KEGG   PATHWAY: mmu05417
Entry
mmu05417                    Pathway                                
Name
Lipid and atherosclerosis - Mus musculus (house mouse)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
mmu05417  Lipid and atherosclerosis
mmu05417

Disease
H02505  Atherosclerosis
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100066  Cyp2j11; cytochrome P450, family 2, subfamily j, polypeptide 11 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
106759  Ticam1; TIR domain containing adaptor molecule 1 [KO:K05842]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
108078  Olr1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
109905  Rap1a; RAS-related protein 1a [KO:K04353]
11303  Abca1; ATP-binding cassette, sub-family A member 1 [KO:K05641]
11307  Abcg1; ATP binding cassette subfamily G member 1 [KO:K05679]
11596  Ager; advanced glycosylation end product-specific receptor [KO:K19722]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
117149  Tirap; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein [KO:K05403]
11783  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
11806  Apoa1; apolipoprotein A-I [KO:K08757]
11808  Apoa4; apolipoprotein A-IV [KO:K08760]
11848  Rhoa; ras homolog family member A [KO:K04513]
11911  Atf4; activating transcription factor 4 [KO:K04374]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
12028  Bax; BCL2-associated X protein [KO:K02159]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12313  Calm1; calmodulin 1 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12362  Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
12368  Casp6; caspase 6 [KO:K04396] [EC:3.4.22.59]
12369  Casp7; caspase 7 [KO:K04397] [EC:3.4.22.60]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12371  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12475  Cd14; CD14 antigen [KO:K04391]
12491  Cd36; CD36 molecule [KO:K06259]
12540  Cdc42; cell division cycle 42 [KO:K04393]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
13057  Cyba; cytochrome b-245, alpha polypeptide [KO:K08009]
13058  Cybb; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis [KO:K08738]
13076  Cyp1a1; cytochrome P450, family 1, subfamily a, polypeptide 1 [KO:K07408] [EC:1.14.14.1]
13109  Cyp2j5; cytochrome P450, family 2, subfamily j, polypeptide 5 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
13110  Cyp2j6; cytochrome P450, family 2, subfamily j, polypeptide 6 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
13198  Ddit3; DNA-damage inducible transcript 3 [KO:K04452]
13665  Eif2s1; eukaryotic translation initiation factor 2, subunit 1 alpha [KO:K03237]
13666  Eif2ak3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
14083  Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
14102  Fas; Fas cell surface death receptor [KO:K04390]
14103  Fasl; Fas ligand [KO:K04389]
14281  Fos; FBJ osteosarcoma oncogene [KO:K04379]
14825  Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505]
14828  Hspa5; heat shock protein 5 [KO:K09490] [EC:3.6.4.10]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
15481  Hspa8; heat shock protein 8 [KO:K03283]
15482  Hspa1l; heat shock protein 1-like [KO:K03283]
15510  Hspd1; heat shock protein 1 (chaperonin) [KO:K04077] [EC:5.6.1.7]
15511  Hspa1b; heat shock protein 1B [KO:K03283]
15512  Hspa2; heat shock protein 2 [KO:K26598]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
15525  Hspa4; heat shock protein 4 [KO:K09489]
15894  Icam1; intercellular adhesion molecule 1 [KO:K06490]
15962  Ifna1; interferon alpha 1 [KO:K05414]
15964  Ifna11; interferon alpha 11 [KO:K05414]
15965  Ifna2; interferon alpha 2 [KO:K05414]
15967  Ifna4; interferon alpha 4 [KO:K05414]
15968  Ifna5; interferon alpha 5 [KO:K05414]
15969  Ifna6; interferon alpha 6 [KO:K05414]
15970  Ifna7; interferon alpha 7 [KO:K05414]
15972  Ifna9; interferon alpha 9 [KO:K05414]
15974  Ifnab; interferon alpha B [KO:K05414]
15977  Ifnb1; interferon beta 1, fibroblast [KO:K05415]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16159  Il12a; interleukin 12a [KO:K05406]
16160  Il12b; interleukin 12b [KO:K05425]
16173  Il18; interleukin 18 [KO:K05482]
16176  Il1b; interleukin 1 beta [KO:K04519]
16179  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
16193  Il6; interleukin 6 [KO:K05405]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16452  Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16476  Jun; jun proto-oncogene [KO:K04448]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
16801  Arhgef1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
16803  Lbp; lipopolysaccharide binding protein [KO:K05399]
16835  Ldlr; low density lipoprotein receptor [KO:K12473]
17087  Ly96; lymphocyte antigen 96 [KO:K05400]
17096  Lyn; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
17392  Mmp3; matrix metallopeptidase 3 [KO:K01394] [EC:3.4.24.17]
17395  Mmp9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
17874  Myd88; myeloid differentiation primary response gene 88 [KO:K04729]
17969  Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
17970  Ncf2; neutrophil cytosolic factor 2 [KO:K08010]
17972  Ncf4; neutrophil cytosolic factor 4 [KO:K08012]
18018  Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
18024  Nfe2l2; nuclear factor, erythroid derived 2, like 2 [KO:K05638]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18127  Nos3; nitric oxide synthase 3, endothelial cell [KO:K13242] [EC:1.14.13.39]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18607  Pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18803  Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
18986  Pou2f1; POU domain, class 2, transcription factor 1 [KO:K09364]
18987  Pou2f2; POU domain, class 2, transcription factor 2 [KO:K09364]
18988  Pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
19016  Pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
193740  Hspa1a; heat shock protein 1A [KO:K03283]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
19878  Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
20181  Rxra; retinoid X receptor alpha [KO:K08524]
20182  Rxrb; retinoid X receptor beta [KO:K08525]
20183  Rxrg; retinoid X receptor gamma [KO:K08526]
20293  Ccl12; C-C motif chemokine ligand 12 [KO:K14624]
20296  Ccl2; C-C motif chemokine ligand 2 [KO:K14624]
20302  Ccl3; C-C motif chemokine ligand 3 [KO:K05408]
20304  Ccl5; C-C motif chemokine ligand 5 [KO:K12499]
20310  Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505]
20339  Sele; selectin, endothelial cell [KO:K06494]
20344  Selp; selectin, platelet [KO:K06496]
20656  Sod2; superoxide dismutase 2, mitochondrial [KO:K04564] [EC:1.15.1.1]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20848  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
21353  Tank; TRAF family member-associated Nf-kappa B activator [KO:K12650]
215449  Rap1b; RAS related protein 1b [KO:K07836]
216799  Nlrp3; NLR family, pyrin domain containing 3 [KO:K12800]
21898  Tlr4; toll-like receptor 4 [KO:K10160]
21899  Tlr6; toll-like receptor 6 [KO:K10169]
21926  Tnf; tumor necrosis factor [KO:K03156]
21933  Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
21939  Cd40; CD40 antigen [KO:K03160]
21947  Cd40lg; CD40 ligand [KO:K03161]
22027  Hsp90b1; heat shock protein 90, beta (Grp94), member 1 [KO:K09487]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
22031  Traf3; TNF receptor-associated factor 3 [KO:K03174]
22034  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
22035  Tnfsf10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
22059  Trp53; transformation related protein 53 [KO:K04451]
22324  Vav1; vav 1 oncogene [KO:K05730]
22325  Vav2; vav 2 oncogene [KO:K05730]
22329  Vcam1; vascular cell adhesion molecule 1 [KO:K06527]
22359  Vldlr; very low density lipoprotein receptor [KO:K20053]
22433  Xbp1; X-box binding protein 1 [KO:K09027]
225164  Mib1; MIB E3 ubiquitin protein ligase 1 [KO:K10645] [EC:2.3.2.27]
225471  Ticam2; TIR domain containing adaptor molecule 2 [KO:K05409]
226641  Atf6; activating transcription factor 6 [KO:K09054]
230396  Ifna13; interferon alpha 13 [KO:K05414]
230398  Ifna16; interferon alpha 16 [KO:K05414]
230459  Cyp2j13; cytochrome P450, family 2, subfamily j, polypeptide 13 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
237038  Nox1; NADPH oxidase 1 [KO:K08008]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
238055  Apob; apolipoprotein B [KO:K14462]
24088  Tlr2; toll-like receptor 2 [KO:K10159]
242517  Ifna15; interferon alpha 15 [KO:K05414]
242519  Ifna12; interferon alpha 12 [KO:K05414]
242546  Cyp2j12; cytochrome P450, family 2, subfamily j, polypeptide 12 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
26397  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
26398  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26399  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
26400  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26409  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
266632  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
330122  Cxcl3; C-X-C motif chemokine ligand 3 [KO:K05505]
404549  Ifna14; interferon alpha 14 [KO:K05414]
494124  Calm5; calmodulin 5 [KO:K02183]
50527  Ero1a; endoplasmic reticulum oxidoreductase 1 alpha [KO:K10950] [EC:1.8.4.-]
54123  Irf7; interferon regulatory factor 7 [KO:K09447]
54131  Irf3; interferon regulatory factor 3 [KO:K05411]
546837  Cyp2j7; cytochrome P450, family 2, subfamily j, polypeptide 7 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
56480  Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
56489  Ikbke; inhibitor of kappaB kinase epsilon [KO:K07211] [EC:2.7.11.10]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
57257  Vav3; vav 3 oncogene [KO:K05730]
665095  Cyp2j8; cytochrome P450, family 2, subfamily j, polypeptide 8 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
66513  Tab1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
66824  Pycard; PYD and CARD domain containing [KO:K12799]
67653  4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
68652  Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
70405  Calml3; calmodulin-like 3 [KO:K02183]
74519  Cyp2j9; cytochrome P450, family 2, subfamily j, polypeptide 9 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75600  Calml4; calmodulin-like 4 [KO:K02183]
76580  Mib2; mindbomb E3 ubiquitin protein ligase 2 [KO:K10645] [EC:2.3.2.27]
78943  Ern1; endoplasmic reticulum to nucleus signalling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
80796  Calm4; calmodulin 4 [KO:K02183]
83995  Mmp1a; matrix metallopeptidase 1a (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
83996  Mmp1b; matrix metallopeptidase 1b (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
Nat Rev Immunol 13:709-21 (2013)
DOI:10.1038/nri3520
Reference
PMID:25403963
  Authors
Butoi E, Gan AM, Manduteanu I
  Title
Molecular and functional interactions among monocytes/macrophages and smooth muscle cells and their relevance for atherosclerosis.
  Journal
Crit Rev Eukaryot Gene Expr 24:341-55 (2014)
DOI:10.1615/critreveukaryotgeneexpr.2014012157
Reference
PMID:24048132
  Authors
Sheedy FJ, Moore KJ
  Title
IL-1 signaling in atherosclerosis: sibling rivalry.
  Journal
Nat Immunol 14:1030-2 (2013)
DOI:10.1038/ni.2711
Reference
PMID:21529710
  Authors
Moore KJ, Tabas I
  Title
Macrophages in the pathogenesis of atherosclerosis.
  Journal
Cell 145:341-55 (2011)
DOI:10.1016/j.cell.2011.04.005
Reference
PMID:22577254
  Authors
Gui T, Shimokado A, Sun Y, Akasaka T, Muragaki Y
  Title
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
  Journal
Mediators Inflamm 2012:693083 (2012)
DOI:10.1155/2012/693083
Reference
PMID:17442283
  Authors
Collot-Teixeira S, Martin J, McDermott-Roe C, Poston R, McGregor JL
  Title
CD36 and macrophages in atherosclerosis.
  Journal
Cardiovasc Res 75:468-77 (2007)
DOI:10.1016/j.cardiores.2007.03.010
Reference
PMID:19065049
  Authors
Park YM, Febbraio M, Silverstein RL
  Title
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima.
  Journal
J Clin Invest 119:136-45 (2009)
DOI:10.1172/JCI35535
Reference
PMID:24903227
  Authors
Park YM
  Title
CD36, a scavenger receptor implicated in atherosclerosis.
  Journal
Exp Mol Med 46:e99 (2014)
DOI:10.1038/emm.2014.38
Reference
PMID:21035758
  Authors
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I
  Title
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
  Journal
Cell Metab 12:467-82 (2010)
DOI:10.1016/j.cmet.2010.09.010
Reference
PMID:25869517
  Authors
Nimgulkar C, Ghosh S, Sankar AB, Uday KP, Surekha MV, Madhusudhanachary P, Annapurna BR, Raghu P, Bharatraj DK
  Title
Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis.
  Journal
Vascul Pharmacol 72:53-63 (2015)
DOI:10.1016/j.vph.2015.02.014
Reference
PMID:23928573
  Authors
Canton J, Neculai D, Grinstein S
  Title
Scavenger receptors in homeostasis and immunity.
  Journal
Nat Rev Immunol 13:621-34 (2013)
DOI:10.1038/nri3515
Reference
PMID:20375591
  Authors
Erridge C
  Title
The roles of Toll-like receptors in atherosclerosis.
  Journal
J Innate Immun 1:340-9 (2009)
DOI:10.1159/000191413
Reference
PMID:21884686
  Authors
Seneviratne AN, Sivagurunathan B, Monaco C
  Title
Toll-like receptors and macrophage activation in atherosclerosis.
  Journal
Clin Chim Acta 413:3-14 (2012)
DOI:10.1016/j.cca.2011.08.021
Reference
PMID:21252151
  Authors
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL
  Title
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
  Journal
Circ Res 108:235-48 (2011)
DOI:10.1161/CIRCRESAHA.110.223875
Reference
PMID:20884885
  Authors
Tabas I
  Title
The role of endoplasmic reticulum stress in the progression of atherosclerosis.
  Journal
Circ Res 107:839-50 (2010)
DOI:10.1161/CIRCRESAHA.110.224766
Reference
PMID:29360955
  Authors
Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR, De Meyer GRY
  Title
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.
  Journal
Cardiovasc Res 114:622-634 (2018)
DOI:10.1093/cvr/cvy007
Reference
PMID:12730091
  Authors
Lipskaia L, Pourci ML, Delomenie C, Combettes L, Goudouneche D, Paul JL, Capiod T, Lompre AM
  Title
Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation.
  Journal
Circ Res 92:1115-22 (2003)
DOI:10.1161/01.RES.0000074880.25540.D0
Reference
PMID:28230726
  Authors
Cervantes Gracia K, Llanas-Cornejo D, Husi H
  Title
CVD and Oxidative Stress.
  Journal
J Clin Med 6:E22 (2017)
DOI:10.3390/jcm6020022
Reference
PMID:21321594
  Authors
Hansson GK, Hermansson A
  Title
The immune system in atherosclerosis.
  Journal
Nat Immunol 12:204-12 (2011)
DOI:10.1038/ni.2001
Reference
PMID:19301036
  Authors
Roy H, Bhardwaj S, Yla-Herttuala S
  Title
Molecular genetics of atherosclerosis.
  Journal
Hum Genet 125:467-91 (2009)
DOI:10.1007/s00439-009-0654-5
Reference
PMID:15451808
  Authors
Lusis AJ, Fogelman AM, Fonarow GC
  Title
Genetic basis of atherosclerosis: part I: new genes and pathways.
  Journal
Circulation 110:1868-73 (2004)
DOI:10.1161/01.CIR.0000143041.58692.CC
Reference
PMID:15485348
  Authors
Lusis AJ, Mar R, Pajukanta P
  Title
Genetics of atherosclerosis.
  Journal
Annu Rev Genomics Hum Genet 5:189-218 (2004)
DOI:10.1146/annurev.genom.5.061903.175930
Related
pathway
mmu04020  Calcium signaling pathway
mmu04115  p53 signaling pathway
mmu04141  Protein processing in endoplasmic reticulum
mmu04151  PI3K-Akt signaling pathway
mmu04210  Apoptosis
mmu04620  Toll-like receptor signaling pathway
mmu04621  NOD-like receptor signaling pathway
mmu04668  TNF signaling pathway
mmu04670  Leukocyte transendothelial migration
mmu04975  Fat digestion and absorption
mmu04979  Cholesterol metabolism
mmu05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   

DBGET integrated database retrieval system