KEGG   PATHWAY: mlf04151
Entry
mlf04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Myotis lucifugus (little brown bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlf04151  PI3K-Akt signaling pathway
mlf04151

Other DBs
GO: 0043491
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102434624  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102440089  EREG; proepiregulin [KO:K09784]
102426617  AREG; amphiregulin [KO:K09782]
102431344  FGF1; fibroblast growth factor 1 [KO:K18496]
111825710  FGF2; fibroblast growth factor 2 [KO:K18497]
102420818  FGF16; fibroblast growth factor 16 [KO:K04358]
102438838  FGF10; fibroblast growth factor 10 [KO:K04358]
102421786  FGF6; fibroblast growth factor 6 [KO:K04358]
102422136  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102432454  FGF20; fibroblast growth factor 20 [KO:K04358]
102442835  FGF9; fibroblast growth factor 9 [KO:K04358]
102426314  FGF4; fibroblast growth factor 4 [KO:K04358]
102428863  FGF7; fibroblast growth factor 7 [KO:K04358]
102428528  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102429928  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
102426634  FGF3; fibroblast growth factor 3 [KO:K04358]
102440432  FGF18; fibroblast growth factor 18 [KO:K04358]
102426451  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102426004  FGF19; fibroblast growth factor 19 [KO:K22603]
102432520  FGF21; fibroblast growth factor 21 [KO:K22429]
102439118  fibroblast growth factor 21-like [KO:K22429]
102432233  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
102427030  NGF; beta-nerve growth factor [KO:K02582]
102440705  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102418196  NTF3; neurotrophin-3 [KO:K04356]
102430737  INS; insulin [KO:K04526]
102424041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102442814  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102418575  PDGFD; platelet-derived growth factor D [KO:K05450]
102429105  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
102416825  KITLG; kit ligand isoform X6 [KO:K05461]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102438597  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102421300  PGF; placenta growth factor isoform X1 [KO:K16859]
102421161  VEGFD; vascular endothelial growth factor D [KO:K05449]
102438038  VEGFC; vascular endothelial growth factor C [KO:K05449]
102441297  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102434406  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
106695515  uncharacterized protein LOC106695515 [KO:K05466]
102439232  ANGPT4; angiopoietin-4 [KO:K05467]
102418395  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102436484  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
102428621  EFNA1; ephrin-A1 [KO:K05462]
102436800  EFNA4; ephrin-A4 [KO:K05462]
102435571  ephrin-A2 [KO:K05462]
102431995  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102437124  NRTN; neurturin isoform X2 [KO:K25414]
102441458  PSPN; persephin [KO:K25416]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102427788  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102438329  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
102442922  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102423450  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102419131  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102420805  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102431497  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102426842  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102437355  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
102430595  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102442629  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
102442787  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
102420687  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102417951  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102422327  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102430005  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102442473  KDR; vascular endothelial growth factor receptor 2 isoform X3 [KO:K05098] [EC:2.7.10.1]
102441042  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102429943  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102437052  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102420377  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102430744  NRAS; GTPase NRas [KO:K07828]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102442509  IRS1; insulin receptor substrate 1 [KO:K16172]
102424442  TLR2; toll-like receptor 2 [KO:K10159]
102437402  TLR4; toll-like receptor 4 [KO:K10160]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102428843  SYK; tyrosine-protein kinase SYK isoform X2 [KO:K05855] [EC:2.7.10.2]
102438786  CD19; B-lymphocyte antigen CD19 [KO:K06465]
102426073  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
102442251  somatotropin-like precursor [KO:K05438]
102420245  PRL; LOW QUALITY PROTEIN: prolactin [KO:K05439]
102433200  IL2; interleukin-2 [KO:K05429]
106699073  interleukin-3-like [KO:K04736]
102431882  IL6; interleukin-6 [KO:K05405]
102437928  IL4; interleukin-4 [KO:K05430]
102418120  IL7; interleukin-7 isoform X1 [KO:K05431]
102417209  IFNB1; interferon beta [KO:K05415]
102419335  EPO; erythropoietin isoform X1 [KO:K05437]
102428419  CSF3; granulocyte colony-stimulating factor [KO:K05423]
102429474  growth hormone receptor [KO:K05080]
102425246  PRLR; prolactin receptor isoform X1 [KO:K05081]
102433573  OSMR; LOW QUALITY PROTEIN: oncostatin-M-specific receptor subunit beta [KO:K05057]
102427118  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102420320  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
102441989  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102438125  IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
102423070  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
102436222  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102426075  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102427197  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
102419381  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
102441273  EPOR; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
102427246  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102442353  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102420466  JAK2; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102428976  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102434359  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
102440571  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102427340  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102419751  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102428769  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
102428453  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102420284  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102443143  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102416916  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102418832  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
102436416  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
102437036  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102437344  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
102434127  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
102434641  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102419595  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102442455  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102423308  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102436659  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
102426930  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102421945  LAMA5; laminin subunit alpha-5 [KO:K06240]
106694687  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
102434140  LAMA3; laminin subunit alpha-3 [KO:K06240]
102434037  LAMA4; laminin subunit alpha-4 [KO:K06241]
102438476  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102420016  LAMB3; laminin subunit beta-3 [KO:K06244]
102438166  LAMB4; laminin subunit beta-4 [KO:K06245]
102419814  LAMC1; laminin subunit gamma-1 [KO:K05635]
102438305  LAMC2; laminin subunit gamma-2 [KO:K06246]
102434681  LAMC3; laminin subunit gamma-3 [KO:K06247]
102433247  LOW QUALITY PROTEIN: laminin subunit gamma-3-like [KO:K06247]
102422748  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
102441094  THBS1; thrombospondin-1 [KO:K16857]
102431756  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
102423421  THBS4; thrombospondin-4 [KO:K04659]
102437320  COMP; cartilage oligomeric matrix protein [KO:K04659]
102435863  THBS3; thrombospondin-3 [KO:K04659]
102440437  FN1; fibronectin isoform X7 [KO:K05717]
102417152  SPP1; osteopontin [KO:K06250]
102427760  VTN; vitronectin [KO:K06251]
102442551  TNN; tenascin-N [KO:K06252]
102421464  TNR; tenascin-R [KO:K06252]
102424435  TNC; tenascin isoform X3 [KO:K06252]
102426871  VWF; von Willebrand factor [KO:K03900]
102442831  IBSP; bone sialoprotein 2 [KO:K06253]
102434163  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102420344  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
102441901  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102439596  ITGA4; integrin alpha-4 [KO:K06483]
102438432  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
102426340  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102427655  ITGA7; integrin alpha-7 [KO:K06583]
102422404  ITGA8; integrin alpha-8 [KO:K06584]
102438448  ITGA9; integrin alpha-9 [KO:K06585]
102432339  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102430047  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
102439153  ITGAV; integrin alpha-V [KO:K06487]
102438984  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102421777  ITGB3; integrin beta-3 [KO:K06493]
102429864  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
102424308  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
102428536  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102418373  ITGB7; integrin beta-7 [KO:K06590]
102435389  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102442955  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102421923  F2R; proteinase-activated receptor 1 [KO:K03914]
102431567  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102418229  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
102420275  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102417048  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
102443146  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102423544  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102435690  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102420431  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102420482  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102428334  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102431535  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
102420203  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102441805  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102442437  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102428001  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102422498  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106697041  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102432910  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102432599  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102428066  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102431853  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102432692  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
102420164  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102439715  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102425527  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
102429282  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
102431196  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102421316  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102440094  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102438720  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102428383  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102440346  TSC1; hamartin [KO:K07206]
102422720  TSC2; tuberin isoform X1 [KO:K07207]
102422024  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
102441557  RHEB; GTP-binding protein Rheb [KO:K07208]
102424858  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102434974  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102430610  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
102418433  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102437938  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102433516  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102416807  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102431191  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
102429245  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
102433676  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102439562  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
102437206  RPS6; 40S ribosomal protein S6 [KO:K02991]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102419743  PKN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102423597  PKN2; serine/threonine-protein kinase N2 isoform X2 [KO:K23691] [EC:2.7.11.13]
102426035  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
102421134  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
111825186  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
102417188  serine/threonine-protein kinase Sgk3 isoform X12 [KO:K13304] [EC:2.7.11.1]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102422076  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
102428304  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102427328  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
102417517  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
102432188  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102430803  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
102421388  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
102442817  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102431175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102423271  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
102440385  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
102437363  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
102422214  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102433629  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102428034  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102433480  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102417642  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
102432946  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
102430062  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584]
102442935  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
102419327  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102433810  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102422639  HSP90B1; endoplasmin [KO:K09487]
102433533  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
102417307  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
102443079  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102417191  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
111823854  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
111823855  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
111823856  protein p13 MTCP-1-like [KO:K10167]
111823857  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102430704  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
111823858  protein p13 MTCP-1-like [KO:K10167]
111823860  protein p13 MTCP-1-like [KO:K10167]
102433877  protein p13 MTCP-1-like [KO:K10167]
102417604  protein p13 MTCP-1-like [KO:K10167]
102417922  protein p13 MTCP-1-like [KO:K10167]
102417087  protein p13 MTCP-1-like [KO:K10167]
106694939  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
106694941  protein p13 MTCP-1-like [KO:K10167]
106695998  protein p13 MTCP-1-like [KO:K10167]
102423705  T-cell leukemia/lymphoma protein 1A-like isoform X1 [KO:K10167]
102423254  protein p13 MTCP-1-like [KO:K10167]
102423558  protein p13 MTCP-1-like [KO:K10167]
102423864  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102424787  protein p13 MTCP-1-like [KO:K10167]
102426360  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102426678  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102426988  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102427926  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102429472  protein p13 MTCP-1-like [KO:K10167]
102430082  protein p13 MTCP-1-like [KO:K10167]
102430388  protein p13 MTCP-1-like [KO:K10167]
102432124  MTCP1; protein p13 MTCP-1 [KO:K16837]
106694940  protein p13 MTCP-1-like [KO:K16837]
102436714  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102434930  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
102428794  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
102422372  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
102439331  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
102423798  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2 [KO:K01596] [EC:4.1.1.32]
102430158  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
102439281  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
102425980  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
102438112  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
102426511  MYC; myc proto-oncogene protein [KO:K04377]
102441858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
102439094  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
102429961  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102440300  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102431798  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102430068  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102422703  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102435083  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102431579  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102429544  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102440021  FOXO3; forkhead box protein O3 [KO:K09408]
102423035  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
102439228  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102422727  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
102425387  YWHAQ; 14-3-3 protein theta [KO:K16197]
102430844  YWHAB; 14-3-3 protein beta/alpha isoform X4 [KO:K16197]
102441239  YWHAE; 14-3-3 protein epsilon [KO:K06630]
102438996  YWHAG; 14-3-3 protein gamma [KO:K16198]
102433319  14-3-3 protein eta [KO:K16198]
102437980  BAD; bcl2-associated agonist of cell death [KO:K02158]
102443091  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102432611  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
102428235  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
102428529  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102418405  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102429560  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102431250  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102416978  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
102443216  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102427186  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102421849  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102439961  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102428756  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
102441536  MCL1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
102430829  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102428614  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102436137  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102424236  RELA; transcription factor p65 [KO:K04735]
102435748  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102440245  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
102416898  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102431418  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mlf00010  Glycolysis / Gluconeogenesis
mlf04010  MAPK signaling pathway
mlf04012  ErbB signaling pathway
mlf04062  Chemokine signaling pathway
mlf04064  NF-kappa B signaling pathway
mlf04068  FoxO signaling pathway
mlf04110  Cell cycle
mlf04115  p53 signaling pathway
mlf04150  mTOR signaling pathway
mlf04210  Apoptosis
mlf04370  VEGF signaling pathway
mlf04510  Focal adhesion
mlf04620  Toll-like receptor signaling pathway
mlf04630  JAK-STAT signaling pathway
mlf04662  B cell receptor signaling pathway
mlf04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

DBGET integrated database retrieval system