Entry
Name
Salmonella infection - Salmo salar (Atlantic salmon)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Salmo salar (Atlantic salmon) [GN:
sasa ]
Gene
106579266 pleckstrin homology domain-containing family M member 1-like [KO:K23282 ]
106578308 putative pleckstrin homology domain-containing family M member 1P [KO:K23282 ]
106574734 vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
106592068 vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
106608270 vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
106571062 vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
100195256 vps41; vacuolar protein sorting 41 homolog (S. cerevisiae) [KO:K20184 ]
106610906 dync2li1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417 ]
106574038 FYVE and coiled-coil domain-containing protein 1-like [KO:K21954 ]
106597278 FYVE and coiled-coil domain-containing protein 1-like [KO:K21954 ]
106613556 FYVE and coiled-coil domain-containing protein 1-like [KO:K21954 ]
106572009 pleckstrin homology domain-containing family M member 2-like [KO:K15348 ]
106566865 pleckstrin homology domain-containing family M member 2-like [KO:K15348 ]
106586531 GRIP and coiled-coil domain-containing protein 2-like [KO:K20282 ]
106582210 GRIP and coiled-coil domain-containing protein 2-like [KO:K20282 ]
106582185 GRIP and coiled-coil domain-containing protein 2-like [KO:K20282 ]
106606541 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106604153 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106612274 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106610951 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106587593 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106586451 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106587602 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106564740 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
106576941 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
100194979 elmo1; engulfment and cell motility 1 (ced-12 homolog, C. elegans) [KO:K12366 ]
106583376 myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351 ]
100196342 mlrv; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
106585309 myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351 ]
106568026 myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756 ]
100196805 mlrb; Myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756 ]
106606900 mlc-2; myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758 ]
106580483 myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758 ]
106606735 RAC1; ras-related C3 botulinum toxin substrate 1-like [KO:K04392 ]
106589605 rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392 ]
106602952 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106609034 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106563594 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106563679 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106579509 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106591173 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106590445 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
106574678 arpc2; actin-related protein 2/3 complex subunit 2-like [KO:K05758 ]
106563156 ARPC3; actin-related protein 2/3 complex subunit 3-like [KO:K05756 ]
106565815 ARPC4; actin-related protein 2/3 complex subunit 4-like [KO:K05755 ]
106599093 ARPC5; actin-related protein 2/3 complex subunit 5-like [KO:K05754 ]
106562824 ARP5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
100196346 arpc5l; actin related protein 2/3 complex subunit 5 like [KO:K05754 ]
106598808 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
106568747 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
106576084 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289 ] [EC:2.7.1.153 ]
106572104 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289 ] [EC:2.7.1.153 ]
106609208 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289 ] [EC:2.7.1.153 ]
106561747 WASP homolog-associated protein with actin, membranes and microtubules-like [KO:K23612 ]
106581078 toll/interleukin-1 receptor domain-containing adapter protein-like [KO:K05403 ]
106590780 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
106594427 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
106607744 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
106571309 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
106613526 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like [KO:K12793 ]
106573999 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like [KO:K12793 ]
106590733 ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210 ]
106579390 nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727 ]
106605511 nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727 ]
106585935 nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727 ]
100136360 hsp90ab1; heat shock protein 90 alpha family class B member 1 [KO:K04079 ]
106600411 jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
106568625 myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377 ]
106575188 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
100196751 tnr1a; Tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
106567387 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
106562229 tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171 ]
106587422 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
106578371 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
106590519 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
106567553 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
106563139 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
106580524 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
106584955 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
106573461 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
106582385 ASC; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
106605228 ASC; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
106568745 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
sasa04621 NOD-like receptor signaling pathway
KO pathway
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