KEGG   PATHWAY: cide04010
Entry
cide04010                   Pathway                                
Name
MAPK signaling pathway - Ctenopharyngodon idella (grass carp)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cide04010  MAPK signaling pathway
cide04010

Other DBs
GO: 0000165
Organism
Ctenopharyngodon idella (grass carp) [GN:cide]
Gene
127522219  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
127509613  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
127503301  probable voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
127512553  calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
127511476  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
127522496  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
127516967  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127502814  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
127517709  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
127517750  calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
127517829  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
127523400  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
127508583  voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
127509117  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
127513821  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
127521648  calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
127517752  calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
127500200  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
127510912  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
127514315  voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
127519739  voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
127522375  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
127517678  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
127507589  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
127511413  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
127508001  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
127515831  voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
127504675  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
127505207  voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
127514640  voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
127519101  voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
127514580  calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
127509378  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
127509690  calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
127513841  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
127509757  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127513418  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127514582  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
127509756  calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
127514579  calcium channel, voltage-dependent, gamma subunit 5a isoform X1 [KO:K04870]
127508891  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
127501576  calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
127496746  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
127501554  calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
127497717  voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
127501571  calcium channel, voltage-dependent, gamma subunit 8a isoform X1 [KO:K04873]
127496743  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
127506489  protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
127522428  protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127519370  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127514577  protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127508774  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127525757  protein kinase C, beta a isoform X2 [KO:K19662] [EC:2.7.11.13]
127509047  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127497283  LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
127509296  guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
127515001  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
127496838  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
127515598  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127494678  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127504005  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127513672  protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
127520624  protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
127509346  calcineurin subunit B type 1b [KO:K06268]
127524878  calcineurin subunit B type 1 [KO:K06268]
127499509  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
127520301  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
127513526  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
127499309  RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
127515925  RAS guanyl-releasing protein 2 [KO:K12361]
127503906  RAS guanyl-releasing protein 2 [KO:K12361]
127498373  ras guanyl-releasing protein 3 [KO:K12362]
127510384  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127525669  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127495010  neurofibromin isoform X1 [KO:K08052]
127520127  neurofibromin isoform X1 [KO:K08052]
127512021  ras GTPase-activating protein 1 [KO:K04352]
127521096  ras GTPase-activating protein 1 [KO:K04352]
127499379  ras GTPase-activating protein 2 [KO:K08053]
127522029  ras-related protein rap1ab isoform X1 [KO:K04353]
127517991  RAP1A, member of RAS oncogene family a [KO:K04353]
127511385  ras-related protein Rap-1b [KO:K07836]
127494859  pro-epidermal growth factor [KO:K04357]
127514085  protransforming growth factor alpha isoform X1 [KO:K08774]
127494177  putative fibroblast growth factor 1 [KO:K18496]
127504117  fibroblast growth factor 1b [KO:K18496]
127494051  fibroblast growth factor 2 [KO:K18497]
127499683  fibroblast growth factor 7 [KO:K04358]
127507304  fibroblast growth factor 6a [KO:K04358]
127494219  fibroblast growth factor 20b [KO:K04358]
127516554  fibroblast growth factor 3 [KO:K04358]
127516556  fibroblast growth factor 4 [KO:K04358]
127494721  fibroblast growth factor 16 [KO:K04358]
127494727  fibroblast growth factor 18a isoform X1 [KO:K04358]
127494743  fibroblast growth factor 24 isoform X1 [KO:K04358]
127517908  fibroblast growth factor 17 isoform X1 [KO:K04358]
127503711  fibroblast growth factor 10a [KO:K04358]
127511471  fibroblast growth factor 6b [KO:K04358]
127512992  fibroblast growth factor 8b [KO:K04358]
127525567  fibroblast growth factor 8 isoform X1 [KO:K04358]
127513306  fibroblast growth factor 5 [KO:K04358]
127520056  fibroblast growth factor 18b isoform X1 [KO:K04358]
127513624  fibroblast growth factor 10b [KO:K04358]
127513718  fibroblast growth factor 20a [KO:K04358]
127520792  fibroblast growth factor 22 [KO:K04358]
127516555  fibroblast growth factor 19 [KO:K22603]
127509094  fibroblast growth factor 21 [KO:K22429]
127511010  fibroblast growth factor 23 [KO:K22428]
127514744  nerve growth factor isoform X1 [KO:K02582]
127505462  neurotrophin-7 [KO:K02582]
127516382  brain-derived neurotrophic factor isoform X1 [KO:K04355]
127511485  neurotrophin-3 [KO:K04356]
127508035  insulin [KO:K04526]
127512529  insulin [KO:K04526]
127525708  LOW QUALITY PROTEIN: preproinsulin b [KO:K04526]
127511009  insulin-like growth factor I isoform X1 [KO:K05459]
127515409  insulin-like growth factor 2a [KO:K13769]
127507222  insulin-like growth factor 2b [KO:K13769]
127508464  protein kinase 4 [KO:K04359]
127509581  platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
127520426  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
127521425  si:ch211-79m20.1; adenylate cyclase, terminal-differentiation specific isoform X1 [KO:K17386]
127494511  platelet-derived growth factor C isoform X1 [KO:K05450]
127495214  platelet-derived growth factor D [KO:K05450]
127522054  macrophage colony-stimulating factor 1a isoform X1 [KO:K05453]
127507380  kit ligand a [KO:K05461]
127511000  kit ligand b isoform X1 [KO:K05461]
127510490  vascular endothelial growth factor Ab isoform X1 [KO:K05448]
127496928  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
127501973  placenta growth factor [KO:K16859]
127498919  placenta growth factor isoform X1 [KO:K16859]
127522324  vascular endothelial growth factor D isoform X1 [KO:K05449]
127515561  vascular endothelial growth factor C isoform X1 [KO:K05449]
127500203  hepatocyte growth factor isoform X1 [KO:K05460]
127511019  hepatocyte growth factor a isoform X1 [KO:K05460]
127501223  angiopoietin-1 [KO:K05465]
127497858  angiopoietin-1-like isoform X1 [KO:K05465]
127501603  angiopoietin-2b [KO:K05466]
127524847  angiopoietin-2a isoform X1 [KO:K05466]
127522725  ephrin-A2-like isoform X1 [KO:K05462]
127501429  ephrin-A1a [KO:K05462]
127501545  ephrin-A3 [KO:K05462]
127517891  ephrin-A5b isoform X1 [KO:K05462]
127503709  ephrin-A5 [KO:K05462]
127504376  ephrin-A2 isoform X1 [KO:K05462]
127497931  ephrin-A1b [KO:K05462]
127497934  ephrin-A3b [KO:K05462]
127497935  ephrin-A4 [KO:K05462]
127520494  glial cell line-derived neurotrophic factor [KO:K05452]
127522590  neurturin [KO:K25414]
127502590  glial cell line-derived neurotrophic factor [KO:K25414]
127515018  glial cell line-derived neurotrophic factor [KO:K25415]
127497466  neurturin [KO:K25415]
127506254  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
127505760  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
127523623  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
127514588  receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
127505101  receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
127510799  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
127518750  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
127521512  fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
127516937  fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
127524789  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
127525140  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
127503953  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
127508616  tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
127524059  nerve growth factor receptor b [KO:K02583]
127497682  tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
127497004  LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
127517760  neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
127513233  neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
127521177  insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
127525545  insulin receptor a [KO:K04527] [EC:2.7.10.1]
127500363  insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
127516213  insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
127502375  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
127494775  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
127494776  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
127504098  LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
127502651  mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
127520728  KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
127506104  receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
127506102  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
127494123  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
127494582  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
127502409  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
127506703  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
127512113  tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
127504982  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
127514087  ephrin type-A receptor 2a isoform X1 [KO:K05103] [EC:2.7.10.1]
127524401  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
127508627  growth factor receptor-bound protein 2b [KO:K04364]
127514131  growth factor receptor-bound protein 2a [KO:K04364]
127522075  son of sevenless homolog 1 isoform X1 [KO:K03099]
127525055  son of sevenless homolog 2 [KO:K03099]
127507367  HRas proto-oncogene, GTPase a [KO:K02833]
127516364  HRas proto-oncogene, GTPase b [KO:K02833]
127506985  GTPase KRas isoform X1 [KO:K07827]
127508487  zgc:55558; GTPase KRas [KO:K07827]
127517208  GTPase NRas [KO:K07828]
127515439  ras-related protein R-Ras2 isoform X1 [KO:K07830]
127508034  ras-related protein R-Ras [KO:K07830]
127521489  ras-related protein M-Ras [KO:K07831]
127518891  ras-related protein M-Ras [KO:K07831]
127512955  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
127522563  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127504685  raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127499431  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127502256  dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
127519987  dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
127525091  ragulator complex protein LAMTOR3 [KO:K04370]
127509562  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127513496  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
127499455  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
127522645  MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
127495820  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
127517873  MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
127499143  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
127494438  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
127512180  ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
127524846  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
127505799  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
127508471  LOW QUALITY PROTEIN: activating transcription factor 4b [KO:K04374]
127513836  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
127517506  ETS domain-containing protein Elk-1 [KO:K04375]
127522051  ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
127506190  transcriptional regulator Myc-A [KO:K04377]
127506739  transcriptional regulator Myc-B [KO:K04377]
127524932  serum response factor b isoform X1 [KO:K04378]
127520512  serum response factor a isoform X1 [KO:K04378]
127502293  v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
127502294  si:ch211-153j24.3; protein c-Fos isoform X1 [KO:K04379]
127498056  protein c-Fos [KO:K04379]
127523233  microtubule-associated protein tau isoform X1 [KO:K04380]
127500780  stathmin 1a [KO:K04381]
127497454  stathmin 1b [KO:K04381]
127502123  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
127495782  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127512115  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127512273  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127512906  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127512908  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513086  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513088  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513089  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513090  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513122  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513529  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127498743  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
127498856  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
127498857  cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
127500528  tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
127520202  interleukin-1 beta isoform X1 [KO:K04519]
127495355  transforming growth factor, beta 1a isoform X1 [KO:K13375]
127503585  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
127494595  transforming growth factor beta-2 proprotein [KO:K13376]
127496922  transforming growth factor beta-2 proprotein [KO:K13376]
127498052  transforming growth factor beta-3 proprotein [KO:K13377]
127496665  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
127518735  zmp:0000000936; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
127518736  interleukin-1 receptor type 1-like [KO:K04386]
127495168  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
127506415  TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
127498181  TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
127497383  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
127519363  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
127502691  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
127499172  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
127508687  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127508911  ras-related C3 botulinum toxin substrate 1b [KO:K04392]
127524274  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127505389  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127509135  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127509821  ras-related C3 botulinum toxin substrate 3a isoform X1 [KO:K07861]
127523939  ras-related C3 botulinum toxin substrate 3b [KO:K07861]
127522841  cell division control protein 42 homolog isoform X1 [KO:K04393]
127497067  cell division cycle 42, like [KO:K04393]
127505518  cell division cycle 42 like 2 isoform X1 [KO:K04393]
127515345  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
127494251  caspase-3b [KO:K02187] [EC:3.4.22.56]
127517789  caspase-3a [KO:K02187] [EC:3.4.22.56]
127512151  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127512173  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127513416  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127501163  LOW QUALITY PROTEIN: death domain-associated protein 6 [KO:K02308]
127506001  myeloid differentiation primary response protein MyD88 [KO:K04729]
127517057  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
127507772  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
127515905  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
127515000  growth arrest and DNA-damage-inducible, alpha, b isoform X1 [KO:K04402]
127522598  growth arrest and DNA-damage-inducible, beta a [KO:K04402]
127518010  growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
127496831  growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
127503716  growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
127498920  growth arrest and DNA-damage-inducible, beta b [KO:K04402]
127513828  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
127502214  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
127515210  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
127522232  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
127498531  mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
127494436  si:zfos-2326c3.2; misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
127499914  serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
127501177  serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
127521069  serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
127501360  serine/threonine-protein kinase 3 [KO:K04412]
127515203  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
127503297  mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
127523392  mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
127520635  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
127515910  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
127514127  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
127509155  mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
127505843  mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
127524701  mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
127500049  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
127524464  mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
127518306  mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
127518754  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
127518616  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
127514624  protein kinase Npk [KO:K04424] [EC:2.7.11.25]
127518417  mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
127502840  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
127497386  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
127502775  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
127525563  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
127508608  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
127523437  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
127495297  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
127503349  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
127512416  serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
127512819  serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
127508428  dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
127523337  dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
127514659  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127524204  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
127507600  C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
127515857  C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
127499788  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
127509669  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
127504771  filamin-A [KO:K04437]
127496065  adapter molecule crk [KO:K04438]
127503702  crk-like protein [KO:K04438]
127515728  arrestin, beta 2b isoform X1 [KO:K04439]
127495626  beta-arrestin-1 isoform X1 [KO:K04439]
127520341  arrestin, beta 2a isoform X1 [KO:K04439]
127523601  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503188  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127524755  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127524923  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503882  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127499931  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
127522287  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
127517001  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
127517204  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
127510537  mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
127510539  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127505446  zgc:171775; LOW QUALITY PROTEIN: STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
127513244  MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
127522414  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
127517896  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
127517920  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
127522641  MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
127498807  ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
127512723  ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
127524651  M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
127501241  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
127507856  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127515993  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
127513691  junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127502688  transcription factor AP-1 [KO:K04448]
127497715  transcription factor jun-D [KO:K04449]
127519043  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
127516134  cellular tumor antigen p53-like [KO:K04451]
127512451  cellular tumor antigen p53 isoform X1 [KO:K04451]
127514667  DNA damage-inducible transcript 3 protein [KO:K04452]
127502025  protein max isoform X1 [KO:K04453]
127521130  myocyte enhancer factor 2ca isoform X1 [KO:K04454]
127512440  myocyte enhancer factor 2cb isoform X1 [KO:K04454]
127513115  heat shock protein beta-1 [KO:K04455]
127499652  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127521951  v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
127502735  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127525380  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127498588  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127498690  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127513634  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127495478  protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
127502510  protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
127524416  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
127503885  protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
127511097  tyrosine-protein phosphatase non-receptor type 5 [KO:K04458] [EC:3.1.3.48]
127516339  tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
127494586  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
127521404  dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127507162  dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127522960  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127510779  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127517828  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127503697  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127507324  dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
127502543  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
127509104  dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
127523940  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
127495346  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
127523637  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
127523649  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
127524745  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
127521599  heat shock cognate 71 kDa protein [KO:K03283]
127508413  heat shock 70 kDa protein [KO:K03283]
127508414  heat shock cognate 70-kd protein, tandem duplicate 3 [KO:K03283]
127494936  heat shock protein family A (Hsp70) member 8b [KO:K03283]
127509502  heat shock 70 kDa protein-like [KO:K03283]
127496297  heat shock cognate 71 kDa protein [KO:K03283]
127518011  heat shock 70 kDa protein-like [KO:K03283]
127495479  MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
127515733  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
127523710  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
127505057  nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
127509022  mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
127505789  uncharacterized protein LOC127505789 [KO:K04466] [EC:2.7.11.25]
127524669  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
127517699  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
127505066  NF-kappa-B essential modulator isoform X1 [KO:K07210]
127508611  nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
127495013  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
127525667  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
127524547  nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469]
127515912  transcription factor p65 [KO:K04735]
127496146  transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cide04070  Phosphatidylinositol signaling system
cide04110  Cell cycle
cide04115  p53 signaling pathway
cide04210  Apoptosis
cide04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system