KEGG   PATHWAY: bta05170
Entry
bta05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Bos taurus (cow)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
bta05170  Human immunodeficiency virus 1 infection
bta05170

Disease
H00406  Acquired immunodeficiency syndrome (AIDS)
H01563  HIV infection
Organism
Bos taurus (cow) [GN:bta]
Gene
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100126076  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100140945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100297344  CALM2; calmodulin-2 [KO:K02183]
100298356  [KO:K06731]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100300510  [KO:K10785]
100300850  [KO:K10784]
100301478  CCNB3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
100335490  [KO:K05414]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100847184  [KO:K02833]
100847304  [KO:K08738]
100847700  [KO:K08738]
100848709  [KO:K05415]
101905399  [KO:K04368] [EC:2.7.12.2]
104968964  [KO:K04542]
104973792  [KO:K02183]
108771180  APOBEC3H; DNA dC->dU-editing enzyme APOBEC-3H [KO:K18750] [EC:3.5.4.-]
112441471  [KO:K05415]
112441480  [KO:K05415]
112441507  [KO:K06731]
112446327  [KO:K03347]
112447733  [KO:K08738]
112447877  [KO:K05415]
112447878  [KO:K05415]
112447879  [KO:K05415]
112447880  [KO:K05415]
132343864  [KO:K03873]
132345077  [KO:K05868]
132345931  [KO:K05414]
280729  B2M; beta-2-microglobulin precursor [KO:K08055]
280730  BAX; apoptosis regulator BAX [KO:K02159]
280795  FOS; protein c-Fos [KO:K04379]
280831  JUN; transcription factor Jun [KO:K04448]
280943  TNF; tumor necrosis factor [KO:K03156]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281020  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
281036  CALR; calreticulin precursor [KO:K08057]
281053  CD3D; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
281054  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
281055  CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
281056  CD247; T-cell surface glycoprotein CD3 zeta chain precursor [KO:K06453]
281061  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281534  TLR2; toll-like receptor 2 precursor [KO:K10159]
281536  TLR4; toll-like receptor 4 precursor [KO:K10160]
281586  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
281668  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
281788  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
281792  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
281803  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
281845  IFNB1; interferon beta precursor [KO:K05415]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
281878  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
281879  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
282152  BCL2L1; bcl-2-like protein 1 [KO:K04570]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
282527  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
286852  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
286883  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
317697  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
326597  CALM; calmodulin [KO:K02183]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
327679  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
338033  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
407098  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
407173  JSP.1; MHC Class I JSP.1 precursor [KO:K06751]
407228  CUL1; cullin-1 [KO:K03347]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
444881  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
493720  FADD; FAS-associated death domain protein [KO:K02373]
497017  CCR5; C-C chemokine receptor type 5 [KO:K04180]
504310  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
504335  TAPBP; tapasin precursor [KO:K08058]
504505  APOBEC3Z2; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B [KO:K18750] [EC:3.5.4.-]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
504707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
504727  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
504869  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
505265  TRIM5; tripartite motif-containing protein 5 [KO:K10648] [EC:2.3.2.27]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
506192  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
506322  NRAS; GTPase NRas [KO:K07828]
507162  APOBEC3Z1; probable DNA dC->dU-editing enzyme APOBEC-3A [KO:K18750] [EC:3.5.4.-]
507234  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
507481  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
507677  AP1G1; AP-1 complex subunit gamma-1 [KO:K12391]
507731  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
507917  [KO:K06751]
508233  RELA; transcription factor p65 [KO:K04735]
509513  [KO:K10785]
510331  CUL5; cullin-5 isoform X2 [KO:K10612]
510373  BID; BH3-interacting domain death agonist [KO:K04726]
510417  BOLA-NC1; non-classical MHC class I antigen precursor [KO:K06751]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
510726  IFNA16; interferon alpha-H [KO:K05414]
510767  CYCS; cytochrome c [KO:K08738]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
511951  DDB1; DNA damage-binding protein 1 [KO:K10610]
512355  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
512672  [KO:K06751]
512841  CRK; adapter molecule crk [KO:K04438]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
513432  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
513539  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
513673  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
513678  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
514090  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
515595  RNF7; RING-box protein 2 [KO:K10611]
515712  BOLA; MHC class I heavy chain isoform 1 precursor [KO:K06751]
515766  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
516039  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
516599  [KO:K10648] [EC:2.3.2.27]
516979  IRF3; interferon regulatory factor 3 [KO:K05411]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
517016  [KO:K05415]
517108  [KO:K05414]
517456  PXN; paxillin isoform X3 [KO:K05760]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
518180  CRKL; crk-like protein [KO:K04438]
518880  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
519958  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
520049  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
520277  CALM3; calmodulin-3 [KO:K02183]
520404  CALML5; calmodulin-like protein 5 [KO:K02183]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
523244  [KO:K05414]
524683  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
524959  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
525550  [KO:K05415]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
526824  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
529141  TAPBPL; tapasin-related protein precursor [KO:K28445]
529146  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
530401  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
533050  BoLA; major histocompatibility complex, class I, A precursor [KO:K06751]
533141  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
533661  STING1; stimulator of interferon genes protein [KO:K12654]
533692  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
533953  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
534072  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
534526  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
534553  CFL1; cofilin-1 [KO:K05765]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535225  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
539224  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
539277  CALML4; calmodulin-like protein 4 [KO:K02183]
539332  CFL2; cofilin-2 [KO:K05765]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
539668  CUL4B; cullin-4B isoform X1 [KO:K10609]
539742  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
540203  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
540322  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
540642  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
540693  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
540859  ELOC; elongin-C [KO:K03872]
541008  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
541140  KRAS; GTPase KRas [KO:K07827]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
615427  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
616331  AP1S2; AP-1 complex subunit sigma-2 [KO:K12394]
616942  [KO:K06751]
616948  [KO:K10648] [EC:2.3.2.27]
616977  [KO:K05415]
617095  CALM1; calmodulin-1 [KO:K02183]
617277  ELOB; elongin-B [KO:K03873]
617412  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
617556  [KO:K05414]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
617935  CUL4A; cullin-4A [KO:K10609]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
618733  [KO:K05654] [EC:7.4.2.14]
618737  [KO:K06731]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
618946  IFNB3; interferon beta-3 precursor [KO:K05415]
618947  [KO:K05414]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
767904  MGC126945; LOW QUALITY PROTEIN: uncharacterized protein LOC767904 [KO:K06751]
768053  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
780968  [KO:K03868] [EC:2.3.2.32]
781996  CYCT; cytochrome c 2 [KO:K08738]
782032  [KO:K03175] [EC:2.3.2.27]
782472  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
783680  [KO:K08055]
783912  [KO:K05414]
784525  [KO:K05415]
785711  DCAF1; DDB1- and CUL4-associated factor 1 isoform X1 [KO:K11789] [EC:2.7.11.1]
786870  [KO:K10648] [EC:2.3.2.27]
787278  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
787343  [KO:K05414]
788119  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
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J Virol 86:757-72 (2012)
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Related
pathway
bta03050  Proteasome
bta04010  MAPK signaling pathway
bta04020  Calcium signaling pathway
bta04064  NF-kappa B signaling pathway
bta04110  Cell cycle
bta04141  Protein processing in endoplasmic reticulum
bta04142  Lysosome biogenesis
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04210  Apoptosis
bta04612  Antigen processing and presentation
bta04620  Toll-like receptor signaling pathway
bta04623  Cytosolic DNA-sensing pathway
bta04668  TNF signaling pathway
bta04810  Regulation of actin cytoskeleton
KO pathway
ko05170   

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