Entry
Name
Human immunodeficiency virus 1 infection - Rattus norvegicus (rat)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
rno05170 Human immunodeficiency virus 1 infection
Disease
H00406 Acquired immunodeficiency syndrome (AIDS)
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
100361818 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446 ]
100362547 Ap1g2; adaptor related protein complex 1 subunit gamma 2 [KO:K12391 ]
102546590 H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
114117 Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
114118 Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
114119 Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
114120 Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
120093125 RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751 ]
156767 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
171378 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
171494 Ap1g1; AP-1 complex subunit gamma-1 isoform 1 [KO:K12391 ]
24400 Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
245986 Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
24675 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
246756 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
24747 RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751 ]
24888 Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570 ]
24932 Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
24973 RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751 ]
24974 RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751 ]
24988 RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751 ]
25262 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958 ]
25300 Cd247; T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor [KO:K06453 ]
25385 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
25643 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
25679 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
25686 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
25710 Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
266610 Fadd; FAS-associated death domain protein [KO:K02373 ]
287280 Skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
294213 RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751 ]
294962 Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
300678 Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452 ]
301059 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
303024 Fbxw11; F-box/WD repeat-containing protein 11 isoform 1 [KO:K03362 ]
305897 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
308267 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
309600 RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751 ]
309603 RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751 ]
309607 RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751 ]
311580 Samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544 ] [EC:3.1.5.-]
311658 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
315137 Apobec3; DNA dC->dU-editing enzyme APOBEC3 [KO:K18750 ] [EC:3.5.4.-]
315139 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
315609 Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451 ]
360785 Ap1s1; adaptor-related protein complex 1, sigma 1 subunit [KO:K12394 ]
361400 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
361765 Btrc; F-box/WD repeat-containing protein 1A [KO:K03362 ]
361787 RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751 ]
363855 Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431 ] [EC:2.7.12.2 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
365527 RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
368153 RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751 ]
406194 RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751 ]
414779 RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751 ]
414783 RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751 ]
414784 RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751 ]
414785 RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751 ]
414786 RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751 ]
414788 RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751 ]
414789 RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751 ]
414790 RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751 ]
414791 RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751 ]
414792 RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751 ]
414793 RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751 ]
414819 RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751 ]
498840 Sting1; stimulator of interferon genes protein [KO:K12654 ]
499400 RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751 ]
499402 H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
50664 Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform B [KO:K04534 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
58979 Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
60449 Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
60628 Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
64199 Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
64625 Bid; BH3-interacting domain death agonist [KO:K04726 ]
64639 Bad; bcl2-associated agonist of cell death [KO:K02158 ]
680149 Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
680842 RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751 ]
685451 Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
685513 Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
688319 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
690825 Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
79218 Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
80850 Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
81662 Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635 ]
81664 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
81667 Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
81678 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
83579 Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
Title
HIV persistence: chemokines and their signalling pathways.
Journal
Reference
Authors
Abbas W, Herbein G
Title
Plasma membrane signaling in HIV-1 infection.
Journal
Reference
Authors
Wu Y, Yoder A
Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
Journal
Reference
Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
Journal
Reference
Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
Journal
Reference
Authors
Das SR, Jameel S
Title
Biology of the HIV Nef protein.
Journal
Indian J Med Res 121:315-32 (2005)
Reference
Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
Journal
Reference
Authors
Magadan JG, Bonifacino JS
Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Journal
Reference
Authors
Kumar A, Herbein G
Title
The macrophage: a therapeutic target in HIV-1 infection.
Journal
Reference
Authors
Yokota S, Okabayashi T, Fujii N
Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
Journal
Reference
Authors
Sauter D, Kirchhoff F
Title
HIV replication: a game of hide and sense.
Journal
Reference
Authors
Altfeld M, Gale M Jr
Title
Innate immunity against HIV-1 infection.
Journal
Reference
Authors
Pasquereau S, Kumar A, Herbein G
Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
Journal
Reference
Authors
Herbein G, Khan KA
Title
Is HIV infection a TNF receptor signalling-driven disease?
Journal
Reference
Authors
Kumar A, Abbas W, Herbein G
Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
Journal
Reference
Authors
Abbas W, Herbein G
Title
T-Cell Signaling in HIV-1 Infection.
Journal
Reference
Authors
Cummins NW, Badley AD
Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
Journal
Reference
Authors
Gougeon ML
Title
Apoptosis as an HIV strategy to escape immune attack.
Journal
Reference
Authors
Fevrier M, Dorgham K, Rebollo A
Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
Journal
Reference
Authors
Ross TM
Title
Using death to one's advantage: HIV modulation of apoptosis.
Journal
Reference
Authors
Hurley JH, Bonifacino JS
Title
Nef-arious goings-on at the Golgi.
Journal
Reference
Authors
Wonderlich ER, Leonard JA, Collins KL
Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
Journal
Reference
Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
Journal
Reference
Authors
Pereira EA, daSilva LL
Title
HIV-1 Nef: Taking Control of Protein Trafficking.
Journal
Reference
Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
Journal
Reference
Authors
Bagga S, Bouchard MJ
Title
Cell cycle regulation during viral infection.
Journal
Reference
Authors
Andersen JL, Planelles V
Title
The role of Vpr in HIV-1 pathogenesis.
Journal
Reference
Authors
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
Journal
Reference
Authors
Takaori-Kondo A, Shindo K
Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
Journal
Reference
Authors
Malim MH
Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
Journal
Reference
Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
Journal
Related pathway
rno04141 Protein processing in endoplasmic reticulum
rno04612 Antigen processing and presentation
rno04620 Toll-like receptor signaling pathway
rno04810 Regulation of actin cytoskeleton
KO pathway