KEGG   PATHWAY: nsu04151
Entry
nsu04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Neomonachus schauinslandi (Hawaiian monk seal)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
nsu04151  PI3K-Akt signaling pathway
nsu04151

Other DBs
GO: 0043491
Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110575510  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
110588715  TGFA; protransforming growth factor alpha [KO:K08774]
110591375  EREG; proepiregulin [KO:K09784]
110591506  AREG; amphiregulin [KO:K09782]
110590990  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110573062  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
110588038  FGF18; fibroblast growth factor 18 [KO:K04358]
110588591  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110581035  FGF6; fibroblast growth factor 6 [KO:K04358]
110589506  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
110576064  FGF4; fibroblast growth factor 4 [KO:K04358]
110583827  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110591486  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110570244  FGF9; fibroblast growth factor 9 [KO:K04358]
110576213  FGF3; fibroblast growth factor 3 [KO:K04358]
110584236  FGF20; fibroblast growth factor 20 [KO:K04358]
110578384  FGF16; fibroblast growth factor 16 [KO:K04358]
110586488  FGF10; fibroblast growth factor 10 [KO:K04358]
110593959  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
110576212  FGF19; fibroblast growth factor 19 [KO:K22603]
110572846  FGF21; LOW QUALITY PROTEIN: fibroblast growth factor 21 [KO:K22429]
110581002  FGF23; fibroblast growth factor 23 [KO:K22428]
110580497  NGF; beta-nerve growth factor [KO:K02582]
110576669  BDNF; brain-derived neurotrophic factor [KO:K04355]
110580991  NTF3; neurotrophin-3 [KO:K04356]
110572858  NTF4; neurotrophin-4 [KO:K12457]
110576080  INS; insulin [KO:K04526]
110578055  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110576079  IGF2; insulin-like growth factor II [KO:K13769]
110571958  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110578163  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110588527  PDGFC; platelet-derived growth factor C [KO:K05450]
110586385  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110580319  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110577997  KITLG; kit ligand [KO:K05461]
110572873  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110581991  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110575938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
110571448  PGF; placenta growth factor isoform X2 [KO:K16859]
110584200  VEGFC; vascular endothelial growth factor C [KO:K05449]
110572650  VEGFD; vascular endothelial growth factor D [KO:K05449]
110580160  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110578785  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
110584268  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
110579420  ANGPT4; angiopoietin-4 [KO:K05467]
110590694  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
110573487  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
110594092  EFNA2; ephrin-A2 [KO:K05462]
110573566  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
110573567  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
110586138  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
110593961  neurturin [KO:K25414]
123323821  neurturin [KO:K25414]
110578833  ARTN; artemin [KO:K25415]
110594058  PSPN; persephin [KO:K25416]
110592687  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110593180  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X5 [KO:K05083] [EC:2.7.10.1]
110577757  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110592019  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
110573154  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110592729  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110569786  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110588399  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110593102  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110573455  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123323631  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
110569991  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
110593671  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110572370  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110590873  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110586749  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110590120  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110590818  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110570275  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110570210  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110580280  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110590753  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110588887  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110572635  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
110575141  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110589447  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110572604  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110590530  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110587156  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110582206  HRAS; GTPase HRas isoform X1 [KO:K02833]
123323805  GTPase HRas-like [KO:K02833]
110580861  KRAS; GTPase KRas isoform X1 [KO:K07827]
110580342  NRAS; GTPase NRas [KO:K07828]
110584928  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110584045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110593734  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110589825  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110578336  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110574308  IRS1; insulin receptor substrate 1 [KO:K16172]
110588386  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
110588474  TLR2; toll-like receptor 2 [KO:K10159]
110581529  TLR4; toll-like receptor 4 [KO:K10160]
110572663  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110584304  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
110589861  CD19; B-lymphocyte antigen CD19 [KO:K06465]
110589313  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
110570393  somatotropin [KO:K05438]
110586744  PRL; prolactin isoform X1 [KO:K05439]
110592544  OSM; oncostatin-M [KO:K05418]
110573034  IL2; interleukin-2 [KO:K05429]
110591202  interleukin-3-like [KO:K04736]
110580018  IL6; interleukin-6 isoform X1 [KO:K05405]
110590985  IL4; interleukin-4 [KO:K05430]
110579061  IL7; interleukin-7 isoform X1 [KO:K05431]
123326492  interferon alpha-1/2-like [KO:K05414]
123326498  interferon alpha-like [KO:K05414]
110587126  LOW QUALITY PROTEIN: interferon alpha [KO:K05414]
110587131  interferon alpha-16-like [KO:K05414]
110587130  IFNB1; interferon beta [KO:K05415]
110571877  EPO; erythropoietin [KO:K05437]
110593135  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
110589921  GHR; growth hormone receptor [KO:K05080]
110586008  PRLR; prolactin receptor isoform X1 [KO:K05081]
110589867  OSMR; oncostatin-M-specific receptor subunit beta isoform X4 [KO:K05057]
110586503  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
110578110  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
110572174  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
110573377  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
110589743  interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
123323761  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
110586033  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
110570024  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
110570027  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
110593765  EPOR; erythropoietin receptor [KO:K05079]
110574902  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
110571840  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110584421  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
110574431  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110579928  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110593078  COL1A1; collagen alpha-1(I) chain [KO:K06236]
110593502  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
110574310  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
110574312  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
110570517  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
110585841  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
110585858  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
110570444  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
110584443  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
110570657  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
110570658  collagen alpha-4(VI) chain-like [KO:K06238]
110570750  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
110570948  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
110571035  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
110582103  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
110575423  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
110583252  LAMA2; laminin subunit alpha-2 [KO:K05637]
110576957  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
110569873  LAMA5; laminin subunit alpha-5 [KO:K06240]
110576845  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
110583696  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
110574287  LAMB1; laminin subunit beta-1 [KO:K05636]
110577559  LAMB2; laminin subunit beta-2 [KO:K06243]
110574097  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
110574288  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
110574201  LAMC1; laminin subunit gamma-1 [KO:K05635]
110574114  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
110581544  LAMC3; laminin subunit gamma-3 [KO:K06247]
110593282  CHAD; chondroadherin [KO:K06248]
110574240  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110585587  THBS1; thrombospondin-1 [KO:K16857]
110574410  cartilage oligomeric matrix protein [KO:K04659]
110589275  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
110583019  THBS2; thrombospondin-2 [KO:K04659]
110573481  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
110592312  FN1; fibronectin isoform X1 [KO:K05717]
110591433  SPP1; osteopontin isoform X2 [KO:K06250]
110592960  VTN; vitronectin [KO:K06251]
110581363  TNC; tenascin [KO:K06252]
110574213  TNN; tenascin-N [KO:K06252]
110586907  TNXB; tenascin-X [KO:K06252]
110573994  TNR; tenascin-R isoform X1 [KO:K06252]
110580753  VWF; von Willebrand factor [KO:K03900]
110591437  LOW QUALITY PROTEIN: bone sialoprotein 2 [KO:K06253]
110585214  ITGA1; integrin alpha-1 [KO:K06480]
110589982  ITGA2; integrin alpha-2 [KO:K06481]
110573267  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
110592861  ITGA3; integrin alpha-3 [KO:K06482]
110592014  ITGA4; integrin alpha-4 [KO:K06483]
110577463  ITGA5; integrin alpha-5 [KO:K06484]
110592022  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
110577746  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
110586470  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
110569664  ITGA9; integrin alpha-9 [KO:K06585]
110578563  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
110583735  ITGA11; integrin alpha-11 [KO:K06587]
110592349  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
110576795  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
110570379  ITGB3; integrin beta-3 [KO:K06493]
110581886  ITGB4; integrin beta-4 [KO:K06525]
110582565  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
110591806  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
110577390  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
110580084  ITGB8; integrin beta-8 [KO:K06591]
110579255  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110589522  F2R; proteinase-activated receptor 1 [KO:K03914]
110575918  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
110582928  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
110581471  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
110574387  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
110580413  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
110579030  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
110580922  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
110579771  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
110575102  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110571879  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110581074  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110582429  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110583964  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110590624  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
110575905  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110586041  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110590844  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
110580660  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110575312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
110593950  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110572795  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110588574  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
110581444  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110582181  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
110580003  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110583870  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
110587626  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
110588681  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
110571845  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110588033  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123323680  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110579839  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
110592985  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
110574259  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
110584628  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
110584669  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
110587808  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
110593994  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110575074  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
110586258  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110589233  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
110581464  TSC1; hamartin isoform X1 [KO:K07206]
110588066  tuberin [KO:K07207]
123323688  tuberin-like [KO:K07207]
110582977  RHEB; GTP-binding protein Rheb [KO:K07208]
110587851  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
110575132  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
110572566  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110573083  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110580681  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110585545  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
110572118  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
110576039  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
110592787  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110577385  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
110571790  40S ribosomal protein S6-like [KO:K02991]
110582265  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
110578445  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
110573840  RPS6; 40S ribosomal protein S6 [KO:K02991]
110570410  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110593674  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
110580296  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
110581884  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
110583655  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
110579369  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
110579077  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110584791  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
110579864  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
110578501  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
110591313  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110584068  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110586118  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
110572998  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
110588530  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
110569697  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
110591291  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
110592690  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
110570835  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
110585176  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
110579038  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
110574100  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
110580711  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
110582173  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
110590730  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
110575958  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
110571677  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
110578653  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
110581943  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
110571680  HSP90AA1; heat shock protein HSP 90-alpha isoform X2 [KO:K04079]
110577902  HSP90B1; LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
110593685  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
110573504  CRTC2; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2 [KO:K16333]
110592201  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
110577010  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
110571757  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
110571756  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
110574079  MTCP1; protein p13 MTCP-1 [KO:K16837]
110582947  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110573207  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
110582720  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110580940  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
110572856  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
110569843  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
110585155  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
110592291  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
110573191  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
110573213  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
110578930  MYC; myc proto-oncogene protein [KO:K04377]
110576391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110575681  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110580846  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
110577806  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
110577858  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110579972  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110580853  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110582036  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110590303  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
110579138  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
110583686  FOXO3; forkhead box protein O3 [KO:K09408]
110594280  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
110574012  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110587324  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
110585121  14-3-3 protein beta/alpha-like [KO:K16197]
110583204  14-3-3 protein zeta/delta-like [KO:K16197]
110579154  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
110579297  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
110587533  YWHAQ; 14-3-3 protein theta [KO:K16197]
110592805  YWHAE; 14-3-3 protein epsilon [KO:K06630]
110589853  YWHAG; 14-3-3 protein gamma [KO:K16198]
110592574  YWHAH; 14-3-3 protein eta [KO:K16198]
110575945  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110579449  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110577152  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
110574689  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
110592296  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
110592390  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110578169  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110581463  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X2 [KO:K09048]
110582887  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
110575757  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
110593955  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110573501  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
110580150  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
110586851  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
110577896  LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
110578602  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
110581628  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
110593540  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
110574194  IKBKG; NF-kappa-B essential modulator [KO:K07210]
110589216  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110573165  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110575986  RELA; transcription factor p65 [KO:K04735]
110572155  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110583260  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
110570608  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110584444  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
nsu00010  Glycolysis / Gluconeogenesis
nsu04010  MAPK signaling pathway
nsu04012  ErbB signaling pathway
nsu04062  Chemokine signaling pathway
nsu04064  NF-kappa B signaling pathway
nsu04068  FoxO signaling pathway
nsu04110  Cell cycle
nsu04115  p53 signaling pathway
nsu04150  mTOR signaling pathway
nsu04210  Apoptosis
nsu04370  VEGF signaling pathway
nsu04510  Focal adhesion
nsu04620  Toll-like receptor signaling pathway
nsu04630  JAK-STAT signaling pathway
nsu04662  B cell receptor signaling pathway
nsu04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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