Entry
Name
PI3K-Akt signaling pathway - Pongo abelii (Sumatran orangutan)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Other DBs
Organism
Pongo abelii (Sumatran orangutan) [GN:
pon ]
Gene
100127093 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
100171710 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
100171833 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
100172457 NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 [KO:K04465 ]
100172647 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
100172734 MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631 ]
100172895 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049 ]
100173039 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
100173260 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
100173589 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
100173664 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
100173941 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584 ]
100173976 EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259 ]
100174027 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
100174298 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
100190818 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
100294619 CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870 ]
100431991 COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131 ]
100432292 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048 ]
100432846 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100432929 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
100433177 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
100433271 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584 ]
100433338 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
100434731 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
100436186 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
100436188 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
100436819 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
100437405 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382 ] [EC:3.1.3.16 ]
100437617 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100437928 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456 ]
100438416 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
100438716 GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452 ]
100438869 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
100439475 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X2 [KO:K04546 ]
100439720 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047 ]
100439816 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X9 [KO:K05454 ]
100439849 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548 ]
100439998 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
100440212 PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359 ]
100440306 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
100441756 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
100442480 CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423 ]
100443271 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392 ]
100443388 MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629 ]
100443527 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
100445641 PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340 ] [EC:3.1.3.16 ]
100448282 EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259 ]
100448353 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584 ]
100448769 VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448 ]
100449812 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
100450554 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
100452144 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
100452739 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
100453085 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
100453295 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
100453366 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
100453407 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
100453483 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825 ]
100453682 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625 ]
100453779 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100454097 BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158 ]
100454903 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
100455169 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
100455593 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290 ]
100455858 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
100455956 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
100456038 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
100456050 VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858 ]
100456700 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
100457751 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
100458096 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
100458183 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
100458345 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
100459702 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
100460977 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
100461418 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
100461595 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580 ]
100461835 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
100462193 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
100462459 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
103889133 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
112129369 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
112130221 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
112130240 GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
Compound
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Engelman JA, Luo J, Cantley LC
Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Journal
Reference
Authors
Song G, Ouyang G, Bao S
Title
The activation of Akt/PKB signaling pathway and cell survival.
Journal
Reference
Authors
Hers I, Vincent EE, Tavare JM
Title
Akt signalling in health and disease.
Journal
Reference
Authors
Duronio V
Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
Journal
Reference
Authors
Kim D, Chung J.
Title
Akt: versatile mediator of cell survival and beyond.
Journal
Reference
Authors
Koyasu S
Title
The role of PI3K in immune cells.
Journal
Reference
Authors
Okkenhaug K, Vanhaesebroeck B.
Title
PI3K in lymphocyte development, differentiation and activation.
Journal
Reference
Authors
Richardson CJ, Schalm SS, Blenis J
Title
PI3-kinase and TOR: PIKTORing cell growth.
Journal
Reference
Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
Title
Akt, FoxO and regulation of apoptosis.
Journal
Reference
Authors
Georgescu MM
Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
Journal
Reference
Authors
West KA, Castillo SS, Dennis PA
Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Journal
Reference
Authors
Wymann MP, Pirola L
Title
Structure and function of phosphoinositide 3-kinases.
Journal
Reference
Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
Title
Regulation of Raf-Akt Cross-talk.
Journal
Reference
Authors
Kikani CK, Dong LQ, Liu F
Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
Journal
Reference
Authors
Blume-Jensen P, Hunter T
Title
Oncogenic kinase signalling.
Journal
Reference
Authors
Osaki M, Oshimura M, Ito H
Title
PI3K-Akt pathway: its functions and alterations in human cancer.
Journal
Reference
Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Related pathway
pon04620 Toll-like receptor signaling pathway
pon04662 B cell receptor signaling pathway
KO pathway