KEGG   PATHWAY: hmh05417
Entry
hmh05417                    Pathway                                
Name
Lipid and atherosclerosis - Hylobates moloch (silvery gibbon)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
hmh05417  Lipid and atherosclerosis
hmh05417

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116480381  APOB; apolipoprotein B-100 [KO:K14462]
116476973  APOA4; apolipoprotein A-IV [KO:K08760]
116476975  APOA1; apolipoprotein A-I [KO:K08757]
116478469  LDLR; low-density lipoprotein receptor [KO:K12473]
116480613  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
116464494  rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
116476864  MMP1; interstitial collagenase isoform X1 [KO:K01388] [EC:3.4.24.7]
116469279  transforming protein RhoA-like [KO:K04513]
116473478  RHOA; transforming protein RhoA [KO:K04513]
116480242  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
116814534  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116478225  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
116468949  BAD; bcl2-associated agonist of cell death [KO:K02158]
116461353  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
116468493  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116473534  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116477070  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
116480616  POU2F2; POU domain, class 2, transcription factor 2 isoform X3 [KO:K09364]
116473283  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
116461078  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
116812081  CD40LG; CD40 ligand [KO:K03161]
116481900  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
116480657  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
116457254  cytochrome P450 2C8 [KO:K17718] [EC:1.14.14.1]
116457268  cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
116457699  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116460305  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
116811135  NOX1; NADPH oxidase 1 [KO:K08008]
116811598  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
116811495  NCF1; neutrophil cytosol factor 1 [KO:K08011]
116470716  cytochrome b-245 light chain [KO:K08009]
116457296  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
116458459  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
116480287  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116461023  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116458453  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
116474863  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
116813051  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
116459332  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116456218  FOS; protein c-Fos [KO:K04379]
116457363  JUN; transcription factor Jun [KO:K04448]
116474482  C-C motif chemokine 2 isoform X1 [KO:K14624]
116478438  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
116467002  CXCL8; interleukin-8 [KO:K10030]
116483006  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116483711  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116458518  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
116458519  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459642  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459649  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116472788  KRAS; GTPase KRas isoform X1 [KO:K07827]
116469568  NRAS; GTPase NRas [KO:K07828]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116473257  SELE; E-selectin [KO:K06494]
116473260  SELP; P-selectin [KO:K06496]
116469708  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
116464292  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
116464293  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
116461334  MMP9; matrix metalloproteinase-9 isoform X2 [KO:K01403] [EC:3.4.24.35]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116483283  IL1B; interleukin-1 beta [KO:K04519]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116810498  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
116480903  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
116456703  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
116477090  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
116460285  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
116460286  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
116460287  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
116473328  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
116484621  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
116470823  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
116485178  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
116460213  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
116478026  HSP90B1; endoplasmin [KO:K09487]
116469780  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
116465400  TLR2; toll-like receptor 2 [KO:K10159]
116461488  LBP; lipopolysaccharide-binding protein [KO:K05399]
116471599  CD14; monocyte differentiation antigen CD14 [KO:K04391]
116812651  LY96; lymphocyte antigen 96 [KO:K05400]
116475593  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
116477149  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
116473667  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
116481090  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116812171  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
116476347  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116458812  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
116463159  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116463202  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116469793  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116470920  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
116457855  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
116483533  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
116485188  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116468676  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
116812785  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
116810749  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
116457541  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116480802  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
116466580  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
116478197  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116458330  interferon alpha-5 [KO:K05414]
116458331  interferon alpha-6 [KO:K05414]
116458332  interferon alpha-2 [KO:K05414]
116458527  interferon alpha-14 [KO:K05414]
116458611  interferon alpha-1/13 [KO:K05414]
116458660  interferon alpha-8 [KO:K05414]
116458843  IFNB1; interferon beta [KO:K05415]
116814164  CD36; platelet glycoprotein 4 [KO:K06259]
116466751  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
116475838  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116460446  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
116472315  RXRG; retinoic acid receptor RXR-gamma isoform X2 [KO:K08526]
116813281  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
116813620  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116475833  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116469686  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116478343  VAV1; proto-oncogene vav [KO:K05730]
116456827  TLR6; toll-like receptor 6 [KO:K10169]
116469612  RAP1A; ras-related protein Rap-1A [KO:K04353]
116478979  RAP1B; ras-related protein Rap-1b [KO:K07836]
116474527  CCL5; C-C motif chemokine 5 [KO:K12499]
116474111  C-C motif chemokine 3-like 1 [KO:K05408]
116474525  CCL3L3; C-C motif chemokine 3-like 1 [KO:K05408]
116466971  C-X-C motif chemokine 2 isoform X1 [KO:K05505]
116475080  C-X-C motif chemokine 3 [KO:K05505]
116475085  CXCL1; growth-regulated alpha protein [KO:K05505]
116463392  interleukin-12 subunit alpha [KO:K05406]
116463424  interleukin-12 subunit alpha [KO:K05406]
116471783  IL12B; interleukin-12 subunit beta [KO:K05425]
116457664  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
116476942  IL18; interleukin-18 [KO:K05482]
116475661  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
116473320  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
116480869  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
116456342  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
116466681  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116459675  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116471714  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116812488  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116463099  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
116483180  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
116485158  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116458613  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116810327  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
116458727  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116472781  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116459428  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
116475500  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
116481446  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
116810621  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
116471192  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
116476876  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
116458562  VLDLR; very low-density lipoprotein receptor isoform X7 [KO:K20053]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116468452  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116461045  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116471414  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
116468938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116461202  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116461370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
116481969  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6 [KO:K05858] [EC:3.1.4.11]
116461010  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116467516  uncharacterized protein LOC116467516 [KO:K02183]
116485193  CALM1; calmodulin-1 isoform X2 [KO:K02183]
116478308  CALM3; calmodulin-3 [KO:K02183]
116482339  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116813883  CALML6; calmodulin-like protein 6 [KO:K02183]
116483146  CALM2; calmodulin-2 isoform X1 [KO:K02183]
116466871  calmodulin-1-like [KO:K02183]
116474613  CALML5; calmodulin-like protein 5 [KO:K02183]
116474621  CALML3; calmodulin-like protein 3 [KO:K02183]
116483814  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
116459475  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116461844  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116483520  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
116475348  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116481248  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
116461997  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
116462001  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
116472296  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116459453  BID; BH3-interacting domain death agonist [KO:K04726]
116476907  cytochrome c-like [KO:K08738]
116809676  cytochrome c-like [KO:K08738]
116811446  cytochrome c-like [KO:K08738]
116471160  cytochrome c [KO:K08738]
116812987  cytochrome c isoform X2 [KO:K08738]
116479141  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
116812958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116462674  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116483412  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
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Related
pathway
hmh04020  Calcium signaling pathway
hmh04115  p53 signaling pathway
hmh04141  Protein processing in endoplasmic reticulum
hmh04151  PI3K-Akt signaling pathway
hmh04210  Apoptosis
hmh04620  Toll-like receptor signaling pathway
hmh04621  NOD-like receptor signaling pathway
hmh04668  TNF signaling pathway
hmh04670  Leukocyte transendothelial migration
hmh04975  Fat digestion and absorption
hmh04979  Cholesterol metabolism
hmh05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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