KEGG   PATHWAY: vpc04010
Entry
vpc04010                    Pathway                                
Name
MAPK signaling pathway - Vicugna pacos (alpaca)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
vpc04010  MAPK signaling pathway
vpc04010

Other DBs
GO: 0000165
Organism
Vicugna pacos (alpaca) [GN:vpc]
Gene
102529757  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102539072  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102538871  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102539274  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102526462  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102540844  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102538143  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X3 [KO:K04854]
102530879  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X4 [KO:K04855]
102530727  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102528399  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102532132  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102545991  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [KO:K04859]
102541000  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102539361  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102535867  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102537235  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
102532996  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
102529782  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
102542838  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102539501  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102526608  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
107033081  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102541675  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102544050  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
102542079  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
107035091  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102528179  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102534902  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102541926  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102526158  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102542323  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102536014  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
107033627  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107033717  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102540381  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
102525703  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102543544  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102538751  calcineurin subunit B type 2 [KO:K06268]
102541827  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102528807  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102538823  RASGRP1; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1 [KO:K04350]
102542043  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102539130  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102534549  RASGRP4; RAS guanyl-releasing protein 4 isoform X2 [KO:K12363]
102546108  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
102545985  NF1; neurofibromin isoform X1 [KO:K08052]
102534377  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102545882  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
102544212  RAP1A; ras-related protein Rap-1A [KO:K04353]
102535500  RAP1B; ras-related protein Rap-1b [KO:K07836]
102537002  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102525265  TGFA; protransforming growth factor alpha [KO:K08774]
102538529  EREG; proepiregulin [KO:K09784]
102534368  AREG; amphiregulin [KO:K09782]
102536166  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102536146  FGF2; fibroblast growth factor 2 [KO:K18497]
102540933  FGF9; fibroblast growth factor 9 [KO:K04358]
102540242  FGF10; fibroblast growth factor 10 [KO:K04358]
102526553  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102532219  FGF20; fibroblast growth factor 20 [KO:K04358]
102526479  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
102529965  FGF8; fibroblast growth factor 8 [KO:K04358]
102544431  FGF6; fibroblast growth factor 6 [KO:K04358]
102537184  FGF18; fibroblast growth factor 18 [KO:K04358]
116285447  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
102526357  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102541492  FGF3; fibroblast growth factor 3 [KO:K04358]
102540992  FGF19; fibroblast growth factor 19 [KO:K22603]
102545650  FGF21; fibroblast growth factor 21 [KO:K22429]
102542330  FGF23; fibroblast growth factor 23 [KO:K22428]
102536531  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102532564  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
102545739  NTF3; neurotrophin-3 isoform X4 [KO:K04356]
102528888  NTF4; neurotrophin-4 [KO:K12457]
116285510  INS; insulin [KO:K04526]
102527219  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102532626  IGF2; insulin-like growth factor II isoform X4 [KO:K13769]
102532201  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102530206  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102539007  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102541506  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102528464  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102546113  KITLG; kit ligand isoform X1 [KO:K05461]
102537904  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
102536403  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102536226  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102531220  PGF; placenta growth factor isoform X3 [KO:K16859]
102525139  VEGFD; vascular endothelial growth factor D [KO:K05449]
102543259  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102532383  HGF; hepatocyte growth factor [KO:K05460]
102525959  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102537175  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102533672  ANGPT4; angiopoietin-4 [KO:K05467]
116278622  EFNA2; ephrin-A2 [KO:K05462]
102532195  EFNA5; ephrin-A5 isoform X3 [KO:K05462]
102536251  ephrin-A2 [KO:K05462]
102526222  EFNA3; ephrin-A3 [KO:K05462]
102526483  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102525976  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
102532449  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
116285110  PSPN; persephin [KO:K25416]
102538051  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102539783  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102541044  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
102544772  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102531272  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
102535372  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102531487  FGFR3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
102531088  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102525766  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102543920  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102536840  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102544508  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
102535933  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102528303  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102545129  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102545389  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102528563  KIT; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
102530902  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102530642  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102527355  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102537256  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102538354  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
102536292  TEK; angiopoietin-1 receptor isoform X2 [KO:K05121] [EC:2.7.10.1]
102539688  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102542942  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102532895  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102541429  SOS2; son of sevenless homolog 2 [KO:K03099]
102543818  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102525363  HRAS; GTPase HRas isoform X1 [KO:K02833]
102529990  KRAS; GTPase KRas isoform X2 [KO:K07827]
102534785  NRAS; GTPase NRas [KO:K07828]
102526809  RRAS; ras-related protein R-Ras [KO:K07829]
102535239  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102538807  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102529339  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102528789  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102543308  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102530118  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102534668  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102527230  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102536713  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102528720  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102542385  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K04372] [EC:2.7.11.1]
102539391  MKNK1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
102534939  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102534734  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X3 [KO:K04373] [EC:2.7.11.1]
102527685  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
102541583  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102531881  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102542104  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102541072  MYC; myc proto-oncogene protein [KO:K04377]
102540796  serum response factor isoform X1 [KO:K04378]
102533186  FOS; proto-oncogene c-Fos [KO:K04379]
102528315  MAPT; microtubule-associated protein tau isoform X2 [KO:K04380]
102543909  STMN1; stathmin [KO:K04381]
102533803  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
102529727  PLA2G4E; LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102535790  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102529998  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
102534320  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102541924  TNF; tumor necrosis factor [KO:K03156]
102529843  IL1A; interleukin-1 alpha [KO:K04383]
102529565  IL1B; interleukin-1 beta [KO:K04519]
102539136  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
102543548  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102534848  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102544341  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102544667  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102545266  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
102526363  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102529547  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102536116  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102535267  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102528618  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102543993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102541733  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102545613  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102530757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102526687  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102541258  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102537793  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
102530608  DAXX; death domain-associated protein 6 [KO:K02308]
102527851  LOW QUALITY PROTEIN: death domain-associated protein 6-like [KO:K02308]
102538305  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102529835  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102544486  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102540938  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102529235  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
102540823  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102544589  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
102530894  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102534039  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102536738  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
102542485  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [KO:K04406] [EC:2.7.11.1]
102540315  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102534297  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
102543166  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102537616  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102534580  STK4; serine/threonine-protein kinase 4 [KO:K04411]
102535285  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
102537945  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102533792  MAP3K8; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102530799  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102539713  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102530654  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102540602  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102535753  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
102543177  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102536376  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102543112  MAP3K12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102534966  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
102528047  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
102533044  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
102544996  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102534059  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102524979  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102543879  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
102539798  TAOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
102532968  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102541172  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102525041  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102530139  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
102545165  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102529333  C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
102543578  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
102533572  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X4 [KO:K04436]
102543963  FLNA; filamin-A isoform X1 [KO:K04437]
102533491  CRKL; crk-like protein [KO:K04438]
102539935  CRK; adapter molecule crk isoform X1 [KO:K04438]
102536324  ARRB2; beta-arrestin-2 [KO:K04439]
102545544  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
102528221  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102543430  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102539859  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102525219  MAPK12; mitogen-activated protein kinase 12 isoform X7 [KO:K04441] [EC:2.7.11.24]
102531650  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102540698  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102541290  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102531617  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
102537860  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102525643  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X2 [KO:K04444] [EC:2.7.11.1]
102539832  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102540294  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
102543227  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102543250  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102529936  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102541687  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102542128  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102530959  TP53; cellular tumor antigen p53 [KO:K04451]
102526258  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102545898  MAX; protein max isoform X2 [KO:K04453]
102535279  MEF2C; myocyte-specific enhancer factor 2C isoform X9 [KO:K04454]
102526513  HSPB1; LOW QUALITY PROTEIN: heat shock protein beta-1 [KO:K04455]
102526860  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102546009  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102542031  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102530257  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
102532807  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102528189  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
102530396  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
102538892  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102525343  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102538133  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102539310  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102526577  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102536417  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102524980  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102530613  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102534455  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102527282  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102534108  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
102536516  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102533561  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
102544230  heat shock 70 kDa protein 1B [KO:K03283]
102538935  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
102526911  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
102545172  MECOM; histone-lysine N-methyltransferase MECOM isoform X5 [KO:K04462] [EC:2.1.1.367]
102532036  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102541255  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102529736  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102526769  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102534431  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102528824  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102541871  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102533857  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
102532161  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102543994  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
102540197  RELA; transcription factor p65 isoform X1 [KO:K04735]
102541891  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
vpc04070  Phosphatidylinositol signaling system
vpc04110  Cell cycle
vpc04115  p53 signaling pathway
vpc04210  Apoptosis
vpc04310  Wnt signaling pathway
vpc04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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