KEGG   PATHWAY: ppad04151
Entry
ppad04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Panthera pardus (leopard)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppad04151  PI3K-Akt signaling pathway
ppad04151

Other DBs
GO: 0043491
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109248153  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
109262472  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109277682  EREG; proepiregulin [KO:K09784]
109277674  AREG; amphiregulin [KO:K09782]
109252228  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109246691  FGF2; fibroblast growth factor 2 [KO:K18497]
109273012  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109277040  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
109276373  FGF6; fibroblast growth factor 6 [KO:K04358]
109267492  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
109263014  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
109266172  FGF9; fibroblast growth factor 9 [KO:K04358]
109257669  FGF22; fibroblast growth factor 22 [KO:K04358]
109247037  FGF4; fibroblast growth factor 4 [KO:K04358]
109247038  FGF3; fibroblast growth factor 3 [KO:K04358]
109258958  FGF16; fibroblast growth factor 16 [KO:K04358]
109275883  FGF10; fibroblast growth factor 10 [KO:K04358]
109277365  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109277393  FGF20; fibroblast growth factor 20 [KO:K04358]
109246904  FGF19; fibroblast growth factor 19 [KO:K22603]
109253108  FGF21; fibroblast growth factor 21 [KO:K22429]
109276197  FGF23; fibroblast growth factor 23 [KO:K22428]
109272115  NGF; beta-nerve growth factor [KO:K02582]
109271282  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
109276150  NTF3; neurotrophin-3 [KO:K04356]
109253087  NTF4; neurotrophin-4 [KO:K12457]
109259395  INS; insulin [KO:K04526]
109265419  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109259410  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109251089  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109265580  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109262483  PDGFC; platelet-derived growth factor C [KO:K05450]
109257520  PDGFD; platelet-derived growth factor D [KO:K05450]
109272007  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109265299  KITLG; kit ligand isoform X1 [KO:K05461]
109253059  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109271390  VEGFA; vascular endothelial growth factor A [KO:K05448]
109246982  VEGFB; vascular endothelial growth factor B [KO:K16858]
109253846  PGF; placenta growth factor isoform X1 [KO:K16859]
109248315  VEGFD; vascular endothelial growth factor D [KO:K05449]
109257848  VEGFC; vascular endothelial growth factor C [KO:K05449]
109268152  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109277940  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
109254262  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
109272630  ANGPT4; angiopoietin-4 [KO:K05467]
109256191  EFNA3; ephrin-A3 [KO:K05462]
109267627  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
109256354  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
109256332  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
109257656  EFNA2; ephrin-A2 [KO:K05462]
109275819  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
109256000  NRTN; neurturin [KO:K25414]
109254836  ARTN; artemin [KO:K25415]
109255852  PSPN; persephin [KO:K25416]
109267979  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109247423  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109270315  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
109265121  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
109262303  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109272992  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109269781  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109267570  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109247323  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109256209  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109251704  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
109254164  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
109273360  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109278988  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109275948  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109275945  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109278960  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109266125  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
109266122  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109278978  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109278955  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109248389  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
109252069  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
109274173  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
109264617  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109276940  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
109268505  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
109265500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109259759  GTPase HRas [KO:K02833]
109268745  KRAS; GTPase KRas isoform X1 [KO:K07827]
109272105  NRAS; GTPase NRas [KO:K07828]
109257492  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109262816  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109255967  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109259699  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109261343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109264970  IRS1; insulin receptor substrate 1 [KO:K16172]
109262509  TLR2; toll-like receptor 2 [KO:K10159]
109269905  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
109251192  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109275517  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109256538  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
109272700  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
109277181  somatotropin [KO:K05438]
109252661  PRL; prolactin [KO:K05439]
109253577  OSM; oncostatin-M isoform X1 [KO:K05418]
109248906  IL2; interleukin-2 [KO:K05429]
109250815  IL3; interleukin-3 [KO:K04736]
109263814  IL6; interleukin-6 isoform X1 [KO:K05405]
109250887  IL4; interleukin-4 [KO:K05430]
109269381  IL7; interleukin-7 isoform X1 [KO:K05431]
109247112  interferon alpha-2-like [KO:K05414]
109247120  interferon alpha-like [KO:K05414]
109247123  interferon alpha-like [KO:K05414]
109261306  interferon alpha-like [KO:K05414]
109261307  interferon alpha [KO:K05414]
109247124  IFNB1; interferon beta [KO:K05415]
109251316  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
109247436  CSF3; granulocyte colony-stimulating factor [KO:K05423]
109275863  GHR; growth hormone receptor isoform X1 [KO:K05080]
109267715  PRLR; prolactin receptor [KO:K05081]
109275827  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
109273771  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
109265527  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
109254610  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
109256147  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
109256188  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
109256524  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
109267711  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
109249714  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109249711  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109254070  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109255488  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
109266731  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109275494  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109247962  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109263702  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
109247299  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
109249029  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
109264962  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
109264069  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
109253654  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
109253658  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109263959  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109264961  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
109258089  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
109258106  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109264846  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
109258923  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
109258949  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
109258972  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
109248201  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
109253350  collagen alpha-3(IX) chain [KO:K08131]
109254858  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
109260619  laminin subunit alpha-2 [KO:K05637]
109248611  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
109276486  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
109253358  LAMA5; laminin subunit alpha-5 [KO:K06240]
109263563  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
109268056  LAMB1; laminin subunit beta-1 [KO:K05636]
109247785  LAMB2; laminin subunit beta-2 [KO:K06243]
109255133  LAMB3; laminin subunit beta-3 [KO:K06244]
109268053  LAMB4; laminin subunit beta-4 [KO:K06245]
109253964  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
109253935  LAMC2; laminin subunit gamma-2 [KO:K06246]
109249948  LAMC3; laminin subunit gamma-3 [KO:K06247]
109247288  CHAD; chondroadherin [KO:K06248]
109268114  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
109263182  THBS1; thrombospondin-1 [KO:K16857]
109274929  THBS4; thrombospondin-4 [KO:K04659]
109247641  COMP; cartilage oligomeric matrix protein [KO:K04659]
109245441  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
109256247  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
109265107  FN1; fibronectin isoform X1 [KO:K05717]
109276169  SPP1; osteopontin isoform X1 [KO:K06250]
109261967  osteopontin [KO:K06250]
109251863  VTN; vitronectin [KO:K06251]
109269912  TNC; tenascin isoform X1 [KO:K06252]
109260500  TNXB; tenascin-X isoform X1 [KO:K06252]
109252955  TNN; tenascin-N isoform X1 [KO:K06252]
109253015  TNR; tenascin-R [KO:K06252]
109276146  VWF; von Willebrand factor [KO:K03900]
109276234  IBSP; bone sialoprotein 2 [KO:K06253]
109275894  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
109275896  ITGA2; integrin alpha-2 [KO:K06481]
109258195  ITGA2B; integrin alpha-IIb [KO:K06476]
109247309  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
109273952  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109249251  ITGA5; integrin alpha-5 [KO:K06484]
109273006  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109270291  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109273690  ITGA8; integrin alpha-8 [KO:K06584]
109248733  ITGA9; integrin alpha-9 [KO:K06585]
109259168  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109262786  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
109274234  ITGAV; integrin alpha-V [KO:K06487]
109276308  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109276923  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109266512  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109271789  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109249190  ITGB7; integrin beta-7 [KO:K06590]
109263803  ITGB8; integrin beta-8 [KO:K06591]
109273067  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109274075  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109275159  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109259912  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109266953  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109275060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109247606  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109274968  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109246616  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109269060  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
109269980  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109247675  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109246190  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
109260287  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
109276125  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109265953  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
109273949  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109251301  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
109276106  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
109275164  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109262977  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
109268480  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
109246597  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
109248876  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
109246185  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109260809  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109253189  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
109269978  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
109263699  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109266704  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109254045  uncharacterized LOC105372280 homolog [KO:K04347]
109259658  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109263698  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109247331  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
109268077  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
109245881  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
109246080  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
109278175  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
109257684  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
109275841  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
109266797  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
109264390  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
109249982  TSC1; hamartin isoform X1 [KO:K07206]
109278145  TSC2; tuberin isoform X1 [KO:K07207]
109252395  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
109278154  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
109274103  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109276800  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
109262313  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
109247116  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
109267401  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
109264897  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
109246850  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
109256121  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
109249183  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
109247060  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
109277056  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109253977  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
109246228  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
109250062  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
109249901  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
109272422  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
109269304  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
109256570  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109251379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109257810  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109279049  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
109268159  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
109255395  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109257030  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
109250803  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
109277271  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109278670  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
109252915  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
109246311  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
109256720  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
109277309  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
109269702  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
109259570  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
109253325  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
109256152  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
109271642  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
109268349  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
109246690  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
109254718  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
109274569  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
109271683  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
109274576  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
109265429  HSP90B1; endoplasmin [KO:K09487]
109254112  CDC37; LOW QUALITY PROTEIN: hsp90 co-chaperone Cdc37 [KO:K09554]
109266293  hsp90 co-chaperone Cdc37-like [KO:K09554]
109256187  CREB-regulated transcription coactivator 2-like [KO:K16333]
109275628  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
109270669  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
109274388  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
109274525  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
109260882  MTCP1; protein p13 MTCP-1 [KO:K16837]
109252365  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
109258507  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
109266441  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109268721  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
109253089  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
109253481  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
109254991  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
109258593  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
109269808  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
109258179  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
109273136  MYC; myc proto-oncogene protein [KO:K04377]
109246902  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109271531  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109268629  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
109270309  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109270390  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
109263689  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
109276198  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109271613  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109251568  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
109269512  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
109263506  FOXO3; forkhead box protein O3 [KO:K09408]
109270926  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
109252525  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109264822  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
109277999  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
109268802  YWHAQ; 14-3-3 protein theta isoform X1 [KO:K16197]
109245715  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
109272389  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
109255159  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
109250570  YWHAG; 14-3-3 protein gamma [KO:K16198]
109253631  YWHAH; 14-3-3 protein eta [KO:K16198]
109246663  BAD; bcl2-associated agonist of cell death [KO:K02158]
109272592  BCL2L1; bcl-2-like protein 1 [KO:K04570]
109275625  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
109274153  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109265159  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109273371  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
109265586  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109270166  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
109256215  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109245089  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
109255940  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
109269067  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
109263891  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
109260558  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
109256986  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
109258269  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
109249134  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
109261148  IKBKG; NF-kappa-B essential modulator [KO:K07210]
109261721  NF-kappa-B essential modulator-like [KO:K07210]
109272766  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109262264  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109246747  RELA; transcription factor p65 isoform X1 [KO:K04735]
109247385  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109249892  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
109270482  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
109245932  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ppad00010  Glycolysis / Gluconeogenesis
ppad04010  MAPK signaling pathway
ppad04012  ErbB signaling pathway
ppad04062  Chemokine signaling pathway
ppad04064  NF-kappa B signaling pathway
ppad04068  FoxO signaling pathway
ppad04110  Cell cycle
ppad04115  p53 signaling pathway
ppad04150  mTOR signaling pathway
ppad04210  Apoptosis
ppad04370  VEGF signaling pathway
ppad04510  Focal adhesion
ppad04620  Toll-like receptor signaling pathway
ppad04630  JAK-STAT signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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