KEGG ORTHOLOGY: K05731

ORTHOLOGY: K05731

Entry

K05731 KO

Name

TIAM1

Definition

T-lymphoma invasion and metastasis-inducing protein 1

Pathway

ko04014

Ras signaling pathway

ko04015

Rap1 signaling pathway

ko04024

cAMP signaling pathway

ko04062

Chemokine signaling pathway

ko04530

Tight junction

ko04810

Regulation of actin cytoskeleton

ko05205

Proteoglycans in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04015 Rap1 signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04024 cAMP signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
Pleckstrin homology (PH) domain-containing proteins
  Dbl-Like RhoGEF family proteins
   K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1

Genes

HSA:	7074(TIAM1)

PTR:	473949(TIAM1)

PPS:	100967869(TIAM1)

GGO:	101125464(TIAM1)

PON:	100431618(TIAM1)

NLE:	100605316(TIAM1)

MCC:	702288(TIAM1)

MCF:	101865530(TIAM1)

CSAB:

103217191(TIAM1)

RRO:	104664652(TIAM1)

RBB:	108536834(TIAM1)

CJC:	100390844(TIAM1)

SBQ:	101042162(TIAM1)

MMU:	21844(Tiam1)

MCAL:

110311394(Tiam1)

MPAH:

110330159(Tiam1)

RNO:	304109(Tiam1)

MUN:	110557645 110557647

CGE:	100756100(Tiam1)

NGI:	103736475(Tiam1)

HGL:	101711984(Tiam1)

CCAN:

109700897(Tiam1)

OCU:	100338333(TIAM1)

TUP:	102500733(TIAM1)

CFA:	487731(TIAM1)

VVP:	112909492(TIAM1)

AML:	105242089(TIAM1)

UMR:	103673212(TIAM1)

UAH:	113266710(TIAM1)

ORO:	101365424(TIAM1)

ELK:

111155650

FCA:	101094530(TIAM1)

PTG:	102955456(TIAM1)

PPAD:

109249680(TIAM1)

AJU:	106977842(TIAM1)

BTA:	536517(TIAM1)

BOM:	102283572(TIAM1)

BIU:	109562052(TIAM1)

BBUB:

102413018(TIAM1)

CHX:	102170463(TIAM1)

OAS:	101103280(TIAM1)

SSC:	100524587(TIAM1)

CDK:	105086777(TIAM1)

BACU:

103016623(TIAM1)

LVE:	103073449(TIAM1)

OOR:	101280455(TIAM1)

DLE:	111172246(TIAM1)

PCAD:

102980632(TIAM1)

ECB:	100052764(TIAM1)

EPZ:	103550555(TIAM1)

EAI:	106847274(TIAM1)

MNA:	107533494(TIAM1)

HAI:	109393508(TIAM1)

DRO:	112304037(TIAM1)

PALE:

102883973(TIAM1)

RAY:	107519567(TIAM1)

LAV:	100675466(TIAM1)

TMU:

101352570

MDO:	100015064(TIAM1)

SHR:	100920711(TIAM1)

PCW:	110214866(TIAM1)

OAA:	100088712(TIAM1)

GGA:	418491(TIAM1)

MGP:	100540208(TIAM1)

CJO:	107322765(TIAM1)

NMEL:

110402256(TIAM1)

APLA:

101803496(TIAM1)

ACYG:

106043428(TIAM1)

TGU:	100219509(TIAM1)

LSR:	110481491(TIAM1)

SCAN:

103818444

GFR:	102040520(TIAM1)

FAB:	101806275(TIAM1)

PHI:	102109961(TIAM1)

PMAJ:

107213264(TIAM1)

CCAE:

111942402(TIAM1)

ETL:	114069404(TIAM1)

FPG:	101914291(TIAM1)

FCH:	102057263(TIAM1)

CLV:	102098791(TIAM1)

EGZ:	104128218(TIAM1)

NNI:	104020113(TIAM1)

ACUN:

113477782(TIAM1)

PADL:

103920307(TIAM1)

AAM:	106494979(TIAM1)

ASN:	102385589(TIAM1)

AMJ:	106737085(TIAM1)

PSS:	102446695(TIAM1)

CMY:	102934808(TIAM1)

CPIC:

101936219(TIAM1)

ACS:	100555790(tiam1)

PVT:	110080375(TIAM1)

PBI:	103061969(TIAM1)

PMUR:

107290521(TIAM1)

TSR:	106546455(TIAM1)

PMUA:

114596030(TIAM1)

GJA:	107109049(TIAM1)

XLA:	108707884 735176(tiam1.S)

XTR:	734013(tiam1)

NPR:	108787811(TIAM1)

DRE:	567621(tiam1a)

SRX:	107718732 107720640

SANH:

107693916 107701134

SGH:	107555129 107557220

CCAR:

109097672

IPU:	108277166(tiam1)

PHYP:

113543504

AMEX:

103029595(tiam1)

TRU:	101072336 101079238

TNG:	GSTEN00035201G001

LCO:	104923304(tiam1) 104923828

NCC:	104963587(tiam1)

MZE:	101474606(tiam1)

ONL:	100694077(tiam1)

OLA:

101174366

XMA:

102234854

XCO:	114161546(tiam1)

PRET:

103474994

CVG:

107095569

NFU:

107380221

KMR:	108236015(tiam1)

ALIM:

106520557(tiam1)

AOCE:

111563695 111575869

CSEM:

103378218

POV:	109630293(tiam1)

LCF:

SDU:

SLAL:

BPEC:

MALB:

ELS:

SFM:

PKI:

DME:	Dmel_CG34418(sif)

DER:

6544675

DSE:

6610901

DYA:	Dyak_GE21504

DAN:

6506624

DPO:	Dpse_GA18858

DPE:

6600320

DMN:

108151736

DWI:

6639209

DGR:	Dgri_GH16464

DMO:	Dmoj_GI12138

DAZ:

DNV:

DHE:

DVI:

LCQ:

AGA:	AgaP_AGAP006590

AAG:

5564449

AALB:

109404936

CQU:	CpipJ_CPIJ014866

AME:

725970

TCA:

662876

PHU:	Phum_PHUM606710

» show all

Reference

PMID:14999151

Authors

Minard ME, Kim LS, Price JE, Gallick GE

Title

The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.

Journal

Breast Cancer Res Treat 84:21-32 (2004)
DOI:10.1023/B:BREA.0000018421.31632.e6

Reference

PMID:20361982

Authors

Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ

Title

The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

Journal

J Mol Biol 398:730-46 (2010)
DOI:10.1016/j.jmb.2010.03.047

Reference

PMID:7999144

Authors

Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG

Title

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

Journal

Cell 77:537-49 (1994)
DOI:10.1016/0092-8674(94)90216-X

Sequence

[mmu:21844]

LinkDB

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