KEGG ORTHOLOGY: K06839

ORTHOLOGY: K06839

Entry

K06839                      KO

Symbol

SLIT2

Name

slit 2

Pathway

map04360

Axon guidance

map04361

Axon regeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K06839  SLIT2; slit 2
   04361 Axon regeneration
    K06839  SLIT2; slit 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K06839  SLIT2; slit 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Axon guidance molecules
   K06839  SLIT2; slit 2

Genes

HSA:	9353(SLIT2)

PTR:	461137(SLIT2)

PPS:	100983369(SLIT2)

GGO:	101128679(SLIT2)

PON:	100434105(SLIT2)

PPYG:

129035710(SLIT2)

NLE:	100584788(SLIT2)

HMH:	116456679(SLIT2)

SSYN:

129464721(SLIT2)

MCC:	715470(SLIT2)

MCF:	101866138(SLIT2)

MTHB:

126954989

MNI:	105487854(SLIT2)

CSAB:

103246295(SLIT2)

CATY:

105579008(SLIT2)

PANU:

101000253(SLIT2)

TGE:	112624821(SLIT2)

MLEU:

105549643(SLIT2)

RRO:	104673234(SLIT2)

RBB:	108526173(SLIT2)

TFN:	117085198(SLIT2)

PTEH:

111539187(SLIT2)

CANG:

105507245(SLIT2)

CJC:	100413159(SLIT2)

SBQ:	101042367(SLIT2)

CIMI:

108312595(SLIT2)

ANAN:

105730915(SLIT2)

CSYR:

103256503(SLIT2)

MMUR:

105856059(SLIT2)

LCAT:

123637329

PCOQ:

105823518(SLIT2)

OGA:	100946215(SLIT2)

MMU:	20563(Slit2)

MCAL:

110293912(Slit2)

MPAH:

110330526(Slit2)

RNO:	360272(Slit2)

MCOC:

116070780(Slit2)

ANU:	117712324(Slit2)

ASYL:

127696495(Slit2)

MUN:	110539991(Slit2)

CGE:

100752994

MAUA:

101823006(Slit2)

PROB:

127213595(Slit2)

PLEU:

114690889(Slit2)

MORG:

121442275(Slit2)

MFOT:

126506492

AAMP:

119815951(Slit2)

NGI:	103731004(Slit2)

HGL:	101707937(Slit2)

CPOC:

100728211(Slit2)

CCAN:

109676411(Slit2)

DORD:

105980308(Slit2)

DSP:	122104076(Slit2)

PLOP:

125364879(Slit2)

NCAR:

124994495

MMMA:

107138924(Slit2)

ITI:	101970706(Slit2)

OCU:

100348211

OPI:	101530170(SLIT2)

TUP:	102478818(SLIT2)

GVR:	103592882(SLIT2)

CFA:	595148(SLIT2)

CLUD:

112653380(SLIT2)

VVP:	112918621(SLIT2)

VLG:	121488892(SLIT2)

NPO:	129510242(SLIT2)

AML:	100471504(SLIT2)

UMR:	103658368(SLIT2)

UAH:	113266740(SLIT2)

UAR:	123775870(SLIT2)

ELK:

111148955

LLV:

125093582

MPUF:

101693599(SLIT2)

MNP:	132005000(SLIT2)

MLK:	131825397(SLIT2)

NVS:	122890160(SLIT2)

ORO:	101369792(SLIT2)

EJU:	114197475(SLIT2)

ZCA:	113925116(SLIT2)

MLX:	118010668(SLIT2)

NSU:	110571298(SLIT2)

LWW:	102731368(SLIT2)

FCA:	101084791(SLIT2)

PYU:	121037665(SLIT2)

PCOO:

112858611(SLIT2)

PBG:	122467232(SLIT2)

PVIV:

125164428(SLIT2)

LRUF:

124520495

LGF:	123596126(SLIT2)

AJU:

106986833

PTG:	102950042(SLIT2)

PPAD:

109269607(SLIT2)

PUC:

125922669

PLEZ:

122218579(SLIT2)

HHV:	120219738(SLIT2)

BTA:	534164(SLIT2)

BOM:	102272753(SLIT2)

BIU:	109560361(SLIT2)

BBUB:

102395026(SLIT2)

BBIS:

105003192(SLIT2)

CHX:	102191126(SLIT2)

OAS:	100125611(SLIT2)

BTAX:

128049964(SLIT2)

CSUM:

138082394(SLIT2)

ODA:	120861971(SLIT2)

CCAD:

122422394(SLIT2)

MREE:

136147823(SLIT2)

OVR:	110130649(SLIT2)

MBEZ:

129561570(SLIT2)

SSC:	100620577(SLIT2)

CFR:	102516198(SLIT2)

CBAI:

105075308(SLIT2)

CDK:	105098377(SLIT2)

VPC:	102534674(SLIT2)

BACU:

102998012(SLIT2)

BMUS:

118895822(SLIT2)

LVE:	103085005(SLIT2)

OOR:	101289133(SLIT2)

LALB:

132519413(SLIT2)

DLE:	111171163(SLIT2)

PCAD:

102981311(SLIT2)

PSIU:

116754550(SLIT2)

NASI:

112397574(SLIT2)

ECB:	100068338(SLIT2)

EPZ:	103553517(SLIT2)

EAI:	106829627(SLIT2)

MYB:	102257391(SLIT2)

MYD:	102772066(SLIT2)

MMYO:

118667178(SLIT2)

MLF:	102427547(SLIT2)

MDT:	132220840(SLIT2)

MYUM:

138997211(SLIT2)

PKL:	118708343(SLIT2)

EFUS:

103284870(SLIT2)

MNA:	107527109(SLIT2)

DRO:	112316743(SLIT2)

SHON:

118986285(SLIT2)

AJM:	119045899(SLIT2)

PDIC:

114492837(SLIT2)

PHAS:

123815708(SLIT2)

MMF:	118637817(SLIT2)

PPAM:

129077549(SLIT2)

HAI:	109389032(SLIT2)

RFQ:	117022310(SLIT2)

PALE:

102888760(SLIT2)

PGIG:

120582791(SLIT2)

PVP:	105295998(SLIT2)

RAY:	107498293(SLIT2)

MJV:	108410070(SLIT2)

TOD:	119261203(SLIT2)

SARA:

101555316(SLIT2)

SFUM:

130038527(SLIT2)

SETR:

126032303(SLIT2)

LAV:	100663413(SLIT2)

TMU:

101343863

ETF:	101653981(SLIT2)

DNM:	101441945(SLIT2)

MDO:	100014153(SLIT2)

GAS:	123252016(SLIT2)

SHR:	100933171(SLIT2)

AFZ:

127542030

PCW:	110212609(SLIT2)

TVP:	118854866(SLIT2)

PBRV:

138146983(SLIT2)

OAA:	100082591(SLIT2)

TACU:

119932801(SLIT2)

GGA:	373967(SLIT2)

PCOC:

116225970(SLIT2)

MGP:	100543362(SLIT2)

CJO:	107313976(SLIT2)

TPAI:

128080498(SLIT2)

LMUT:

125692230(SLIT2)

NMEL:

110398403(SLIT2)

APLA:

101800168(SLIT2)

ACYG:

106033442(SLIT2)

CATA:

118251881(SLIT2)

AFUL:

116489107(SLIT2)

TGU:	100223770(SLIT2)

LSR:	110484047(SLIT2)

SCAN:

103824456(SLIT2)

PMOA:

120497479(SLIT2)

OTC:	121334975(SLIT2)

PRUF:

121356725(SLIT2)

ATRC:

139592556(SLIT2)

GFR:	102034605(SLIT2)

FAB:	101810047(SLIT2)

OMA:	130252667(SLIT2)

PHI:	102114033(SLIT2)

PMAJ:

107203426(SLIT2)

CCAE:

111928155(SLIT2)

CCW:	104690896(SLIT2)

CBRC:

103625667(SLIT2)

ACOE:

138109935(SLIT2)

ETL:	114066955(SLIT2)

ZAB:	102073291(SLIT2)

ZLE:	135447087(SLIT2)

ACHL:

103806478(SLIT2)

SVG:	106858467(SLIT2)

MMEA:

130572995(SLIT2)

HRT:	120752719(SLIT2)

SATI:

136360437(SLIT2)

CCIC:

134044275(SLIT2)

FPG:	101913898(SLIT2)

FCH:	102047951(SLIT2)

CCRI:

104168733(SLIT2)

NNT:	104400072(SLIT2)

SHAB:

115610633(SLIT2)

ACUN:

113479048(SLIT2)

TALA:

104359782(SLIT2)

ACHC:

115341257(SLIT2)

HLE:	104837609(SLIT2)

AGEN:

126035909

HHAR:

128138820(SLIT2)

GCL:

127015464

LDI:

104351500

MNB:	103779530(SLIT2)

DPUB:

104309175(SLIT2)

PPUS:

135179486(SLIT2)

AVIT:

104278427(SLIT2)

BRHI:

104498884(SLIT2)

EGZ:	104134463(SLIT2)

NNI:	104017623(SLIT2)

PCRI:

104035507(SLIT2)

PADL:

103917016(SLIT2)

AFOR:

103898782(SLIT2)

GSTE:

104262389(SLIT2)

CBOY:

140651835(SLIT2)

CLV:	102086466(SLIT2)

MUI:	104546101(SLIT2)

PGUU:

104467555(SLIT2)

PLET:

104614169(SLIT2)

EHS:	104511331(SLIT2)

CUCA:

104067464(SLIT2)

TEO:	104378765(SLIT2)

BREG:

104642284(SLIT2)

OHA:	104329247(SLIT2)

ACAR:

104527063

CPEA:

104391902(SLIT2)

CVF:	104288795(SLIT2)

RTD:	128910075(SLIT2)

CRID:

134516160(SLIT2)

AAM:	106498705(SLIT2)

AROW:

112969569(SLIT2)

NPD:	112958520(SLIT2)

TGT:	104569364(SLIT2)

DNE:	112996478(SLIT2)

SCAM:

104143113(SLIT2)

ASN:	102370081(SLIT2)

AMJ:	102563006(SLIT2)

CPOO:

109322043(SLIT2)

GGN:	109303790(SLIT2)

PSS:	102462186(SLIT2)

CMY:	102947569(SLIT2)

CCAY:

125636119(SLIT2)

DCC:	119854749(SLIT2)

CPIC:

101951540(SLIT2)

TST:	117877761(SLIT2)

CABI:

116817614(SLIT2)

MRV:	120406502(SLIT2)

ACS:	100558087(slit2)

ASAO:

132776352(SLIT2)

PVT:	110072268(SLIT2)

SUND:

121931173(SLIT2)

PBI:	103052201(SLIT2)

PMUR:

107296070(SLIT2)

CTIG:

120304868(SLIT2)

PGUT:

117676496(SLIT2)

APRI:

131203479(SLIT2)

PTEX:

113435741(SLIT2)

NSS:	113419457(SLIT2)

VKO:	123016924(SLIT2)

PMUA:

114604556

PRAF:

128421198(SLIT2)

ZVI:	118083661(SLIT2)

HCG:	128326626(SLIT2)

GJA:	107122953(SLIT2)

STOW:

125439593(SLIT2)

EMC:	129342809(SLIT2)

XLA:	108698051 394404(slit2.S)

XTR:	100492007(slit2)

NPR:	108791311(SLIT2)

RTEM:

120924317(SLIT2)

BBUF:

120990311(SLIT2)

BGAR:

122938598(SLIT2)

PWL:	138248471(SLIT2)

MUO:	115461433(SLIT2)

GSH:	117362373(SLIT2)

DRE:	80353(slit2)

SRX:	107745853(slit2) 107757564

SANH:

107695646 107700301

SGH:	107598298 107600654(slit2)

CCAR:

109054879 109081075

CAUA:

113044130 113108429

CGIB:

127949357 127954792

PTET:

122351334(slit2)

LROH:

127169366(slit2)

OMC:	131540790(slit2)

PPRM:

120494496(slit2)

RKG:	130099394(slit2)

MAMB:

125272675(slit2)

CIDE:

127515534

CERY:

137032294(slit2)

MASI:

127444264 127445145

TROS:

130552690(slit2)

TDW:	130408153(slit2)

MANU:

129444657(slit2)

PDAB:

135735988(slit2)

IPU:

108260585

IFU:	128604181(slit2)

PHYP:

113544359(slit2)

SMEO:

124381263(slit2)

TVC:	132841703(slit2)

CGAR:

128508574(slit2)

NGRA:

132883461(slit2)

TRN:	134325974(slit2)

AMEX:

103027846(slit2)

CMAO:

118817132(slit2)

EEE:	113586902(slit2)

CHAR:

105903887(slit2)

SPIL:

134099816(slit2)

TRU:	101068313(slit2)

TFS:	130527642(slit2)

TNG:	GSTEN00009178G001

LCO:	104923169(slit2)

NCC:

104967810

TBEN:

117474634(slit2)

CGOB:

115008228(slit2)

PGEO:

117445128(slit2)

GACU:

117543364(slit2)

EMAC:

134865061(slit2)

ELY:	117255238(slit2)

EFO:	125886437(slit2)

PLEP:

121941922(slit2)

SLUC:

116040415(slit2)

ECRA:

117935557(slit2)

ESP:	116700511(slit2)

PFLV:

114564361(slit2)

GAT:	120825593(slit2)

PPUG:

119217790(slit2)

AFB:	129095742(slit2)

CLUM:

117735570(slit2)

PSWI:

130189822(slit2)

CANA:

137794819(slit2)

CVE:	137868573(slit2)

MSAM:

119899060(slit2)

SCHU:

122873848(slit2)

CUD:	121508719(slit2)

SPUL:

138594537(slit2)

LMIX:

132992414(slit2)

ALAT:

119012767(slit2)

ASTR:

137600009(slit2)

MZE:	101467229(slit2)

ONL:	100694794(slit2)

OAU:	116329083(slit2)

OLA:	101173607(slit2)

OML:	112157251(slit2)

CSAI:

133418976(slit2)

XMA:	102220623(slit2)

XCO:	114144726(slit2)

XHE:	116719991(slit2)

PRET:

103466945(slit2)

PFOR:

103137906(slit2)

PLAI:

106947374(slit2)

PMEI:

106914213(slit2)

GAF:	122830173(slit2)

CVG:	107093490(slit2)

CTUL:

119788448(slit2)

GMU:	124868241(slit2)

NFU:	107382134(slit2)

KMR:	108230788(slit2)

ALIM:

106520917(slit2)

NWH:	119407513(slit2)

AOCE:

111568163(slit2)

EJA:	138209047(slit2)

BFRE:

138620369(slit2)

MCEP:

125004109(slit2)

CSEM:

103383686(slit2)

POV:	109637842(slit2)

SSEN:

122770997(slit2)

SSOE:

131466738(slit2)

HHIP:

117760180(slit2)

HSP:	118120096(slit2)

PPLT:

128437315(slit2)

SMAU:

118312751(slit2)

LCF:

108896582

SDU:	111231408(slit2)

SLAL:

111664028(slit2)

XGL:	120800409(slit2)

HCQ:	109519858(slit2)

SSCV:

125968547(slit2)

SBIA:

133505997(slit2)

PEE:	133403849(slit2)

PTAO:

133476999(slit2)

BPEC:

110165294(slit2)

ENY:	140378233(slit2)

MALB:

109961362(slit2)

BSPL:

114843628(slit2)

SJO:	128364904(slit2)

SSCO:

133988154(slit2)

SASA:

106591151

OTW:	112262345(slit2)

OMY:	110516422(slit2)

OGO:

124024905

OKI:

109886960

OMM:	135506437 135507226

OCLA:

139374582 139419351

CCLU:

121562013(slit2) 121565232

ELS:	105009147(slit2)

OEP:

134033906

SFM:	108924359(slit2)

PKI:	111837340(slit2)

AANG:

118227911(slit2)

AROT:

135255833(slit2)

CCOG:

133130391(slit2)

LOC:	102694474(slit2)

PSPA:

121324378 121329799

ARUT:

117409251 117421182

PSEX:

120527765(slit2)

LCM:	102367424(SLIT2)

CMK:	103175815(slit2)

RTP:	109920161(slit2)

CPLA:

122555015(slit2)

HOC:	132815917(slit2)

LERI:

129698904(slit2)

PMRN:

116940650 116941376

LRJ:	133343488 133345492

BFO:	118406803 118414987

BBEL:

109467364 109467412 109467413 109478478

CIN:

SCLV:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG43758(sli)

DER:

6548871

DSE:

6609339

DSI:	Dsimw501_GD25590(Dsim_GD25590)

DYA:	Dyak_GE14122

DAN:

DSR:

DPO:

DPE:

DMN:	108159366 117193781

DWI:

6639686

DGR:

6559138

DMO:	Dmoj_GI21301

DAZ:

108616294

DNV:

108654897

DHE:

111599740

DVI:	6627153(sli)

CCAT:

101452860

BOD:

106617891

BDR:

105226846

RZE:	108360647 108378117

AOQ:

ALUD:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135959941(sli)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004328

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:	408960 727408

ACER:

ALAB:

ADR:

AFLR:

BIM:	100745615 100748420

BBIF:

117214354 117216001

BVK:	117237625 117242351

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139112756(Sli)

TLN:	139808006(Sli)

HST:

DQU:

CFO:

FEX:

PMEC:

138934605(Sli)

LHU:	105670472(sli)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:	124947958 124957783

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:	105265548 105267193

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124221352(sli)

NFB:

NLO:

NVG:

AROA:

TCA:	660980(sli)

TMOL:

138134638(sli)

DPA:	109546161 125502386 125504099

ESIM:

136412278(sli)

EFOR:

136341166(sli)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

135800939(sli)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137926414(sli)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110380873(sli)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106691483(sli)

NLU:

111046664

HVI:

124353249

MQU:

128983609

PHU:	Phum_PHUM419730

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138693962(sli)

SGRE:

126266830

BROR:

134527439

IEL:

124156038

HAMR:

139693550(sli)

FCD:

110857956

DPX:	DAPPUDRAFT_304927

DMK:

116916920

DPZ:

124335774

AFRA:

136027015 136027684

PVM:	113800972 113811035

PJA:	122251403 122255042

PCHN:

125027332 125038213

PMOO:

119587186 119594176

HAME:

121864141 121865336

PCLA:

123745526 123769680 138354471

CQD:	128696874 128702170(sli)

PTRU:

123508487 123519388

ESN:	126981393 127003630

MNZ:	135221274 135221781

MRJ:	136832809 136843614

PORN:

139746765 139759459

HAZT:

108675866

EAF:

111710926

LSM:	121122808(sli)

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

CVS:	136981950 136987869

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F40E10.4(slt-1)

CBR:	CBG_07570(Cbr-slt-1)

CRQ:	GCK72_025657

BMY:	BM_BM3960(Bma-slt-1)

LOA:	LOAG_01152

HRO:	HELRODRAFT_103882

LGI:	LOTGIDRAFT_232797

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

EGL:

LLON:

TAD:	TRIADDRAFT_58750

» show all

Reference

PMID:9813312

Authors

Itoh A, Miyabayashi T, Ohno M, Sakano S

Title

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

Journal

Brain Res Mol Brain Res 62:175-86 (1998)
DOI:10.1016/S0169-328X(98)00224-1

Sequence

[hsa:9353]

Reference

PMID:18363568

Authors

Hohenester E

Title

Structural insight into Slit-Robo signalling.

Journal

Biochem Soc Trans 36:251-6 (2008)
DOI:10.1042/BST0360251

LinkDB

DBGET integrated database retrieval system