KEGG   PATHWAY: mcc05163
Entry
mcc05163                    Pathway                                
Name
Human cytomegalovirus infection - Macaca mulatta (rhesus monkey)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcc05163  Human cytomegalovirus infection
mcc05163

Disease
H00368  Cytomegalovirus infection
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100169972  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100187576  MAMU-AG; major histocompatibility complex, class I, AG precursor [KO:K06751]
100423954  [KO:K05408]
100424348  [KO:K06751]
100424606  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100424899  [KO:K04632]
100425223  CYCS; cytochrome c [KO:K08738]
100426197  [KO:K06751]
100426537  [KO:K05408]
100426632  [KO:K12964]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100428682  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
100429106  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
100430627  [KO:K12964]
106992322  [KO:K05414]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106995399  [KO:K08738]
106995452  [KO:K06751]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
106996627  [KO:K06751]
106996676  [KO:K06751]
106997893  [KO:K06751]
114672113  [KO:K08056] [EC:5.3.4.1]
114672301  [KO:K04375]
114672663  [KO:K05414]
114672664  [KO:K05414]
114673087  [KO:K05408]
114673968  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114673987  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
114675515  [KO:K14021]
114676051  [KO:K06751]
114677644  [KO:K06751]
574128  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
574138  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574178  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
574188  CCR1; C-C chemokine receptor type 1 [KO:K04176]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574217  CCL4L1; C-C motif chemokine 4 precursor [KO:K12964]
574225  CX3CL1; fractalkine precursor [KO:K05508]
574258  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574334  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
574394  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
613251  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
619514  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
693753  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
693914  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
694289  [KO:K04632]
694353  TMEM173; stimulator of interferon genes protein [KO:K12654]
694372  [KO:K06751]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694631  [KO:K05414]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
694965  TSC2; tuberin isoform X7 [KO:K07207]
695220  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
695441  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
696336  PXN; paxillin isoform X1 [KO:K05760]
696350  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
696584  CRKL; crk-like protein [KO:K04438]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697718  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
698089  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
698172  AKAP13; A-kinase anchor protein 13 isoform X6 [KO:K16529]
698223  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
698225  [KO:K08738]
698552  CALM1; calmodulin-1 isoform X1 [KO:K02183]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698830  HRAS; GTPase HRas [KO:K02833]
698840  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699072  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
699243  MAMU-A3; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
699310  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
699951  [KO:K08738]
700407  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700606  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
700724  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701185  CRK; adapter molecule crk isoform X1 [KO:K04438]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701246  [KO:K08738]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702390  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
702488  [KO:K08738]
702710  SP1; transcription factor Sp1 [KO:K04684]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
703336  [KO:K04542]
703398  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
703399  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
703514  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
703628  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
703669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
703780  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
703965  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
704383  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
704871  RB1; retinoblastoma-associated protein [KO:K06618]
705449  [KO:K08738]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705680  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
705819  IL6; interleukin-6 precursor [KO:K05405]
706012  IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135]
706351  [KO:K02183]
706455  RHOA; transforming protein RhoA [KO:K04513]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
706955  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707329  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
707756  ITGAV; integrin alpha-V precursor [KO:K06487]
707977  KRAS; GTPase KRas [KO:K07827]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
708013  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
708024  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
708193  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
708233  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
708444  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708714  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
708717  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
708940  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
709076  MAMU-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
709089  NRAS; GTPase NRas [KO:K07828]
709489  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709755  IFNA8; interferon alpha-8 [KO:K05414]
709773  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
709988  [KO:K06621]
710000  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
710200  E2F2; transcription factor E2F2 [KO:K09389]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710487  [KO:K05414]
710528  [KO:K05414]
710548  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710568  [KO:K05414]
710601  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
710751  [KO:K05414]
710848  [KO:K05414]
711029  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
711088  [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
711309  [KO:K08738]
711335  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
711414  IFNB1; interferon beta precursor [KO:K05415]
711532  MAMU-E; major histocompatibility complex, class I, E precursor [KO:K06751]
711726  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
711832  MAMU-A; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
711879  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
711979  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
712096  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
712148  [KO:K08738]
712159  CALML5; calmodulin-like protein 5 [KO:K02183]
712428  B2M; beta-2-microglobulin precursor [KO:K08055]
712610  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
712787  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713368  CCR3; C-C chemokine receptor type 3 [KO:K04178]
713391  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713904  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
713913  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
713965  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
714126  E2F1; transcription factor E2F1 [KO:K17454]
714645  TSC1; hamartin isoform X1 [KO:K07206]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714785  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
714964  [KO:K06751]
714981  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
715270  CALM2; calmodulin-2 [KO:K02183]
715378  RHEB; GTP-binding protein Rheb [KO:K07208]
715467  TNF; tumor necrosis factor [KO:K03156]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715951  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
716056  [KO:K08738]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716584  CALM3; calmodulin-3 isoform X1 [KO:K02183]
716671  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
716690  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
716910  CALR; calreticulin precursor [KO:K08057]
717050  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
717379  ITGB3; integrin beta-3 [KO:K06493]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
717665  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
717686  [KO:K02183]
717726  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
717742  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
718040  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
718144  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
718223  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
718235  TAPBP; tapasin precursor [KO:K08058]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718727  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X12 [KO:K12331]
718948  BAX; apoptosis regulator BAX [KO:K02159]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
719248  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
719250  [KO:K06751]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719702  [KO:K06751]
720132  [KO:K06751]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
721649  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
721731  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721825  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
722033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
722198  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330]
722398  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
722513  CALML3; calmodulin-like protein 3 [KO:K02183]
723473  [KO:K06751]
735311  CCR5; C-C chemokine receptor type 5 [KO:K04180]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
PMID:23145028
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
PMID:15990176
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
PMID:25549333
  Authors
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
  Title
Human cytomegalovirus gene expression in long-term infected glioma stem cells.
  Journal
PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
Reference
PMID:24445563
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:20398729
  Authors
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ
  Title
Herpesvirus-encoded GPCRs rewire cellular signaling.
  Journal
Mol Cell Endocrinol 331:179-84 (2011)
DOI:10.1016/j.mce.2010.04.007
Reference
PMID:11175803
  Authors
Murphy PM
  Title
Viral exploitation and subversion of the immune system through chemokine mimicry.
  Journal
Nat Immunol 2:116-22 (2001)
DOI:10.1038/84214
Reference
PMID:16352349
  Authors
Vischer HF, Leurs R, Smit MJ
  Title
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
  Journal
Trends Pharmacol Sci 27:56-63 (2006)
DOI:10.1016/j.tips.2005.11.006
Reference
PMID:25805993
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
PMID:15172446
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
PMID:29237840
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:22454101
  Authors
Noriega V, Redmann V, Gardner T, Tortorella D
  Title
Diverse immune evasion strategies by human cytomegalovirus.
  Journal
Immunol Res 54:140-51 (2012)
DOI:10.1007/s12026-012-8304-8
Reference
PMID:17145306
  Authors
Loureiro J, Ploegh HL
  Title
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
  Journal
Adv Immunol 92:225-305 (2006)
DOI:10.1016/S0065-2776(06)92006-9
Reference
PMID:10707064
  Authors
Fortunato EA, McElroy AK, Sanchez I, Spector DH
  Title
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
  Journal
Trends Microbiol 8:111-9 (2000)
DOI:10.1016/S0966-842X(00)01699-1
Reference
PMID:15389728
  Authors
Cinatl J Jr, Scholz M, Doerr HW
  Title
Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation.
  Journal
Med Res Rev 25:167-85 (2005)
DOI:10.1002/med.20018
Reference
PMID:14975530
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
PMID:12062798
  Authors
Castillo JP, Kowalik TF
  Title
Human cytomegalovirus immediate early proteins and cell growth control.
  Journal
Gene 290:19-34 (2002)
DOI:10.1016/S0378-1119(02)00566-8
Reference
PMID:15352160
  Authors
Kalejta RF
  Title
Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
  Journal
J Cell Biochem 93:37-45 (2004)
DOI:10.1002/jcb.20177
Reference
PMID:20969904
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
PMID:28869497
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
Reference
PMID:27160907
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
PMID:28488292
  Authors
Wang X, Sanchez J, Stone MJ, Payne RJ
  Title
Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
  Journal
Angew Chem Int Ed Engl 56:8490-8494 (2017)
DOI:10.1002/anie.201703059
Related
pathway
mcc00590  Arachidonic acid metabolism
mcc03050  Proteasome
mcc04010  MAPK signaling pathway
mcc04064  NF-kappa B signaling pathway
mcc04110  Cell cycle
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04612  Antigen processing and presentation
mcc04623  Cytosolic DNA-sensing pathway
mcc04630  JAK-STAT signaling pathway
mcc04668  TNF signaling pathway
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

DBGET integrated database retrieval system