KEGG   PATHWAY: pon04151
Entry
pon04151                    Pathway                                

Name
PI3K-Akt signaling pathway - Pongo abelii (Sumatran orangutan)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pon04151  PI3K-Akt signaling pathway
pon04151

Other DBs
GO: 0043491
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100455021  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100172994  TGFA; protransforming growth factor alpha precursor [KO:K08774]
100443243  EREG; proepiregulin [KO:K09784]
100443606  AREG; amphiregulin [KO:K09782]
100174103  FGF1; fibroblast growth factor 1 [KO:K18496]
100459751  FGF2; fibroblast growth factor 2 [KO:K18497]
100454905  FGF16; fibroblast growth factor 16 [KO:K04358]
100448388  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100454475  FGF9; fibroblast growth factor 9 [KO:K04358]
100460891  FGF20; fibroblast growth factor 20 [KO:K04358]
100450364  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
100440363  FGF3; fibroblast growth factor 3 [KO:K04358]
100440732  FGF4; fibroblast growth factor 4 [KO:K04358]
100459069  FGF6; fibroblast growth factor 6 [KO:K04358]
100432789  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
100437858  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100460498  FGF18; fibroblast growth factor 18 [KO:K04358]
100172539  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
100431992  FGF10; fibroblast growth factor 10 [KO:K04358]
100441475  FGF19; fibroblast growth factor 19 [KO:K22603]
100447289  FGF21; fibroblast growth factor 21 [KO:K22429]
100439010  FGF23; fibroblast growth factor 23 [KO:K22428]
100441497  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100447350  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
100432172  NTF3; neurotrophin-3 [KO:K04356]
100457557  LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
103888645  NTF4; neurotrophin-4 [KO:K12457]
100453978  INS; insulin isoform X1 [KO:K04526]
100444645  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100453365  IGF2; insulin-like growth factor II [KO:K13769]
100440212  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100460243  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100437861  PDGFC; platelet-derived growth factor C [KO:K05450]
100172718  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
100452144  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100459690  KITLG; kit ligand isoform X1 [KO:K05461]
100439816  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100448769  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100456050  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
100440872  PGF; placenta growth factor isoform X1 [KO:K16859]
100453191  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100433743  VEGFD; vascular endothelial growth factor D [KO:K05449]
100462115  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100443653  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100459533  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100434503  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100448360  EFNA1; ephrin-A1 [KO:K05462]
100448970  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100449916  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100451193  EFNA5; ephrin-A5 [KO:K05462]
112130075  EFNA2; ephrin-A2 [KO:K05462]
100459280  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
100450307  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100174431  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
100938677  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100174545  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
100171540  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100433126  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100461105  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100456038  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100452269  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
100441207  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
100451422  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100172156  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100431735  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100460001  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100433386  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100437110  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100454731  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100456061  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100462098  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100462446  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100137030  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100174302  TEK; angiopoietin-1 receptor precursor [KO:K05121] [EC:2.7.10.1]
100451664  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100442255  IRS1; insulin receptor substrate 1 [KO:K16172]
100456464  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
100457237  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100939231  uncharacterized protein LOC100939231 [KO:K06856]
100939054  immunoglobulin alpha-2 heavy chain-like [KO:K06856]
100939294  uncharacterized protein LOC100939294 [KO:K06856]
100431520  immunoglobulin delta heavy chain-like [KO:K06856]
100438875  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100455587  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100458096  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100446663  chorionic somatomammotropin hormone 2 isoform X2 [KO:K05438]
100447767  growth hormone variant isoform X1 [KO:K05438]
100448861  GH1; somatotropin isoform X2 [KO:K05438]
103892869  chorionic somatomammotropin hormone 2-like isoform X1 [KO:K05438]
100450466  PRL; prolactin [KO:K05439]
100448170  OSM; oncostatin-M isoform X1 [KO:K05418]
100455248  IL2; interleukin-2 [KO:K05429]
100447057  IL3; interleukin-3 [KO:K04736]
100453941  IL6; interleukin-6 isoform X2 [KO:K05405]
100451705  IL4; interleukin-4 isoform X1 [KO:K05430]
100447454  IL7; interleukin-7 isoform X1 [KO:K05431]
100459543  interferon alpha-10 [KO:K05414]
100432532  IFNA8; interferon alpha-8 [KO:K05414]
100432906  IFNA2; interferon alpha-2 [KO:K05414]
100434036  IFNA6; interferon alpha-6 [KO:K05414]
100434796  interferon alpha-5 [KO:K05414]
100435169  interferon alpha-14 [KO:K05414]
100438871  interferon alpha-17-like [KO:K05414]
100439978  IFNA21; interferon alpha-21 [KO:K05414]
100432153  interferon alpha-1/13 [KO:K05414]
100445711  interferon alpha-10-like [KO:K05414]
100438149  interferon alpha-4-like [KO:K05414]
100437034  interferon alpha-4-like [KO:K05414]
100433301  interferon alpha-1/13-like [KO:K05414]
112134962  interferon alpha-10-like [KO:K05414]
100443523  interferon alpha-4-like [KO:K05414]
100441074  IFNB1; interferon beta [KO:K05415]
100459890  EPO; erythropoietin isoform X1 [KO:K05437]
100442480  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
100451189  GHR; growth hormone receptor isoform X2 [KO:K05080]
100294567  PRLR; prolactin receptor precursor [KO:K05081]
100440306  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
100440118  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
100460977  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
100454903  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100462256  interleukin-3 receptor subunit alpha [KO:K04737]
100459702  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100449812  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
100461835  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100443118  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100441293  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100452294  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100433338  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100433477  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100172517  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100433988  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100438152  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
100439107  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100433193  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
100457450  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100457807  COL4A5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
100444160  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100444523  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100443710  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100444077  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100460129  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100461602  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100459849  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100434628  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
100431604  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
100461955  collagen alpha-4(VI) chain-like [KO:K06238]
100431991  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100446946  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
100445025  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
100438698  LAMA1; laminin subunit alpha-1 [KO:K05637]
100458901  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100439539  LAMA3; laminin subunit alpha-3 [KO:K06240]
100456580  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
100458670  LAMB1; laminin subunit beta-1 [KO:K05636]
100441641  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100434204  LAMB3; laminin subunit beta-3 [KO:K06244]
100461994  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
100446999  LAMC1; laminin subunit gamma-1 [KO:K05635]
100446634  LAMC2; laminin subunit gamma-2 [KO:K06246]
100441462  LAMC3; laminin subunit gamma-3 [KO:K06247]
100456207  CHAD; chondroadherin [KO:K06248]
100447813  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100453386  THBS1; thrombospondin-1 [KO:K16857]
100461836  THBS4; thrombospondin-4 [KO:K04659]
100443331  THBS3; thrombospondin-3 [KO:K04659]
100447159  COMP; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
100455895  THBS2; thrombospondin-2 [KO:K04659]
100449704  FN1; fibronectin isoform X1 [KO:K05717]
100189638  SPP1; osteopontin precursor [KO:K06250]
100174092  VTN; vitronectin precursor [KO:K06251]
100451868  TNC; tenascin isoform X4 [KO:K06252]
100443502  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100452638  TNR; tenascin-R isoform X1 [KO:K06252]
100453010  TNN; tenascin-N isoform X1 [KO:K06252]
100434817  VWF; von Willebrand factor precursor [KO:K03900]
100432105  IBSP; bone sialoprotein 2 [KO:K06253]
100439453  ITGA1; integrin alpha-1 [KO:K06480]
100452800  ITGA2B; integrin alpha-IIb [KO:K06476]
100459915  ITGA3; integrin alpha-3 [KO:K06482]
100441139  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100453984  ITGA5; integrin alpha-5 [KO:K06484]
100442478  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100439761  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100442074  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100433501  ITGA9; integrin alpha-9 [KO:K06585]
100461052  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100454617  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100451792  ITGAV; integrin alpha-V [KO:K06487]
100172223  ITGB1; integrin beta-1 precursor [KO:K05719]
100445345  ITGB3; integrin beta-3 [KO:K06493]
100453768  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100449826  ITGB5; integrin beta-5 [KO:K06588]
100171913  ITGB6; integrin beta-6 [KO:K06589]
100440010  ITGB7; integrin beta-7 [KO:K06590]
100459025  ITGB8; integrin beta-8 [KO:K06591]
100447959  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100447792  F2R; proteinase-activated receptor 1 [KO:K03914]
100172935  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100450243  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100458931  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100458628  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100448001  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100459511  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100444153  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100432438  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100173664  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100458183  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
100453483  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100455858  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100171833  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100172647  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor [KO:K07826]
100453366  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100190818  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor [KO:K04541]
100171710  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor [KO:K04542]
112130221  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100433177  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100439475  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X2 [KO:K04546]
100173039  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor [KO:K04347]
112130240  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112129369  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100439849  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X3 [KO:K04548]
100452739  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100453085  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100455593  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X2 [KO:K21290]
100455956  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
100452403  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
112129400  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
100460337  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100172060  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.11]
100174304  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.11]
100445736  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100147742  TSC1; hamartin [KO:K07206]
100441126  TSC2; tuberin isoform X1 [KO:K07207]
100447214  RHEB; GTP-binding protein Rheb [KO:K07208]
100443803  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
100456786  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100434731  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100455169  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100173976  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100448282  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
100456700  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100462008  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100459428  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100456988  RPS6KB1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100432929  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100444624  RPS6; 40S ribosomal protein S6 [KO:K02991]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100440176  PKN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
100438192  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
100450739  PKN3; serine/threonine-protein kinase N3 isoform X2 [KO:K23692] [EC:2.7.11.13]
100447685  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
100171824  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
100174621  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100172734  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100443388  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
100171828  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100440874  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
100437405  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100461606  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100173260  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100437928  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100436819  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
100443527  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100174027  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100462193  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
100453295  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
100458345  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100450088  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100173941  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100439998  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100433271  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
100448353  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100457751  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100173428  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100173221  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100445801  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-alpha A5 [KO:K04079]
100447247  heat shock protein HSP 90-beta-like [KO:K04079]
100174651  HSP90B1; endoplasmin precursor [KO:K09487]
100439548  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
100438416  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100445641  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
100436971  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100433470  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100433083  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
100454912  MTCP1; protein p13 MTCP-1 [KO:K16837]
100447953  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
100439533  BRCA1; breast cancer type 1 susceptibility protein isoform X5 [KO:K10605] [EC:2.3.2.27]
100447772  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100452879  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100172871  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100172601  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
100173760  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100446540  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
100453765  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
100458617  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100171625  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100449905  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100446748  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100443314  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100454924  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100457978  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100452570  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100438282  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100461587  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100451077  FOXO3; forkhead box protein O3 [KO:K09408]
100444180  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100461418  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100443209  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
100173609  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100137177  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100171925  YWHAQ; 14-3-3 protein theta [KO:K16197]
100455220  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
112131710  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
100434385  YWHAH; 14-3-3 protein eta [KO:K16198]
100174383  YWHAG; 14-3-3 protein gamma [KO:K16198]
100454097  BAD; bcl2-associated agonist of cell death [KO:K02158]
100453051  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100938429  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100460459  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100294619  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100450554  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100462459  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100431578  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100432292  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100436186  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100438869  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100127093  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100441756  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100439720  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100172895  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
100436188  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100172457  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100449496  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
100174735  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100440586  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100456049  RELA; transcription factor p65 [KO:K04735]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100452954  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
100171532  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100435218  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pon00010  Glycolysis / Gluconeogenesis
pon04010  MAPK signaling pathway
pon04012  ErbB signaling pathway
pon04062  Chemokine signaling pathway
pon04064  NF-kappa B signaling pathway
pon04068  FoxO signaling pathway
pon04110  Cell cycle
pon04115  p53 signaling pathway
pon04150  mTOR signaling pathway
pon04210  Apoptosis
pon04370  VEGF signaling pathway
pon04510  Focal adhesion
pon04620  Toll-like receptor signaling pathway
pon04630  JAK-STAT signaling pathway
pon04662  B cell receptor signaling pathway
pon04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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