KEGG   PATHWAY: cclu04261
Entry
cclu04261                   Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Coregonus clupeaformis (lake whitefish)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
cclu04261  Adrenergic signaling in cardiomyocytes
cclu04261

Other DBs
GO: 0001997
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121530796  [KO:K04515] [EC:2.7.11.17]
121530855  [KO:K04354]
121530915  [KO:K04382] [EC:3.1.3.16]
121531434  [KO:K04441] [EC:2.7.11.24]
121531487  [KO:K04926]
121531631  [KO:K12045]
121531647  [KO:K12314]
121531704  [KO:K04861]
121531908  [KO:K10373]
121531951  [KO:K04858]
121532050  [KO:K05850] [EC:7.2.2.10]
121532106  [KO:K02183]
121532236  [KO:K04630]
121532632  [KO:K04869]
121532896  [KO:K04354]
121533158  [KO:K02677] [EC:2.7.11.13]
121533160  [KO:K04870]
121533161  [KO:K04866]
121533168  [KO:K04456] [EC:2.7.11.1]
121533289  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
121533538  [KO:K09048]
121533600  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
121533872  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121534179  [KO:K01540]
121534524  [KO:K08047] [EC:4.6.1.1]
121534675  [KO:K04632]
121534863  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121534935  [KO:K01540]
121535115  atp1b4; protein ATP1B4 [KO:K01540]
121535162  [KO:K09052]
121535292  [KO:K02161]
121535312  [KO:K08041] [EC:4.6.1.1]
121535328  [KO:K04345] [EC:2.7.11.11]
121535366  [KO:K12749]
121535392  scn12aa; sodium channel, voltage gated, type XII, alpha a [KO:K04838]
121535426  tpm4b; tropomyosin 4b isoform X1 [KO:K10375]
121535438  [KO:K01539] [EC:7.2.2.13]
121535525  [KO:K04351]
121535790  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121535973  adra1d; alpha-1D adrenergic receptor [KO:K04137]
121536742  [KO:K04142]
121536772  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
121536783  [KO:K04351]
121537021  [KO:K08045] [EC:4.6.1.1]
121537025  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
121537064  creb1b; cyclic AMP-responsive element-binding protein 1b isoform X1 [KO:K05870]
121537216  [KO:K04853]
121537424  [KO:K08014]
121537507  [KO:K05865]
121537723  [KO:K04630]
121537818  [KO:K04441] [EC:2.7.11.24]
121537833  [KO:K04441] [EC:2.7.11.24]
121537862  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
121537863  [KO:K08046] [EC:4.6.1.1]
121538101  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
121538102  [KO:K08046] [EC:4.6.1.1]
121538121  [KO:K04632]
121538133  [KO:K04851]
121538138  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
121538239  [KO:K04441] [EC:2.7.11.24]
121538333  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121538406  [KO:K05850] [EC:7.2.2.10]
121538557  [KO:K05865]
121538890  [KO:K04913]
121538904  [KO:K04382] [EC:3.1.3.16]
121539016  [KO:K11584]
121539230  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121539245  [KO:K12314]
121539360  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
121539374  [KO:K04142]
121539445  [KO:K04354]
121539477  [KO:K02183]
121539560  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
121540371  [KO:K09048]
121540378  [KO:K01540]
121540386  [KO:K04345] [EC:2.7.11.11]
121540575  [KO:K04861]
121540606  [KO:K04926]
121540696  atp2b1b; plasma membrane calcium-transporting ATPase 1b [KO:K05850] [EC:7.2.2.10]
121540882  [KO:K04868]
121541171  [KO:K12750]
121541396  [KO:K04382] [EC:3.1.3.16]
121541449  [KO:K04515] [EC:2.7.11.17]
121541614  [KO:K05853] [EC:7.2.2.10]
121541734  [KO:K04135]
121541735  [KO:K04354]
121541829  [KO:K02183]
121541831  [KO:K05849]
121541975  [KO:K04456] [EC:2.7.11.1]
121542142  [KO:K04515] [EC:2.7.11.17]
121542930  [KO:K04873]
121542932  [KO:K04871]
121543039  [KO:K26207]
121543395  [KO:K05850] [EC:7.2.2.10]
121543412  [KO:K04858]
121543494  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121543539  [KO:K04441] [EC:2.7.11.24]
121543540  [KO:K04441] [EC:2.7.11.24]
121543601  [KO:K04630]
121543663  [KO:K21289] [EC:2.7.1.153]
121543669  [KO:K09048]
121543719  [KO:K09048]
121543838  [KO:K04872]
121543969  [KO:K04861]
121544244  [KO:K04913]
121544255  [KO:K04445] [EC:2.7.11.1]
121544287  [KO:K05858] [EC:3.1.4.11]
121544310  [KO:K04354]
121544381  [KO:K05858] [EC:3.1.4.11]
121544557  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
121544568  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121544742  [KO:K11583]
121544751  [KO:K02183]
121544770  [KO:K12314]
121544832  [KO:K11584]
121544945  [KO:K12314]
121544961  [KO:K04456] [EC:2.7.11.1]
121545145  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121545414  [KO:K05865]
121545441  [KO:K08046] [EC:4.6.1.1]
121545466  [KO:K04632]
121545480  [KO:K04851]
121545543  [KO:K05865]
121545550  [KO:K05850] [EC:7.2.2.10]
121545735  [KO:K08014]
121545876  [KO:K04857]
121545889  [KO:K08046] [EC:4.6.1.1]
121545890  [KO:K04864]
121545911  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121545919  [KO:K04441] [EC:2.7.11.24]
121545988  [KO:K04441] [EC:2.7.11.24]
121546088  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
121546142  [KO:K04630]
121546225  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121546232  [KO:K09048]
121546240  [KO:K12045]
121546397  kcnq1.1; potassium voltage-gated channel subfamily KQT member 1.1 [KO:K04926]
121546445  [KO:K04864]
121546475  [KO:K04853]
121546611  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
121547161  [KO:K05853] [EC:7.2.2.10]
121547377  [KO:K04515] [EC:2.7.11.17]
121547615  [KO:K12314]
121547622  agt; angiotensinogen [KO:K09821]
121547648  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121547781  [KO:K01540]
121548165  [KO:K02183]
121548501  [KO:K02183]
121548516  [KO:K12314]
121548560  [KO:K12314]
121548589  [KO:K06269] [EC:3.1.3.16]
121548633  [KO:K11584]
121548687  [KO:K05858] [EC:3.1.4.11]
121548693  [KO:K04441] [EC:2.7.11.24]
121548705  [KO:K04441] [EC:2.7.11.24]
121548707  [KO:K05858] [EC:3.1.4.11]
121548712  [KO:K08043] [EC:4.6.1.1]
121548808  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121548816  kcnk2b; potassium channel subfamily K member 2b isoform X2 [KO:K04913]
121548848  [KO:K04456] [EC:2.7.11.1]
121548949  pln; cardiac phospholamban [KO:K05852]
121549044  [KO:K04630]
121549097  [KO:K11584]
121549503  [KO:K04166]
121549653  [KO:K04838]
121549716  [KO:K17751]
121549717  [KO:K17751]
121549722  [KO:K04858]
121549890  [KO:K02161]
121549909  [KO:K05850] [EC:7.2.2.10]
121549958  [KO:K09052]
121550009  [KO:K04863]
121550334  [KO:K04371] [EC:2.7.11.24]
121550335  [KO:K05853] [EC:7.2.2.10]
121550432  atf4b; activating transcription factor 4b [KO:K04374]
121550496  [KO:K12750]
121550680  [KO:K06269] [EC:3.1.3.16]
121550722  [KO:K05853] [EC:7.2.2.10]
121550898  [KO:K21290]
121550994  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
121551276  [KO:K04634]
121551300  [KO:K04345] [EC:2.7.11.11]
121551465  [KO:K02677] [EC:2.7.11.13]
121551631  [KO:K04869]
121551633  [KO:K04866]
121551797  [KO:K08049] [EC:4.6.1.1]
121551826  [KO:K04867]
121551922  [KO:K04870]
121552067  [KO:K02183]
121552094  [KO:K06269] [EC:3.1.3.16]
121552187  [KO:K05858] [EC:3.1.4.11]
121552196  [KO:K04456] [EC:2.7.11.1]
121552341  [KO:K17751]
121552494  [KO:K04351]
121552601  [KO:K11584]
121552683  [KO:K05858] [EC:3.1.4.11]
121552787  [KO:K05852]
121552791  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121552813  [KO:K12314]
121553321  [KO:K04962]
121553329  [KO:K05849]
121553443  [KO:K11584]
121553568  [KO:K04515] [EC:2.7.11.17]
121553593  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
121553635  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121553751  [KO:K04354]
121553820  [KO:K04345] [EC:2.7.11.11]
121553821  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121553987  [KO:K21290]
121553991  [KO:K21290]
121554284  [KO:K04515] [EC:2.7.11.17]
121554298  [KO:K06269] [EC:3.1.3.16]
121554349  [KO:K05858] [EC:3.1.4.11]
121554350  [KO:K05849]
121554355  [KO:K11584]
121555007  [KO:K04865]
121555148  [KO:K04450]
121555154  [KO:K08045] [EC:4.6.1.1]
121555204  [KO:K05870]
121555345  [KO:K17751]
121555860  [KO:K04867]
121555875  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X2 [KO:K04374]
121556469  [KO:K04871]
121556492  [KO:K04873]
121556499  [KO:K04872]
121557042  [KO:K04868]
121557105  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121557118  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
121557777  [KO:K01540]
121558098  [KO:K01539] [EC:7.2.2.13]
121558335  [KO:K09047]
121559653  [KO:K04515] [EC:2.7.11.17]
121559770  [KO:K01539] [EC:7.2.2.13]
121559874  [KO:K05858] [EC:3.1.4.11]
121559955  [KO:K09048]
121560265  [KO:K04845]
121560280  [KO:K04861]
121560329  [KO:K01539] [EC:7.2.2.13]
121560363  [KO:K02183]
121561116  [KO:K17751]
121561158  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
121561304  [KO:K12314]
121561491  [KO:K01540]
121562186  [KO:K01539] [EC:7.2.2.13]
121562328  [KO:K08047] [EC:4.6.1.1]
121562531  [KO:K04354]
121563282  [KO:K04845]
121563437  [KO:K04962]
121563771  [KO:K04845]
121564074  [KO:K05849]
121565811  [KO:K04859]
121566543  [KO:K10373]
121566954  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121567086  [KO:K04848]
121567314  [KO:K01540]
121567336  [KO:K03456]
121567381  [KO:K02183]
121567398  [KO:K04848]
121567519  [KO:K05849]
121567780  [KO:K04456] [EC:2.7.11.1]
121568799  [KO:K04869]
121568932  [KO:K04867]
121568955  [KO:K06269] [EC:3.1.3.16]
121569143  [KO:K17751]
121569189  scn5lab; sodium channel, voltage gated, type V-like, alpha b [KO:K04838]
121569203  [KO:K02161]
121569347  [KO:K02183]
121569504  [KO:K04862]
121569533  [KO:K06269] [EC:3.1.3.16]
121569578  [KO:K11584]
121569619  [KO:K04862]
121569728  [KO:K04374]
121569874  [KO:K04863]
121570059  [KO:K09290]
121570105  creb3l4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
121570364  [KO:K04866]
121570388  [KO:K04515] [EC:2.7.11.17]
121570393  [KO:K21290]
121570394  [KO:K21290]
121570581  myl4; myosin light chain 4 [KO:K12750]
121570729  [KO:K08049] [EC:4.6.1.1]
121571045  [KO:K04354]
121571092  [KO:K04515] [EC:2.7.11.17]
121571124  [KO:K06269] [EC:3.1.3.16]
121571246  [KO:K11584]
121571248  [KO:K05858] [EC:3.1.4.11]
121571375  [KO:K04845]
121571536  [KO:K04872]
121571537  [KO:K04873]
121571538  [KO:K04871]
121571562  [KO:K01539] [EC:7.2.2.13]
121571686  [KO:K26206]
121571853  [KO:K05742]
121571883  [KO:K08042] [EC:4.6.1.1]
121571974  [KO:K09290]
121571985  [KO:K09049]
121572000  [KO:K05849]
121572047  [KO:K09047]
121572343  [KO:K06269] [EC:3.1.3.16]
121572355  [KO:K05853] [EC:7.2.2.10]
121572361  [KO:K05849]
121572414  [KO:K09290]
121573309  [KO:K09048]
121573520  [KO:K04634]
121573635  [KO:K01540]
121573677  [KO:K04848]
121574003  [KO:K04382] [EC:3.1.3.16]
121574051  ppp2r2bb; protein phosphatase 2, regulatory subunit B, beta b isoform X1 [KO:K04354]
121574059  [KO:K04142]
121574086  [KO:K05853] [EC:7.2.2.10]
121574362  [KO:K04167]
121574452  [KO:K04136]
121574694  [KO:K05850] [EC:7.2.2.10]
121574741  [KO:K08050]
121574773  [KO:K04441] [EC:2.7.11.24]
121574858  [KO:K04859]
121574883  [KO:K04630]
121575227  [KO:K04630]
121575280  [KO:K04630]
121575406  [KO:K05850] [EC:7.2.2.10]
121575421  [KO:K04851]
121575422  [KO:K04857]
121575425  [KO:K04860]
121575495  [KO:K04859]
121575786  [KO:K12045]
121575888  [KO:K10351]
121576421  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
121576614  [KO:K10373]
121576805  [KO:K10375]
121576985  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121577016  [KO:K04630]
121577043  [KO:K12314]
121577057  [KO:K12045]
121577445  [KO:K04858]
121577586  [KO:K04630]
121577636  [KO:K04630]
121577884  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
121577954  [KO:K12314]
121577955  [KO:K08050]
121578080  [KO:K04857]
121578082  [KO:K04860]
121578114  [KO:K04851]
121578138  [KO:K05850] [EC:7.2.2.10]
121578329  [KO:K04441] [EC:2.7.11.24]
121578358  tnnt2b; troponin T, cardiac muscle isoforms [KO:K12045]
121578386  [KO:K04630]
121578410  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
121578496  [KO:K02183]
121578563  [KO:K10351]
121579079  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
121579147  [KO:K05853] [EC:7.2.2.10]
121579186  [KO:K04354]
121579237  [KO:K04382] [EC:3.1.3.16]
121579284  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
121579285  [KO:K05849]
121579478  [KO:K02183]
121579483  [KO:K05849]
121579654  [KO:K04515] [EC:2.7.11.17]
121579671  [KO:K04456] [EC:2.7.11.1]
121579834  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
121579867  [KO:K04354]
121579947  agtr2; type-2 angiotensin II receptor [KO:K04167]
121579980  [KO:K04848]
121580107  tnnt2c; troponin T2c, cardiac [KO:K12045]
121580147  [KO:K04136]
121580152  [KO:K04142]
121580222  [KO:K10373]
121580622  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
121580869  [KO:K09052]
121580926  [KO:K17751]
121580971  [KO:K17751]
121581006  [KO:K08041] [EC:4.6.1.1]
121581015  [KO:K04345] [EC:2.7.11.11]
121581054  [KO:K12749]
121581168  [KO:K04351]
121581286  [KO:K01539] [EC:7.2.2.13]
121581520  [KO:K02161]
121581572  creb3l3b; cyclic AMP-responsive element-binding protein 3-like protein 3-B isoform X1 [KO:K09048]
121581754  [KO:K12750]
121581882  [KO:K09048]
121581964  tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
121581987  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121582124  [KO:K04515] [EC:2.7.11.17]
121582436  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
121582583  [KO:K05853] [EC:7.2.2.10]
121582810  [KO:K04634]
121582930  [KO:K05870]
121582941  [KO:K04865]
121583301  [KO:K04135]
121584160  [KO:K04135]
121584339  [KO:K04371] [EC:2.7.11.24]
121584547  [KO:K04634]
121584577  [KO:K12750]
121584611  [KO:K04382] [EC:3.1.3.16]
121584733  [KO:K05853] [EC:7.2.2.10]
121584736  [KO:K06269] [EC:3.1.3.16]
121584804  [KO:K04354]
121585127  [KO:K09048]
121585184  [KO:K04515] [EC:2.7.11.17]
121585459  [KO:K26207]
121585528  [KO:K04515] [EC:2.7.11.17]
121585572  [KO:K04872]
121585573  [KO:K04871]
121585784  [KO:K08042] [EC:4.6.1.1]
121585851  [KO:K09047]
121585903  [KO:K08043] [EC:4.6.1.1]
121585981  [KO:K09290]
121586001  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
121586274  [KO:K04845]
121586275  [KO:K04845]
121586418  [KO:K04873]
121586446  [KO:K01539] [EC:7.2.2.13]
121586473  [KO:K09049]
121586690  [KO:K09047]
121586886  [KO:K04632]
121587332  [KO:K04135]
121587434  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123481024  [KO:K04515] [EC:2.7.11.17]
123481092  [KO:K21290]
123481327  [KO:K01539] [EC:7.2.2.13]
123481415  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123481863  [KO:K05849]
123482277  [KO:K04870]
123483290  [KO:K02677] [EC:2.7.11.13]
123483294  [KO:K04866]
123483295  [KO:K04869]
123484519  [KO:K04845]
123484597  [KO:K04894]
123486315  [KO:K21290]
123486330  [KO:K04515] [EC:2.7.11.17]
123486571  [KO:K12314]
123487330  [KO:K05742]
123487346  [KO:K04136]
123490770  [KO:K04166]
123491216  [KO:K05853] [EC:7.2.2.10]
123491220  [KO:K04371] [EC:2.7.11.24]
123493066  [KO:K05849]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
cclu04020  Calcium signaling pathway
cclu04260  Cardiac muscle contraction
KO pathway
ko04261   

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