KEGG   PATHWAY: shr04010
Entry
shr04010                    Pathway                                
Name
MAPK signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
shr04010  MAPK signaling pathway
shr04010

Other DBs
GO: 0000165
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100925240  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100933192  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100926503  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100919750  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100915867  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852]
100927554  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100921267  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100934677  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100916832  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100917433  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100915174  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4 [KO:K04858]
100918097  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
100918190  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
100925979  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100929328  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
100928393  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
100925515  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
100924116  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100934787  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100931070  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
100923494  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100934523  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100913776  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
116422929  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100913513  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100929360  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100913731  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100916443  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100920266  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100914479  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100917281  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100915297  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100918408  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100918689  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100920760  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100916434  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
100923297  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100916150  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100913998  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100916458  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
100923893  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018]
100923881  NF1; neurofibromin isoform X1 [KO:K08052]
100933624  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100935390  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100935403  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
100920135  RAP1B; ras-related protein Rap-1b [KO:K07836]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100928770  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100915961  EREG; proepiregulin [KO:K09784]
100924075  AREG; amphiregulin [KO:K09782]
100929695  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100934542  FGF2; fibroblast growth factor 2 [KO:K18497]
100923118  FGF18; fibroblast growth factor 18 [KO:K04358]
100925286  FGF20; fibroblast growth factor 20 [KO:K04358]
100928224  FGF5; fibroblast growth factor 5 [KO:K04358]
100934722  FGF6; fibroblast growth factor 6 [KO:K04358]
100921812  FGF4; fibroblast growth factor 4 [KO:K04358]
100922075  FGF3; fibroblast growth factor 3 [KO:K04358]
100925381  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
100925383  FGF7; fibroblast growth factor 7 [KO:K04358]
100932059  FGF17; fibroblast growth factor 17 [KO:K04358]
100934743  FGF16; fibroblast growth factor 16 [KO:K04358]
100915656  FGF22; fibroblast growth factor 22 [KO:K04358]
100920456  FGF9; fibroblast growth factor 9 [KO:K04358]
116423189  FGF10; fibroblast growth factor 10 [KO:K04358]
100916676  FGF19; fibroblast growth factor 19 [KO:K22603]
100931317  FGF21; fibroblast growth factor 21 [KO:K22429]
100914586  FGF23; fibroblast growth factor 23 [KO:K22428]
100930279  NGF; beta-nerve growth factor [KO:K02582]
100934810  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100918745  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
100918816  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100928068  IGF2; insulin-like growth factor II [KO:K13769]
100924985  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116422035  platelet-derived growth factor subunit A-like [KO:K04359]
100917875  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100928148  PDGFC; platelet-derived growth factor C [KO:K05450]
100916102  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100930278  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
100934452  KITLG; kit ligand isoform X1 [KO:K05461]
100913507  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100913423  VEGFA; vascular endothelial growth factor A [KO:K05448]
100922413  VEGFB; vascular endothelial growth factor B [KO:K16858]
100925473  PGF; placenta growth factor [KO:K16859]
100918372  VEGFD; vascular endothelial growth factor D [KO:K05449]
100928742  VEGFC; vascular endothelial growth factor C [KO:K05449]
100915696  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100923925  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100930153  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
100920602  ANGPT4; angiopoietin-4 [KO:K05467]
100928870  EFNA2; ephrin-A2 [KO:K05462]
100926716  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100927939  EFNA1; ephrin-A1 [KO:K05462]
116423339  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
116423340  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100932324  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
105749408  NRTN; neurturin [KO:K25414]
100920040  ARTN; artemin [KO:K25415]
100932071  PSPN; persephin [KO:K25416]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100914727  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100924586  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100931663  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100914347  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100932215  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
100913979  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100919819  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100931911  death domain-containing membrane protein NRADD [KO:K02583]
100927086  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100916388  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100927322  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100929204  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100916673  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100925116  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
100917212  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100916950  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100929346  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
100929912  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100930426  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111721579  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
100932306  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100929091  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100917007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100926118  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100926384  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100927200  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100928986  NRAS; GTPase NRas [KO:K07828]
100925964  RRAS; LOW QUALITY PROTEIN: ras-related protein R-Ras [KO:K07829]
100935072  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100926472  MRAS; ras-related protein M-Ras [KO:K07831]
100913901  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100919445  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100931320  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
100917828  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
100923157  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100928498  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100931854  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
100931566  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X4 [KO:K04373] [EC:2.7.11.1]
116422810  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100913697  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100914678  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100932794  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100932802  SRF; serum response factor isoform X1 [KO:K04378]
100924435  FOS; proto-oncogene c-Fos [KO:K04379]
100920214  MAPT; microtubule-associated protein tau isoform X10 [KO:K04380]
100916106  STMN1; stathmin [KO:K04381]
100927268  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100913647  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100927005  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
100914602  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100917893  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100918158  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100921875  TNF; tumor necrosis factor [KO:K03156]
105749132  IL1A; interleukin-1 alpha [KO:K04383]
100922350  IL1B; interleukin-1 beta [KO:K04519]
100932607  TGFB1; LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein [KO:K13375]
100914910  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
100929617  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100919788  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100913514  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100933140  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100913844  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100913352  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100919776  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105749219  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100934480  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100932383  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100924669  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100918370  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116421331  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100922757  caspase-3-like [KO:K02187] [EC:3.4.22.56]
100922500  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100934749  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100913341  DAXX; death domain-associated protein 6 isoform X6 [KO:K02308]
100927751  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100923900  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100934112  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100922331  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100926902  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100920439  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116423727  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100917609  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100930713  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100921137  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
100932750  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100926910  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X6 [KO:K04407] [EC:2.7.11.1]
100916981  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
100928883  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100929626  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100933711  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
100925633  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100913571  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
100932989  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
100916713  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100933837  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100916246  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
100932009  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100924042  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
100913706  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
100913796  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
100933813  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
100927077  MAP3K6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
100917439  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100920997  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100928208  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
100919869  TAOK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
100922188  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
100931557  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
100931587  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100926110  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100925586  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
100932199  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
100914535  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X15 [KO:K04436]
100924343  FLNA; filamin-A isoform X1 [KO:K04437]
100923581  CRKL; crk-like protein [KO:K04438]
116423462  CRK; adapter molecule crk isoform X1 [KO:K04438]
100916629  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100919435  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100930815  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928480  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100924267  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928729  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100928990  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100925013  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100925447  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100918701  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
100917693  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100918613  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
100931885  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100927971  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
100927310  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
100926364  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100917473  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100928177  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
100914193  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X3 [KO:K04450]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100931338  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100919026  MAX; protein max isoform X5 [KO:K04453]
100932067  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
100932713  HSPB1; heat shock protein beta-1 [KO:K04455]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100918256  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
100921880  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
100921633  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
100924486  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
100923908  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100926616  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100923803  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100930552  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100928829  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100934414  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100921269  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100915718  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100923042  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100928979  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100927008  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100926097  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100923174  heat shock 70 kDa protein 1-like [KO:K03283]
100932179  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
116419051  heat shock 70 kDa protein 6 [KO:K03283]
116423214  heat shock 70 kDa protein 1 [KO:K03283]
100928711  MECOM; histone-lysine N-methyltransferase MECOM isoform X6 [KO:K04462] [EC:2.1.1.367]
100924259  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
100917749  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100931514  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100918124  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100913624  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100928932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100926701  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
100928564  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100923463  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100932473  RELA; transcription factor p65 [KO:K04735]
100921426  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
shr04070  Phosphatidylinositol signaling system
shr04110  Cell cycle
shr04115  p53 signaling pathway
shr04210  Apoptosis
shr04310  Wnt signaling pathway
shr04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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