KEGG   PATHWAY: ocu05165
Entry
ocu05165                    Pathway                                
Name
Human papillomavirus infection - Oryctolagus cuniculus (rabbit)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
ocu05165  Human papillomavirus infection
ocu05165

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008606  [KO:K14754]
100008609  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100008642  [KO:K06485]
100008676  PKM; pyruvate kinase PKM isoform 1 [KO:K00873] [EC:2.7.1.40]
100008734  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100008735  ITGB3; integrin beta-3 precursor [KO:K06493]
100008806  [KO:K04361] [EC:2.7.10.1]
100008808  [KO:K04357]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100008886  [KO:K04505] [EC:3.4.23.-]
100008898  [KO:K05719]
100008899  [KO:K05448]
100008904  [KO:K04632]
100008956  [KO:K06487]
100008965  [KO:K04393]
100008982  SPP1; osteopontin precursor [KO:K06250]
100008997  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
100009005  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
100009013  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100009024  TLR3; toll-like receptor 3 precursor [KO:K05401]
100009030  WNT11; protein Wnt-11 [KO:K01384]
100009033  [KO:K00312]
100009036  [KO:K10151]
100009037  [KO:K06624]
100009038  [KO:K10152]
100009039  [KO:K02089] [EC:2.7.11.22]
100009040  [KO:K02091] [EC:2.7.11.22]
100009081  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100009128  VTN; vitronectin precursor [KO:K06251]
100009139  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100009141  ITGB8; integrin beta-8 precursor [KO:K06591]
100009165  VWF; von Willebrand factor precursor [KO:K03900]
100009172  [KO:K06484]
100009196  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100009215  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100009216  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100009221  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100009227  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
100009248  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100009252  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100009260  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100009300  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009381  WNT5A; protein Wnt-5a precursor [KO:K00444]
100009388  [KO:K06243]
100009434  [KO:K11584]
100009451  [KO:K14754]
100009533  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100009538  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100101587  [KO:K06525]
100101621  [KO:K06481]
100125982  [KO:K02154]
100125983  [KO:K02154]
100125985  [KO:K02105]
100126569  WNT2; protein Wnt-2 precursor [KO:K00182]
100134864  [KO:K06626]
100134865  [KO:K02206] [EC:2.7.11.22]
100134866  CCNA2; cyclin-A2 [KO:K06627]
100134867  [KO:K06626]
100301551  TNC; tenascin isoform X1 [KO:K06252]
100303773  [KO:K00408]
100328589  FN1; fibronectin isoform X1 [KO:K05717]
100328616  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100328617  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
100328724  IRF1; interferon regulatory factor 1 [KO:K09444]
100328760  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100328967  [KO:K06751]
100337729  [KO:K11643] [EC:5.6.2.-]
100337822  [KO:K00922] [EC:2.7.1.153]
100337888  [KO:K03171]
100337904  [KO:K08957] [EC:2.7.11.1]
100337990  [KO:K09091]
100338097  [KO:K05131]
100338232  [KO:K06589]
100338437  [KO:K06237]
100338604  [KO:K05130]
100338695  [KO:K07206]
100338822  [KO:K06751]
100338850  [KO:K07205]
100338915  [KO:K08131]
100339216  [KO:K02620]
100339253  [KO:K12076]
100339336  [KO:K02353]
100339544  [KO:K02329]
100339551  [KO:K06052]
100339625  [KO:K06585]
100339765  [KO:K04385]
100339815  [KO:K05631]
100339821  [KO:K06751]
100339915  [KO:K06238]
100339977  [KO:K16332]
100340248  [KO:K06586]
100340417  [KO:K06238]
100340471  [KO:K04490]
100340603  PALS1; protein PALS1 [KO:K06091]
100340619  [KO:K04498] [EC:2.3.1.48]
100340815  [KO:K08131]
100340928  [KO:K09091]
100340947  [KO:K09087]
100341367  [KO:K02147]
100341508  [KO:K02153]
100341603  [KO:K06249] [EC:3.4.21.-]
100342046  [KO:K14021]
100342099  [KO:K02354]
100342212  [KO:K04345] [EC:2.7.11.11]
100342365  [KO:K04681]
100342500  [KO:K04364]
100342711  [KO:K06480]
100342825  [KO:K10587] [EC:2.3.2.26]
100342852  [KO:K04456] [EC:2.7.11.1]
100342870  [KO:K00714]
100342872  [KO:K05089] [EC:2.7.10.1]
100342905  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
100342931  [KO:K05415]
100343130  [KO:K09048]
100343365  [KO:K03120]
100343400  [KO:K20996]
100343819  [KO:K20994]
100343886  [KO:K02148]
100343893  [KO:K11220]
100343910  [KO:K04659]
100343947  [KO:K06238]
100344073  [KO:K04389]
100344241  [KO:K07828]
100344251  [KO:K06587]
100344394  [KO:K02376]
100344425  [KO:K06253]
100344432  [KO:K04693]
100344467  [KO:K11221]
100344482  [KO:K04393]
100344527  [KO:K02153]
100344622  [KO:K11219] [EC:2.7.10.2]
100344717  [KO:K09091]
100345030  [KO:K04237]
100345181  [KO:K00922] [EC:2.7.1.153]
100345250  [KO:K02649]
100345475  [KO:K09048]
100345503  [KO:K08957] [EC:2.7.11.1]
100345545  [KO:K02148]
100345650  [KO:K06061]
100345803  [KO:K02842]
100345988  [KO:K12075]
100346005  [KO:K06583]
100346103  [KO:K06483]
100346106  [KO:K03158]
100346323  [KO:K04632]
100346391  [KO:K03099]
100346517  [KO:K06053]
100346886  [KO:K06240]
100346981  [KO:K03120]
100346997  [KO:K11584]
100347324  [KO:K06252]
100347341  [KO:K06248]
100347345  [KO:K04371] [EC:2.7.11.24]
100347359  [KO:K11315]
100347407  [KO:K04366] [EC:2.7.11.1]
100347455  [KO:K05725] [EC:2.7.10.2]
100347487  [KO:K07827]
100347541  [KO:K02154]
100347598  [KO:K06236]
100347673  [KO:K02145] [EC:7.1.2.2]
100347710  [KO:K02155]
100348127  [KO:K02157]
100348286  [KO:K04354]
100348477  [KO:K04398] [EC:3.4.22.61]
100348489  [KO:K06625]
100348492  [KO:K07208]
100348561  [KO:K04371] [EC:2.7.11.24]
100348581  [KO:K08957] [EC:2.7.11.1]
100348584  [KO:K06069] [EC:2.7.11.13]
100348594  [KO:K06482]
100348663  [KO:K00922] [EC:2.7.1.153]
100348723  [KO:K02147]
100348842  [KO:K03083] [EC:2.7.11.26]
100348986  [KO:K00445]
100348995  [KO:K06751]
100349085  [KO:K06751]
100349185  [KO:K21098]
100349247  [KO:K06751]
100349299  [KO:K04728] [EC:2.7.11.1]
100349426  [KO:K02580]
100349557  [KO:K06093]
100349579  [KO:K00444]
100349589  [KO:K02152]
100349757  [KO:K06751]
100349847  [KO:K00182]
100349947  [KO:K03120]
100350157  [KO:K02146]
100350237  [KO:K02146]
100350430  [KO:K16857]
100350500  [KO:K05637]
100350521  [KO:K02235]
100350557  [KO:K06590]
100350591  [KO:K03062]
100350846  [KO:K10389]
100350868  [KO:K12236]
100350899  [KO:K06093]
100351097  [KO:K10389]
100351181  [KO:K06584]
100351316  [KO:K01357]
100351387  [KO:K05635]
100351426  [KO:K09088]
100351640  [KO:K07207]
100351669  [KO:K03661]
100351999  [KO:K05870]
100352205  [KO:K06053]
100352227  [KO:K01064]
100352404  [KO:K02151]
100352479  [KO:K08957] [EC:2.7.11.1]
100352594  [KO:K11217] [EC:2.7.10.2]
100352722  [KO:K20995]
100352785  [KO:K06627]
100352839  [KO:K01357]
100352919  [KO:K02375]
100353090  [KO:K01558]
100353305  [KO:K05760]
100353321  [KO:K06093]
100353383  [KO:K02150]
100353390  [KO:K05414]
100353410  [KO:K02144]
100353545  [KO:K11583]
100353546  [KO:K06588]
100353559  [KO:K01064]
100353706  [KO:K04456] [EC:2.7.11.1]
100353732  [KO:K14608]
100353976  [KO:K02085]
100354018  [KO:K03209]
100354124  [KO:K10691] [EC:2.3.2.27]
100354135  [KO:K04498] [EC:2.3.1.48]
100354167  [KO:K02150]
100354445  [KO:K09087]
100354455  [KO:K07211] [EC:2.7.11.10]
100354566  [KO:K02152]
100354583  [KO:K00312]
100354611  [KO:K06751]
100354654  [KO:K05414]
100354708  [KO:K06061]
100355092  [KO:K03456]
100355156  [KO:K06067] [EC:3.5.1.98]
100355159  [KO:K11583]
100355380  [KO:K06751]
100355669  [KO:K05414]
100355675  [KO:K02159]
100355680  [KO:K03062]
100355697  [KO:K00572]
100355758  [KO:K03456]
100355888  [KO:K04467] [EC:2.7.11.10]
100355912  [KO:K05414]
100355921  [KO:K05948] [EC:2.4.1.222]
100356164  [KO:K07203] [EC:2.7.11.1]
100356196  [KO:K08957] [EC:2.7.11.1]
100356242  [KO:K14608]
100356247  [KO:K14009]
100356305  [KO:K06252]
100356351  [KO:K06061]
100356368  [KO:K02432]
100356371  RLA-A3; MHC class I antigen-like precursor [KO:K06751]
100356380  [KO:K06092]
100356401  [KO:K07209] [EC:2.7.11.10]
100356419  [KO:K05414]
100356474  [KO:K06238]
100356580  [KO:K11583]
100356615  [KO:K03099]
100356678  [KO:K05414]
100356957  [KO:K17454]
100357137  [KO:K04659]
100357194  [KO:K05414]
100357231  [KO:K06252]
100357427  [KO:K06237]
100357431  [KO:K06618]
100357457  [KO:K05948] [EC:2.4.1.222]
100357482  [KO:K05637]
100357483  [KO:K09047]
100357708  [KO:K05414]
100357841  [KO:K02649]
100357876  [KO:K09048]
100357900  [KO:K06237]
100357933  [KO:K00714]
100357972  [KO:K04659]
100358175  [KO:K09048]
100358256  [KO:K06237]
100358367  [KO:K02353]
100358378  [KO:K04491]
100358389  [KO:K06627]
100358471  [KO:K07201]
100358522  [KO:K06237]
100358587  [KO:K02158]
100358679  [KO:K05636]
100358704  [KO:K06054]
100358716  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100358771  [KO:K05410] [EC:2.7.11.10]
100359014  [KO:K14754]
100359062  [KO:K06640] [EC:2.7.11.1]
100359083  [KO:K03174]
100359318  [KO:K02152]
103345292  [KO:K06247]
103345754  [KO:K06238]
103345790  [KO:K06094]
103346018  [KO:K02085]
103346208  [KO:K09087]
103346571  [KO:K05411]
103346639  [KO:K06090]
103347398  [KO:K06240]
103348146  [KO:K02151]
103348917  [KO:K02432]
103349793  [KO:K08131]
103350383  [KO:K06585]
103352372  [KO:K02375]
108176892  [KO:K06237]
108177458  [KO:K06241]
127482567  [KO:K06067] [EC:3.5.1.98]
127482719  [KO:K02599]
127484730  [KO:K04688] [EC:2.7.11.1]
127485184  [KO:K04735]
127485674  [KO:K02085]
127486116  [KO:K04456] [EC:2.7.11.1]
127486605  [KO:K02833]
127487218  [KO:K11315]
127487418  [KO:K06583]
127487420  [KO:K02206] [EC:2.7.11.22]
127488898  [KO:K06252]
127488906  [KO:K20996]
127488928  [KO:K11220]
127489175  [KO:K17454]
127489236  [KO:K07827]
127489271  [KO:K02353]
127489461  [KO:K04368] [EC:2.7.12.2]
127491150  [KO:K11221]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:26008697
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
  Authors
Pang CL, Thierry F
  Title
Human papillomavirus proteins as prospective therapeutic targets.
  Journal
Microb Pathog 58:55-65 (2013)
DOI:10.1016/j.micpath.2012.11.002
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:16259056
  Authors
Kim YT, Zhao M
  Title
Aberrant cell cycle regulation in cervical carcinoma.
  Journal
Yonsei Med J 46:597-613 (2005)
DOI:10.3349/ymj.2005.46.5.597
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
  Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
  Journal
Viruses 7:4734-55 (2015)
DOI:10.3390/v7082842
Reference
PMID:26289783
  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
  Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
  Journal
Sci Rep 5:13446 (2015)
DOI:10.1038/srep13446
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
  Journal
Nat Rev Cancer 12:877-86 (2012)
DOI:10.1038/nrc3400
Reference
PMID:19029942
  Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
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Related
pathway
ocu04064  NF-kappa B signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04310  Wnt signaling pathway
ocu04330  Notch signaling pathway
ocu04510  Focal adhesion
ocu04520  Adherens junction
ocu04530  Tight junction
ocu04612  Antigen processing and presentation
ocu04620  Toll-like receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
KO pathway
ko05165   

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