KEGG   PATHWAY: pswi04510
Entry
pswi04510                   Pathway                                
Name
Focal adhesion - Pseudoliparis swirei (Mariana hadal snailfish)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pswi04510  Focal adhesion
pswi04510

Other DBs
GO: 0005925
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130188028  [KO:K05725] [EC:2.7.10.2]
130188200  [KO:K06236]
130188238  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
130188305  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
130188310  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
130188608  [KO:K19662] [EC:2.7.11.13]
130188804  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
130188845  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
130188869  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
130188951  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
130188983  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
130189015  itgb3a; integrin beta-3a [KO:K06493]
130189054  ccndx; cyclin Dx [KO:K10151]
130189193  emp2; epithelial membrane protein 2 [KO:K26256]
130189232  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
130189263  [KO:K26255]
130189340  actb2; actin, cytoplasmic 2 [KO:K05692]
130189362  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130189534  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
130189546  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130189644  [KO:K02677] [EC:2.7.11.13]
130189721  si:ch211-79m20.1; platelet-derived growth factor subunit B [KO:K17386]
130189891  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
130189990  rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
130190241  [KO:K19662] [EC:2.7.11.13]
130190351  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
130190604  [KO:K05730]
130190716  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
130190730  actb1; actin, cytoplasmic 1 isoform X1 [KO:K05692]
130190804  emp1; epithelial membrane protein 1 [KO:K26255]
130190886  lamc1; laminin subunit gamma-1 [KO:K05635]
130190903  lamc2; laminin subunit gamma-2 [KO:K06246]
130191238  [KO:K03853] [EC:3.4.22.53]
130191246  [KO:K03853] [EC:3.4.22.53]
130191725  [KO:K04438]
130191945  [KO:K05733] [EC:2.7.11.1]
130192017  [KO:K06251]
130192235  fn1b; fibronectin 1b isoform X1 [KO:K05717]
130192280  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
130192325  tln2a; talin-2a [KO:K06271]
130192406  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
130192562  itga11a; integrin alpha-11a [KO:K06587]
130192590  [KO:K04349]
130192652  vegfd; vascular endothelial growth factor D [KO:K05449]
130192855  itgb8; integrin beta-8 [KO:K06591]
130192985  itgb6; LOW QUALITY PROTEIN: integrin beta-6 [KO:K06589]
130193040  [KO:K00889] [EC:2.7.1.68]
130193444  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
130193754  [KO:K00922] [EC:2.7.1.153]
130193789  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
130193792  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
130193807  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
130193912  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
130194122  [KO:K02649]
130194358  [KO:K02105]
130194412  comp; cartilage oligomeric matrix protein [KO:K04659]
130194462  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
130194485  jun; transcription factor AP-1 [KO:K04448]
130194877  [KO:K06271]
130194898  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
130194904  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
130194907  [KO:K04503]
130194916  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
130194985  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130194990  [KO:K04349]
130195100  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
130195190  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
130195240  vwf; von Willebrand factor [KO:K03900]
130195294  itga11b; integrin alpha-11 [KO:K06587]
130195324  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
130195330  col9a2; collagen alpha-2(IX) chain [KO:K08131]
130195343  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
130195368  parvaa; parvin, alpha a [KO:K06275]
130195436  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
130195721  parvb; beta-parvin isoform X1 [KO:K06275]
130195735  [KO:K05460]
130195882  parvg; gamma-parvin [KO:K06275]
130195891  [KO:K02833]
130195973  lamb4; laminin subunit beta-4 [KO:K06245]
130196122  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
130196123  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
130196195  [KO:K02649]
130196278  thbs4a; thrombospondin-4a [KO:K04659]
130196379  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
130196458  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130196656  [KO:K05760]
130196678  [KO:K06252]
130196758  [KO:K06277]
130197274  itga2.2; integrin alpha-2 isoform X1 [KO:K06481]
130197323  [KO:K05692]
130197371  col1a2; collagen alpha-2(I) chain [KO:K06236]
130197449  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
130197660  [KO:K02649]
130197673  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
130197839  tnr; tenascin-R [KO:K06252]
130197846  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
130197849  itga6b; integrin alpha-6b isoform X1 [KO:K06485]
130197919  col6a1; collagen alpha-1(VI) chain [KO:K06238]
130197944  [KO:K04448]
130197983  [KO:K06237]
130198080  [KO:K00922] [EC:2.7.1.153]
130198140  [KO:K06240]
130198144  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
130198187  [KO:K05730]
130198242  [KO:K08131]
130198327  [KO:K00889] [EC:2.7.1.68]
130198426  [KO:K06237]
130198429  tnn; tenascin-N [KO:K06252]
130198439  [KO:K06252]
130198625  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
130198641  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
130198899  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
130198925  itga5; integrin alpha-5 [KO:K06484]
130199025  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
130199044  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
130199077  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
130199147  [KO:K04513]
130199269  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
130199288  col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
130199297  flna; filamin-A isoform X1 [KO:K04437]
130199341  [KO:K04393]
130199344  col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
130199381  [KO:K04513]
130199386  [KO:K04513]
130199442  lamb2; laminin subunit beta-2 [KO:K06243]
130199451  [KO:K04353]
130199605  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
130199744  lamb2l; laminin subunit beta-2 [KO:K06243]
130199948  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
130200048  [KO:K05459]
130200387  [KO:K07836]
130200455  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
130200474  lamb1b; laminin subunit beta-1b isoform X1 [KO:K05636]
130200517  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
130200559  itga4; integrin alpha-4 isoform X1 [KO:K06483]
130200604  hgfa; hepatocyte growth factor a [KO:K05460]
130200639  [KO:K10151]
130200655  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
130200763  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
130200969  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
130201051  [KO:K04410] [EC:2.7.11.1]
130201236  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
130201245  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130201447  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
130201567  pgfb; placenta growth factor [KO:K16859]
130201611  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
130201630  [KO:K06238]
130201662  [KO:K16857]
130201761  [KO:K06269] [EC:3.1.3.16]
130201873  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
130202027  [KO:K05735] [EC:2.7.11.1]
130202043  [KO:K05717]
130202120  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
130202304  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
130202379  [KO:K17388] [EC:2.7.11.1]
130202425  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
130202451  lama4; laminin subunit alpha-4 [KO:K06241]
130202566  [KO:K16859]
130202602  pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
130202755  thbs1b; thrombospondin-1 [KO:K16857]
130202775  [KO:K06269] [EC:3.1.3.16]
130203063  itgav; integrin alpha-V [KO:K06487]
130203154  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
130203227  pdpk1b; 3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
130203252  col1a1b; collagen, type I, alpha 1b [KO:K06236]
130203259  chad; chondroadherin [KO:K06248]
130203325  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
130203361  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
130203394  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
130203416  [KO:K00907] [EC:2.7.11.18]
130203598  [KO:K04392]
130203653  [KO:K05700]
130203721  itgb4; integrin beta-4 isoform X1 [KO:K06525]
130203935  [KO:K06493]
130203941  itgb5; integrin beta-5 [KO:K06588]
130203967  itga3b; integrin alpha-3b [KO:K06482]
130203988  [KO:K06238]
130204081  [KO:K06269] [EC:3.1.3.16]
130204088  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
130204140  [KO:K04659]
130204681  [KO:K05449]
130204846  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
130204878  rapgef1b; rap guanine nucleotide exchange factor 1b [KO:K06277]
130204896  tln1; talin-1 isoform X1 [KO:K06271]
130205037  lamc3; laminin subunit gamma-3 [KO:K06247]
130205086  itga1; integrin alpha-1 [KO:K06480]
130205168  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
130205193  tnca; tenascin isoform X1 [KO:K06252]
130205358  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130205446  crkl; crk-like protein [KO:K04438]
130205466  shc3; SHC-transforming protein 3 [KO:K17448]
130205606  thbs4b; thrombospondin-4-B [KO:K04659]
130205706  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
130205915  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
130205921  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
130205993  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
130206052  [KO:K05730]
130206209  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
130206261  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
130206605  [KO:K04361] [EC:2.7.10.1]
130206752  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130206778  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130206846  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
130206935  itga9; integrin alpha-9 [KO:K06585]
130206983  [KO:K03853] [EC:3.4.22.53]
130207033  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
130207327  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
130207436  [KO:K03853] [EC:3.4.22.53]
130207611  [KO:K05700]
130207780  [KO:K04353]
130207902  rhoca; ras homolog family member Ca [KO:K04513]
130207934  [KO:K06484]
130208099  [KO:K04393]
130208111  [KO:K06244]
130208146  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
130208155  [KO:K04513]
130208232  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
130208326  [KO:K05760]
130208386  itga7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
130208481  [KO:K27392]
130208564  [KO:K05704] [EC:2.7.10.2]
130208631  [KO:K12958]
130208632  cav3; caveolin-3 [KO:K12959]
130208803  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
130208925  [KO:K12958]
130209311  [KO:K05740]
130209426  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
130209500  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
130209511  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
130209516  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
130209526  col4a1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
130209694  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
130209766  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
130209792  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
130209810  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
130209818  [KO:K06485]
130209934  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
130210120  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
130210275  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
130210282  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
130210317  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
130210442  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
130210443  crk; adapter molecule crk [KO:K04438]
130210495  [KO:K06272] [EC:2.7.11.1]
130210496  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130210554  vtna; vitronectin a [KO:K06251]
130210815  [KO:K04456] [EC:2.7.11.1]
130210962  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
130211057  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
130211342  pdgfd; platelet-derived growth factor D [KO:K05450]
130211486  [KO:K06269] [EC:3.1.3.16]
130211516  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
130211665  badb; BCL2 associated agonist of cell death b [KO:K02158]
130211773  col4a5; collagen alpha-5(IV) chain [KO:K06237]
130212043  [KO:K00922] [EC:2.7.1.153]
130212676  [KO:K05459]
130212698  [KO:K00889] [EC:2.7.1.68]
130212715  thbs3a; thrombospondin-3a isoform X1 [KO:K04659]
130212740  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
130213027  tnxba; tenascin [KO:K06252]
130213058  itga10; integrin alpha-10 [KO:K06586]
130213082  col6a4a; collagen alpha-6(VI) chain [KO:K06238]
130213117  itga8; integrin alpha-8 isoform X1 [KO:K06584]
130213123  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
130213272  [KO:K05459]
130213274  [KO:K05459]
130213275  [KO:K05459]
130213282  [KO:K05459]
130213386  ctnnb1; catenin beta-1 [KO:K02105]
130213443  zyx; zyxin [KO:K06273]
130213488  cdc42l; cell division cycle 42, like [KO:K04393]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
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PMID:14519391
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Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
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Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
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PMID:10698680
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Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
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Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
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PMID:11882383
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Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
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Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
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Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
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PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
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PMID:15034601
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Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pswi04010  MAPK signaling pathway
pswi04060  Cytokine-cytokine receptor interaction
pswi04070  Phosphatidylinositol signaling system
pswi04110  Cell cycle
pswi04310  Wnt signaling pathway
pswi04512  ECM-receptor interaction
pswi04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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