KEGG   PATHWAY: opi05417
Entry
opi05417                    Pathway                                
Name
Lipid and atherosclerosis - Ochotona princeps (American pika)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
opi05417  Lipid and atherosclerosis
opi05417

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101518778  APOB; apolipoprotein B-100 [KO:K14462]
101525990  APOA4; apolipoprotein A-IV [KO:K08760]
101526234  APOA1; apolipoprotein A-I [KO:K08757]
101522903  LDLR; low-density lipoprotein receptor [KO:K12473]
101526360  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101527019  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
101527643  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101525255  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101535305  transforming protein RhoA-like isoform X1 [KO:K04513]
101533973  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101520691  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101517703  BAX; apoptosis regulator BAX [KO:K02159]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101518143  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101517543  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101531538  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101528189  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
101520990  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101526579  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101522956  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101526084  CD40LG; CD40 ligand [KO:K03161]
101533768  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
101531516  cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101531357  cytochrome P450 2J1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101535661  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101535940  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
101520179  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101524956  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
105941756  cytochrome b-245 light chain [KO:K08009]
101522690  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101533751  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101527518  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101517070  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101518245  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101528287  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101532470  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101535581  cell division control protein 42 homolog [KO:K04393]
101517343  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101518825  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101526067  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101528497  C-C motif chemokine 2 [KO:K14624]
101533287  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101535726  CXCL8; interleukin-8 [KO:K10030]
101517788  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101519949  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101525120  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101525684  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101524339  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101524571  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101531636  HRAS; GTPase HRas [KO:K02833]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101524465  NRAS; GTPase NRas [KO:K07828]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101525427  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101530066  RELA; transcription factor p65 [KO:K04735]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101532543  LOW QUALITY PROTEIN: P-selectin [KO:K06496]
101536660  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101528146  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101532937  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101528938  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101529213  IL1B; interleukin-1 beta [KO:K04519]
101531329  IL6; interleukin-6 precursor [KO:K05405]
101525561  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101526281  HSPD1; 60 kDa heat shock protein, mitochondrial isoform X1 [KO:K04077] [EC:5.6.1.7]
101520309  60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101520225  heat shock 70 kDa protein 1 isoform X1 [KO:K03283]
101520474  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
101517130  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
101517817  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101526653  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101516749  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
101524887  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101524703  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101523562  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
101525047  HSP90B1; endoplasmin [KO:K09487]
101523730  TLR2; toll-like receptor 2 [KO:K10159]
101534959  lipopolysaccharide-binding protein [KO:K05399]
101535206  lipopolysaccharide-binding protein-like [KO:K05399]
101522877  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101517656  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
101536535  TLR4; toll-like receptor 4 [KO:K10160]
101536280  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101524248  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
101526929  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101523491  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101518298  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101519619  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101517735  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101533713  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101536073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101517015  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101535976  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101536420  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101535341  TIR domain-containing adapter molecule 2 [KO:K05409]
101530235  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101522714  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101523168  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
101529840  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101524998  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101529588  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101524697  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101519172  IRF7; interferon regulatory factor 7 [KO:K09447]
101528748  IRF3; interferon regulatory factor 3 [KO:K05411]
101532843  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
101533081  interferon alpha-1/13-like [KO:K05414]
101533318  IFNB1; interferon beta [KO:K05415]
101516681  CD36; platelet glycoprotein 4 [KO:K06259]
101533802  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101530642  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101533583  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101523534  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
101531240  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101527700  PTK2; focal adhesion kinase 1 isoform X21 [KO:K05725] [EC:2.7.10.2]
101530917  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101531375  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101523885  VAV1; proto-oncogene vav [KO:K05730]
101522853  TLR6; toll-like receptor 6 [KO:K10169]
101516340  RAP1A; ras-related protein Rap-1A [KO:K04353]
101518056  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101524583  CCL5; C-C motif chemokine 5 [KO:K12499]
101523213  C-C motif chemokine 3-like [KO:K05408]
101534565  C-C motif chemokine 3 [KO:K05408]
101521831  growth-regulated protein homolog gamma-like [KO:K05505]
101534748  growth-regulated protein homolog gamma-like [KO:K05505]
101534993  growth-regulated protein homolog gamma-like [KO:K05505]
101518190  IL12A; interleukin-12 subunit alpha [KO:K05406]
101520638  interleukin-12 subunit beta-like [KO:K05425]
101523854  IL12B; interleukin-12 subunit beta [KO:K05425]
101533498  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101536496  IL18; interleukin-18 [KO:K05482]
101516293  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101524018  ATF6; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101525099  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101531732  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101524859  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101519593  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101528216  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11 [KO:K04515] [EC:2.7.11.17]
101524356  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
101535936  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101527487  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101522715  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101521567  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101526751  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101527835  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101530376  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101536694  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101516816  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
101522828  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
101522597  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101522554  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
101525933  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
101528473  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101533693  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101518851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101525829  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101536244  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101524349  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101524739  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101529337  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101520538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101520175  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101522293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
101516106  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101519171  CALML4; calmodulin-like protein 4 [KO:K02183]
101529054  CALML5; calmodulin-like protein 5 [KO:K02183]
101529298  CALML3; calmodulin-like protein 3 [KO:K02183]
101516467  CALM3; calmodulin-3 [KO:K02183]
101525028  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101520360  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101532074  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101516165  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101517961  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101522735  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X3 [KO:K04721]
101530319  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101528266  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101521762  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101530204  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
101519014  cytochrome c, somatic [KO:K08738]
105941493  cytochrome c, testis-specific [KO:K08738]
105941968  cytochrome c-like [KO:K08738]
101526617  cytochrome c, somatic-like [KO:K08738]
101527226  cytochrome c, somatic-like [KO:K08738]
101517311  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
101526499  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101516136  caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
101516376  caspase-6-like [KO:K04396] [EC:3.4.22.59]
101531640  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101528295  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
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Related
pathway
opi04020  Calcium signaling pathway
opi04115  p53 signaling pathway
opi04141  Protein processing in endoplasmic reticulum
opi04151  PI3K-Akt signaling pathway
opi04210  Apoptosis
opi04620  Toll-like receptor signaling pathway
opi04621  NOD-like receptor signaling pathway
opi04668  TNF signaling pathway
opi04670  Leukocyte transendothelial migration
opi04975  Fat digestion and absorption
opi04979  Cholesterol metabolism
opi05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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