KEGG   PATHWAY: mpah04514
Entry
mpah04514                   Pathway                                
Name
Cell adhesion molecules - Mus pahari (shrew mouse)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mpah04514  Cell adhesion molecules
mpah04514

Other DBs
GO: 0050839
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110320578  Cd2; T-cell surface antigen CD2 [KO:K06449]
110326585  Vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
110329780  Igsf11; immunoglobulin superfamily member 11 [KO:K06791]
110329945  Cd80; T-lymphocyte activation antigen CD80 [KO:K05412]
110338267  Cd274; programmed cell death 1 ligand 1 [KO:K06745]
110322470  Cd28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
110330066  Cd86; T-lymphocyte activation antigen CD86 [KO:K05413]
110322369  Ctla4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
110327093  Icoslg; ICOS ligand [KO:K06710]
110321146  Icos; inducible T-cell costimulator [KO:K06713]
110335630  class II histocompatibility antigen, M alpha chain [KO:K06752]
110335686  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
110335782  H-2 class II histocompatibility antigen, E-K alpha chain [KO:K06752]
110335853  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
110335947  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
110335433  H-2 class II histocompatibility antigen, A-S beta chain [KO:K06752]
110335519  H-2 class II histocompatibility antigen, I-E beta chain [KO:K06752]
110335565  H-2 class II histocompatibility antigen, A-B alpha chain [KO:K06752]
110335584  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
110316786  uncharacterized protein LOC110316786 [KO:K10785]
110317139  Cd4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
110314816  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110314822  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
110314930  HLA class I histocompatibility antigen, A-25 alpha chain-like [KO:K06751]
110314994  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
110335754  HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
110335755  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
110335756  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
110315033  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110315071  HLA class I histocompatibility antigen, A-25 alpha chain-like [KO:K06751]
110335839  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X1 [KO:K06751]
110335840  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
110335841  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
110315143  HLA class I histocompatibility antigen, A-25 alpha chain-like [KO:K06751]
110315275  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
110315312  HLA class I histocompatibility antigen, A-32 alpha chain-like [KO:K06751]
110335989  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
110336005  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
110336006  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110336017  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
110315373  HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
110336104  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, D-B alpha chain-like [KO:K06751]
110315457  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
110315468  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
110315518  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110314674  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
110314692  H-2 class I histocompatibility antigen, Q7 alpha chain-like isoform X1 [KO:K06751]
110317311  Cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
110316834  Cd8b; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
110332215  Pdcd1lg2; programmed cell death 1 ligand 2 [KO:K06708]
110327915  Cd276; CD276 antigen [KO:K06746]
110320616  Vtcn1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
110322459  Pdcd1; programmed cell death protein 1 [KO:K06744]
110318846  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110314146  Cd40lg; CD40 ligand [KO:K03161]
110329549  Alcam; CD166 antigen isoform X1 [KO:K06547]
110327622  Cd6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
110333295  Cd226; CD226 antigen isoform X1 [KO:K06567]
110336368  Nectin2; nectin-2 isoform X1 [KO:K06531]
110329383  Tigit; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
110338926  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110326926  Itgb2; integrin beta-2 [KO:K06464]
110330040  LOW QUALITY PROTEIN: integrin beta-2-like protein [KO:K06464]
110327515  Icam1; intercellular adhesion molecule 1 [KO:K06490]
110332367  Icam2; intercellular adhesion molecule 2 [KO:K06523]
110329687  Cd22; B-cell receptor CD22 [KO:K06467]
110321703  Ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
110319037  Siglec1; sialoadhesin [KO:K06548]
110312788  Spn; leukosialin [KO:K06477]
110329804  Nectin3; nectin-3 isoform X1 [KO:K06592]
110314553  claudin-34-like [KO:K06087]
110313292  Cldn34; claudin-34 [KO:K06087]
110314217  Cldn2; claudin-2 [KO:K06087]
110313198  claudin-13-like [KO:K06087]
110325649  Cldn10; claudin-10 isoform X1 [KO:K06087]
110323517  Cldn19; claudin-19 [KO:K06087]
110329976  Cldn16; claudin-16 [KO:K06087]
110320316  Cldn11; claudin-11 [KO:K06087]
110328136  Cldn18; claudin-18 isoform X1 [KO:K06087]
110329625  Cldn1; claudin-1 [KO:K06087]
110329722  Cldn5; claudin-5 [KO:K06087]
110337052  Cldn23; claudin-23 [KO:K06087]
110338212  Cldn20; claudin-20 [KO:K06087]
110330140  Cldn17; claudin-17 [KO:K06087]
110312976  Cldn4; claudin-4 [KO:K06087]
110312980  Cldn3; claudin-3 [KO:K06087]
110313087  Cldn15; claudin-15 [KO:K06087]
110313250  claudin-34-like [KO:K06087]
110327149  Cldn25; putative claudin-25 [KO:K06087]
110332203  Cldn7; claudin-7 [KO:K06087]
110330072  Cldn8; claudin-8 [KO:K06087]
110330109  Cldn14; claudin-14 [KO:K06087]
110337128  claudin-22 [KO:K06087]
110338251  Cldn6; claudin-6 [KO:K06087]
110338269  Cldn9; claudin-9 [KO:K06087]
110313291  claudin-34-like [KO:K06087]
110329108  Ocln; occludin [KO:K06088]
110322186  F11r; junctional adhesion molecule A [KO:K06089]
110329778  Jam2; junctional adhesion molecule B [KO:K06735]
110327722  Jam3; junctional adhesion molecule C [KO:K06785]
110327920  Esam; endothelial cell-selective adhesion molecule [KO:K06787]
110337332  Cdh5; cadherin-5 [KO:K06533]
110331583  Pecam1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
110313902  Cd99l2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
110327528  Itgam; integrin alpha-M isoform X1 [KO:K06461]
110313083  Selplg; P-selectin glycoprotein ligand 1 isoform X1 [KO:K06544]
110322112  Selp; P-selectin [KO:K06496]
110317910  Itga4; integrin alpha-4 [KO:K06483]
110337225  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
110327901  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
110319965  Vcam1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
110334491  Itgb7; integrin beta-7 [KO:K06590]
110326961  Madcam1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779]
110321853  Sell; L-selectin isoform X1 [KO:K06495]
110335249  glycosylation-dependent cell adhesion molecule 1 isoform X1 [KO:K06815]
110321750  Cd34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
110337287  Glg1; Golgi apparatus protein 1 isoform X1 [KO:K06816]
110322592  Sele; E-selectin [KO:K06494]
110327633  Nectin1; nectin-1 [KO:K06081]
110332848  Cdh2; cadherin-2 isoform X1 [KO:K06736]
110327227  Ncam1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
110329638  Ncam2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
110313446  L1cam; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
110328543  Cadm1; cell adhesion molecule 1 isoform X1 [KO:K06781]
110320074  Negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
110319931  Ntng1; netrin-G1 isoform X1 [KO:K07522]
110318921  Lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
110318092  Ntng2; netrin-G2 isoform X1 [KO:K16359]
110316627  Lrrc4; leucine-rich repeat-containing protein 4 [KO:K16351]
110322814  Ptprf; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
110327828  Lrrc4b; leucine-rich repeat-containing protein 4B [KO:K16360]
110324352  Sdc1; syndecan-1 isoform X1 [KO:K06257]
110334725  Sdc2; syndecan-2 [KO:K16336]
110323105  Sdc3; syndecan-3 [KO:K16337]
110318807  Sdc4; syndecan-4 [KO:K16338]
110318229  Itgav; integrin alpha-V isoform X1 [KO:K06487]
110324417  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
110317810  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
110324936  Nrxn3; neurexin 3 isoform X1 [KO:K07377]
110328701  Nrxn2; neurexin-2-beta isoform X1 [KO:K07377]
110335619  Nrxn1; neurexin-1 isoform X1 [KO:K07377]
110331101  Nlgn2; neuroligin-2 isoform X1 [KO:K07378]
110313442  Nlgn3; neuroligin-3 isoform X1 [KO:K07378]
110320059  Nlgn1; neuroligin-1 isoform X1 [KO:K07378]
110321796  Cadm3; cell adhesion molecule 3 isoform X1 [KO:K06780]
110324782  Nrcam; neuronal cell adhesion molecule isoform X1 [KO:K06756]
110334620  Cntn1; contactin-1 [KO:K06759]
110336078  Ptprm; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
110321338  Cntn2; contactin-2 [KO:K06760]
110322514  Nfasc; neurofascin isoform X1 [KO:K06757]
110331961  Cntnap1; contactin-associated protein 1 [KO:K07379]
110316798  Cntnap2; contactin-associated protein-like 2 [KO:K07380]
110321573  Mpzl1; myelin protein zero-like protein 1 isoform X1 [KO:K06770]
110321906  Mpz; myelin protein P0 [KO:K06770]
110321770  Mag; myelin-associated glycoprotein isoform X1 [KO:K06771]
110337432  Cdh1; cadherin-1 isoform X1 [KO:K05689]
110328863  Vcan; versican core protein isoform X1 [KO:K06793]
110317477  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
110337298  Cdh3; cadherin-3 isoform X1 [KO:K06796]
110317778  Cdh4; cadherin-4 isoform X1 [KO:K06797]
110337562  Cdh15; cadherin-15 [KO:K06809]
110328212  Neo1; neogenin isoform X1 [KO:K06766]
Reference
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
mpah04520  Adherens junction
mpah04530  Tight junction
mpah04610  Complement and coagulation cascades
mpah04660  T cell receptor signaling pathway
mpah04670  Leukocyte transendothelial migration
KO pathway
ko04514   
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