KEGG   PATHWAY: pgig04010
Entry
pgig04010                   Pathway                                
Name
MAPK signaling pathway - Pteropus giganteus (Indian flying fox)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pgig04010  MAPK signaling pathway
pgig04010

Other DBs
GO: 0000165
Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120618508  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
120599733  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120607351  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120606299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120617592  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120587067  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
120588958  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
120620209  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120602993  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120619319  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
120591750  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
120582393  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
120606296  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
120607171  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
120611206  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
120614654  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
120618213  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
120596875  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
120600168  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
120614863  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
120584533  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
120600066  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
120600150  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
120616490  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
120616483  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
120616497  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
120583269  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120618485  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120600384  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120584534  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120616484  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120615752  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
120583204  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120618548  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120591098  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120606631  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
120609542  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120594548  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120596960  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120599359  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
120612491  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
120587204  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
120600706  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
120621790  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
120596314  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K12363]
120613457  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
120620932  NF1; neurofibromin isoform X1 [KO:K08052]
120612507  RASA1; ras GTPase-activating protein 1 [KO:K04352]
120582154  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
120585025  RAP1A; ras-related protein Rap-1A [KO:K04353]
120605040  RAP1B; ras-related protein Rap-1b [KO:K07836]
120591156  EGF; pro-epidermal growth factor [KO:K04357]
120594411  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
120587961  EREG; proepiregulin [KO:K09784]
120587962  AREG; amphiregulin [KO:K09782]
120581479  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120616271  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120591936  FGF16; fibroblast growth factor 16 [KO:K04358]
120602936  FGF9; fibroblast growth factor 9 [KO:K04358]
120614279  FGF10; fibroblast growth factor 10 [KO:K04358]
120614873  FGF18; fibroblast growth factor 18 [KO:K04358]
120583667  FGF22; fibroblast growth factor 22 [KO:K04358]
120583832  FGF20; fibroblast growth factor 20 [KO:K04358]
120606452  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120584645  FGF4; fibroblast growth factor 4 [KO:K04358]
120607305  FGF6; fibroblast growth factor 6 [KO:K04358]
120588259  FGF5; fibroblast growth factor 5 [KO:K04358]
120609690  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120623126  FGF7; fibroblast growth factor 7 [KO:K04358]
120584636  FGF19; fibroblast growth factor 19 [KO:K22603]
120606965  FGF21; fibroblast growth factor 21 [KO:K22429]
120607306  FGF23; fibroblast growth factor 23 [KO:K22428]
120585075  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
120605221  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
120611625  NTF3; neurotrophin-3 [KO:K04356]
120606989  NTF4; LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
120584612  INS; insulin [KO:K04526]
120614955  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120584609  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120615920  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120603004  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
120613440  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120599685  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
120584998  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120607273  KITLG; kit ligand isoform X1 [KO:K05461]
120615548  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
120596132  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
120600634  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120619506  PGF; placenta growth factor isoform X1 [KO:K16859]
120618403  VEGFC; vascular endothelial growth factor C [KO:K05449]
120611103  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
120591565  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
120595559  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
120614411  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
120603492  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
120590791  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
120592138  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
120592189  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
120592258  EFNA4; ephrin-A4 [KO:K05462]
120583690  EFNA2; ephrin-A2 [KO:K05462]
120586177  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
120615430  NRTN; neurturin [KO:K25414]
120615468  neurturin-like [KO:K25414]
120619427  ARTN; artemin [KO:K25415]
120615444  PSPN; persephin [KO:K25416]
120602477  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120611190  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120604897  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120587606  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
120595650  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120608860  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120582906  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120616553  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120588929  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120606120  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
120612943  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
120599285  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120587362  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120588066  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
120581545  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
120581540  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
120588075  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
120602461  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
120602420  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120592792  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
120616609  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120588082  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120601224  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120617099  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
120585765  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
120594602  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
120600272  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120604448  SOS2; son of sevenless homolog 2 [KO:K03099]
120621751  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120584662  HRAS; GTPase HRas isoform X1 [KO:K02833]
120618351  KRAS; GTPase KRas isoform X1 [KO:K07827]
120585069  NRAS; GTPase NRas isoform X1 [KO:K07828]
120615540  RRAS; ras-related protein R-Ras [KO:K07829]
120603233  RRAS2; ras-related protein R-Ras2 [KO:K07830]
120582129  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
120605533  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120601203  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120621476  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120604492  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120615382  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120591252  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
120606851  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120620121  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120583719  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
120620328  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
120594292  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
120595986  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120618267  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
120608284  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
120602997  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120605522  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120617947  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
120595433  MYC; myc proto-oncogene protein [KO:K04377]
120596153  SRF; serum response factor [KO:K04378]
120619517  FOS; proto-oncogene c-Fos [KO:K04379]
120589267  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
120595970  STMN1; stathmin isoform X1 [KO:K04381]
120617546  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
120622753  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
120622754  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
120622755  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
120622836  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
120618944  TNF; tumor necrosis factor [KO:K03156]
120593734  interleukin-1 alpha-like [KO:K04383]
120610305  IL1A; interleukin-1 alpha [KO:K04383]
120593744  IL1B; interleukin-1 beta [KO:K04519]
120586591  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
120619172  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120619522  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
120611633  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120584449  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
120593046  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
120597204  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120586804  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120617668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120609345  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120581412  CD14; monocyte differentiation antigen CD14 [KO:K04391]
120616613  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120614848  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120600327  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120596202  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120623059  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120618435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120599784  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120597636  DAXX; death domain-associated protein 6 [KO:K02308]
120586750  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
120605933  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
120618259  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120606104  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120583203  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120594128  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120583737  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
120603000  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
120589386  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
120610819  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
120621745  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
120584424  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
120596745  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
120590385  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
120592835  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120603711  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
120595596  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
120600826  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
120584101  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
120608191  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
120584643  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
120593428  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
120600282  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
120619461  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
120595736  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
120592593  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
120602239  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
120592996  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
120596953  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
120596161  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
120615779  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120595002  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120618266  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
120606767  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
120620109  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
120620992  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
120589749  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120598851  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120589895  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
120600014  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120606586  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
120602814  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
120620227  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
120614038  crk-like protein [KO:K04438]
120606834  CRKL; crk-like protein [KO:K04438]
120609335  LOW QUALITY PROTEIN: crk-like protein [KO:K04438]
120621033  CRK; adapter molecule crk isoform X1 [KO:K04438]
120607869  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
120590357  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
120616614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120609636  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120588349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120602825  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
120602826  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
120597571  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120597692  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120616106  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
120617932  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
120582400  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
120619775  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
120600689  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
120603442  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
120583821  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120593904  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120621837  JUN; transcription factor AP-1 [KO:K04448]
120606555  JUND; transcription factor jun-D [KO:K04449]
120597156  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120589680  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120604962  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
120612751  MAX; protein max isoform X1 [KO:K04453]
120612514  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
120591585  HSPB1; heat shock protein beta-1 [KO:K04455]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120603614  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
120605067  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
120604581  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
120619281  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
120615021  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
120613724  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120582418  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120584596  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120609105  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120610264  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120589064  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120607276  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
120605883  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
120619206  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120589194  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120617881  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
120621703  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
120618906  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
120618910  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
120618911  heat shock 70 kDa protein 1-like [KO:K03283]
120612399  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
120598778  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
120604478  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
120589838  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
120602137  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
120589252  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120609204  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120595665  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120605919  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120620948  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120609155  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
120584840  RELA; transcription factor p65 [KO:K04735]
120605283  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pgig04070  Phosphatidylinositol signaling system
pgig04110  Cell cycle
pgig04115  p53 signaling pathway
pgig04210  Apoptosis
pgig04310  Wnt signaling pathway
pgig04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system