KEGG   PATHWAY: umr05163
Entry
umr05163                    Pathway                                
Name
Human cytomegalovirus infection - Ursus maritimus (polar bear)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
umr05163  Human cytomegalovirus infection
umr05163

Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103672737  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103670250  TSC1; hamartin [KO:K07206]
103668779  TSC2; tuberin isoform X1 [KO:K07207]
103660943  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
103666660  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103659121  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103679516  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103667329  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103679680  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103677947  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103679584  RELA; transcription factor p65 [KO:K04735]
103674660  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103665736  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103671891  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103665409  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103669173  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K02833]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103669422  NRAS; GTPase NRas [KO:K07828]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103666919  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103675530  SP1; transcription factor Sp1 [KO:K04684]
103659655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
103665892  ITGB3; integrin beta-3 [KO:K06493]
103669776  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103676407  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103666008  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103657480  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
103663769  STING1; stimulator of interferon genes protein isoform X2 [KO:K12654]
103656833  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103657131  IRF3; interferon regulatory factor 3 [KO:K05411]
103662147  interferon alpha-1/2-like [KO:K05414]
103662148  interferon alpha-1/2-like [KO:K05414]
103662149  interferon alpha-2-like [KO:K05414]
103680385  interferon alpha-1/2-like [KO:K05414]
103680386  interferon alpha-1/2-like [KO:K05414]
103666985  interferon alpha-1/2-like [KO:K05414]
121103043  interferon alpha-1/2-like [KO:K05414]
103662150  IFNB1; interferon beta [KO:K05415]
103682322  TNF; tumor necrosis factor [KO:K03156]
103656234  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103664964  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103673673  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103672476  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
103675245  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103671495  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
103670641  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
103666055  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103667270  C-C motif chemokine 2 [KO:K14624]
103667294  CCL5; C-C motif chemokine 5 [KO:K12499]
103665307  CXCL8; interleukin-8 [KO:K10030]
103658871  IL6; interleukin-6 [KO:K05405]
103682042  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
103670041  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103656186  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103676121  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
103676755  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103672837  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103678196  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103661898  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103663109  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103681653  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
103657071  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103663361  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
103678657  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103658734  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103663028  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103682158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
103668461  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103658731  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
103660550  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
103663281  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103681813  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
103673552  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103674425  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103674426  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103679549  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121099746  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
103669597  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103665275  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103665553  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103670304  CALM1; calmodulin-1 isoform X1 [KO:K02183]
103682041  CALML6; calmodulin-like protein 6 [KO:K02183]
103676238  calmodulin [KO:K02183]
103676239  CALML3; calmodulin-like protein 3 [KO:K02183]
103671240  CALM2; calmodulin-2 [KO:K02183]
103679049  CALML4; calmodulin-like protein 4 isoform X3 [KO:K02183]
103657204  CALM3; calmodulin-3 [KO:K02183]
103673318  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103677943  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103667825  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103678534  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103671340  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103658473  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103669832  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103673717  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103679332  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103668648  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103658775  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103674803  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103675000  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
103673898  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
103674675  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103679250  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103671685  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103679331  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
103678826  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103675618  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103673916  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
103661704  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103668547  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103662972  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103682183  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103667298  C-C motif chemokine 3-like [KO:K05408]
103667297  C-C motif chemokine 3 [KO:K05408]
103667299  regakine-1-like [KO:K05408]
103667295  C-C motif chemokine 4 isoform X2 [KO:K12964]
103673762  CX3CL1; fractalkine [KO:K05508]
103669942  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103665670  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103680187  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
103680778  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11-like [KO:K12331]
103668671  ARHGEF11; rho guanine nucleotide exchange factor 11 [KO:K12331]
103680455  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11-like [KO:K12331]
103680621  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11-like [KO:K12331]
121104344  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11-like [KO:K12331]
103662491  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
103660053  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
103662842  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
103660117  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103680384  CTNNB1; catenin beta-1 [KO:K02105]
121102528  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
103672874  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
103663132  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
103664680  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
103670935  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
103670936  neuroendocrine secretory protein 55 [KO:K04632]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103671139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103661697  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103668717  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
103663059  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103672573  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
103664148  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103665687  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103674115  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103665451  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103665538  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103674004  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103659802  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103659593  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103676372  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103681679  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103668409  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103667087  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
103669052  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
103672393  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103658932  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103682282  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103667923  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103667676  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103668895  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103672914  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103675966  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103670589  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103662115  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103669230  CRKL; crk-like protein [KO:K04438]
103678355  PXN; paxillin isoform X1 [KO:K05760]
103662345  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
121099743  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
103662772  C-X-C chemokine receptor type 2 [KO:K05050]
103674891  C-C chemokine receptor type 1 isoform X1 [KO:K04176]
103674890  C-C chemokine receptor type 3 isoform X2 [KO:K04178]
103674885  CCR5; C-C chemokine receptor type 5 [KO:K04180]
103665513  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103665515  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103665491  tapasin [KO:K08058]
103673527  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103682146  CALR; calreticulin [KO:K08057]
103680441  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
103656357  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
103680561  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103672268  class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
103682344  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121104340  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103673380  B2M; beta-2-microglobulin [KO:K08055]
103666989  cyclin-dependent kinase 4 inhibitor B-like isoform X1 [KO:K06621]
103656869  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
103660368  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103665536  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103656694  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103658796  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103677688  RB1; retinoblastoma-associated protein [KO:K06618]
103674455  E2F1; transcription factor E2F1 [KO:K17454]
103666789  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
103678383  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
103668115  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103661934  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103671072  FADD; FAS-associated death domain protein [KO:K02373]
103659742  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
103675694  BID; BH3-interacting domain death agonist [KO:K04726]
103657107  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103665481  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103658902  cytochrome c [KO:K08738]
103662923  cytochrome c-like [KO:K08738]
121104237  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
103666628  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
103680991  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
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Related
pathway
umr00590  Arachidonic acid metabolism
umr03050  Proteasome
umr04010  MAPK signaling pathway
umr04064  NF-kappa B signaling pathway
umr04110  Cell cycle
umr04150  mTOR signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04210  Apoptosis
umr04612  Antigen processing and presentation
umr04623  Cytosolic DNA-sensing pathway
umr04630  JAK-STAT signaling pathway
umr04668  TNF signaling pathway
umr04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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