTCP1; protein p13 MTCP-1 [KO:K16837]
122897137  FGF16; fibroblast growth factor 16 [KO:K04358]
122897329  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
122897563  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122897668  [KO:K06237]
122897670  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122897962  [KO:K09487]
122897992  [KO:K03259]
122898661  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
122898876  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
122898999  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122899136  [KO:K07828]
122899273  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122899348  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122899425  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122899446  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122899479  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
122899490  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122899811  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
122899868  ARTN; artemin [KO:K25415]
122899916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122900018  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122900048  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122900073  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122900135  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122900138  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
122900165  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
122900302  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122900359  NRAS; GTPase NRas [KO:K07828]
122900366  NGF; beta-nerve growth factor [KO:K02582]
122900394  [KO:K04079]
122900421  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
122900437  MCL1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
122900522  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
122900668  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122900777  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
122900969  PIK3AP1; LOW QUALITY PROTEIN: phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
122901015  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122901170  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122901177  VEGFA; vascular endothelial growth factor A [KO:K05448]
122901225  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
122901601  IL4; interleukin-4 [KO:K05430]
122901791  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
122901830  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
122901985  [KO:K04542]
122902027  OSM; oncostatin-M [KO:K05418]
122902211  FGF10; fibroblast growth factor 10 [KO:K04358]
122902244  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122902255  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122902268  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122902278  FN1; fibronectin isoform X1 [KO:K05717]
122902369  IRS1; insulin receptor substrate 1 [KO:K16172]
122902371  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
122902372  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
122902422  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
122902449  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
122902527  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
122902545  THBS2; thrombospondin-2 [KO:K04659]
122902595  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122902614  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122902649  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
122902666  ITGAV; integrin alpha-V [KO:K06487]
122902835  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122902837  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
122902977  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
122903025  LAMA1; laminin subunit alpha-1 [KO:K05637]
122903200  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122903233  YWHAH; 14-3-3 protein eta [KO:K16198]
122903425  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
122904039  FOXO3; forkhead box protein O3 [KO:K09408]
122904064  IL6; interleukin-6 [KO:K05405]
122904271  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122904298  MYC; myc proto-oncogene protein [KO:K04377]
122904371  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122904393  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
122904429  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
122904498  IL7; interleukin-7 [KO:K05431]
122904546  [KO:K13304] [EC:2.7.11.1]
122904647  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122904695  LAMB1; laminin subunit beta-1 [KO:K05636]
122904697  LAMB4; laminin subunit beta-4 [KO:K06245]
122904709  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122904732  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
122904754  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
122904762  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122904813  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122904821  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
122904822  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
122904829  COL1A2; collagen alpha-2(I) chain [KO:K06236]
122904886  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
122904940  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
122905007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122905107  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
122905111  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
122905198  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
122905217  RHEB; GTP-binding protein Rheb [KO:K07208]
122905906  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
122905982  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
122905991  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122906063  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
122906101  ITGB3; integrin beta-3 [KO:K06493]
122906138  ITGA2B; integrin alpha-IIb [KO:K06476]
122906150  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
122906161  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
122906169  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
122906294  CSF3; granulocyte colony-stimulating factor [KO:K05423]
122906299  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122906357  YWHAE; 14-3-3 protein epsilon [KO:K06630]
122906409  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
122906417  VTN; vitronectin [KO:K06251]
122906460  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122906505  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122906579  CHAD; chondroadherin [KO:K06248]
122906585  COL1A1; collagen alpha-1(I) chain [KO:K06236]
122906591  ITGA3; integrin alpha-3 [KO:K06482]
122906596  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122906603  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
122906719  TP53; cellular tumor antigen p53 [KO:K04451]
122906749  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
122906750  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
122906782  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
122906918  FGF9; fibroblast growth factor 9 [KO:K04358]
122906945  [KO:K04542]
122906985  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122906988  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122907083  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
122907241  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
122907242  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
122907321  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122907558  [KO:K05438]
122907697  [KO:K03259]
122908116  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122908220  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
122908221  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
122908330  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
122908332  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
122908357  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
122908538  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122908712  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122908715  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122908716  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
122908860  ITGB5; integrin beta-5 [KO:K06588]
122908899  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122908920  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
122908954  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
122908955  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
122909085  ITGA9; integrin alpha-9 [KO:K06585]
122909192  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122909286  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
122909436  LAMB2; laminin subunit beta-2 [KO:K06243]
122909513  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
122909538  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
122909568  [KO:K04659]
122909583  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
122909588  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122909601  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
122909693  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
122909708  EPOR; erythropoietin receptor [KO:K05079]
122909734  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
122909778  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122909871  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122909910  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
122909957  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
122909963  EFNA2; ephrin-A2 [KO:K05462]
122909984  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
122910132  [KO:K06238]
122910806  PSPN; persephin [KO:K25416]
122910810  [KO:K25414]
122910812  [KO:K25414]
122910819  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
122911273  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
122911345  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
122911352  TNXB; tenascin-X isoform X1 [KO:K06252]
122911451  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
122911494  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122911710  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
122911823  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122911839  NTF4; neurotrophin-4 [KO:K12457]
122911840  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
122912036  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122912247  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122912265  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
122912303  [KO:K04079]
122912801  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122912878  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
122913015  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122913029  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
122913054  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122913061  BAD; bcl2-associated agonist of cell death [KO:K02158]
122913079  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
122913121  RELA; transcription factor p65 [KO:K04735]
122913186  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122913189  PRL; prolactin [KO:K05439]
122913220  HRAS; GTPase HRas isoform X1 [KO:K02833]
122913248  IGF2; insulin-like growth factor II [KO:K13769]
122913270  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
122913721  FGF3; fibroblast growth factor 3 [KO:K04358]
122913879  FGF21; fibroblast growth factor 21 [KO:K22429]
122913893  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
122914590  INS; insulin [KO:K04526]
122914602  FGF4; fibroblast growth factor 4 [KO:K04358]
122914603  FGF19; fibroblast growth factor 19 [KO:K22603]
122915099  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
122915138  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122915324  YWHAQ; 14-3-3 protein theta [KO:K16197]
122915444  TGFA; protransforming growth factor alpha [KO:K08774]
122915575  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122915847  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
122915910  LAMA5; laminin subunit alpha-5 [KO:K06240]
122915943  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
122916044  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
122916064  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
122916174  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
122916188  ANGPT4; angiopoietin-4 [KO:K05467]
122916735  [KO:K05414]
122916921  [KO:K05414]
122916922  [KO:K05414]
122916923  [KO:K05414]
122916924  [KO:K05414]
122916925  [KO:K05414]
122916926  [KO:K05414]
122916927  [KO:K05414]
122916929  [KO:K05414]
122916930  [KO:K05414]
122916931  [KO:K05414]
122916932  [KO:K05414]
122916933  [KO:K05414]
122916934  [KO:K05414]
122916935  [KO:K05414]
122916936  [KO:K05414]
122916937  [KO:K05414]
122916938  IFNB1; interferon beta [KO:K05415]
122917051  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
122917108  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122917138  TSC1; hamartin [KO:K07206]
122917156  LAMC3; laminin subunit gamma-3 [KO:K06247]
122917193  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
122917312  TLR4; toll-like receptor 4 [KO:K10160]
122917316  TNC; tenascin isoform X1 [KO:K06252]
122917340  [KO:K16197]
122917352  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
122917357  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
122917481  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
122917546  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122917563  [KO:K05414]
122917564  [KO:K05414]
122917575  RPS6; 40S ribosomal protein S6 [KO:K02991]
122917648  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122917753  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
122917804  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
122918121  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122918167  THBS4; thrombospondin-4 [KO:K04659]
122918219  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
122918221  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
122918234  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
122918247  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
122918249  EFNA4; ephrin-A4 [KO:K05462]
122918251  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
122918264  EFNA1; ephrin-A1 [KO:K05462]
122918316  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122918388  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
122918447  [KO:K04079]
122918524  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122918553  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
122918605  LAMC1; laminin subunit gamma-1 [KO:K05635]
122918607  LAMC2; laminin subunit gamma-2 [KO:K06246]
122918658  TNR; tenascin-R isoform X1 [KO:K06252]
122918661  TNN; tenascin-N [KO:K06252]
122918721  LAMB3; laminin subunit beta-3 [KO:K06244]
122918946  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122919116  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122919222  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
nvs00010  Glycolysis / Gluconeogenesis
nvs04010  MAPK signaling pathway
nvs04012  ErbB signaling pathway
nvs04062  Chemokine signaling pathway
nvs04064  NF-kappa B signaling pathway
nvs04068  FoxO signaling pathway
nvs04110  Cell cycle
nvs04115  p53 signaling pathway
nvs04150  mTOR signaling pathway
nvs04210  Apoptosis
nvs04370  VEGF signaling pathway
nvs04510  Focal adhesion
nvs04620  Toll-like receptor signaling pathway
nvs04630  JAK-STAT signaling pathway
nvs04662  B cell receptor signaling pathway
nvs04910  Insulin signaling pathway
KO pathway
ko04151   

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