KEGG   PATHWAY: mlx04151
Entry
mlx04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Mirounga leonina (Southern elephant seal)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlx04151  PI3K-Akt signaling pathway
mlx04151

Other DBs
GO: 0043491
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118027092  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118007998  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118010450  EREG; proepiregulin [KO:K09784]
118010449  AREG; amphiregulin [KO:K09782]
118016762  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118022565  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
118022368  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118015651  FGF4; fibroblast growth factor 4 [KO:K04358]
118016329  FGF3; fibroblast growth factor 3 [KO:K04358]
118016658  FGF18; fibroblast growth factor 18 [KO:K04358]
118009586  FGF9; fibroblast growth factor 9 [KO:K04358]
118009863  FGF20; fibroblast growth factor 20 [KO:K04358]
118010198  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
118003624  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
118025764  FGF6; fibroblast growth factor 6 [KO:K04358]
118026046  FGF16; fibroblast growth factor 16 [KO:K04358]
118005157  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
118006439  fibroblast growth factor 10 [KO:K04358]
118020821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118006573  fibroblast growth factor 10 [KO:K04358]
118016328  FGF19; fibroblast growth factor 19 [KO:K22603]
117998046  FGF21; fibroblast growth factor 21 [KO:K22429]
118025498  FGF23; fibroblast growth factor 23 [KO:K22428]
118000488  NGF; beta-nerve growth factor [KO:K02582]
118015716  BDNF; brain-derived neurotrophic factor [KO:K04355]
118025755  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
117998047  NTF4; neurotrophin-4 [KO:K12457]
118015656  INS; insulin [KO:K04526]
117998812  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118016186  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
117999262  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117998664  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118022209  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
118013160  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118019025  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117998915  KITLG; kit ligand isoform X1 [KO:K05461]
117998303  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
118001628  VEGFA; vascular endothelial growth factor A [KO:K05448]
118015992  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118002257  PGF; placenta growth factor isoform X1 [KO:K16859]
118010093  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
118006945  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
118020685  HGF; hepatocyte growth factor [KO:K05460]
118015118  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118010108  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
118011370  ANGPT4; angiopoietin-4 [KO:K05467]
118017065  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118005351  EFNA2; ephrin-A2 [KO:K05462]
118013606  EFNA3; ephrin-A3 [KO:K05462]
118013871  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
118013873  EFNA1; ephrin-A1 [KO:K05462]
118006370  glial cell line-derived neurotrophic factor [KO:K05452]
118006498  glial cell line-derived neurotrophic factor [KO:K05452]
118008524  NRTN; neurturin [KO:K25414]
118004959  PSPN; persephin [KO:K25416]
118024535  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118024846  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118008728  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118012082  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
118009956  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118027178  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
118010795  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118017149  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118024782  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118013921  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118023317  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118005442  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118023006  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118010522  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118006692  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
118006827  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
118006674  macrophage colony-stimulating factor 1 receptor-like [KO:K05090] [EC:2.7.10.1]
118006802  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118010521  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118009555  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118009553  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118026502  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118010519  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118021010  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118018047  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
118019964  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118023454  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118024273  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118007794  SOS1; son of sevenless homolog 1 [KO:K03099]
118002069  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118000495  NRAS; GTPase NRas [KO:K07828]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118011983  IRS1; insulin receptor substrate 1 [KO:K16172]
118022230  TLR2; toll-like receptor 2 [KO:K10159]
118022538  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
118017761  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118018155  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117999338  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118026369  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
117999661  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
118024316  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
118024458  somatotropin [KO:K05438]
117997464  PRL; prolactin isoform X1 [KO:K05439]
118018643  OSM; oncostatin-M [KO:K05418]
118022354  IL2; interleukin-2 [KO:K05429]
118017097  interleukin-3-like [KO:K04736]
118020856  IL6; interleukin-6 [KO:K05405]
118017175  IL4; interleukin-4 [KO:K05430]
118014946  IL7; interleukin-7 [KO:K05431]
117998991  LOW QUALITY PROTEIN: interferon alpha-4-like [KO:K05414]
117998992  interferon alpha-1/2-like [KO:K05414]
117998993  interferon alpha-14-like [KO:K05414]
117999009  interferon alpha-2-like [KO:K05414]
117998994  IFNB1; interferon beta [KO:K05415]
117999193  EPO; erythropoietin [KO:K05437]
118025070  CSF3; granulocyte colony-stimulating factor [KO:K05423]
118006412  growth hormone receptor isoform X1 [KO:K05080]
118006541  growth hormone receptor isoform X1 [KO:K05080]
118006337  prolactin receptor-like [KO:K05081]
118006470  prolactin receptor-like [KO:K05081]
118006407  oncostatin-M-specific receptor subunit beta-like isoform X1 [KO:K05057]
118006499  oncostatin-M-specific receptor subunit beta-like isoform X1 [KO:K05057]
118021614  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
117998718  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
118025926  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
118026667  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
118013760  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
117999673  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
118006362  interleukin-7 receptor subunit alpha-like [KO:K05072]
118006490  interleukin-7 receptor subunit alpha-like isoform X1 [KO:K05072]
118018831  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
118018829  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118005163  EPOR; erythropoietin receptor [KO:K05079]
118019680  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118019316  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118026348  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118005338  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118024771  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118020776  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118008509  COL2A1; collagen alpha-1(II) chain [KO:K19719]
118009236  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
118009237  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
118011976  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
118011978  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
118011980  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
118011987  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
118003458  collagen alpha-4(VI) chain-like [KO:K06238]
118003466  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
118003477  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118026936  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
118026938  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118011895  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
118000978  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
118024036  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118019571  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118000741  LAMA2; laminin subunit alpha-2 [KO:K05637]
118004427  LAMA1; laminin subunit alpha-1 [KO:K05637]
118024031  LAMA5; laminin subunit alpha-5 [KO:K06240]
118004707  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118001619  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
118020609  LAMB1; laminin subunit beta-1 [KO:K05636]
118005984  LAMB2; laminin subunit beta-2 [KO:K06243]
118014280  LAMB3; laminin subunit beta-3 [KO:K06244]
118020611  LAMB4; laminin subunit beta-4 [KO:K06245]
118014371  LAMC1; laminin subunit gamma-1 [KO:K05635]
118014372  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
118018107  LAMC3; laminin subunit gamma-3 [KO:K06247]
118024764  CHAD; chondroadherin [KO:K06248]
118020651  RELN; reelin [KO:K06249] [EC:3.4.21.-]
118003756  THBS1; thrombospondin-1 [KO:K16857]
118001778  thrombospondin-2 isoform X1 [KO:K04659]
118001902  thrombospondin-2 isoform X1 [KO:K04659]
118016945  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
118005658  COMP; cartilage oligomeric matrix protein [KO:K04659]
118013877  THBS3; thrombospondin-3 [KO:K04659]
118012071  FN1; fibronectin isoform X1 [KO:K05717]
118010349  SPP1; osteopontin isoform X1 [KO:K06250]
118025294  VTN; vitronectin [KO:K06251]
118017766  TNC; tenascin isoform X1 [KO:K06252]
118027196  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
118014437  TNR; tenascin-R [KO:K06252]
118014453  TNN; tenascin-N [KO:K06252]
118025754  VWF; von Willebrand factor [KO:K03900]
118010352  IBSP; bone sialoprotein 2 [KO:K06253]
118006650  integrin alpha-1 isoform X1 [KO:K06480]
118006776  integrin alpha-1-like isoform X1 [KO:K06480]
118006689  integrin alpha-2 [KO:K06481]
118006810  integrin alpha-2 [KO:K06481]
118024979  ITGA2B; integrin alpha-IIb [KO:K06476]
118024776  ITGA3; integrin alpha-3 [KO:K06482]
118012261  ITGA4; integrin alpha-4 [KO:K06483]
118008757  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118012328  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118008748  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118021548  ITGA8; integrin alpha-8 [KO:K06584]
118001833  ITGA9; integrin alpha-9 [KO:K06585]
118000263  ITGA10; integrin alpha-10 [KO:K06586]
118003019  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
118012237  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118026614  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118027184  ITGB3; integrin beta-3 [KO:K06493]
118024262  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118007005  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
118012407  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118008801  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118020850  ITGB8; integrin beta-8 [KO:K06591]
118015244  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118016916  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
118015629  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118021391  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118017823  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
118005502  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
118019215  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
118026055  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
118025737  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
118009435  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
118020099  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
117999428  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118025725  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
118006633  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118003742  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
118002589  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118015951  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118012933  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118009573  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118019223  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118010631  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118005543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
117998037  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118022245  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118001310  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118017819  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118003372  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
118020767  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118019289  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118005796  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
118021679  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118020768  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118024789  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118020625  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
118000062  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
118000064  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
118021736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118005809  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
118019366  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118006331  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118006463  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118021201  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
118017558  TSC1; hamartin isoform X1 [KO:K07206]
118021717  TSC2; tuberin isoform X1 [KO:K07207]
118026819  RHEB; GTP-binding protein Rheb [KO:K07208]
118021723  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
118020008  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118024187  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
118009966  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118015501  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
118010310  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
118011934  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
118016129  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118024673  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118008810  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
118015851  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
118002114  40S ribosomal protein S6-like [KO:K02991]
118017309  40S ribosomal protein S6-like [KO:K02991]
118018960  40S ribosomal protein S6-like [KO:K02991]
117999029  RPS6; 40S ribosomal protein S6 [KO:K02991]
118024347  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118005930  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
118019178  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
118017619  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
118000805  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
118011501  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
118014888  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118005981  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118020673  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
118012969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118000360  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
118016640  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118009990  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117998379  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
118013220  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118022103  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118016779  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118010733  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
117997823  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118002828  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118002870  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118004050  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
118026663  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
118001186  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
118016017  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
118002322  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
118002344  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118014309  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
118014942  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118001625  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118002022  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
117998807  HSP90B1; endoplasmin [KO:K09487]
118005036  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
118013831  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
118023598  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
118004718  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
118002482  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
118002483  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
118014367  MTCP1; protein p13 MTCP-1 [KO:K16837]
118026800  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118024950  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
118007057  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118025587  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
117998248  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
118023997  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
118003117  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
118024941  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
118024966  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
118011813  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
118015212  MYC; myc proto-oncogene protein [KO:K04377]
118016166  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118000822  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118025649  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118008734  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118008659  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118020759  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118025766  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118001139  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
118015032  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
118022752  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118001573  FOXO3; forkhead box protein O3 [KO:K09408]
118023785  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
118014469  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118007843  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118015079  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
118001153  14-3-3 protein zeta/delta-like [KO:K16197]
118011520  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
118007304  14-3-3 protein theta-like [KO:K16197]
118007361  14-3-3 protein theta-like [KO:K16197]
118007388  YWHAQ; 14-3-3 protein theta [KO:K16197]
118025227  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
118018680  YWHAH; 14-3-3 protein eta [KO:K16198]
117999466  YWHAG; 14-3-3 protein gamma [KO:K16198]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
118011353  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118004389  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118019979  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118012101  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118012308  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117998657  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118015807  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118017967  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118005189  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
118013832  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
118021134  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118021299  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
118027308  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
118000307  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
118017535  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
118008825  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118014480  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118016059  RELA; transcription factor p65 [KO:K04735]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118001373  MYB; transcriptional activator Myb [KO:K09420]
118008591  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118000034  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mlx00010  Glycolysis / Gluconeogenesis
mlx04010  MAPK signaling pathway
mlx04012  ErbB signaling pathway
mlx04062  Chemokine signaling pathway
mlx04064  NF-kappa B signaling pathway
mlx04068  FoxO signaling pathway
mlx04110  Cell cycle
mlx04115  p53 signaling pathway
mlx04150  mTOR signaling pathway
mlx04210  Apoptosis
mlx04370  VEGF signaling pathway
mlx04510  Focal adhesion
mlx04620  Toll-like receptor signaling pathway
mlx04630  JAK-STAT signaling pathway
mlx04662  B cell receptor signaling pathway
mlx04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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