KEGG   PATHWAY: aml05163
Entry
aml05163                    Pathway                                
Name
Human cytomegalovirus infection - Ailuropoda melanoleuca (giant panda)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
aml05163  Human cytomegalovirus infection
aml05163

Disease
H00368  Cytomegalovirus infection
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100463753  CCL5; C-C motif chemokine 5 [KO:K12499]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100464006  [KO:K05408]
100464196  NRAS; GTPase NRas [KO:K07828]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100464796  [KO:K04178]
100464798  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100464853  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100464886  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100464991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100464998  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100465045  [KO:K04180]
100465223  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100465369  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
100465439  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100465448  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100465476  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100465524  [KO:K06751]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100465690  TSC2; tuberin isoform X1 [KO:K07207]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465977  RHEB; GTP-binding protein Rheb [KO:K07208]
100466003  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
100466130  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
100466219  [KO:K05050]
100466374  [KO:K06751]
100466408  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100466609  CRKL; crk-like protein [KO:K04438]
100466965  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100467161  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
100467255  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100467322  CRK; adapter molecule crk isoform X1 [KO:K04438]
100467653  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100467683  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100468194  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100468197  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100468235  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100468796  [KO:K12964]
100468916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100468971  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100469047  [KO:K05408]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100469111  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100469231  [KO:K04632]
100469295  [KO:K05408]
100469546  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
100469605  AKAP13; A-kinase anchor protein 13 isoform X18 [KO:K16529]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100469689  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100469737  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100469745  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100469787  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
100469872  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100469938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100470409  CXCR2; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2 [KO:K05050]
100470482  CX3CL1; fractalkine isoform X2 [KO:K05508]
100470489  B2M; beta-2-microglobulin [KO:K08055]
100470568  AIME-128; DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
100470778  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100470861  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100470867  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100470909  CALM2; calmodulin-2 [KO:K02183]
100471078  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100471122  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100471164  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100471184  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100471277  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100471530  TSC1; hamartin isoform X1 [KO:K07206]
100471563  TNF; tumor necrosis factor [KO:K03156]
100471590  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
100471622  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100471691  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100471747  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100471767  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100471940  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100472054  CXCL8; interleukin-8 [KO:K10030]
100472074  [KO:K08738]
100472104  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100472122  CALM3; calmodulin-3 [KO:K02183]
100472171  [KO:K06621]
100472241  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100472777  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100472906  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100472991  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100473195  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100473460  JAK1; tyrosine-protein kinase JAK1 isoform X2 [KO:K11217] [EC:2.7.10.2]
100473680  [KO:K04632]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100473848  STING1; stimulator of interferon genes protein isoform X2 [KO:K12654]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100474121  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100474135  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
100474261  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100474271  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100474348  [KO:K14624]
100474396  SOS2; son of sevenless homolog 2 isoform X9 [KO:K03099]
100474469  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
100474482  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100474505  PXN; paxillin isoform X4 [KO:K05760]
100474673  ARHGEF11; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331]
100474742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100474825  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100474970  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474983  SP1; transcription factor Sp1 [KO:K04684]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100475394  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100475485  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100475635  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100475779  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100475872  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100476017  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
100476214  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100476256  ITGB3; integrin beta-3 [KO:K06493]
100476284  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100476389  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100476495  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100476550  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100476556  IFNB1; interferon beta [KO:K05415]
100476691  AIME-152; class I histocompatibility antigen, Aime-152 precursor [KO:K06751]
100476723  RHOA; transforming protein RhoA [KO:K04513]
100476812  [KO:K05414]
100476922  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100476938  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100477081  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100477151  IL6; interleukin-6 precursor [KO:K05405]
100477221  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100477225  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
100477289  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100477312  [KO:K05414]
100477326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100477562  [KO:K05414]
100477711  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100477714  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100477832  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100477834  CTNNB1; catenin beta-1 [KO:K02105]
100477888  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100478007  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100478040  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100478068  [KO:K05414]
100478321  [KO:K05414]
100478600  CALML6; calmodulin-like protein 6 [KO:K02183]
100478732  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100478801  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100479247  TAPBPL; tapasin-related protein [KO:K28445]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479448  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
100479481  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100479734  CALR; calreticulin [KO:K08057]
100479883  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100480040  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100480235  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100480483  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100480537  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100481177  CALM1; calmodulin-1 [KO:K02183]
100481236  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100481494  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100481615  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100482029  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100482519  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100482526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100482629  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
100482983  VEGFA; vascular endothelial growth factor A [KO:K05448]
100483125  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100483209  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100483482  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100483589  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100483760  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100483811  [KO:K04176]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100483894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100483904  AIME-1906; class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100484104  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100484519  [KO:K02183]
100484531  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100484544  E2F3; transcription factor E2F3 [KO:K06620]
100484553  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100484719  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100484770  [KO:K02183]
100484786  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100484836  TAPBP; tapasin [KO:K08058]
100484923  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100484933  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105236417  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105236905  [KO:K04545]
105238442  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
105241648  [KO:K08738]
105241843  [KO:K06751]
109488333  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
109488766  [KO:K06751]
117795744  E2F1; transcription factor E2F1 [KO:K17454]
117799706  [KO:K02183]
117803984  [KO:K05405]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
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Related
pathway
aml00590  Arachidonic acid metabolism
aml03050  Proteasome
aml04010  MAPK signaling pathway
aml04064  NF-kappa B signaling pathway
aml04110  Cell cycle
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04612  Antigen processing and presentation
aml04623  Cytosolic DNA-sensing pathway
aml04630  JAK-STAT signaling pathway
aml04668  TNF signaling pathway
aml04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

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