KEGG   PATHWAY: ncar05014
Entry
ncar05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Sciurus carolinensis (gray squirrel)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ncar05014  Amyotrophic lateral sclerosis
ncar05014

Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124980281  cellular tumor antigen p53 [KO:K04451]
124958768  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
124982226  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
124965545  apoptosis regulator Bcl-2 [KO:K02161]
124976128  bcl-2-like protein 1 isoform X1 [KO:K04570]
124966672  apoptosis regulator BAX isoform X1 [KO:K02159]
124958534  bcl2-associated agonist of cell death-like [KO:K02158]
124982341  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
124994683  cytochrome c, somatic-like [KO:K08738]
124991556  cytochrome c, somatic [KO:K08738]
124991711  cytochrome c, somatic-like [KO:K08738]
124979232  cytochrome c, somatic-like [KO:K08738]
124961943  cytochrome c, somatic-like [KO:K08738]
124962143  cytochrome c-like [KO:K08738]
124962144  cytochrome c-like [KO:K08738]
124962145  cytochrome c-like [KO:K08738]
124962146  cytochrome c-like [KO:K08738]
124970186  cytochrome c, somatic-like [KO:K08738]
124980035  cytochrome c, testis-specific [KO:K08738]
124965714  cytochrome c, somatic-like [KO:K08738]
124966493  caspase-9-like [KO:K04399] [EC:3.4.22.62]
124972492  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
124983898  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124992482  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
124960411  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
124965286  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
124993284  suppressor protein SRP40-like isoform X1 [KO:K03944]
124962734  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
124980697  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
124971899  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
124986769  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
124967150  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
124958341  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124989721  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124991046  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
124966837  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124972400  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124983813  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
124993505  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
124991763  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
124982312  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
124968718  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
124985829  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
124964968  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
124983572  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
124979118  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
124986398  LOW QUALITY PROTEIN: acyl carrier protein, mitochondrial-like [KO:K03955]
124970777  acyl carrier protein, mitochondrial-like [KO:K03955]
124972499  acyl carrier protein, mitochondrial-like [KO:K03955]
124968683  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
124983083  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
124967816  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
124977589  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
124990972  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
124980197  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
124992578  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
124992876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
124987541  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124982958  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124983344  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124964468  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
124968580  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
124984628  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
124962972  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
124970425  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
124971919  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
124979719  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
124994753  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
124958469  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
124987567  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
124992960  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
124987606  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
124968482  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
124958631  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
124994343  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
124981096  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
124960623  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
124986669  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
124994572  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
124961406  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
124958779  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
124967159  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
124976441  cytochrome c1, heme protein, mitochondrial [KO:K00413]
124993792  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
124985946  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
124969833  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
124976494  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
124960250  cytochrome b-c1 complex subunit 7 [KO:K00417]
124963228  cytochrome b-c1 complex subunit 7-like [KO:K00417]
124986976  cytochrome b-c1 complex subunit 8 [KO:K00418]
124991001  cytochrome b-c1 complex subunit 9 [KO:K00419]
124969484  cytochrome b-c1 complex subunit 10 [KO:K00420]
124977244  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
124967440  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
124977063  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
124959708  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
124963339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
124991034  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
124970560  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
124966941  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
124979836  cytochrome c oxidase subunit 6B1-like [KO:K02267]
124966431  cytochrome c oxidase subunit 6B1 [KO:K02267]
124984069  cytochrome c oxidase subunit 6C [KO:K02268]
124979038  cytochrome c oxidase subunit 6C-like [KO:K02268]
124961590  cytochrome c oxidase subunit 6C-like [KO:K02268]
124988296  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
124963329  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
124966433  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
124994104  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
124978951  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
124972073  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
124986386  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124986478  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124987029  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
124980275  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124980291  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124959872  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
124988623  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
124965845  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
124983743  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
124961688  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
124968690  ATP synthase subunit delta, mitochondrial [KO:K02134]
124978256  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
124984257  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
124994886  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
124961875  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
124979929  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
124980241  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
124983026  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
124958764  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
124980569  ATP synthase subunit d, mitochondrial [KO:K02138]
124993299  ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
124992905  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
124986880  voltage-dependent anion-selective channel protein 1 [KO:K05862]
124967586  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
124985084  mitochondrial import receptor subunit TOM40B [KO:K11518]
124980274  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
124985196  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
124983421  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
124987958  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
124962278  optineurin isoform X1 [KO:K19946]
124986635  sequestosome-1 [KO:K14381]
124960323  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
124977765  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
124962379  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
124966331  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
124983333  LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
124979950  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
124987577  WD repeat-containing protein 41 isoform X1 [KO:K23610]
124980778  guanine nucleotide exchange protein SMCR8 isoform X1 [KO:K23611]
124964945  guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
124985792  LOW QUALITY PROTEIN: ras-related protein Rab-8A-like [KO:K07901]
124969448  ras-related protein Rab-8A [KO:K07901]
124972087  ras-related protein Rab-39B [KO:K07925]
124963464  ras-related protein Rab-1A [KO:K07874]
124979992  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
124990355  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
124985429  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
124979750  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
124982613  autophagy-related protein 101 [KO:K19730]
124959733  autophagy-related protein 13 isoform X1 [KO:K08331]
124992972  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
124958674  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
124961355  beclin-2-like [KO:K08334]
124979174  beclin-1 isoform X1 [KO:K08334]
124992962  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
124977862  beclin 1-associated autophagy-related key regulator [KO:K17889]
124984919  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
124965428  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
124960149  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
124972994  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
124970455  WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
124980634  WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
124979695  alsin isoform X1 [KO:K04575]
124968730  ras-related protein Rab-5A [KO:K07887]
124970797  ras-related protein Rab-5A-like [KO:K07887]
124970154  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
124971456  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124992306  charged multivesicular body protein 2b [KO:K12192]
124989551  polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
124977421  spatacsin-like isoform X1 [KO:K19026]
124994051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124984768  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124982403  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124963548  calcineurin subunit B type 1 [KO:K06268]
124963939  calcineurin subunit B type 2 [KO:K06268]
124960390  ubiquilin-3-like [KO:K04523]
124963757  ubiquilin-4 [KO:K04523]
124964295  ubiquilin-1 isoform X1 [KO:K04523]
124972532  ubiquilin-2 [KO:K04523]
124964729  transitional endoplasmic reticulum ATPase [KO:K13525]
124995293  derlin-1 [KO:K11519]
124971341  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
124991689  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
124978206  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
124988985  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
124965646  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
124976222  proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
124964531  proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
124960605  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
124986978  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
124977179  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
124980525  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
124964184  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
124981343  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
124991378  LOW QUALITY PROTEIN: proteasome subunit beta type-2-like [KO:K02734] [EC:3.4.25.1]
124962291  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
124978282  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
124989624  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
124959256  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
124991795  26S proteasome regulatory subunit 7 [KO:K03061]
124975937  26S proteasome regulatory subunit 7-like [KO:K03061]
124977836  26S proteasome regulatory subunit 4 [KO:K03062]
124966865  26S proteasome regulatory subunit 6B [KO:K03063]
124977927  26S proteasome regulatory subunit 10B [KO:K03064]
124994866  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A-like [KO:K03065]
124995331  26S proteasome regulatory subunit 6A [KO:K03065]
124979791  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
124992732  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
124979673  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
124980991  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
124991897  26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
124960430  26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
124980492  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
124981390  26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
124968854  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
124967565  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
124958474  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
124982161  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
124973164  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
124975004  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
124980521  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
124966972  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
124964751  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
124976847  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
124973604  LOW QUALITY PROTEIN: proteasomal ubiquitin receptor ADRM1-like [KO:K06691]
124983588  26S proteasome complex subunit SEM1 [KO:K10881]
124972407  LOW QUALITY PROTEIN: histone deacetylase 6-like [KO:K11407] [EC:3.5.1.98]
124991957  TAR DNA-binding protein 43 isoform X1 [KO:K23600]
124970068  LOW QUALITY PROTEIN: RNA-binding protein FUS-like [KO:K13098]
124987063  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
124994243  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
124990988  heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741]
124970956  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
124980340  heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
124963255  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
124971648  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
124964578  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
124982220  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
124983350  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
124966627  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
124991022  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
124990900  LOW QUALITY PROTEIN: ataxin-2-like [KO:K23625]
124970572  ataxin-2-like protein isoform X1 [KO:K23625]
124986668  matrin-3 isoform X1 [KO:K13213]
124974590  LOW QUALITY PROTEIN: matrin-3-like [KO:K13213]
124977125  angiogenin-like [KO:K16631] [EC:3.1.27.-]
124964306  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
124979691  THO complex subunit 4 [KO:K12881]
124989034  serine/arginine-rich splicing factor 3 [KO:K12892]
124963439  serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
124958414  nuclear RNA export factor 1 [KO:K14284]
124971571  nuclear RNA export factor 2-like [KO:K14284]
124971577  nuclear RNA export factor 2-like [KO:K14284]
124971583  nuclear RNA export factor 3-like [KO:K14284]
124972280  nuclear RNA export factor 2-like [KO:K14284]
124972282  nuclear RNA export factor 2-like [KO:K14284]
124977508  NTF2-related export protein 1 [KO:K14285]
124971600  NTF2-related export protein 2 [KO:K14285]
124964918  mRNA export factor GLE1 [KO:K18723]
124961508  nucleoprotein TPR isoform X1 [KO:K09291]
124983460  nuclear pore complex protein Nup50-like [KO:K14295]
124989464  nuclear pore complex protein Nup153 [KO:K14296]
124960084  LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
124976202  mRNA export factor [KO:K14298]
124970957  protein SEC13 homolog [KO:K14004]
124965626  nucleoporin SEH1 isoform X1 [KO:K14299]
124961929  nuclear pore complex protein Nup133 [KO:K14300]
124984000  nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
124983006  nucleoporin Nup37 [KO:K14302]
124960492  nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
124980320  nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
124989632  nucleoporin Nup43 [KO:K14305]
124974141  LOW QUALITY PROTEIN: nucleoporin Nup43-like [KO:K14305]
124967126  nuclear pore glycoprotein p62-like [KO:K14306]
124972019  nucleoporin-62 C-terminal-like protein [KO:K14306]
124984931  nucleoporin p58/p45 [KO:K14307]
124994445  nucleoporin p54 isoform X1 [KO:K14308]
124967382  nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
124991721  nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
124964182  nucleoporin NUP188 [KO:K14311]
124986992  nuclear pore complex protein Nup155 [KO:K14312]
124980125  nucleoporin NUP35 isoform X1 [KO:K14313]
124988119  LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like [KO:K14314]
124971022  nuclear pore membrane glycoprotein 210-like [KO:K14314]
124986539  nucleoporin NDC1 isoform X1 [KO:K14315]
124989436  POM121-like protein 2 [KO:K14316]
124978052  LOW QUALITY PROTEIN: nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
124970283  nuclear envelope pore membrane protein POM 121C-like isoform X1 [KO:K14316]
124974415  putative POM121-like protein 1-like [KO:K14316]
124964284  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
124979624  LOW QUALITY PROTEIN: nuclear pore complex protein Nup88-like [KO:K14318]
124962933  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
124964042  probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
124990856  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
124964798  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
124976087  vesicle-associated membrane protein-associated protein B/C [KO:K10707]
124986518  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
124983170  LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein-like [KO:K04452]
124979930  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124991760  LOW QUALITY PROTEIN: uncharacterized protein LOC124991760 [KO:K09027]
124964641  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
124988565  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
124975124  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
124976810  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
124984025  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124988553  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
124965028  sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
124988890  tumor necrosis factor [KO:K03156]
124984003  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
124983857  tumor necrosis factor receptor superfamily member 1B-like isoform X1 [KO:K05141]
124988670  death domain-associated protein 6 [KO:K02308]
124980599  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
124981341  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
124988515  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
124989076  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124978202  mitogen-activated protein kinase 14-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124982485  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
124982486  LOW QUALITY PROTEIN: mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124991150  nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
124960609  copper chaperone for superoxide dismutase [KO:K04569]
124986561  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
124958491  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
124992895  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
124987590  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
124988541  epididymal secretory glutathione peroxidase-like isoform X1 [KO:K00432] [EC:1.11.1.9]
124988542  glutathione peroxidase 6-like isoform X1 [KO:K00432] [EC:1.11.1.9]
124976946  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
124959884  catalase [KO:K03781] [EC:1.11.1.6]
124981894  neurofilament light polypeptide [KO:K04572]
124983779  neurofilament medium polypeptide-like [KO:K04573]
124990122  neurofilament heavy polypeptide isoform X1 [KO:K04574]
124986524  profilin-3 [KO:K05759]
124992328  profilin-2 isoform X1 [KO:K05759]
124980465  profilin-1 [KO:K05759]
124971472  profilin-2-like [KO:K05759]
124963744  profilin-4 [KO:K05759]
124958454  actin, muscle-like [KO:K05692]
124976675  actin, cytoplasmic 2-like [KO:K05692]
124984855  actin, cytoplasmic 1-like [KO:K05692]
124969779  actin, cytoplasmic 1 [KO:K05692]
124979796  actin, cytoplasmic 2 [KO:K05692]
124971792  actin, cytoplasmic 1-like [KO:K05692]
124982432  actin, cytoplasmic 1-like [KO:K05692]
124984763  annexin A11 isoform X1 [KO:K17095]
124985401  annexin A7 isoform X1 [KO:K17095]
124961723  kinesin-1 heavy chain [KO:K10396]
124979764  kinesin heavy chain [KO:K10396]
124982292  LOW QUALITY PROTEIN: kinesin heavy chain-like [KO:K10396]
124958444  kinesin light chain 2 isoform X1 [KO:K10407]
124988614  kinesin light chain 4 [KO:K10407]
124976841  kinesin light chain 1 isoform X1 [KO:K10407]
124966675  kinesin light chain 3 [KO:K10407]
124990413  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
124990575  tubulin alpha-3 chain [KO:K07374]
124990878  tubulin alpha-3 chain [KO:K07374]
124992512  tubulin alpha-1A chain-like [KO:K07374]
124978858  tubulin alpha-1D chain [KO:K07374]
124978859  tubulin alpha-4A chain [KO:K07374]
124961678  tubulin alpha-8 chain isoform X1 [KO:K07374]
124961964  tubulin alpha chain-like 3 [KO:K07374]
124982222  tubulin alpha-1B chain isoform X1 [KO:K07374]
124982223  tubulin alpha-1A chain [KO:K07374]
124982391  tubulin alpha-8 chain [KO:K07374]
124986665  tubulin beta chain-like [KO:K07375]
124988071  tubulin beta chain [KO:K07375]
124988155  tubulin beta-2A chain [KO:K07375]
124989446  tubulin beta-2A chain-like [KO:K07375]
124989671  tubulin beta-2B chain [KO:K07375]
124990586  tubulin beta chain-like [KO:K07375]
124968782  tubulin beta-4A chain [KO:K07375]
124978255  tubulin beta-1 chain [KO:K07375]
124964452  tubulin beta-4B chain [KO:K07375]
124965280  tubulin beta-5 chain [KO:K07375]
124966012  tubulin beta-3 chain [KO:K07375]
124963060  dynactin subunit 1 isoform X1 [KO:K04648]
124982924  LOW QUALITY PROTEIN: dynactin subunit 2-like [KO:K10424]
124964864  dynactin subunit 3 isoform X1 [KO:K10425]
124987220  dynactin subunit 4 [KO:K10426]
124970248  dynactin subunit 5 [KO:K10427]
124983775  dynactin subunit 6 isoform X1 [KO:K10428]
124985187  alpha-centractin [KO:K16575]
124963652  beta-centractin isoform X1 [KO:K16575]
124977628  actin-related protein 10 [KO:K16576]
124980080  huntingtin-associated protein 1-like isoform X1 [KO:K04647]
124987094  LOW QUALITY PROTEIN: dynein axonemal heavy chain 5-like [KO:K10408]
124988587  LOW QUALITY PROTEIN: dynein axonemal heavy chain 8-like [KO:K10408]
124991529  LOW QUALITY PROTEIN: dynein axonemal heavy chain 10-like [KO:K10408]
124991625  LOW QUALITY PROTEIN: dynein axonemal heavy chain 11-like [KO:K10408]
124968533  LOW QUALITY PROTEIN: dynein axonemal heavy chain 1-like [KO:K10408]
124978883  dynein axonemal heavy chain 17 [KO:K10408]
124969088  dynein axonemal heavy chain 12 [KO:K10408]
124962941  LOW QUALITY PROTEIN: dynein axonemal heavy chain 6-like [KO:K10408]
124970714  dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
124980287  dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
124980995  LOW QUALITY PROTEIN: dynein axonemal heavy chain 7-like [KO:K10408]
124981143  dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
124958810  axonemal dynein light intermediate polypeptide 1 [KO:K10410]
124964088  LOW QUALITY PROTEIN: dynein axonemal intermediate chain 1-like [KO:K10409]
124981414  dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
124977604  dynein axonemal light chain 1 [KO:K10411]
124983212  dynein axonemal light chain 4 [KO:K10412]
124958647  excitatory amino acid transporter 2 isoform X1 [KO:K05613]
124979775  nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
124986940  glutamate receptor 1 isoform X1 [KO:K05197]
124994514  glutamate receptor 2 isoform X1 [KO:K05198]
124964369  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
124970656  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A-like [KO:K05209]
124983215  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
124979849  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
124966828  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
124982587  LOW QUALITY PROTEIN: pro-neuregulin-1, membrane-bound isoform-like [KO:K05455]
124987119  pro-neuregulin-2, membrane-bound isoform isoform X1 [KO:K05456]
124985016  pro-neuregulin-3, membrane-bound isoform isoform X1 [KO:K05457]
124976125  pro-neuregulin-4, membrane-bound isoform-like isoform X1 [KO:K05458]
124979980  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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PMID:29299811
  Authors
Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A
  Title
Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1(G93A) Rodent Spinal Cord Tissue.
  Journal
Neurochem Res 44:228-233 (2019)
DOI:10.1007/s11064-017-2461-z
Reference
PMID:30242016
  Authors
Benarroch EE
  Title
Sigma-1 receptor and amyotrophic lateral sclerosis.
  Journal
Neurology 91:743-747 (2018)
DOI:10.1212/WNL.0000000000006347
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
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Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Related
pathway
ncar00190  Oxidative phosphorylation
ncar03013  Nucleocytoplasmic transport
ncar03050  Proteasome
ncar04010  MAPK signaling pathway
ncar04012  ErbB signaling pathway
ncar04020  Calcium signaling pathway
ncar04115  p53 signaling pathway
ncar04137  Mitophagy - animal
ncar04140  Autophagy - animal
ncar04141  Protein processing in endoplasmic reticulum
ncar04210  Apoptosis
ncar04724  Glutamatergic synapse
ncar04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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