KEGG   PATHWAY: pps04151
Entry
pps04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Pan paniscus (bonobo)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pps04151  PI3K-Akt signaling pathway
pps04151

Other DBs
GO: 0043491
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100975632  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
100973153  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100973869  EREG; proepiregulin [KO:K09784]
100973516  AREG; amphiregulin [KO:K09782]
100972676  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100968351  FGF2; fibroblast growth factor 2 [KO:K18497]
100992612  FGF10; fibroblast growth factor 10 [KO:K04358]
100989491  FGF6; fibroblast growth factor 6 [KO:K04358]
100982572  FGF17; fibroblast growth factor 17 isoform X6 [KO:K04358]
100985264  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
100967980  FGF3; fibroblast growth factor 3 [KO:K04358]
100979704  FGF9; fibroblast growth factor 9 [KO:K04358]
100968963  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100967638  FGF4; fibroblast growth factor 4 [KO:K04358]
100969230  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117974215  FGF7; fibroblast growth factor 7 [KO:K04358]
117980428  FGF18; fibroblast growth factor 18 [KO:K04358]
100970008  FGF20; fibroblast growth factor 20 [KO:K04358]
100967291  FGF19; fibroblast growth factor 19 [KO:K22603]
100975521  FGF21; fibroblast growth factor 21 [KO:K22429]
100989835  FGF23; fibroblast growth factor 23 [KO:K22428]
100995667  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100983866  BDNF; brain-derived neurotrophic factor isoform X3 [KO:K04355]
100985907  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
100986199  LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
103785360  LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
100969387  INS; insulin [KO:K04526]
100982978  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100968468  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
100991389  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100984583  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100982459  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100992738  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100994576  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100973372  KITLG; kit ligand isoform X1 [KO:K05461]
100987536  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X6 [KO:K05454]
100970217  VEGFA; vascular endothelial growth factor A isoform X5 [KO:K05448]
117974938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100984147  PGF; placenta growth factor isoform X1 [KO:K16859]
100969999  VEGFD; vascular endothelial growth factor D [KO:K05449]
100990660  VEGFC; vascular endothelial growth factor C [KO:K05449]
100983117  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100981222  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100980556  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100984695  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100989942  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
100995408  EFNA3; ephrin-A3 isoform X2 [KO:K05462]
100967324  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100976740  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100979613  EFNA2; ephrin-A2 [KO:K05462]
100969352  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100967915  NRTN; neurturin [KO:K25414]
100976984  ARTN; artemin isoform X1 [KO:K25415]
100989254  PSPN; persephin [KO:K25416]
100974885  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100977227  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100974494  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
100996186  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
100988115  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100981139  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100976551  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100991315  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
100969001  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100994887  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100991905  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100981083  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100982337  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
100975853  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100974967  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100985935  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
100989601  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100977352  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100969442  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100986594  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100991777  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100980629  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100985931  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100994039  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100993451  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100972953  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100980038  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100993386  HRAS; GTPase HRas isoform X1 [KO:K02833]
100990801  KRAS; GTPase KRas isoform X1 [KO:K07827]
100970465  NRAS; GTPase NRas isoform X2 [KO:K07828]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100977025  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100988437  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100979542  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100971596  IRS1; insulin receptor substrate 1 [KO:K16172]
100994768  TLR2; toll-like receptor 2 precursor [KO:K10159]
100980644  TLR4; toll-like receptor 4 precursor [KO:K10160]
100989777  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100976112  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117975722  uncharacterized protein LOC117975722 [KO:K06856]
100978194  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100992335  CD19; B-lymphocyte antigen CD19 [KO:K06465]
100978197  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100972442  growth hormone variant isoform X3 [KO:K05438]
100973020  chorionic somatomammotropin hormone 2 isoform X4 [KO:K05438]
100971425  somatotropin [KO:K05438]
100983900  chorionic somatomammotropin hormone 1-like isoform X1 [KO:K05438]
117976712  CSH1; chorionic somatomammotropin hormone 1 [KO:K05438]
100970831  PRL; prolactin [KO:K05439]
100971653  OSM; oncostatin-M [KO:K05418]
100984780  IL2; interleukin-2 [KO:K05429]
100967294  IL3; interleukin-3 [KO:K04736]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100988878  IL4; interleukin-4 isoform X1 [KO:K05430]
100986540  IL7; interleukin-7 [KO:K05431]
100968579  interferon alpha-7 [KO:K05414]
100968923  interferon alpha-4-like [KO:K05414]
100969275  interferon alpha-10-like [KO:K05414]
100969624  interferon alpha-16 [KO:K05414]
100970300  interferon alpha-17-like [KO:K05414]
100970658  interferon alpha-14 [KO:K05414]
100971675  IFNA6; interferon alpha-6 [KO:K05414]
100972005  interferon alpha-1/13-like [KO:K05414]
100972354  interferon alpha-2 [KO:K05414]
100972691  IFNA8; interferon alpha-8 [KO:K05414]
100973049  interferon alpha-1/13 [KO:K05414]
100995734  interferon alpha-5 [KO:K05414]
100967539  interferon alpha-21 [KO:K05414]
117981650  interferon alpha-17 [KO:K05414]
117981651  interferon alpha-4-like [KO:K05414]
100968231  LOW QUALITY PROTEIN: interferon alpha-10 [KO:K05414]
117981652  interferon alpha-7-like [KO:K05414]
117981653  interferon alpha-7 [KO:K05414]
100995851  IFNB1; interferon beta [KO:K05415]
100981507  EPO; erythropoietin [KO:K05437]
100972250  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
100980367  GHR; growth hormone receptor [KO:K05080]
100982237  PRLR; prolactin receptor isoform X2 [KO:K05081]
100972785  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
100974407  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
100992438  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100986679  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100972031  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
100969808  IL4R; interleukin-4 receptor subunit alpha isoform X6 [KO:K05071]
100981232  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100995446  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100995792  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100980274  EPOR; erythropoietin receptor isoform X2 [KO:K05079]
100974292  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100972202  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100979742  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100972035  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100974826  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100991060  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100983139  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
100983653  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100984686  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100972511  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100972868  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100976901  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100977235  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100978109  COL6A3; collagen alpha-3(VI) chain isoform X5 [KO:K06238]
100968217  collagen alpha-6(VI) chain [KO:K06238]
100967866  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
100980925  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
100976833  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100978062  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100987158  COL9A1; collagen alpha-1(IX) chain isoform X3 [KO:K08131]
100970548  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
100972784  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100990839  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
100995714  LAMA2; laminin subunit alpha-2 isoform X2 [KO:K05637]
100977893  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
100973904  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100994583  LAMB1; laminin subunit beta-1 [KO:K05636]
100969648  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100980738  LAMB3; laminin subunit beta-3 [KO:K06244]
100995715  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100968935  LAMC1; laminin subunit gamma-1 [KO:K05635]
100967996  LAMC2; laminin subunit gamma-2 isoform X2 [KO:K06246]
100995906  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
100987217  CHAD; chondroadherin [KO:K06248]
100987617  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
100994890  THBS1; thrombospondin-1 [KO:K16857]
100985431  THBS3; thrombospondin-3 isoform X4 [KO:K04659]
100991072  THBS2; thrombospondin-2 [KO:K04659]
100978289  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
100967906  COMP; cartilage oligomeric matrix protein [KO:K04659]
100992555  FN1; fibronectin isoform X4 [KO:K05717]
100994106  SPP1; osteopontin isoform X1 [KO:K06250]
103786698  osteopontin [KO:K06250]
100980616  VTN; vitronectin [KO:K06251]
100980229  TNN; tenascin-N isoform X2 [KO:K06252]
100981352  TNR; tenascin-R isoform X1 [KO:K06252]
100977568  tenascin isoform X1 [KO:K06252]
100992963  tenascin-X isoform X1 [KO:K06252]
100985238  VWF; von Willebrand factor [KO:K03900]
100992477  IBSP; bone sialoprotein 2 [KO:K06253]
100978092  ITGA1; integrin alpha-1 [KO:K06480]
100978441  ITGA2; integrin alpha-2 [KO:K06481]
100991197  ITGA2B; integrin alpha-IIb [KO:K06476]
100993709  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
100983460  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100968295  ITGA5; integrin alpha-5 [KO:K06484]
100967602  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100986603  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
100967547  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100994889  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100967359  ITGA10; integrin alpha-10 [KO:K06586]
100993366  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100975589  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100992059  ITGB1; integrin beta-1 [KO:K05719]
100974497  ITGB3; integrin beta-3 [KO:K06493]
100986193  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
100979758  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100987022  ITGB6; integrin beta-6 isoform X5 [KO:K06589]
100989804  ITGB7; integrin beta-7 [KO:K06590]
100970723  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
100989953  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100986369  F2R; proteinase-activated receptor 1 [KO:K03914]
100970743  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103782638  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100981266  LPAR1; lysophosphatidic acid receptor 1 isoform X2 [KO:K04289]
100988354  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100975023  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100989638  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100974345  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100974511  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100978523  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100982509  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100968267  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100967770  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100990010  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100970547  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100995028  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100980807  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100973322  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
117975026  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
100983091  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100987458  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
112437196  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100978647  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100976735  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100992242  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X2 [KO:K04347]
112437428  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100977074  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X2 [KO:K04548]
100994102  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100988420  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
100981656  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100981987  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100981220  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100971139  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
100989684  STK11; serine/threonine-protein kinase STK11 isoform X3 [KO:K07298] [EC:2.7.11.1]
100975618  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
100991417  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
100988345  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100975575  TSC1; hamartin isoform X2 [KO:K07206]
100971050  TSC2; tuberin isoform X7 [KO:K07207]
100982968  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
100976275  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
100980204  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100976440  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100972246  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100992392  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100967756  EIF4E; eukaryotic translation initiation factor 4E isoform X3 [KO:K03259]
100987712  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
117976254  eukaryotic translation initiation factor 4E [KO:K03259]
100968316  eukaryotic translation initiation factor 4E-like [KO:K03259]
100986739  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
100995177  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100977376  eukaryotic translation initiation factor 4B-like [KO:K03258]
100981855  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100972194  RPS6; 40S ribosomal protein S6 [KO:K02991]
100979187  40S ribosomal protein S6-like [KO:K02991]
100967981  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100972885  PKN1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
100992814  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
100993271  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
100984960  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
100969822  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
100987089  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100974840  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13 [KO:K05631]
100968847  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100983152  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100995377  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100981869  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
100969253  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
100987323  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100981626  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100976101  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100995920  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100991308  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
100983884  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
100991998  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100990236  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5 [KO:K04354]
100968814  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
100980790  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
100987804  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100970249  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
117977740  uncharacterized protein LOC117977740 [KO:K11583]
100987951  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X12 [KO:K11584]
100973399  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100968779  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100990138  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100990047  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100973292  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100979779  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-beta 4 [KO:K04079]
100983575  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100980415  HSP90B1; endoplasmin [KO:K09487]
100977183  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
103785804  LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
100979428  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
100976458  CRTC2; CREB-regulated transcription coactivator 2 isoform X2 [KO:K16333]
100984856  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100988777  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
100971119  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100970085  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
100991005  MTCP1; protein p13 MTCP-1 [KO:K16837]
100974638  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
100986197  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
100972306  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100990031  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
100972797  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100982462  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100973241  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
100993144  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100974757  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
100984489  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
103786410  MYC; myc proto-oncogene protein [KO:K04377]
100995605  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100977916  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100985362  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100981695  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100976294  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
100981258  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100990850  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100972595  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100982783  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100972365  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100976373  FOXO3; forkhead box protein O3 [KO:K09408]
100978830  RBL2; retinoblastoma-like protein 2 [KO:K16332]
100970360  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100973549  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
100983141  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100977477  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100985680  14-3-3 protein zeta/delta-like [KO:K16197]
103786771  14-3-3 protein theta-like [KO:K16197]
100991126  YWHAQ; 14-3-3 protein theta [KO:K16197]
100967426  14-3-3 protein zeta/delta-like [KO:K16197]
117977099  14-3-3 protein zeta/delta [KO:K16197]
100975327  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100978515  14-3-3 protein epsilon-like [KO:K06630]
100992216  YWHAH; 14-3-3 protein eta [KO:K16198]
100994439  YWHAG; 14-3-3 protein gamma [KO:K16198]
100988665  BAD; bcl2-associated agonist of cell death [KO:K02158]
100979809  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100992951  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100992567  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100974672  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100985706  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100980724  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100988487  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100986194  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100981063  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100977804  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100989680  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100977358  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100973232  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
100993334  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100979595  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100989625  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
100976569  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X4 [KO:K04465]
100987483  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117977645  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
100995228  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100989390  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100988429  RELA; transcription factor p65 isoform X1 [KO:K04735]
100979341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100992375  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
100968756  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100973941  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pps00010  Glycolysis / Gluconeogenesis
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04062  Chemokine signaling pathway
pps04064  NF-kappa B signaling pathway
pps04068  FoxO signaling pathway
pps04110  Cell cycle
pps04115  p53 signaling pathway
pps04150  mTOR signaling pathway
pps04210  Apoptosis
pps04370  VEGF signaling pathway
pps04510  Focal adhesion
pps04620  Toll-like receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04662  B cell receptor signaling pathway
pps04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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