KEGG   PATHWAY: lcf05132
Entry
lcf05132                    Pathway                                
Name
Salmonella infection - Lates calcarifer (barramundi perch)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
lcf05132  Salmonella infection
lcf05132

Organism
Lates calcarifer (barramundi perch) [GN:lcf]
Gene
108897451  podocalyxin [KO:K06817]
108896044  receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
108879430  receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
108897856  LOW QUALITY PROTEIN: ras-related protein Rab-5A [KO:K07887]
108895551  ras-related protein Rab-5A [KO:K07887]
108899526  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
108902502  rab5b; ras-related protein Rab-5B [KO:K07888]
108887069  ras-related protein Rab-5C [KO:K07889]
108901243  ras-related protein Rab-5C [KO:K07889]
108901708  ras-related protein Rab-5C [KO:K07889]
108903074  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
108885587  si:dkey-13a21.4; ras-related protein rab7 isoform X1 [KO:K07897]
108885638  rab7a; ras-related protein Rab-7a [KO:K07897]
108881496  ras-related protein rab7 [KO:K07897]
108894802  LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 1-like [KO:K23282]
108893620  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
108881120  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
108896873  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
108878733  vacuolar protein sorting-associated protein 33A [KO:K20182]
108876625  vam6/Vps39-like protein isoform X1 [KO:K20183]
108895021  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
108890373  LOW QUALITY PROTEIN: RILP-like protein 1 [KO:K13883]
108874887  LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
108886628  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
108876973  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
108883639  dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
108888685  dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
108887654  cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
108897832  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
108901794  cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
108897408  LOW QUALITY PROTEIN: cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
108876084  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
108881664  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
108893549  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
108889741  dynein light chain roadblock-type 1 [KO:K10419]
108875262  dynein light chain roadblock-type 2 [KO:K10419]
108873165  dynein light chain Tctex-type 1 [KO:K10420]
108880924  dynlt1b; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
108880449  dynein light chain Tctex-type 1 [KO:K10420]
108876595  LOW QUALITY PROTEIN: dynactin subunit 1 [KO:K04648]
108888751  dctn1a; dynactin subunit 1 isoform X1 [KO:K04648]
108884825  dynactin subunit 2 [KO:K10424]
108883164  dynactin subunit 3 [KO:K10425]
108891183  dynactin subunit 3 [KO:K10425]
108882832  dynactin subunit 4 isoform X1 [KO:K10426]
108881088  dynactin subunit 5 [KO:K10427]
108890905  dynactin subunit 6 [KO:K10428]
108896430  dynactin subunit 6 [KO:K10428]
108895827  actr1b; actin related protein 1B [KO:K16575]
108896940  actin-related protein 10 [KO:K16576]
108873085  tubulin alpha chain [KO:K07374]
108873086  tubulin alpha-1C chain [KO:K07374]
108873129  si:ch211-114n24.6; tubulin alpha-1A chain [KO:K07374]
108873135  tubulin alpha chain [KO:K07374]
108888647  tubulin alpha-1B chain isoform X2 [KO:K07374]
108889028  tubulin alpha-1B chain isoform X2 [KO:K07374]
108890957  tubulin alpha-1A chain isoform X1 [KO:K07374]
108890986  tubulin alpha-1B chain [KO:K07374]
108880419  tubulin alpha chain [KO:K07374]
108880420  tubulin alpha chain-like [KO:K07374]
108890513  tuba5; tubulin alpha 5 [KO:K07374]
108880471  tubulin alpha chain isoform X1 [KO:K07374]
108895642  tubulin alpha-1B chain [KO:K07374]
108899879  tubulin alpha chain isoform X1 [KO:K07374]
108881914  tubulin beta chain [KO:K07375]
108874814  tubb6; tubulin, beta 6 class V [KO:K07375]
108880694  tubb5; tubulin beta-5 chain isoform X1 [KO:K07375]
108883425  tubulin beta-2A chain [KO:K07375]
108885438  tubulin beta-4B chain [KO:K07375]
108902714  tubb4bl; tubulin beta-4B chain [KO:K07375]
108896145  tubulin beta-4B chain [KO:K07375]
108878511  tubb2b; tubulin beta-2b chain [KO:K07375]
108883288  FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
108877414  LOW QUALITY PROTEIN: FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
108885562  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
108879747  ADP-ribosylation factor-like protein 8A [KO:K07955]
108889980  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
108882593  pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
108873065  kinesin heavy chain [KO:K10396]
108891638  kif5aa; kinesin family member 5Aa [KO:K10396]
108874535  kinesin heavy chain isoform X2 [KO:K10396]
108891780  kinesin heavy chain [KO:K10396]
108884342  kinesin-1 heavy chain [KO:K10396]
108881562  kinesin-1 heavy chain [KO:K10396]
108884834  kif5ab; kinesin heavy chain [KO:K10396]
108885774  klc1b; kinesin light chain 1b isoform X1 [KO:K10407]
108883162  klc1a; LOW QUALITY PROTEIN: kinesin light chain 1 [KO:K10407]
108876147  klc3; kinesin light chain 3 [KO:K10407]
108883704  LOW QUALITY PROTEIN: kinesin light chain 2 [KO:K10407]
108895634  LOW QUALITY PROTEIN: Golgi resident protein GCP60 [KO:K23935]
108877880  rho-related GTP-binding protein RhoA-C [KO:K04513]
108900458  rho-related GTP-binding protein RhoA-C [KO:K04513]
108886517  transforming protein RhoA [KO:K04513]
108882564  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
108876465  rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
108887332  cation-dependent mannose-6-phosphate receptor [KO:K10089]
108892875  ras-related protein Rab-9A [KO:K07899]
108901565  ras-related protein Rab-9A [KO:K07899]
108882887  rab9b; ras-related protein Rab-9B [KO:K07900]
108885746  LOW QUALITY PROTEIN: GRIP and coiled-coil domain-containing protein 2-like [KO:K20282]
108900563  LOW QUALITY PROTEIN: GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
108880801  syntaxin-10 [KO:K23937]
108883784  profilin-2 isoform X1 [KO:K05759]
108892772  profilin-1 [KO:K05759]
108881238  profilin-2 isoform X1 [KO:K05759]
108892701  pfn1; profilin-1 [KO:K05759]
108899610  flna; filamin-A isoform X1 [KO:K04437]
108892028  LOW QUALITY PROTEIN: exocyst complex component 7 [KO:K07195]
108892533  exocyst complex component 5 [KO:K19984]
108879654  exocyst complex component 4 isoform X1 [KO:K06111]
108879566  exocyst complex component 2 [KO:K17637]
108900002  ralaa; ras-related protein Ral-A [KO:K07834]
108899372  LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
108877582  actb2; actin, cytoplasmic 2 [KO:K05692]
108888880  s100a10a; protein S100-A10a [KO:K17274]
108885938  s100a10b; protein S100-A10b [KO:K17274]
108886019  annexin A2 [KO:K17092]
108894308  annexin A2 [KO:K17092]
108903146  anxa14; annexin A2 [KO:K17092]
108884797  si:ch211-125o16.4; neuroblast differentiation-associated protein AHNAK [KO:K23934]
108878419  LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934]
108902189  LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934]
108883943  si:ch211-69b7.6; neuroblast differentiation-associated protein AHNAK [KO:K23934]
108900946  rho guanine nucleotide exchange factor 26 [KO:K13744]
108882894  rhogd; ras homolog gene family, member Gd [KO:K07863]
108897787  rho-related GTP-binding protein RhoG [KO:K07863]
108897786  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
108898932  engulfment and cell motility protein 2 isoform X1 [KO:K18985]
108895959  rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.1]
108896154  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
108899709  myl2a; myosin regulatory light chain 2a isoform X2 [KO:K10351]
108878787  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
108892278  myosin light chain 5 [KO:K12753]
108881388  myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
108884031  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
108893358  myl10; myosin regulatory light chain 10 [KO:K12756]
108895010  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
108883281  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
108890423  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
108880619  mylpfa; myosin regulatory light chain 11 [KO:K12758]
108894225  fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
108890858  si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 [KO:K23938]
108882149  cell division control protein 42 homolog isoform X1 [KO:K04393]
108877499  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108880752  cdc42l; cell division cycle 42, like [KO:K04393]
108887526  cell division control protein 42 homolog [KO:K04393]
108880774  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108872916  nck-associated protein 1 isoform X1 [KO:K05750]
108884853  LOW QUALITY PROTEIN: nck-associated protein 1-like [KO:K05750]
108882784  cyfip2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
108878859  cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
108899997  abi1a; abl interactor 1a isoform X1 [KO:K23649]
108883867  abl interactor 1 isoform X1 [KO:K23649]
108889989  probable protein BRICK1 [KO:K05752]
108882264  actin-binding protein WASF3 [KO:K06083]
108893524  wasf3a; actin-binding protein WASF3 [KO:K06083]
108881887  zgc:109889; actin-binding protein WASF3 isoform X1 [KO:K06083]
108881758  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
108883757  zgc:101810; actin-related protein 2 [KO:K17260]
108882300  actin-related protein 2-A [KO:K17260]
108873292  LOW QUALITY PROTEIN: actin-related protein 2-A [KO:K17260]
108901285  actin-related protein 3 [KO:K18584]
108890124  actr3b; actin-related protein 3B [KO:K18584]
108873094  actin-related protein 3 [KO:K18584]
108897948  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
108899365  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
108899367  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
108892865  actin-related protein 2/3 complex subunit 2 [KO:K05758]
108879238  actin-related protein 2/3 complex subunit 3 [KO:K05756]
108885623  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
108881500  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
108896790  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
108885334  actin-related protein 2/3 complex subunit 5-A [KO:K05754]
108882370  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108893764  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
108889729  unconventional myosin-VI [KO:K10358]
108882251  myo6a; myosin VIa isoform X1 [KO:K10358]
108876542  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108892325  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108883763  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108888220  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108882207  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
108880106  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108884757  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
108888339  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289] [EC:2.7.1.153]
108889298  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
108876669  phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
108890688  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
108879512  cytohesin-3 isoform X1 [KO:K18441]
108888629  cyth4a; cytohesin-2 [KO:K18441]
108885890  cyth2; cytohesin-2 isoform X1 [KO:K18441]
108880771  cytohesin-3 [KO:K18441]
108876142  cyth1b; cytohesin-1 isoform X1 [KO:K18441]
108889052  cyth4b; cytohesin 4b [KO:K18441]
108902661  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
108892593  arf6b; ADP-ribosylation factor 6b [KO:K07941]
108896929  arf6a; ADP-ribosylation factor 6a [KO:K07941]
108892037  arf2b; ADP-ribosylation factor 2b [KO:K07937]
108883362  ADP-ribosylation factor 1 [KO:K07937]
108900874  LOW QUALITY PROTEIN: ADP-ribosylation factor 2a [KO:K07937]
108886032  sorting nexin-18 [KO:K17923]
108883035  sorting nexin-33 [KO:K17923]
108881129  sorting nexin-9 isoform X1 [KO:K17923]
108881135  snx18a; LOW QUALITY PROTEIN: sorting nexin-18a [KO:K17923]
108895631  snx9b; sorting nexin-9b isoform X1 [KO:K17923]
108903022  LOW QUALITY PROTEIN: WASP like actin nucleation promoting factor a [KO:K23612]
108890541  WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
108889854  actin nucleation-promoting factor WASL-like isoform X1 [KO:K23612]
108881499  si:dkey-197j19.6; actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
108885422  LOW QUALITY PROTEIN: dynamin-2-like [KO:K23484] [EC:3.6.5.5]
108902656  LOW QUALITY PROTEIN: dynamin-2-like [KO:K23484] [EC:3.6.5.5]
108885865  toll-like receptor 2 type-2 [KO:K10159]
108901668  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
108902352  toll-like receptor 2 type-2 [KO:K10159]
108883170  tlr18; toll-like receptor 2 type-2 [KO:K10159]
108898789  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
108881704  myeloid differentiation primary response protein MyD88 [KO:K04729]
108888912  LOW QUALITY PROTEIN: toll-like receptor 5 [KO:K10168]
108895804  toll-like receptor 5 [KO:K10168]
108895805  toll-like receptor 5 [KO:K10168]
108890558  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
108888551  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
108887802  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108897885  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
108899288  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
108889064  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
108899320  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108881311  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
108899625  LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
108891107  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108892003  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
108881598  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
108895835  NF-kappa-B inhibitor alpha [KO:K04734]
108873754  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108882042  LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
108876271  nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
108896797  hsp90aa1.1; heat shock protein HSP 90-alpha 1 isoform X3 [KO:K04079]
108873465  heat shock protein HSP 90-beta isoform X1 [KO:K04079]
108888494  endoplasmin [KO:K09487]
108883753  receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
108886450  exportin-2 [KO:K18423]
108881724  importin subunit alpha-5 [KO:K23940]
108900927  importin subunit alpha-3 [KO:K23583]
108901233  importin subunit alpha-4 [KO:K23583]
108888997  40S ribosomal protein S3 [KO:K02985]
108889145  40S ribosomal protein S3 [KO:K02985]
108875409  GTPase HRas [KO:K02833]
108900163  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
108886445  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108877315  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
108883596  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X2 [KO:K04369] [EC:2.7.12.2]
108881026  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108891348  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108876848  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
108902699  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
108901376  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
108875352  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108901401  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108882620  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108876452  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
108884069  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
108882672  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
108890897  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
108873371  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
108875834  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108888287  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108873059  mapk8b; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
108874078  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108899231  LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
108892487  fosaa; protein c-Fos isoform X2 [KO:K04379]
108895610  si:ch211-153j24.3; protein c-Fos [KO:K04379]
108895611  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
108883834  transcription factor Jun [KO:K04448]
108879142  jun; transcription factor AP-1 isoform X2 [KO:K04448]
108896372  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
108899401  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
108895307  il1b; interleukin-1 beta [KO:K04519]
108878374  interleukin-1 beta [KO:K04519]
108897837  interleukin-6 [KO:K05405]
108903099  C-X-C motif chemokine 19 [KO:K10030]
108896630  permeability factor 2 [KO:K10030]
108896631  interleukin-8 [KO:K10030]
108888404  catenin beta-1 [KO:K02105]
108897809  catenin beta-1 [KO:K02105]
108893669  transcription factor 7 isoform X1 [KO:K02620]
108895925  LOW QUALITY PROTEIN: transcription factor 7-like 1-A [KO:K04490]
108878678  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
108900803  transcription factor 7-like 1-B [KO:K04490]
108901696  transcription factor 7-like 2 isoform X4 [KO:K04491]
108888246  lymphoid enhancer-binding factor 1 isoform X4 [KO:K04492]
108895017  LOW QUALITY PROTEIN: transcriptional regulator Myc-A [KO:K04377]
108882464  transcriptional regulator Myc-B [KO:K04377]
108874403  mych; myelocytomatosis oncogene homolog [KO:K04377]
108898635  LOW QUALITY PROTEIN: serine/threonine-protein kinase N1b [KO:K06071] [EC:2.7.11.13]
108875836  LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
108876926  F-box only protein 22 [KO:K10302]
108893670  S-phase kinase-associated protein 1 [KO:K03094]
108887354  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
108874450  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108878507  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
108895456  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108877852  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
108893387  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
108883409  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
108887350  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
108886974  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
108885067  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108875098  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108878624  hdr; hematopoietic death receptor isoform X2 [KO:K04722]
108895430  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
108880505  fadd; protein FADD [KO:K02373]
108883888  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108881527  caspase-8 [KO:K04398] [EC:3.4.22.61]
108890753  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
108875165  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
108880508  zgc:153993; apoptosis regulator BAX [KO:K02159]
108898556  apoptosis regulator BAX isoform X1 [KO:K02159]
108900795  apoptosis regulator BAX [KO:K02159]
108874378  apoptosis regulator BAX-like isoform X1 [KO:K02159]
108882983  cytochrome c [KO:K08738]
108877511  cytochrome c-a [KO:K08738]
108872926  cytochrome c [KO:K08738]
108883441  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108890128  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108901489  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
108893087  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
108895937  caspase-3 [KO:K04397] [EC:3.4.22.60]
108895947  caspase-3 [KO:K04397] [EC:3.4.22.60]
108898722  caspase-7 [KO:K04397] [EC:3.4.22.60]
108895950  rho-related GTP-binding protein RhoB [KO:K07856]
108896604  rho-related GTP-binding protein RhoH [KO:K07873]
108882522  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108898795  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108892520  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108893445  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108897414  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108872681  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
108872682  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
108898663  thioredoxin, mitochondrial [KO:K03671]
108886423  thioredoxin [KO:K03671]
108886424  thioredoxin [KO:K03671]
108903054  thioredoxin [KO:K03671]
108903063  thioredoxin [KO:K03671]
108903072  thioredoxin [KO:K03671]
108899584  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
108900839  LOW QUALITY PROTEIN: uncharacterized protein LOC108900839 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
lcf04010  MAPK signaling pathway
lcf04210  Apoptosis
lcf04217  Necroptosis
lcf04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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