KEGG   ORTHOLOGY: K05731
Entry
K05731                      KO                                     

Name
TIAM1
Definition
T-lymphoma invasion and metastasis-inducing protein 1
Pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04530  Tight junction
ko04810  Regulation of actin cytoskeleton
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04015 Rap1 signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04024 cAMP signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
 Pleckstrin homology (PH) domain-containing proteins
  Dbl-Like RhoGEF family proteins
   K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Genes
HSA: 7074(TIAM1)
PTR: 473949(TIAM1)
PPS: 100967869(TIAM1)
GGO: 101125464(TIAM1)
PON: 100431618(TIAM1)
NLE: 100605316(TIAM1)
MCC: 702288(TIAM1)
MCF: 101865530(TIAM1)
CSAB: 103217191(TIAM1)
RRO: 104664652(TIAM1)
RBB: 108536834(TIAM1)
CJC: 100390844(TIAM1)
SBQ: 101042162(TIAM1)
MMU: 21844(Tiam1)
MCAL: 110311394(Tiam1)
MPAH: 110330159(Tiam1)
RNO: 304109(Tiam1)
CGE: 100756100(Tiam1)
NGI: 103736475(Tiam1)
HGL: 101711984(Tiam1)
CCAN: 109700897(Tiam1)
OCU: 100338333(TIAM1)
TUP: 102500733(TIAM1)
CFA: 487731(TIAM1)
VVP: 112909492(TIAM1)
AML: 105242089(TIAM1)
UMR: 103673212(TIAM1)
UAH: 113266710(TIAM1)
ORO: 101365424(TIAM1)
ELK: 111155650
FCA: 101094530(TIAM1)
PTG: 102955456(TIAM1)
PPAD: 109249680(TIAM1)
AJU: 106977842(TIAM1)
BTA: 536517(TIAM1)
BOM: 102283572(TIAM1)
BIU: 109562052(TIAM1)
BBUB: 102413018(TIAM1)
CHX: 102170463(TIAM1)
OAS: 101103280(TIAM1)
SSC: 100524587(TIAM1)
CDK: 105086777(TIAM1)
BACU: 103016623(TIAM1)
LVE: 103073449(TIAM1)
OOR: 101280455(TIAM1)
DLE: 111172246(TIAM1)
PCAD: 102980632(TIAM1)
ECB: 100052764(TIAM1)
EPZ: 103550555(TIAM1)
EAI: 106847274(TIAM1)
MNA: 107533494(TIAM1)
HAI: 109393508(TIAM1)
DRO: 112304037(TIAM1)
PALE: 102883973(TIAM1)
RAY: 107519567(TIAM1)
LAV: 100675466(TIAM1)
TMU: 101352570
MDO: 100015064(TIAM1)
SHR: 100920711(TIAM1)
PCW: 110214866(TIAM1)
OAA: 100088712(TIAM1)
GGA: 418491(TIAM1)
MGP: 100540208(TIAM1)
CJO: 107322765(TIAM1)
NMEL: 110402256(TIAM1)
APLA: 101803496(TIAM1)
ACYG: 106043428(TIAM1)
TGU: 100219509(TIAM1)
LSR: 110481491(TIAM1)
SCAN: 103818444
GFR: 102040520(TIAM1)
FAB: 101806275(TIAM1)
PHI: 102109961(TIAM1)
PMAJ: 107213264(TIAM1)
CCAE: 111942402(TIAM1)
ETL: 114069404(TIAM1)
FPG: 101914291(TIAM1)
FCH: 102057263(TIAM1)
CLV: 102098791(TIAM1)
EGZ: 104128218(TIAM1)
NNI: 104020113(TIAM1)
ACUN: 113477782(TIAM1)
PADL: 103920307(TIAM1)
AAM: 106494979(TIAM1)
ASN: 102385589(TIAM1)
AMJ: 106737085(TIAM1)
PSS: 102446695(TIAM1)
CMY: 102934808(TIAM1)
CPIC: 101936219(TIAM1)
ACS: 100555790(tiam1)
PVT: 110080375(TIAM1)
PBI: 103061969(TIAM1)
PMUR: 107290521(TIAM1)
TSR: 106546455(TIAM1)
PMUA: 114596030(TIAM1)
GJA: 107109049(TIAM1)
XLA: 108707884 735176(tiam1.S)
XTR: 734013(tiam1)
NPR: 108787811(TIAM1)
DRE: 567621(tiam1a)
CCAR: 109097672
IPU: 108277166(tiam1)
PHYP: 113543504
AMEX: 103029595(tiam1)
LCO: 104923304(tiam1) 104923828
NCC: 104963587(tiam1)
MZE: 101474606(tiam1)
ONL: 100694077(tiam1)
OLA: 101174366
XMA: 102234854
XCO: 114161546(tiam1)
PRET: 103474994
CVG: 107095569
NFU: 107380221
KMR: 108236015(tiam1)
ALIM: 106520557(tiam1)
CSEM: 103378218
POV: 109630293(tiam1)
LCF: 108876057
SDU: 111224422
SLAL: 111657801
BPEC: 110175098
MALB: 109967522
ELS: 105012849
SFM: 108936219
PKI: 111840433
DME: Dmel_CG34418(sif)
DER: 6544675
DSE: 6610901
DAN: 6506624
DPE: 6600320
DMN: 108151736
DWI: 6639209
DAZ: 108613077
DNV: 108651046
DHE: 111597752
DVI: 6624022
LCQ: 111690717
AAG: 5564449
AALB: 109404936
AME: 725970
TCA: 662876
 » show all
Reference
  Authors
Minard ME, Kim LS, Price JE, Gallick GE
  Title
The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
  Journal
Breast Cancer Res Treat 84:21-32 (2004)
DOI:10.1023/B:BREA.0000018421.31632.e6
Reference
  Authors
Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ
  Title
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
  Journal
J Mol Biol 398:730-46 (2010)
DOI:10.1016/j.jmb.2010.03.047
Reference
PMID:7999144
  Authors
Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG
  Title
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.
  Journal
Cell 77:537-49 (1994)
DOI:10.1016/0092-8674(94)90216-X
  Sequence
[mmu:21844]
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