KEGG   PATHWAY: hhv04010
Entry
hhv04010                    Pathway                                
Name
MAPK signaling pathway - Hyaena hyaena (striped hyena)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hhv04010  MAPK signaling pathway
hhv04010

Other DBs
GO: 0000165
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120245276  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120222772  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120243774  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
120239388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120243238  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120221013  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120229078  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
120241536  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120234330  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120228884  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
120221165  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
120229292  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
120223632  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
120234476  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
120229015  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
120240969  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
120223021  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
120225730  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
120234176  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
120241174  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
120233279  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
120234212  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
120234221  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
120239638  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
120239747  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
120239748  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
120241649  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120245321  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120228022  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
120220331  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120245305  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120225617  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120233735  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120239494  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120220964  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120236651  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120219964  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
120222317  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
120224815  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
120240123  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
120244026  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
120220621  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
120220354  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
120245671  NF1; neurofibromin isoform X1 [KO:K08052]
120224108  RASA1; ras GTPase-activating protein 1 [KO:K04352]
120242649  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
120247125  RAP1A; ras-related protein Rap-1A [KO:K04353]
120240794  RAP1B; ras-related protein Rap-1b [KO:K07836]
120236138  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120236624  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
120231054  EREG; proepiregulin [KO:K09784]
120231060  AREG; amphiregulin [KO:K09782]
120234333  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120238033  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120224487  FGF16; fibroblast growth factor 16 [KO:K04358]
120243219  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120233064  FGF10; fibroblast growth factor 10 [KO:K04358]
120233875  FGF4; fibroblast growth factor 4 [KO:K04358]
120233886  FGF3; fibroblast growth factor 3 [KO:K04358]
120234087  FGF18; fibroblast growth factor 18 [KO:K04358]
120239484  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120235046  FGF7; fibroblast growth factor 7 [KO:K04358]
120222265  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
120242355  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
120247465  FGF9; fibroblast growth factor 9 [KO:K04358]
120247728  FGF6; fibroblast growth factor 6 [KO:K04358]
120248082  FGF20; fibroblast growth factor 20 [KO:K04358]
120233885  FGF19; fibroblast growth factor 19 [KO:K22603]
120243454  FGF21; fibroblast growth factor 21 [KO:K22429]
120247734  FGF23; fibroblast growth factor 23 [KO:K22428]
120238779  NGF; beta-nerve growth factor [KO:K02582]
120220096  BDNF; brain-derived neurotrophic factor [KO:K04355]
120221154  NTF3; neurotrophin-3 [KO:K04356]
120240806  NTF4; neurotrophin-4 [KO:K12457]
120226896  INS; insulin [KO:K04526]
120245431  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120225512  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120226895  insulin-like growth factor II isoform X1 [KO:K13769]
120227991  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120233377  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120223081  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120246757  PDGFD; platelet-derived growth factor D [KO:K05450]
120244521  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120237065  KITLG; kit ligand isoform X1 [KO:K05461]
120244135  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
120231199  VEGFA; vascular endothelial growth factor A [KO:K05448]
120240107  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120232932  VEGFD; vascular endothelial growth factor D [KO:K05449]
120222108  VEGFC; vascular endothelial growth factor C [KO:K05449]
120221164  hepatocyte growth factor-like [KO:K05460]
120245413  HGF; hepatocyte growth factor [KO:K05460]
120222328  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
120221654  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
120235433  ANGPT4; angiopoietin-4 [KO:K05467]
120240773  EFNA5; ephrin-A5 [KO:K05462]
120242369  EFNA2; ephrin-A2 [KO:K05462]
120244682  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
120244722  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
120244725  EFNA1; ephrin-A1 [KO:K05462]
120244146  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
120227750  NRTN; neurturin [KO:K25414]
120223289  PSPN; persephin [KO:K25416]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120229105  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
120219930  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120245818  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
120238662  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120244115  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120231844  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120236775  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120228984  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120244665  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120224500  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
120244875  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120233674  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120222584  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120236611  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120236560  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
120222581  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
120247007  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
120247154  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120225370  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120243048  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120223826  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120223605  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
120229831  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
120249234  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
120228194  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120220282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120244628  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120223531  KRAS; GTPase KRas [KO:K07827]
120243068  NRAS; GTPase NRas [KO:K07828]
120244187  RRAS; ras-related protein R-Ras [KO:K07829]
120244997  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
120222404  MRAS; ras-related protein M-Ras [KO:K07831]
120219872  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120232948  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120242086  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120220784  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
120245727  ragulator complex protein LAMTOR3-like [KO:K04370]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242349  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
120247087  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
120225127  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
120241964  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
120231219  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120248702  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
120235229  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120219889  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120228830  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
120240874  MYC; myc proto-oncogene protein [KO:K04377]
120231250  SRF; serum response factor [KO:K04378]
120231952  FOS; proto-oncogene c-Fos [KO:K04379]
120244270  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
120232505  STMN1; stathmin [KO:K04381]
120232221  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
120232262  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
120232263  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
120232300  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
120248736  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
120221913  TNF; tumor necrosis factor [KO:K03156]
120231610  IL1A; interleukin-1 alpha [KO:K04383]
120231517  IL1B; interleukin-1 beta [KO:K04519]
120243258  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
120221741  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120231992  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
120221151  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
120245902  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
120233109  interleukin-1 receptor accessory protein [KO:K04723]
120233513  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120224680  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120224200  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120223778  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
120245610  CD14; monocyte differentiation antigen CD14 [KO:K04391]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120241186  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120228188  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120233626  cell division control protein 42 homolog [KO:K04393]
120231260  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120223347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
120246375  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120226445  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120238210  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
120235110  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120221716  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
120246010  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120232555  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120232638  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120237943  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120242325  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
120233644  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
120237570  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
120244479  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
120244630  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
120245887  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
120220612  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
120229608  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120244384  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120242604  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
120247534  STK3; serine/threonine-protein kinase 3 [KO:K04412]
120240143  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
120221616  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
120239952  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
120240184  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
120245944  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
120234206  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
120245000  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
120244690  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
120242870  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
120247231  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
120238093  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
120236409  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
120231421  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
120239371  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
120222015  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120231881  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120224269  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
120228483  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
120242209  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
120244912  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
120231429  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120244848  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120228759  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
120230246  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120228468  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
120235158  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
120241510  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
120227474  FLNA; filamin-A isoform X1 [KO:K04437]
120238810  CRKL; crk-like protein [KO:K04438]
120245519  CRK; adapter molecule crk isoform X1 [KO:K04438]
120226697  ARRB2; beta-arrestin-2 [KO:K04439]
120229571  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
120244180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120232781  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120245677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120233796  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120233829  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120234701  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
120235253  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120232724  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
120245595  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
120229382  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
120232080  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
120240200  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
120226460  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
120240942  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120223543  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120236252  JUN; transcription factor AP-1 [KO:K04448]
120239248  JUND; transcription factor jun-D [KO:K04449]
120243894  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120231386  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120248009  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
120238410  MAX; protein max isoform X1 [KO:K04453]
120221793  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
120239263  HSPB1; heat shock protein beta-1 [KO:K04455]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120237456  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
120240777  PTPRR; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
120234805  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
120228824  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
120234102  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
120244306  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120225942  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120239434  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120222824  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120231606  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120236873  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120237084  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
120221727  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
120223049  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120222900  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120243911  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
120232012  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
120227766  heat shock 70 kDa protein 1 [KO:K03283]
120220580  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120240081  heat shock cognate 71 kDa protein-like [KO:K03283]
120221892  heat shock 70 kDa protein 1-like [KO:K03283]
120221893  heat shock 70 kDa protein 1 [KO:K03283]
120221952  heat shock cognate 71 kDa protein-like [KO:K03283]
120241045  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
120249032  heat shock cognate 71 kDa protein-like [KO:K03283]
120234625  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
120222273  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
120228757  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
120237917  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
120222278  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120243217  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120233999  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120226622  IKBKG; NF-kappa-B essential modulator [KO:K07210]
120246055  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120222817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120239622  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
120240185  RELA; transcription factor p65 [KO:K04735]
120242548  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Chem Rev 101:2449-76 (2001)
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PMID:12947395
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Methods Mol Biol 846:1-12 (2012)
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
hhv04070  Phosphatidylinositol signaling system
hhv04110  Cell cycle
hhv04115  p53 signaling pathway
hhv04210  Apoptosis
hhv04310  Wnt signaling pathway
hhv04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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