KEGG   PATHWAY: tup04010
Entry
tup04010                    Pathway                                
Name
MAPK signaling pathway - Tupaia chinensis (Chinese tree shrew)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tup04010  MAPK signaling pathway
tup04010

Other DBs
GO: 0000165
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102473903  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
102498317  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102484770  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102488737  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
102482779  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102486198  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
102497538  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
102481015  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102482417  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
102494398  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
102489976  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
102472656  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
102475272  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
102473215  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
102502262  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
102474154  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
102496795  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
102495760  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
102493923  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
102489456  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
102496364  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
102483172  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
102482749  CACNG7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
102497622  CACNG8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
102502506  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102478525  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102495954  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102469271  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102497204  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102501406  GNA12; G protein subunit alpha 12 [KO:K04346]
102501535  GNG12; G protein subunit gamma 12 [KO:K04347]
102480885  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102478870  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102478627  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102478386  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102474096  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102482167  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102479101  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
102468376  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102468592  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102498774  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102492372  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
102476593  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102503100  RASA1; RAS p21 protein activator 1 [KO:K04352]
102493211  RASA2; RAS p21 protein activator 2 [KO:K08053]
102475072  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102472381  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102490423  EGF; epidermal growth factor [KO:K04357]
102497817  TGFA; transforming growth factor alpha [KO:K08774]
102475723  EREG; epiregulin [KO:K09784]
102476130  AREG; amphiregulin [KO:K09782]
102472932  FGF1; fibroblast growth factor 1 [KO:K18496]
102498637  FGF2; fibroblast growth factor 2 [KO:K18497]
102489294  FGF9; fibroblast growth factor 9 [KO:K04358]
102500824  FGF16; fibroblast growth factor 16 [KO:K04358]
102496950  FGF18; fibroblast growth factor 18 [KO:K04358]
102470973  FGF20; fibroblast growth factor 20 [KO:K04358]
102477924  FGF17; fibroblast growth factor 17 [KO:K04358]
102492980  FGF5; fibroblast growth factor 5 [KO:K04358]
102478652  FGF6; fibroblast growth factor 6 [KO:K04358]
102470048  FGF3; fibroblast growth factor 3 [KO:K04358]
102470471  FGF4; fibroblast growth factor 4 [KO:K04358]
102496545  FGF8; fibroblast growth factor 8 [KO:K04358]
102500031  FGF10; fibroblast growth factor 10 [KO:K04358]
102494532  FGF22; fibroblast growth factor 22 [KO:K04358]
102476072  FGF7; fibroblast growth factor 7 [KO:K04358]
102470889  FGF19; fibroblast growth factor 19 [KO:K22603]
102480823  fibroblast growth factor 19-like [KO:K22603]
102474175  FGF21; fibroblast growth factor 21 [KO:K22429]
102479073  FGF23; fibroblast growth factor 23 [KO:K22428]
102501945  NGF; nerve growth factor [KO:K02582]
102475289  BDNF; brain derived neurotrophic factor [KO:K04355]
102484355  NTF3; neurotrophin 3 [KO:K04356]
102468545  NTF4; neurotrophin 4 [KO:K12457]
102481191  INS; insulin [KO:K04526]
102490248  IGF1; insulin like growth factor 1 [KO:K05459]
102481608  IGF2; insulin like growth factor 2 [KO:K13769]
102499235  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102482500  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102485007  PDGFD; platelet derived growth factor D [KO:K05450]
102487522  PDGFC; platelet derived growth factor C [KO:K05450]
102492960  CSF1; colony stimulating factor 1 [KO:K05453]
102501429  KITLG; KIT ligand [KO:K05461]
102494016  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102499303  VEGFA; vascular endothelial growth factor A [KO:K05448]
102494761  VEGFB; vascular endothelial growth factor B [KO:K16858]
102480300  PGF; placental growth factor [KO:K16859]
102498502  VEGFC; vascular endothelial growth factor C [KO:K05449]
102486007  VEGFD; vascular endothelial growth factor D [KO:K05449]
102483689  HGF; hepatocyte growth factor [KO:K05460]
102471695  ANGPT1; angiopoietin 1 [KO:K05465]
102472273  angiopoietin-2 [KO:K05466]
102500020  ANGPT2; angiopoietin 2 [KO:K05466]
102482199  ANGPT4; angiopoietin 4 [KO:K05467]
102502764  EFNA5; ephrin A5 [KO:K05462]
102477308  EFNA1; ephrin A1 [KO:K05462]
102477745  EFNA4; ephrin A4 [KO:K05462]
102468360  EFNA2; ephrin A2 [KO:K05462]
102490934  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102475541  NRTN; neurturin [KO:K25414]
102486201  ARTN; artemin [KO:K25415]
102472577  PSPN; persephin [KO:K25416]
102485304  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102487164  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102468023  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102482008  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102484087  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102484403  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102500041  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102475159  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102498614  NGFR; nerve growth factor receptor [KO:K02583]
102485200  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102497563  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102469167  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102473496  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102488187  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102492413  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102491581  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102489301  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
106733545  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102480253  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102482918  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102489981  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102485847  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102498017  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102487364  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102497228  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102493080  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102494629  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102477222  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102493230  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102500069  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102496534  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102491386  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
106734036  ras-related protein R-Ras2-like [KO:K07830]
102496329  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102468234  MRAS; muscle RAS oncogene homolog [KO:K07831]
102493239  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102477389  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102497488  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102476496  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102483700  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102478313  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102494294  ragulator complex protein LAMTOR3-like [KO:K04370]
102496453  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102483057  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102491698  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
102493702  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
102494867  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102476057  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102483845  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102492722  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102478154  ATF4; activating transcription factor 4 [KO:K04374]
102494763  ELK1; ELK1, ETS transcription factor [KO:K04375]
102473755  ELK4; ELK4, ETS transcription factor [KO:K04376]
102501999  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102500554  SRF; serum response factor [KO:K04378]
102491199  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102487338  MAPT; microtubule associated protein tau [KO:K04380]
102473475  STMN1; stathmin 1 [KO:K04381]
102473333  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
102470223  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
102471767  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
102472618  JMJD7; jmjC domain-containing protein 7 [KO:K16342] [EC:3.1.1.4]
102470647  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102477396  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102497973  TNF; tumor necrosis factor [KO:K03156]
102475560  IL1A; interleukin 1 alpha [KO:K04383]
102475138  IL1B; interleukin 1 beta [KO:K04519]
102488524  TGFB1; transforming growth factor beta 1 [KO:K13375]
102500482  TGFB2; transforming growth factor beta 2 [KO:K13376]
102497029  TGFB3; transforming growth factor beta 3 [KO:K13377]
102493692  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102492414  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
102486497  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
102476700  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102486518  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102502878  FASLG; Fas ligand [KO:K04389]
102476587  FAS; Fas cell surface death receptor [KO:K04390]
102502997  CD14; CD14 molecule [KO:K04391]
102479102  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102495436  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102494727  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102488344  CDC42; cell division cycle 42 [KO:K04393]
102478636  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102487119  caspase-3-like [KO:K02187] [EC:3.4.22.56]
102472926  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102473925  C8G; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
102481062  DAXX; death domain associated protein [KO:K02308]
102499350  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102473549  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102490347  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102482652  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102496861  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102476523  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102502813  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102479566  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102478674  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102478524  ECSIT; ECSIT signalling integrator [KO:K04405]
102495445  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
102477286  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102493076  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
102495430  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102472173  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102481933  STK4; serine/threonine kinase 4 [KO:K04411]
102498416  STK3; serine/threonine kinase 3 [KO:K04412]
102474660  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102493021  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102483890  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102490022  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102485186  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102477673  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102470721  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102471323  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102479529  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102474694  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102478254  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102501118  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102503262  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
102495244  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102477331  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102479582  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102468021  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
102475791  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
102481100  TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
102493856  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102500732  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102499419  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102482054  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102490526  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
102498000  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
102482334  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
102493536  FLNA; filamin A [KO:K04437]
102482865  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102486599  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102491217  ARRB1; arrestin beta 1 [KO:K04439]
102497124  ARRB2; arrestin beta 2 [KO:K04439]
102475730  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102472233  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102497095  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102487603  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102501733  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102495693  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102481241  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102488226  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102483974  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102493562  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102486242  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
102502234  RPS6KA4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
102474077  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102481120  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102498127  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102496870  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102473406  ATF2; activating transcription factor 2 [KO:K04450]
102503238  TP53; tumor protein p53 [KO:K04451]
102500216  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102480187  MAX; MYC associated factor X [KO:K04453]
102499043  MEF2C; myocyte enhancer factor 2C [KO:K04454]
102469463  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
102472172  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102492771  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102474297  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102486395  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
102485985  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
102479366  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102476814  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102481474  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102488964  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102495637  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102476191  dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102501251  DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102491845  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102470411  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102503417  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102478158  DUSP9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102492309  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102483914  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102492208  PPP5C; protein phosphatase 5 catalytic subunit [KO:K04460] [EC:3.1.3.16]
102470353  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
102498690  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
102492021  heat shock cognate 71 kDa protein-like [KO:K03283]
102477173  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
102477588  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
102488085  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
102499912  heat shock cognate 71 kDa protein-like [KO:K03283]
102488385  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
102469877  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102475335  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102490723  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102500729  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102501308  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102467954  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102476758  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102468920  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
102487413  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102497537  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102490451  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102490100  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
tup04070  Phosphatidylinositol signaling system
tup04110  Cell cycle
tup04115  p53 signaling pathway
tup04210  Apoptosis
tup04310  Wnt signaling pathway
tup04668  TNF signaling pathway
KO pathway
ko04010   
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