KEGG   PATHWAY: pcad05417
Entry
pcad05417                   Pathway                                
Name
Lipid and atherosclerosis - Physeter catodon (sperm whale)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
pcad05417  Lipid and atherosclerosis
pcad05417

Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
114487276  APOB; apolipoprotein B-100 [KO:K14462]
102992794  APOA4; apolipoprotein A-IV [KO:K08760]
102992508  APOA1; apolipoprotein A-I [KO:K08757]
102984457  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102974327  oxidized low-density lipoprotein receptor 1 [KO:K08763]
102984815  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X6 [KO:K12330]
102996438  MMP1; interstitial collagenase isoform X1 [KO:K01388] [EC:3.4.24.7]
102983639  RHOA; transforming protein RhoA [KO:K04513]
102994518  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
102985806  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102990087  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102974655  BAD; bcl2-associated agonist of cell death [KO:K02158]
102980439  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102987942  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102996353  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
102977417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102984741  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102981093  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102989864  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
102995233  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
102986691  POU domain, class 2, transcription factor 2 isoform X11 [KO:K09364]
102979165  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
102974041  CD40LG; CD40 ligand [KO:K03161]
102984326  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
102995526  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102976074  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
102975652  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
102993493  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102982542  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
102973615  cytochrome b-245 light chain [KO:K08009]
102987030  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
102993692  NCF4; neutrophil cytosol factor 4 [KO:K08012]
102979195  rho-related BTB domain-containing protein 2 [KO:K04392]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102983882  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102978811  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
102976764  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102993818  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102991774  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
102982453  FOS; protein c-Fos [KO:K04379]
102975458  JUN; transcription factor Jun [KO:K04448]
102990067  monocyte chemotactic protein 1B [KO:K14624]
102988478  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102979960  CXCL8; interleukin-8 [KO:K10030]
102978047  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
102982175  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
102977531  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102989111  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102990302  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
102977994  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102992439  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102974198  RELA; transcription factor p65 isoform X1 [KO:K04735]
102981135  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102995870  SELE; E-selectin [KO:K06494]
102975503  SELP; P-selectin isoform X1 [KO:K06496]
102996805  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
102979086  LOW QUALITY PROTEIN: vascular cell adhesion protein 1-like [KO:K06527]
102983506  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
102977941  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102985097  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102994188  IL1B; interleukin-1 beta [KO:K04519]
102980126  IL6; interleukin-6 [KO:K05405]
102983069  TNF; tumor necrosis factor [KO:K03156]
102975361  HSPD1; 60 kDa heat shock protein, mitochondrial isoform X1 [KO:K04077] [EC:5.6.1.7]
102982689  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
102974358  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102994908  heat shock 70 kDa protein 1B [KO:K03283]
102995190  heat shock 70 kDa protein 1B [KO:K03283]
102995465  heat shock 70 kDa protein 1-like [KO:K03283]
102989030  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102990601  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102983803  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102973375  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102986227  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
102974164  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
102989263  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
102980083  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
102988570  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102985047  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102978403  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
102990733  HSP90B1; endoplasmin [KO:K09487]
102976342  TLR2; toll-like receptor 2 [KO:K10159]
102981965  LBP; lipopolysaccharide-binding protein [KO:K05399]
102990526  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102993075  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
102983076  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
102979480  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
102974002  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102982312  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112062410  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102993207  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
102983590  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
102996495  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102995727  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102977668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102976706  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
114485485  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
102980964  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102973672  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102988467  TICAM2; TIR domain-containing adapter molecule 2 isoform X1 [KO:K05409]
102975837  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102974816  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102981648  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
102991389  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X5 [KO:K10645] [EC:2.3.2.27]
102975438  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
102994478  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102994775  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102996452  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
102986279  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112065747  interferon alpha-1-like [KO:K05414]
102980314  interferon alpha-1-like [KO:K05414]
102990155  IFNB1; interferon beta [KO:K05415]
102975405  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
102973323  platelet glycoprotein 4 [KO:K06259]
102974359  platelet glycoprotein 4-like [KO:K06259]
102986529  PPARG; peroxisome proliferator-activated receptor gamma isoform X3 [KO:K08530]
102992401  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102973179  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
102980836  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
102984630  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
102982229  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102976346  VAV1; proto-oncogene vav [KO:K05730]
102973743  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102988564  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102979734  TLR6; toll-like receptor 6 [KO:K10169]
102985661  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102980344  RAP1B; ras-related protein Rap-1b [KO:K07836]
102989853  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
102975625  CCL5; C-C motif chemokine 5 [KO:K12499]
102996195  C-C motif chemokine 3 [KO:K05408]
112065981  LOW QUALITY PROTEIN: C-C motif chemokine 3-like [KO:K05408]
102981375  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
112062060  growth-regulated protein homolog beta [KO:K05505]
102982314  growth-regulated protein homolog beta [KO:K05505]
102982335  IL12A; interleukin-12 subunit alpha [KO:K05406]
102980587  IL12B; interleukin-12 subunit beta [KO:K05425]
102976103  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
102976313  IL18; interleukin-18 [KO:K05482]
102983768  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102983292  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3 [KO:K09054]
102979652  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102980242  DNA damage-inducible transcript 3 protein-like [KO:K04452]
102987621  ERO1A; ERO1-like protein alpha isoform X2 [KO:K10950] [EC:1.8.4.-]
102980540  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102995187  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
102988954  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X25 [KO:K04515] [EC:2.7.11.17]
102994812  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
102981822  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102975968  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102984157  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102987670  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102996185  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102976909  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102985576  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
102979910  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X3 [KO:K05641]
102975074  ATP-binding cassette sub-family G member 1 [KO:K05679]
102992099  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
102986634  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102995954  LOW QUALITY PROTEIN: apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102982110  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
102980841  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
102977392  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102978702  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114484431  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102988344  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102993777  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X5 [KO:K17332]
102984161  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102995357  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102985636  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102974165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102983015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102992700  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102976671  CALM1; calmodulin-1 [KO:K02183]
102988232  calmodulin-alpha [KO:K02183]
102996886  calmodulin-1-like [KO:K02183]
102993731  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102988309  CALM3; calmodulin-3 [KO:K02183]
102977506  uncharacterized protein LOC102977506 [KO:K02183]
129392645  neo-calmodulin-like [KO:K02183]
102994784  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102973173  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102990815  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348] [EC:3.1.3.16]
112065477  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
112067521  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102992913  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
102979472  tumor necrosis factor receptor superfamily member 10B [KO:K04722]
102980036  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
102980613  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102979864  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102988082  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102980282  cytochrome c-like [KO:K08738]
112066660  cytochrome c [KO:K08738]
112063874  cytochrome c-like [KO:K08738]
102978471  cytochrome c-like [KO:K08738]
102986675  cytochrome c-like [KO:K08738]
102977457  cytochrome c 2 [KO:K08738]
102978194  cytochrome c-like [KO:K08738]
102994125  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102989458  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102979663  CASP6; caspase-6 [KO:K04396] [EC:3.4.22.59]
102980899  LOW QUALITY PROTEIN: caspase-6-like [KO:K04396] [EC:3.4.22.59]
102977692  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102974187  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
102985658  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
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Related
pathway
pcad04020  Calcium signaling pathway
pcad04115  p53 signaling pathway
pcad04141  Protein processing in endoplasmic reticulum
pcad04151  PI3K-Akt signaling pathway
pcad04210  Apoptosis
pcad04620  Toll-like receptor signaling pathway
pcad04621  NOD-like receptor signaling pathway
pcad04668  TNF signaling pathway
pcad04670  Leukocyte transendothelial migration
pcad04975  Fat digestion and absorption
pcad04979  Cholesterol metabolism
pcad05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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