KEGG   PATHWAY: cclu04148
Entry
cclu04148                   Pathway                                
Name
Efferocytosis - Coregonus clupeaformis (lake whitefish)
Class
Cellular Processes; Transport and catabolism
Pathway map
cclu04148  Efferocytosis
cclu04148

Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121530796  [KO:K04515] [EC:2.7.11.17]
121530878  [KO:K07897]
121530914  [KO:K20182]
121531176  ch25hl1.2; LOW QUALITY PROTEIN: cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
121531177  ch25hl1.1; LOW QUALITY PROTEIN: cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
121531434  [KO:K04441] [EC:2.7.11.24]
121531577  [KO:K19480]
121531778  [KO:K06129] [EC:3.1.1.5]
121531861  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121531977  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
121532002  cpt1ab; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
121532054  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121532121  [KO:K17253]
121532134  [KO:K26934]
121532153  [KO:K17333]
121532277  [KO:K00411] [EC:7.1.1.8]
121532654  [KO:K04718] [EC:2.7.1.91]
121533374  [KO:K26934]
121533403  [KO:K08057]
121533527  [KO:K04369] [EC:2.7.12.2]
121533555  bsg; basigin isoform X1 [KO:K06535]
121533564  [KO:K01052] [EC:3.1.1.13]
121533616  [KO:K08057]
121533699  [KO:K04288]
121533909  [KO:K09355]
121534010  pecam1b; platelet endothelial cell adhesion molecule [KO:K06471]
121534037  [KO:K05641]
121534073  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121534793  [KO:K14802] [EC:7.6.2.1]
121534794  [KO:K04261]
121534848  [KO:K08536]
121535088  [KO:K11987] [EC:1.14.99.1]
121535113  [KO:K08057]
121535238  [KO:K26811]
121535286  [KO:K09355]
121535423  calr3b; calreticulin 3b isoform X1 [KO:K08057]
121535511  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121535617  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121535748  [KO:K05641]
121535790  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121536096  [KO:K07909]
121536441  [KO:K06487]
121536479  [KO:K23285]
121536519  tmem30c; transmembrane protein 30C [KO:K26935]
121536533  [KO:K26934]
121537031  [KO:K06588]
121537056  [KO:K07888]
121537064  creb1b; cyclic AMP-responsive element-binding protein 1b isoform X1 [KO:K05870]
121537189  [KO:K01476] [EC:3.5.3.1]
121537337  [KO:K04438]
121537434  [KO:K10048]
121537818  [KO:K04441] [EC:2.7.11.24]
121537833  [KO:K04441] [EC:2.7.11.24]
121537838  [KO:K04504]
121537905  [KO:K04550]
121537964  [KO:K17332]
121538059  [KO:K26811]
121538162  [KO:K14802] [EC:7.6.2.1]
121538196  [KO:K07299]
121538239  [KO:K04441] [EC:2.7.11.24]
121538245  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
121538408  [KO:K23678]
121538431  [KO:K19501]
121538556  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121538561  [KO:K08530]
121538728  tmem30b; cell cycle control protein 50B [KO:K26935]
121539043  [KO:K14802] [EC:7.6.2.1]
121539112  [KO:K01476] [EC:3.5.3.1]
121539116  [KO:K07299]
121539128  [KO:K20183]
121539151  [KO:K26935]
121539254  [KO:K16857]
121539356  [KO:K08268]
121539398  [KO:K06059] [EC:3.4.24.86]
121539434  [KO:K01581] [EC:4.1.1.17]
121539541  tyro3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
121539590  [KO:K17398] [EC:2.1.1.37]
121539647  [KO:K04259]
121539927  [KO:K11987] [EC:1.14.99.1]
121539994  [KO:K19503]
121540218  [KO:K26934]
121540242  [KO:K08057]
121540361  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121540504  [KO:K09355]
121540691  [KO:K06704] [EC:3.4.24.81]
121540702  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121540742  [KO:K19498]
121540745  [KO:K19480]
121540809  [KO:K17253]
121540876  [KO:K04446]
121541132  [KO:K10223] [EC:1.14.99.38]
121541234  [KO:K13375]
121541324  [KO:K05115] [EC:2.7.10.1]
121541401  [KO:K24068]
121541449  [KO:K04515] [EC:2.7.11.17]
121541494  [KO:K04261]
121541536  zgc:100918; ras-related protein rab7-like [KO:K07897]
121541614  [KO:K05853] [EC:7.2.2.10]
121541627  [KO:K04438]
121541668  [KO:K07881]
121541725  [KO:K08524]
121541793  epob; erythropoietin b [KO:K05437]
121541907  [KO:K13375]
121541916  [KO:K05641]
121542142  [KO:K04515] [EC:2.7.11.17]
121542333  [KO:K13302] [EC:2.7.11.1]
121542422  [KO:K13302] [EC:2.7.11.1]
121542504  [KO:K06259]
121542543  [KO:K19013]
121542649  [KO:K05725] [EC:2.7.10.2]
121542962  [KO:K05697] [EC:3.1.3.48]
121543027  [KO:K04596]
121543028  [KO:K26934]
121543307  [KO:K05725] [EC:2.7.10.2]
121543471  [KO:K19500]
121543482  [KO:K19499]
121543539  [KO:K04441] [EC:2.7.11.24]
121543540  [KO:K04441] [EC:2.7.11.24]
121543826  sphk2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121543963  [KO:K19499]
121544284  [KO:K26811]
121544445  si:ch211-266g18.9; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
121544529  [KO:K20183]
121544542  [KO:K01476] [EC:3.5.3.1]
121544650  [KO:K17398] [EC:2.1.1.37]
121544687  [KO:K05116] [EC:2.7.10.1]
121544790  [KO:K01581] [EC:4.1.1.17]
121544836  [KO:K08268]
121544935  [KO:K16857]
121545039  [KO:K26935]
121545088  [KO:K06059] [EC:3.4.24.86]
121545172  [KO:K04259]
121545358  [KO:K04443] [EC:2.7.11.1]
121545409  [KO:K08530]
121545415  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121545522  [KO:K07299]
121545553  [KO:K23678]
121545691  [KO:K26811]
121545782  [KO:K17332]
121545850  [KO:K04550]
121545907  [KO:K04504]
121545911  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121545919  [KO:K04441] [EC:2.7.11.24]
121545928  [KO:K23285]
121545977  [KO:K07293] [EC:3.1.3.48]
121545988  [KO:K04441] [EC:2.7.11.24]
121546369  [KO:K24068]
121546394  [KO:K08765] [EC:2.3.1.21]
121546644  [KO:K08179]
121546674  ano11; LOW QUALITY PROTEIN: anoctamin-7 [KO:K19501]
121546710  cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
121546821  [KO:K26811]
121547054  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
121547151  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
121547161  [KO:K05853] [EC:7.2.2.10]
121547179  [KO:K07889]
121547334  [KO:K01052] [EC:3.1.1.13]
121547377  [KO:K04515] [EC:2.7.11.17]
121547551  [KO:K04392]
121547668  [KO:K05117] [EC:2.7.10.1]
121547961  [KO:K10223] [EC:1.14.99.38]
121547962  [KO:K10223] [EC:1.14.99.38]
121548316  [KO:K00411] [EC:7.1.1.8]
121548479  [KO:K13302] [EC:2.7.11.1]
121548526  [KO:K20181]
121548536  thbs1b; thrombospondin-1 [KO:K16857]
121548630  [KO:K26811]
121548693  [KO:K04441] [EC:2.7.11.24]
121548705  [KO:K04441] [EC:2.7.11.24]
121549048  [KO:K26935]
121549050  [KO:K06259]
121549169  [KO:K19500]
121549216  [KO:K04259]
121549343  [KO:K08426]
121549833  atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
121550027  [KO:K20184]
121550334  [KO:K04371] [EC:2.7.11.24]
121550335  [KO:K05853] [EC:7.2.2.10]
121550532  [KO:K08765] [EC:2.3.1.21]
121550536  [KO:K07889]
121550722  [KO:K05853] [EC:7.2.2.10]
121550985  [KO:K05079]
121551044  [KO:K04718] [EC:2.7.1.91]
121551085  [KO:K06471]
121551381  [KO:K04392]
121552072  [KO:K16857]
121552138  [KO:K20181]
121552249  [KO:K26935]
121552254  [KO:K26811]
121552431  [KO:K17398] [EC:2.1.1.37]
121552441  [KO:K08426]
121552834  ptger2b; prostaglandin E receptor 2b subtype EP2 [KO:K04259]
121553196  [KO:K00461] [EC:1.13.11.34]
121553217  [KO:K11411] [EC:2.3.1.286]
121553263  [KO:K10223] [EC:1.14.99.38]
121553265  [KO:K10223] [EC:1.14.99.38]
121553266  [KO:K10223] [EC:1.14.99.38]
121553268  [KO:K10223] [EC:1.14.99.38]
121553269  [KO:K10223] [EC:1.14.99.38]
121553568  [KO:K04515] [EC:2.7.11.17]
121553933  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121553997  [KO:K26934]
121554012  [KO:K04446]
121554258  [KO:K05641]
121554284  [KO:K04515] [EC:2.7.11.17]
121554923  [KO:K23285]
121554961  [KO:K06588]
121555029  rab5b; ras-related protein Rab-5B [KO:K07888]
121555201  [KO:K06487]
121555204  [KO:K05870]
121555444  [KO:K13302] [EC:2.7.11.1]
121555566  [KO:K08524]
121556298  [KO:K19503]
121556299  [KO:K19480]
121556599  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121556762  [KO:K20177]
121556769  gas6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
121556778  vps8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
121557115  [KO:K04392]
121557798  [KO:K06493]
121557937  stab1; stabilin-1 isoform X1 [KO:K19020]
121558445  c1qa; complement C1q subcomponent subunit A [KO:K03986]
121558446  [KO:K03987]
121558447  [KO:K03988]
121558590  atp11a; phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
121558909  [KO:K06704] [EC:3.4.24.81]
121559236  [KO:K07889]
121559653  [KO:K04515] [EC:2.7.11.17]
121559870  [KO:K26811]
121560052  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121560121  [KO:K07887]
121560752  [KO:K08530]
121561955  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
121563139  [KO:K04438]
121563319  [KO:K13708]
121563703  [KO:K23285]
121564213  [KO:K08268]
121564859  [KO:K09097]
121565661  [KO:K03443]
121566605  [KO:K24318]
121566828  adam17b; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
121567009  [KO:K23678]
121567173  [KO:K04298]
121567200  [KO:K04269]
121567201  [KO:K04272]
121567311  ano7; anoctamin-7 [KO:K19501]
121567460  [KO:K04438]
121567527  [KO:K08268]
121567594  [KO:K23678]
121567657  [KO:K01370] [EC:3.4.22.36]
121567662  [KO:K01370] [EC:3.4.22.36]
121567690  [KO:K13375]
121567830  [KO:K04272]
121567893  [KO:K24318]
121568054  [KO:K19498]
121568068  [KO:K06704] [EC:3.4.24.81]
121568102  [KO:K05115] [EC:2.7.10.1]
121568308  [KO:K04298]
121568359  [KO:K04269]
121568365  [KO:K03443]
121568758  [KO:K11411] [EC:2.3.1.286]
121569264  [KO:K14802] [EC:7.6.2.1]
121569416  [KO:K05079]
121569604  [KO:K06493]
121569769  [KO:K08765] [EC:2.3.1.21]
121569894  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
121570277  [KO:K26814]
121570388  [KO:K04515] [EC:2.7.11.17]
121570397  [KO:K04718] [EC:2.7.1.91]
121571092  [KO:K04515] [EC:2.7.11.17]
121571806  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
121571839  [KO:K05725] [EC:2.7.10.2]
121571875  [KO:K13302] [EC:2.7.11.1]
121572061  [KO:K04397] [EC:3.4.22.60]
121572162  [KO:K05437]
121572355  [KO:K05853] [EC:7.2.2.10]
121572604  si:dkey-165a24.9; G-protein coupled receptor 4 [KO:K08426]
121572937  dusp2; dual specificity protein phosphatase 2 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121573016  [KO:K26813]
121573295  [KO:K08536]
121573445  [KO:K04447] [EC:2.7.10.2]
121573668  [KO:K03443]
121573868  [KO:K07293] [EC:3.1.3.48]
121573896  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121573963  [KO:K20179]
121574086  [KO:K05853] [EC:7.2.2.10]
121574773  [KO:K04441] [EC:2.7.11.24]
121574901  [KO:K08179]
121574930  [KO:K07299]
121574970  [KO:K07897]
121575193  [KO:K04550]
121575235  [KO:K07897]
121575434  [KO:K04504]
121575592  [KO:K17332]
121575645  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
121575719  [KO:K19013]
121575727  pros1; vitamin K-dependent protein S [KO:K03908]
121575974  [KO:K05443]
121576342  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
121576461  [KO:K04288]
121576652  [KO:K05726]
121576733  [KO:K06129] [EC:3.1.1.5]
121576756  [KO:K06535]
121576809  [KO:K06704] [EC:3.4.24.81]
121576815  [KO:K08057]
121576855  abca7; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
121576894  [KO:K17333]
121576985  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121577143  [KO:K04261]
121577452  [KO:K10223] [EC:1.14.99.38]
121577453  [KO:K10223] [EC:1.14.99.38]
121577556  [KO:K04550]
121577595  [KO:K07897]
121577599  [KO:K04392]
121577748  [KO:K07299]
121577855  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
121577881  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121577963  [KO:K17332]
121578091  [KO:K04504]
121578211  [KO:K07897]
121578217  [KO:K05117] [EC:2.7.10.1]
121578329  [KO:K04441] [EC:2.7.11.24]
121578367  [KO:K08179]
121578429  [KO:K06834] [EC:3.4.24.-]
121578587  [KO:K05443]
121578588  [KO:K05443]
121578917  [KO:K13708]
121579147  [KO:K05853] [EC:7.2.2.10]
121579296  [KO:K20179]
121579542  [KO:K05115] [EC:2.7.10.1]
121579543  [KO:K13375]
121579654  [KO:K04515] [EC:2.7.11.17]
121580269  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121580333  [KO:K05437]
121580802  ptgs2a; prostaglandin G/H synthase 2a [KO:K11987] [EC:1.14.99.1]
121580826  [KO:K08057]
121580937  [KO:K26811]
121580977  [KO:K09355]
121581335  [KO:K17334]
121581348  [KO:K04369] [EC:2.7.12.2]
121581456  [KO:K04261]
121581877  [KO:K04261]
121581969  [KO:K08268]
121582008  megf10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
121582023  [KO:K10223] [EC:1.14.99.38]
121582124  [KO:K04515] [EC:2.7.11.17]
121582214  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121582242  [KO:K07293] [EC:3.1.3.48]
121582449  [KO:K08524]
121582512  [KO:K07881]
121582565  [KO:K04438]
121582583  [KO:K05853] [EC:7.2.2.10]
121582665  [KO:K07897]
121582706  [KO:K04261]
121582930  [KO:K05870]
121583006  [KO:K17253]
121583278  [KO:K00411] [EC:7.1.1.8]
121583352  ch25hl2; cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
121583361  [KO:K04397] [EC:3.4.22.60]
121583968  [KO:K00461] [EC:1.13.11.34]
121584225  [KO:K04261]
121584339  [KO:K04371] [EC:2.7.11.24]
121584493  [KO:K08524]
121584584  rab14; ras-related protein Rab-14 [KO:K07881]
121584601  adam9; disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [KO:K06834] [EC:3.4.24.-]
121584672  jak2b; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
121584733  [KO:K05853] [EC:7.2.2.10]
121584863  [KO:K20182]
121585038  [KO:K02187] [EC:3.4.22.56]
121585145  [KO:K06471]
121585184  [KO:K04515] [EC:2.7.11.17]
121585528  [KO:K04515] [EC:2.7.11.17]
121586009  [KO:K04596]
121586205  [KO:K05697] [EC:3.1.3.48]
121586267  [KO:K04446]
121586705  [KO:K07887]
121586778  [KO:K05725] [EC:2.7.10.2]
121586798  [KO:K13302] [EC:2.7.11.1]
121586799  [KO:K26813]
121586839  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
121586932  [KO:K08524]
121587193  [KO:K10223] [EC:1.14.99.38]
123481024  [KO:K04515] [EC:2.7.11.17]
123481345  [KO:K06493]
123482934  [KO:K05437]
123484354  [KO:K08765] [EC:2.3.1.21]
123485654  [KO:K20177]
123485820  [KO:K06704] [EC:3.4.24.81]
123486330  [KO:K04515] [EC:2.7.11.17]
123486914  [KO:K19503]
123487491  [KO:K06834] [EC:3.4.24.-]
123489090  [KO:K26814]
123490926  [KO:K10223] [EC:1.14.99.38]
123491216  [KO:K05853] [EC:7.2.2.10]
123491220  [KO:K04371] [EC:2.7.11.24]
123492215  [KO:K04438]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
cclu00010  Glycolysis / Gluconeogenesis
cclu04140  Autophagy - animal
cclu04145  Phagosome
KO pathway
ko04148   

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