KEGG   PATHWAY: ocu05132
Entry
ocu05132                    Pathway                                
Name
Salmonella infection - Oryctolagus cuniculus (rabbit)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ocu05132  Salmonella infection
ocu05132

Disease
H00111  Typhoid fever
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008650  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
100008682  RAB7A; ras-related protein Rab-7a [KO:K07897]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100008790  [KO:K18584]
100008822  [KO:K05692]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100008856  JUN; transcription factor Jun [KO:K04448]
100008922  S100A10; protein S100-A10 [KO:K17274]
100008953  [KO:K07863]
100008965  [KO:K04393]
100008983  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
100008990  IL1B; interleukin-1 beta precursor [KO:K04519]
100009074  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100009129  CXCL8; interleukin-8 precursor [KO:K10030]
100009272  ACTB; actin, cytoplasmic 1 [KO:K05692]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009327  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100009456  [KO:K09487]
100009497  TLR4; toll-like receptor 4 [KO:K10160]
100009542  MYL11; myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
100009552  PODXL; podocalyxin precursor [KO:K06817]
100009578  TLR2; toll-like receptor 2 precursor [KO:K10159]
100009589  LY96; lymphocyte antigen 96 precursor [KO:K05400]
100101588  [KO:K01370] [EC:3.4.22.36]
100101591  [KO:K04397] [EC:3.4.22.60]
100125985  [KO:K02105]
100144338  IL18; interleukin-18 [KO:K05482]
100327265  MYC; myc proto-oncogene protein [KO:K04377]
100328754  FLNA; filamin-A [KO:K04437]
100328756  RA_M006_JSM7BED4F; FLNA protein [KO:K04437]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100337727  [KO:K00923] [EC:2.7.1.154]
100337822  [KO:K00922] [EC:2.7.1.153]
100337888  [KO:K03171]
100337891  [KO:K05750]
100337999  [KO:K04440] [EC:2.7.11.24]
100338118  [KO:K16060]
100338265  [KO:K16576]
100338345  [KO:K04379]
100338635  [KO:K20917]
100338694  [KO:K04079]
100338708  [KO:K05403]
100338905  [KO:K10415]
100338936  [KO:K23282]
100338990  [KO:K12807]
100339119  [KO:K03671]
100339187  [KO:K10424]
100339213  [KO:K17260]
100339216  [KO:K02620]
100339463  [KO:K03094]
100339491  [KO:K10420]
100339519  [KO:K07955]
100339597  [KO:K10396] [EC:5.6.1.3]
100339678  [KO:K12793]
100339839  [KO:K05749]
100339873  [KO:K04392]
100339953  [KO:K04432] [EC:2.7.12.2]
100340043  [KO:K03094]
100340120  [KO:K16060]
100340348  [KO:K23934]
100340471  [KO:K04490]
100340483  [KO:K07374]
100340661  [KO:K04513]
100340704  [KO:K00923] [EC:2.7.1.154]
100340735  [KO:K05759]
100340811  [KO:K04729]
100340824  [KO:K05750]
100340863  [KO:K10420]
100340939  [KO:K07374]
100340957  [KO:K07195]
100341037  [KO:K05692]
100341050  [KO:K08738]
100341175  [KO:K08738]
100341458  [KO:K16575]
100341461  [KO:K10418]
100341515  [KO:K08738]
100341579  [KO:K12756]
100341581  [KO:K07375]
100341605  [KO:K04733] [EC:2.7.11.1]
100341695  [KO:K04441] [EC:2.7.11.24]
100341741  [KO:K10425]
100341971  [KO:K13883]
100342046  [KO:K14021]
100342249  [KO:K04404]
100342525  [KO:K16575]
100342664  [KO:K04440] [EC:2.7.11.24]
100342852  [KO:K04456] [EC:2.7.11.1]
100342867  [KO:K10428]
100342921  [KO:K10302]
100343095  [KO:K23583]
100343190  [KO:K03175] [EC:2.3.2.27]
100343368  [KO:K04513]
100343384  [KO:K12755]
100343474  [KO:K18584]
100343501  [KO:K07937]
100343571  [KO:K04427] [EC:2.7.11.25]
100343680  [KO:K04513]
100343722  [KO:K20184]
100344127  [KO:K10414]
100344144  [KO:K21289] [EC:2.7.1.153]
100344161  [KO:K04441] [EC:2.7.11.24]
100344276  [KO:K20182]
100344359  [KO:K05754]
100344431  [KO:K20183]
100344473  [KO:K06111]
100344482  [KO:K04393]
100344721  [KO:K03671]
100344852  [KO:K04430] [EC:2.7.12.2]
100344995  [KO:K17923]
100345125  [KO:K17923]
100345181  [KO:K00922] [EC:2.7.1.153]
100345319  [KO:K10426]
100345423  [KO:K08727]
100345562  [KO:K18441]
100345591  [KO:K12757]
100345872  [KO:K07941]
100345886  [KO:K07900]
100346065  [KO:K05752]
100346106  [KO:K03158]
100346112  [KO:K12757]
100346609  [KO:K04648]
100346652  [KO:K07374]
100346759  [KO:K05757]
100346810  [KO:K10416]
100346815  [KO:K23935]
100346837  [KO:K17388] [EC:2.7.11.39]
100346856  [KO:K04513]
100346929  [KO:K04440] [EC:2.7.11.24]
100346957  [KO:K10419]
100347020  [KO:K05757]
100347053  [KO:K23612]
100347146  [KO:K10415]
100347273  [KO:K05733] [EC:2.7.11.1]
100347345  [KO:K04371] [EC:2.7.11.24]
100347407  [KO:K04366] [EC:2.7.11.1]
100347816  [KO:K10089]
100347858  [KO:K07375]
100348021  [KO:K07889]
100348075  [KO:K07374]
100348141  [KO:K10396] [EC:5.6.1.3]
100348290  [KO:K07375]
100348306  [KO:K07888]
100348451  [KO:K23484]
100348477  [KO:K04398] [EC:3.4.22.61]
100348561  [KO:K04371] [EC:2.7.11.24]
100348663  [KO:K00922] [EC:2.7.1.153]
100348790  [KO:K15348]
100348967  [KO:K04513]
100349142  [KO:K23938]
100349209  [KO:K07374]
100349259  [KO:K23583]
100349265  [KO:K23649]
100349310  [KO:K23934]
100349426  [KO:K02580]
100349573  [KO:K10427]
100349792  [KO:K07375]
100349794  [KO:K18985]
100349913  [KO:K05758]
100349917  [KO:K21954]
100349997  [KO:K10416]
100350027  [KO:K07374]
100350028  TLR5; toll-like receptor 5 precursor [KO:K10168]
100350045  [KO:K07375]
100350046  [KO:K07374]
100350140  [KO:K18441]
100350198  [KO:K05759]
100350205  [KO:K18423]
100350252  [KO:K07375]
100350614  [KO:K04441] [EC:2.7.11.24]
100350719  [KO:K23937]
100350923  [KO:K07887]
100350942  [KO:K07864]
100350967  [KO:K07374]
100350986  [KO:K07897]
100351037  [KO:K08738]
100351334  [KO:K10358]
100351440  [KO:K19984]
100351901  [KO:K08846] [EC:2.7.11.1]
100351938  [KO:K00923] [EC:2.7.1.154]
100352056  [KO:K04409] [EC:2.7.11.1]
100352081  [KO:K12366]
100352110  [KO:K12799]
100352485  [KO:K05749]
100352691  [KO:K04492]
100352693  [KO:K10396] [EC:5.6.1.3]
100352965  [KO:K02861] [EC:2.7.11.1]
100353304  [KO:K10351]
100353478  [KO:K07374]
100353601  [KO:K06083]
100353673  [KO:K08738]
100353706  [KO:K04456] [EC:2.7.11.1]
100353753  TLR6; toll-like receptor 6 [KO:K10169]
100353930  [KO:K10407]
100353953  [KO:K20181]
100354017  [KO:K20180]
100354138  [KO:K17637]
100354283  [KO:K07834]
100354334  [KO:K07937]
100354352  [KO:K07374]
100354468  [KO:K08738]
100354724  [KO:K08738]
100354735  [KO:K10407]
100354743  [KO:K04730] [EC:2.7.11.1]
100354856  [KO:K10419]
100355053  [KO:K17923]
100355060  [KO:K13744]
100355084  [KO:K08738]
100355230  [KO:K04433] [EC:2.7.12.2]
100355248  [KO:K07374]
100355675  [KO:K02159]
100355808  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100355888  [KO:K04467] [EC:2.7.11.10]
100355907  [KO:K07834]
100355995  [KO:K07195]
100356070  [KO:K05759]
100356086  [KO:K02985]
100356250  [KO:K04513]
100356401  [KO:K07209] [EC:2.7.11.10]
100356448  [KO:K00914] [EC:2.7.1.137]
100356611  [KO:K07873]
100357012  [KO:K10413]
100357065  [KO:K07937]
100357297  [KO:K10417]
100357329  [KO:K08738]
100357334  [KO:K23940]
100357341  [KO:K04734]
100357380  [KO:K05759]
100357567  [KO:K07374]
100357607  [KO:K05756]
100357671  [KO:K17092]
100357840  [KO:K08738]
100358246  [KO:K04403]
100358336  [KO:K18584]
100358378  [KO:K04491]
100358481  [KO:K20179]
100358485  [KO:K10419]
100358541  [KO:K05759]
100358689  [KO:K07375]
100358690  [KO:K04079]
100358807  [KO:K06478] [EC:3.1.3.48]
100358853  [KO:K20282]
100359113  [KO:K07856]
100359184  [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100359245  [KO:K03671]
100359246  [KO:K19984]
103345313  [KO:K04431] [EC:2.7.12.2]
103345506  [KO:K05755]
103346035  [KO:K04441] [EC:2.7.11.24]
103346134  [KO:K18441]
103346289  [KO:K05754]
103347723  [KO:K08738]
103349397  [KO:K02161]
103350994  [KO:K07898]
103351007  [KO:K07955]
103351757  [KO:K10418]
103351864  RHOGL; rho-related GTP-binding protein RhoG-like [KO:K07863]
103352096  [KO:K07955]
108175836  [KO:K08738]
108177422  [KO:K08738]
108178730  [KO:K08738]
127482754  [KO:K18441]
127483176  [KO:K10420]
127483320  [KO:K08738]
127485184  [KO:K04735]
127485982  [KO:K05755]
127486116  [KO:K04456] [EC:2.7.11.1]
127486310  [KO:K03671]
127486605  [KO:K02833]
127487421  [KO:K07888]
127488115  [KO:K06071] [EC:2.7.11.13]
127488679  [KO:K07375]
127489362  [KO:K07829]
127489461  [KO:K04368] [EC:2.7.12.2]
127489660  [KO:K04513]
127489739  [KO:K10407]
127492634  [KO:K12754]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ocu04010  MAPK signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04210  Apoptosis
ocu04217  Necroptosis
ocu04621  NOD-like receptor signaling pathway
KO pathway
ko05132   

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