PATHWAY: ghi03018 Help
Entry
Name
RNA degradation - Gossypium hirsutum (upland cotton)
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Gossypium hirsutum (upland cotton) [GN:
ghi ]
Gene
107954781 exosome complex exonuclease RRP44 homolog A [KO:K12585 ] [EC:3.1.13.-]
107955297 exosome complex exonuclease RRP44 homolog A [KO:K12585 ] [EC:3.1.13.-]
107920252 LOW QUALITY PROTEIN: protein RRP6-like 2 [KO:K12591 ] [EC:3.1.13.-]
107905709 LOW QUALITY PROTEIN: tetratricopeptide repeat protein SKI3 [KO:K12600 ]
107945544 LOW QUALITY PROTEIN: CCR4-NOT transcription complex subunit 1 [KO:K12604 ]
107931419 probable NOT transcription complex subunit VIP2 isoform X1 [KO:K12605 ]
107938436 probable NOT transcription complex subunit VIP2 isoform X1 [KO:K12605 ]
107959074 probable NOT transcription complex subunit VIP2 isoform X2 [KO:K12605 ]
107906175 probable NOT transcription complex subunit VIP2 isoform X1 [KO:K12605 ]
107932511 probable NOT transcription complex subunit VIP2 isoform X1 [KO:K12605 ]
121212693 probable NOT transcription complex subunit VIP2 isoform X1 [KO:K12605 ]
107920023 LOW QUALITY PROTEIN: general negative regulator of transcription subunit 3 [KO:K12580 ]
107901685 probable CCR4-associated factor 1 homolog 6 isoform X1 [KO:K12581 ]
107948451 probable CCR4-associated factor 1 homolog 6 isoform X1 [KO:K12581 ]
121225310 CCR4-NOT transcription complex subunit 9-like isoform X1 [KO:K12606 ]
121225227 CCR4-NOT transcription complex subunit 10-like isoform X1 [KO:K12607 ]
107901326 CCR4-NOT transcription complex subunit 10-like isoform X1 [KO:K12607 ]
121212589 CCR4-NOT transcription complex subunit 10-like isoform X1 [KO:K12607 ]
107922770 uncharacterized CRM domain-containing protein At3g25440, chloroplastic isoform X1 [KO:K01148 ] [EC:3.1.13.4 ]
107954602 mRNA-decapping enzyme-like protein isoform X2 [KO:K12611 ] [EC:3.-.-.-]
107929788 mRNA-decapping enzyme-like protein isoform X1 [KO:K12611 ] [EC:3.-.-.-]
107949044 mRNA-decapping enzyme-like protein isoform X2 [KO:K12611 ] [EC:3.-.-.-]
107896331 mRNA-decapping enzyme-like protein isoform X1 [KO:K12611 ] [EC:3.-.-.-]
107947387 LOW QUALITY PROTEIN: heat shock 70 kDa protein, mitochondrial [KO:K04043 ]
Reference
Authors
Houseley J, Tollervey D
Title
The many pathways of RNA degradation.
Journal
Reference
Authors
Buttner K, Wenig K, Hopfner KP
Title
The exosome: a macromolecular cage for controlled RNA degradation.
Journal
Reference
Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
Title
Cell and molecular biology of the exosome: how to make or break an RNA.
Journal
Reference
Authors
Hartung S, Hopfner KP
Title
The exosome, plugged.
Journal
Reference
Authors
Carpousis AJ
Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
Journal
Reference
Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
Journal
Reference
Authors
Condon C
Title
Maturation and degradation of RNA in bacteria.
Journal
Related pathway
KO pathway
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