KEGG Orthology (KO)

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 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
   09131 Membrane transport
 
   09132 Signal transduction
     02020 Two-component system [PATH:ko02020]
     04010 MAPK signaling pathway [PATH:ko04010]
       K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
       K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
       K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
       K04852  CACNA1E, CAV2.3; voltage-dependent calcium channel R type alpha-1E
       K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
       K04854  CACNA1G, CAV3.1; voltage-dependent calcium channel T type alpha-1G
       K04855  CACNA1H, CAV3.2; voltage-dependent calcium channel T type alpha-1H
       K04856  CACNA1I, CAV3.3; voltage-dependent calcium channel T type alpha-1I
       K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
       K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
       K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
       K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
       K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
       K04862  CACNB1; voltage-dependent calcium channel beta-1
       K04863  CACNB2; voltage-dependent calcium channel beta-2
       K04864  CACNB3; voltage-dependent calcium channel beta-3
       K04865  CACNB4; voltage-dependent calcium channel beta-4
       K04866  CACNG1; voltage-dependent calcium channel gamma-1
       K04867  CACNG2; voltage-dependent calcium channel gamma-2
       K04868  CACNG3; voltage-dependent calcium channel gamma-3
       K04869  CACNG4; voltage-dependent calcium channel gamma-4
       K04870  CACNG5; voltage-dependent calcium channel gamma-5
       K04871  CACNG6; voltage-dependent calcium channel gamma-6
       K04872  CACNG7; voltage-dependent calcium channel gamma-7
       K04873  CACNG8; voltage-dependent calcium channel gamma-8
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04349  RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
       K12326  RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12363  RASGRP4; RAS guanyl-releasing protein 4
       K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
       K08052  NF1; neurofibromin 1
       K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K04357  EGF; epidermal growth factor
       K08774  TGFA; transforming growth factor, alpha
       K09784  EREG; epiregulin
       K09782  AREG; amphiregulin
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K22603  FGF19; fibroblast growth factor 19
       K22429  FGF21; fibroblast growth factor 21
       K22428  FGF23; fibroblast growth factor 23
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04355  BDNF; brain-derived neurotrophic factor
       K04356  NTF3; neurotrophin 3
       K12457  NTF4; neurotrophin 4
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K13769  IGF2; insulin-like growth factor 2
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K05452  GDNF; glial cell derived neurotrophic factor
       K25414  NRTN; neurturin
       K25415  ARTN; artemin
       K25416  PSPN; persephin
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
       K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K05126  RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-bound protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04370  LAMTOR3, MP1, MAP2K1IP1; ragulator complex protein LAMTOR3
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04372  MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
       K04373  RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K04375  ELK1; ETS domain-containing protein Elk-1
       K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
       K04377  MYC; Myc proto-oncogene protein
       K04378  SRF; serum response factor
       K04379  FOS; proto-oncogene protein c-fos
       K04380  MAPT, TAU; microtubule-associated protein tau
       K04381  STMN1; stathmin 1
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K04386  IL1R1, CD121a; interleukin 1 receptor type I
       K04723  IL1RAP; interleukin 1 receptor accessory protein
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K04391  CD14; monocyte differentiation antigen CD14
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04393  CDC42; cell division control protein 42
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K02308  DAXX; death-associated protein 6
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K04405  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway
       K04406  MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]
       K04407  MAP4K4, HGK; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]
       K04408  MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K04411  STK4, MST1; serine/threonine kinase 4
       K04412  STK3, MST2; serine/threonine kinase 3
       K04414  MAP4K2, GCK; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]
       K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
       K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
       K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
       K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]
       K04418  MAP3K10, MLK2; mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]
       K17534  MLK4, KIAA1804; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]
       K04423  MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
       K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
       K04424  ZAK, MLTK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
       K04425  MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
       K04429  TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04434  MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1
       K04435  MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2
       K04436  MAPK8IP3, JIP3; mitogen-activated protein kinase 8 interacting protein 3
       K04437  FLNA; filamin-A
       K04438  CRK, CRKII; C-crk adapter molecule crk
       K04439  ARRB; beta-arrestin
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04442  MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
       K04445  RPS6KA5, MSK1; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K16510  RPS6KA4, MSK2; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]
       K05866  CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K04448  JUN; transcription factor AP-1
       K04449  JUND; transcription factor jun-D
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04451  TP53, P53; tumor protein p53
       K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
       K04453  MAX; Max protein
       K04454  MEF2C; MADS-box transcription enhancer factor 2C
       K04455  HSPB1; heat shock protein beta-1
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04457  PPM1A, PP2CA; protein phosphatase 1A [EC:3.1.3.16]
       K04458  PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]
       K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]
       K18019  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [EC:3.1.3.48]
       K21278  DUSP1; dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]
       K04459  DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
       K21946  DUSP6; dual specificity phosphatase 6 [EC:3.1.3.16 3.1.3.48]
       K18498  DUSP9, MKP4; dual specificity phosphatase 9 [EC:3.1.3.16 3.1.3.48]
       K20216  DUSP10; dual specificity phosphatase 10 [EC:3.1.3.16 3.1.3.48]
       K17614  DUSP3, VHR; dual specificity phosphatase 3 [EC:3.1.3.16 3.1.3.48]
       K04460  PPP5C; serine/threonine-protein phosphatase 5 [EC:3.1.3.16]
       K04461  PPM1B, PP2CB; protein phosphatase 1B [EC:3.1.3.16]
       K03283  HSPA1_6_8; heat shock 70kDa protein 1/6/8
       K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
       K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
       K04464  MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]
       K04465  NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04468  NLK; nemo like kinase [EC:2.7.11.24]
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K04735  RELA; transcription factor p65
       K09253  RELB; transcription factor RelB
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04016 MAPK signaling pathway - plant [PATH:ko04016]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04014 Ras signaling pathway [PATH:ko04014]
     04015 Rap1 signaling pathway [PATH:ko04015]
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K07831  MRAS; Ras-related protein M-Ras
       K08019  RAPGEF5; Rap guanine nucleotide exchange factor 5
       K17697  DOCK4; dedicator of cytokinesis protein 4
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K02183  CALM; calmodulin
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
       K04270  P2RY1; P2Y purinoceptor 1
       K04172  FPR1; formyl peptide receptor 1
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04266  ADORA2A, ADOR; adenosine receptor A2a
       K04267  ADORA2B; adenosine receptor A2b
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
       K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K04357  EGF; epidermal growth factor
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K22603  FGF19; fibroblast growth factor 19
       K22429  FGF21; fibroblast growth factor 21
       K22428  FGF23; fibroblast growth factor 23
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04438  CRK, CRKII; C-crk adapter molecule crk
       K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
       K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
       K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
       K02105  CTNNB1; catenin beta 1
       K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
       K05629  AIP1; atrophin-1 interacting protein 1
       K06112  MAGI3; membrane-associated guanylate kinase-related
       K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
       K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K07362  LAT; linker for activation of T cells family member 1
       K17698  FYB, ADAP; FYN binding protein
       K07361  LCP2; lymphocyte cytosolic protein 2
       K17699  SKAP1, SKAP55; src kinase associated phosphoprotein 1
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K06070  PKD; protein kinase D [EC:2.7.11.13]
       K04145  DRD2; dopamine receptor D2
       K04277  CNR1; cannabinoid receptor 1
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K17700  RAP1GAP, RAPGAP; RAP1 GTPase activating protein 1
       K17701  SIPA1L1, E6TP1; signal-induced proliferation-associated 1 like protein 1
       K08013  SIPA1; signal-induced proliferation-associated gene 1
       K17702  SIPA1L2, SPAL2; signal-induced proliferation-associated 1 like protein 2
       K17703  SIPA1L3, SPAL3; signal-induced proliferation-associated 1 like protein 3
       K04680  ID1; DNA-binding protein inhibitor ID1
       K16857  THBS1; thrombospondin 1
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K17704  APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein
       K06271  TLN; talin
       K06476  ITGA2B, CD41; integrin alpha 2B
       K06493  ITGB3, CD61; integrin beta 3
       K05759  PFN; profilin
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K05746  ENAH, MENA; enabled
       K23487  EVL; Ena/VASP-like protein
       K05692  ACTB_G1; actin beta/gamma 1
       K12490  ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
       K04513  RHOA; Ras homolog gene family, member A
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K06082  FARP2, FRG; FERM, RhoGEF and pleckstrin domain protein 2
       K04393  CDC42; cell division control protein 42
       K05730  VAV; guanine nucleotide exchange factor VAV
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K04237  PARD3; partitioning defective protein 3
       K06093  PARD6; partitioning defective protein 6
       K18952  PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
       K06069  PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
       K05702  AF6, MLLT4; afadin
       K05690  CTNND1; catenin (cadherin-associated protein), delta 1
       K17705  KRIT1, CCM1; Krev interaction trapped protein 1
       K17706  RGS14; regulator of G-protein signaling 14
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K05718  ITGAL, CD11a; integrin alpha L
       K06461  ITGAM, CD11b; integrin alpha M
       K06464  ITGB2, CD18; integrin beta 2
       K05719  ITGB1, CD29; integrin beta 1
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04341 Hedgehog signaling pathway - fly [PATH:ko04341]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway - fly [PATH:ko04391]
     04392 Hippo signaling pathway - multiple species [PATH:ko04392]
     04370 VEGF signaling pathway [PATH:ko04370]
     04371 Apelin signaling pathway [PATH:ko04371]
     04630 JAK-STAT signaling pathway [PATH:ko04630]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
     04668 TNF signaling pathway [PATH:ko04668]
     04066 HIF-1 signaling pathway [PATH:ko04066]
     04068 FoxO signaling pathway [PATH:ko04068]
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04072 Phospholipase D signaling pathway [PATH:ko04072]
     04071 Sphingolipid signaling pathway [PATH:ko04071]
     04024 cAMP signaling pathway [PATH:ko04024]
     04022 cGMP-PKG signaling pathway [PATH:ko04022]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
     04152 AMPK signaling pathway [PATH:ko04152]
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   09133 Signaling molecules and interaction
 
 09140 Cellular Processes
 
   09141 Transport and catabolism
 
   09143 Cell growth and death
 
   09144 Cellular community - eukaryotes
     04510 Focal adhesion [PATH:ko04510]
     04520 Adherens junction [PATH:ko04520]
     04530 Tight junction [PATH:ko04530]
       K06090  CRB3; crumbs 3
       K06087  CLDN; claudin
       K06088  OCLN; occludin
       K06089  F11R, JAM1, CD321; junctional adhesion molecule 1
       K06735  JAM2, CD322; junctional adhesion molecule 2
       K06785  JAM3; junctional adhesion molecule 3
       K21108  BVES, POPDC1; blood vessel epicardial substance
       K04393  CDC42; cell division control protein 42
       K06093  PARD6; partitioning defective protein 6
       K06091  MPP5, PALS1; MAGUK p55 subfamily member 5
       K21109  MPP4; MAGUK p55 subfamily member 4
       K06097  TJP3, ZO3; tight junction protein 3
       K06092  INADL, PATJ; InaD-like protein
       K06095  MPDZ, MUPP1, Patj; multiple PDZ domain protein
       K18952  PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
       K06069  PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
       K16819  AMOT; angiomotin
       K06104  AMOTL; angiomotin like
       K20638  ARHGAP17, RICH1; Rho GTPase-activating protein 17
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K16684  NF2; merlin
       K06094  LLGL; lethal(2) giant larvae protein
       K12076  DLG1; disks large protein 1
       K16175  SCRIB; protein scribble
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K04237  PARD3; partitioning defective protein 3
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K05701  TJP1, ZO1; tight junction protein 1
       K06105  TJP4, PILT; tight junction protein 4
       K12075  DLG2; discs large protein 2
       K21098  DLG3; discs large protein 3
       K10591  NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
       K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
       K06102  CGN; cingulin
       K21110  CGNL1; cingulin-like protein 1
       K12791  ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
       K04513  RHOA; Ras homolog gene family, member A
       K09183  GATA4; GATA-binding protein 4
       K21099  MARVELD3; MARVEL domain-containing protein 3
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K06448  CD1; T-cell surface glycoprotein CD1
       K05031  CFTR, ABCC7; cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K06099  CSDA, ZONAB; cold shock domain protein A
       K06100  SYMPK; symplekin
       K04802  PCNA; proliferating cell nuclear antigen
       K04503  CCND1; G1/S-specific cyclin-D1
       K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K08367  RUNX1, AML1; runt-related transcription factor 1
       K09489  HSPA4; heat shock 70kDa protein 4
       K13365  SLC9A3R1, NHERF1; sodium/hydrogen exchange regulatory cofactor NHE-RF1
       K08007  EZR, VIL2; ezrin
       K05762  RDX; radixin
       K05763  MSN; moesin
       K18050  PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
       K05692  ACTB_G1; actin beta/gamma 1
       K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K06106  CTTN, EMS1; cortactin
       K17260  ACTR2, ARP2; actin-related protein 2
       K18584  ACTR3, ARP3; actin-related protein 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K20479  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K06109  RAB13; Ras-related protein Rab-13
       K21066  ARHGEF18; A-kinase anchor protein 18
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K10351  MYL2; myosin regulatory light chain 2
       K21111  EPB41L4B, EHM2, LULU2; band 4.1-like protein 4B
       K07298  STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K10352  MYH9s; myosin heavy chain 9/10/11/14
       K12751  MYL6; myosin light chain 6
       K12755  MYL9; myosin regulatory light chain 9
       K12757  MYL12; myosin regulatory light chain 12
       K06786  JAM4, JCAM; junctional adhesion molecule 4
       K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
       K21112  SYNPO; synaptopodin
       K05699  ACTN1_4; actinin alpha 1/4
       K21068  MICALL2, JRAB; MICAL-like protein 2
       K07901  RAB8A, MEL; Ras-related protein Rab-8A
       K07902  RAB8B; Ras-related protein Rab-8B
       K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
       K04353  RAP1A; Ras-related protein Rap-1A
       K05719  ITGB1, CD29; integrin beta 1
       K05702  AF6, MLLT4; afadin
       K06098  TJP2, ZO2; tight junction protein 2
       K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
       K07839  RAP2C; Ras-related protein Rap-2C
       K17291  MARVELD2; MARVEL domain-containing protein 2
       K07374  TUBA; tubulin alpha
     04540 Gap junction [PATH:ko04540]
     04550 Signaling pathways regulating pluripotency of stem cells [PATH:ko04550]
 
   09145 Cellular community - prokaryotes
 
   09142 Cell motility
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: April 25, 2024