KEGG   PATHWAY: rno05168
Entry
rno05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Rattus norvegicus (rat)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05168  Herpes simplex virus 1 infection
rno05168

Disease
H00365  Herpes simplex virus infection
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100361294  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100910660  [KO:K12892]
100910669  Pilra; paired immunoglobin-like type 2 receptor alpha precursor [KO:K15411]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912314  [KO:K05414]
100912356  [KO:K05414]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114859  Eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
116465  Ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116544  Pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
116636  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
117019  Eif2b4; translation initiation factor eIF2B subunit delta [KO:K03680]
117058  Pou2f2; POU domain, class 2, transcription factor 2 [KO:K09364]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
120099910  [KO:K08738]
134478843  [KO:K15411]
134478844  [KO:K15411]
134478917  [KO:K15411]
134481169  [KO:K15411]
134481328  [KO:K15411]
134481329  [KO:K15411]
134481331  [KO:K15411]
134484121  [KO:K00922] [EC:2.7.1.153]
134487075  [KO:K05414]
134487077  [KO:K05414]
140926  Daxx; death domain-associated protein 6 [KO:K02308]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
171068  Pou2f1; POU domain, class 2, transcription factor 1 [KO:K09364]
171145  Eif2b3; translation initiation factor eIF2B subunit gamma [KO:K03241]
192183  Nectin1; nectin-1 precursor [KO:K06081]
192234  Eif2b5; translation initiation factor eIF2B subunit epsilon [KO:K03240]
192281  Oas1a; 2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24223  B2m; beta-2-microglobulin precursor [KO:K08055]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
24232  C3; complement C3 precursor [KO:K03990]
24481  Ifnb1; interferon beta precursor [KO:K05415]
24494  Il1b; interleukin-1 beta [KO:K04519]
24498  Il6; interleukin-6 precursor [KO:K05405]
24514  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
246268  Oas1b; inactive 2'-5'-oligoadenylate synthase 1B [KO:K14216] [EC:2.7.7.84]
24668  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
24669  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24770  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
24811  Tap1; antigen peptide transporter 1 precursor [KO:K05653] [EC:7.4.2.14]
24812  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
24835  Tnf; tumor necrosis factor [KO:K03156]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24855  Tsc2; tuberin [KO:K07207]
24887  Bax; apoptosis regulator BAX [KO:K02159]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25008  Lta; lymphotoxin-alpha precursor [KO:K05468]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
25155  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
25217  Tapbp; tapasin precursor [KO:K08058]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
252832  Zc3hav1; zinc finger CCCH-type antiviral protein 1 isoform 1 [KO:K28004]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25594  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
25599  Cd74; H-2 class II histocompatibility antigen gamma chain [KO:K06505]
25622  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform 2 [KO:K07293] [EC:3.1.3.48]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
25712  Ifng; interferon gamma precursor [KO:K04687]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
26954  Rheb; GTP-binding protein Rheb [KO:K07208]
27137  Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
287562  Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
288701  Srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
290019  Cycsl3; cytochrome c, somatic-like [KO:K08738]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
293624  Irf7; interferon regulatory factor 7 [KO:K09447]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
29468  Pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
29667  Srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
29702  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 precursor [KO:K08860] [EC:2.7.11.1]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
297602  Tapbpl; tapasin-related protein precursor [KO:K28445]
297989  Rig1; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
299314  Cfp; properdin precursor [KO:K15412]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
301133  Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
302591  Nxf3; nuclear RNA export factor 3 [KO:K14284]
304382  Pilrb2; similar to cell surface receptor FDFACT precursor [KO:K15411]
304507  Oas1i; 2 ' -5 ' oligoadenylate synthetase 1I [KO:K14216] [EC:2.7.7.84]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
308267  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
308417  Nectin2; nectin-2 precursor [KO:K06531]
308653  Nxf2; nuclear RNA export factor 2 isoform X1 [KO:K14284]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311430  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
314704  Hcfc2; host cell factor 2 [KO:K27390]
315139  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
315346  Itga5; integrin alpha-5 [KO:K06484]
315713  Pml; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
338457  Tlr9; toll-like receptor 9 precursor [KO:K10161]
359726  Rnasel; 2-5A-dependent ribonuclease [KO:K01165]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
360697  Ifngr2; interferon gamma receptor 2 precursor [KO:K05133]
360777  Pilrb2l2; paired immunoglobulin-like type 2 receptor beta-2 isoform X1 [KO:K15411]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
361811  Srpk1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
361814  Srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
362119  C5; complement C5 precursor [KO:K03994]
362264  Srsf6; serine/arginine-rich splicing factor 6 [KO:K12893]
362612  Srsf4; serine/arginine-rich splicing factor 4 [KO:K12893]
362687  Srsf7; serine/arginine-rich splicing factor 7 [KO:K12896]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
363328  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
363519  Hcfc1; host cell factor 1 [KO:K14966]
363520  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
363899  Pilrb2l5; paired immunoglobulin-like type 2 receptor beta isoform X1 [KO:K15411]
363938  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
364594  Tlr3; toll-like receptor 3 precursor [KO:K05401]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
366518  Tnfrsf14; tumor necrosis factor receptor superfamily member 14 precursor [KO:K05152]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
378947  Bst2; bone marrow stromal antigen 2 [KO:K06731]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
494202  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
494445  Srsf2; serine/arginine-rich splicing factor 2 [KO:K12891]
498169  Pilrb2l3; paired immunoglobulin-like type 2 receptor beta isoform X2 [KO:K15411]
498840  Sting1; stimulator of interferon genes protein [KO:K12654]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
499801  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
501621  Nxf7; nuclear RNA export factor 7 [KO:K14284]
501828  Pilrb2l1; paired immunoglobulin-like type 2 receptor beta [KO:K15411]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
54287  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
54318  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
58918  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
59087  Nxf1; nuclear RNA export factor 1 [KO:K14284]
60371  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
60445  Tsc1; hamartin [KO:K07206]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
64171  Card9; caspase recruitment domain-containing protein 9 [KO:K12794]
64202  Calr; calreticulin precursor [KO:K08057]
64514  Eif2b1; translation initiation factor eIF2B subunit alpha [KO:K03239]
64546  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
64625  Bid; BH3-interacting domain death agonist [KO:K04726]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
679794  Cycsl1; cytochrome c, somatic-like [KO:K08738]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
681182  Pilrb1l1; paired immunoglobulin-like type 2 receptor beta [KO:K15411]
681314  [KO:K02159]
681341  Pilrb1; paired immunoglobulin-like type 2 receptor beta isoform X1 [KO:K15411]
682147  Cgas; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
684173  Traf5; TNF receptor-associated factor 5 [KO:K09849]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
689537  Calr4; calreticulin isoform X1 [KO:K08057]
689890  Srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
690585  Alyref; THO complex subunit 4 [KO:K12881]
690675  Cycsl2; cytochrome c, somatic-like [KO:K08738]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
78963  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
78971  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81780  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
84005  Eif2b2; translation initiation factor eIF2B subunit beta [KO:K03754]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84405  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
89829  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
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  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:23 (2016)
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PMID:15163721
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
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PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
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PMID:21146386
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Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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PMID:25798530
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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PMID:28468873
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Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
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PMID:18508584
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Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
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PMID:15078920
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Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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PMID:27154074
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Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
rno03040  Spliceosome
rno03050  Proteasome
rno04115  p53 signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04610  Complement and coagulation cascades
rno04612  Antigen processing and presentation
rno04620  Toll-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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