KEGG   PATHWAY: uar05417
Entry
uar05417                    Pathway                                
Name
Lipid and atherosclerosis - Ursus americanus (American black bear)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
uar05417  Lipid and atherosclerosis
uar05417

Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123802617  APOB; LOW QUALITY PROTEIN: apolipoprotein B-100 [KO:K14462]
123792468  APOA4; apolipoprotein A-IV [KO:K08760]
123792594  APOA1; apolipoprotein A-I [KO:K08757]
123777712  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
123781624  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
123778847  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
123792352  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
123792354  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
123780073  RHOA; transforming protein RhoA [KO:K04513]
123778572  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
123788781  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123776228  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123778440  BAD; bcl2-associated agonist of cell death [KO:K02158]
123798690  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123787450  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123797500  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
123803224  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123792111  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
123792380  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
123779345  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
123797062  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
123787604  CD40LG; LOW QUALITY PROTEIN: CD40 ligand [KO:K03161]
123790682  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
123795371  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123790961  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
123796195  NOX1; NADPH oxidase 1 [KO:K08008]
123787655  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
123784723  NCF1; neutrophil cytosol factor 1 [KO:K08011]
123776589  LOW QUALITY PROTEIN: cytochrome b-245 light chain [KO:K08009]
123801424  NCF2; neutrophil cytosol factor 2 [KO:K08010]
123780782  NCF4; neutrophil cytosol factor 4 [KO:K08012]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123776417  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
123781851  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
123803163  cell division control protein 42 homolog [KO:K04393]
123782153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123792071  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123777544  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123798968  FOS; proto-oncogene c-Fos [KO:K04379]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123777113  C-C motif chemokine 2 [KO:K14624]
123777616  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123789115  CXCL8; interleukin-8 [KO:K10030]
123779716  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
123803240  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
123803776  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123803793  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
123776209  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123776212  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123795037  NRAS; GTPase NRas [KO:K07828]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123778302  RELA; transcription factor p65 [KO:K04735]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123792517  SELE; E-selectin [KO:K06494]
123792492  P-selectin isoform X1 [KO:K06496]
123795153  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
123792353  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
123792355  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
123797065  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
123795545  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
123799741  IL1B; interleukin-1 beta [KO:K04519]
123788681  IL6; interleukin-6 [KO:K05405]
123791076  TNF; tumor necrosis factor [KO:K03156]
123798166  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
123792681  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123783522  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
123790987  heat shock 70 kDa protein 1 [KO:K03283]
123790988  heat shock 70 kDa protein 1 [KO:K03283]
123790989  heat shock 70 kDa protein 1-like [KO:K03283]
123800587  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
123790354  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
123795038  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123778170  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
123780490  HSP90B1; endoplasmin [KO:K09487]
123793207  TLR2; toll-like receptor 2 [KO:K10159]
123796979  lipopolysaccharide-binding protein [KO:K05399]
123796980  lipopolysaccharide-binding protein-like [KO:K05399]
123790266  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
123800464  LY96; lymphocyte antigen 96 [KO:K05400]
123788027  TLR4; toll-like receptor 4 [KO:K10160]
123792727  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
123792836  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
123794834  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
123799411  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123780921  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
123797428  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
123798551  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123795860  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123780295  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123791737  NF-kappa-B essential modulator-like [KO:K07210]
123793902  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123790445  TIR domain-containing adapter molecule 2-like [KO:K05409]
123796797  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
123779266  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
123796112  MIB2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MIB2 [KO:K10645] [EC:2.3.2.27]
123782093  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
123781383  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
123785662  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
123787173  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
123775465  IRF7; interferon regulatory factor 7 [KO:K09447]
123776252  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
123781241  interferon alpha-1/2-like [KO:K05414]
123781249  interferon alpha-1/2-like [KO:K05414]
123781251  interferon alpha-1/2-like [KO:K05414]
123781252  interferon alpha-1/2-like [KO:K05414]
123781255  interferon alpha-1/2-like [KO:K05414]
123781256  interferon alpha-1/2-like [KO:K05414]
123781260  interferon alpha-1/2-like [KO:K05414]
123781283  interferon alpha-1/2-like [KO:K05414]
123781329  interferon alpha-2-like [KO:K05414]
123781031  IFNB1; interferon beta [KO:K05415]
123789351  CD36; platelet glycoprotein 4 [KO:K06259]
123801980  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
123775752  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
123790933  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
123800144  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
123786722  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
123779697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123795136  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123779019  VAV1; proto-oncogene vav [KO:K05730]
123775750  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
123804286  TLR6; toll-like receptor 6 [KO:K10169]
123795072  RAP1A; ras-related protein Rap-1A [KO:K04353]
123787151  RAP1B; ras-related protein Rap-1b [KO:K07836]
123776933  CCL5; C-C motif chemokine 5 [KO:K12499]
123776927  regakine-1-like [KO:K05408]
123776969  C-C motif chemokine 3 [KO:K05408]
123777065  C-C motif chemokine 3-like [KO:K05408]
123787104  growth-regulated alpha protein-like [KO:K05505]
123789130  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
123789142  growth-regulated alpha protein-like [KO:K05505]
123801580  IL12A; interleukin-12 subunit alpha [KO:K05406]
123788629  IL12B; interleukin-12 subunit beta [KO:K05425]
123796485  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
123792571  IL18; interleukin-18 isoform X1 [KO:K05482]
123787974  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
123783524  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
123787214  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123800622  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
123799165  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123793341  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123803651  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
123789460  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123782837  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123799721  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
123800625  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123780649  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123802936  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123796334  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123803353  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123788139  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
123781247  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
123777472  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
123798077  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
123784680  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
123776444  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
123783746  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123784023  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123787495  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123799385  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
123803502  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123799710  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123799736  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
123804253  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123778465  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123796994  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123785908  CALM2; calmodulin-2 [KO:K02183]
123800842  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123802291  calmodulin-like [KO:K02183]
123802321  CALML3; calmodulin-like protein 3 [KO:K02183]
123796079  CALML6; calmodulin-like protein 6 [KO:K02183]
123798898  CALM1; calmodulin-1 [KO:K02183]
123778741  CALM3; calmodulin-3 [KO:K02183]
123788880  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123782828  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123777460  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123786008  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
123781022  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123786394  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
123781572  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123803052  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123798200  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
123778036  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
123782054  cytochrome c-like [KO:K08738]
123789159  cytochrome c [KO:K08738]
123798082  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
123780504  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
123777792  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123793366  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
123784520  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123795973  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
123792132  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
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Related
pathway
uar04020  Calcium signaling pathway
uar04115  p53 signaling pathway
uar04141  Protein processing in endoplasmic reticulum
uar04151  PI3K-Akt signaling pathway
uar04210  Apoptosis
uar04620  Toll-like receptor signaling pathway
uar04621  NOD-like receptor signaling pathway
uar04668  TNF signaling pathway
uar04670  Leukocyte transendothelial migration
uar04975  Fat digestion and absorption
uar04979  Cholesterol metabolism
uar05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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