KEGG   PATHWAY: ocu04120
ocu04120                    Pathway                                
Ubiquitin mediated proteolysis - Oryctolagus cuniculus (rabbit)
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ocu04120  Ubiquitin mediated proteolysis

Other DBs
GO: 0016567
Oryctolagus cuniculus (rabbit) [GN:ocu]
100351347  UBB; ubiquitin B [KO:K04551]
100343047  ubiquitin [KO:K02927]
100348379  ubiquitin-40S ribosomal protein S27a [KO:K02977]
100009225  UBA1; ubiquitin like modifier activating enzyme 1 [KO:K03178] [EC:]
100357447  SAE1; SUMO1 activating enzyme subunit 1 [KO:K10684] [EC:]
100355779  UBA2; ubiquitin like modifier activating enzyme 2 [KO:K10685] [EC:]
100343309  UBA3; ubiquitin like modifier activating enzyme 3 [KO:K10686] [EC:]
100338238  UBA7; ubiquitin like modifier activating enzyme 7 [KO:K10698] [EC:]
100356574  UBA6; ubiquitin like modifier activating enzyme 6 [KO:K10699] [EC:]
100339096  UBE2A; ubiquitin conjugating enzyme E2 A [KO:K10573] [EC:]
100009132  UBE2B; ubiquitin conjugating enzyme E2 B [KO:K10574] [EC:]
100338187  UBE2C; ubiquitin conjugating enzyme E2 C [KO:K06688] [EC:]
100341176  UBE2D4; ubiquitin conjugating enzyme E2 D4 (putative) [KO:K06689] [EC:]
100344895  UBE2D2; ubiquitin conjugating enzyme E2 D2 [KO:K06689] [EC:]
100347511  UBE2D3; ubiquitin conjugating enzyme E2 D3 [KO:K06689] [EC:]
100355225  UBE2D1; ubiquitin conjugating enzyme E2 D1 [KO:K06689] [EC:]
100354960  UBE2E1; ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:]
100357218  UBE2E3; ubiquitin conjugating enzyme E2 E3 [KO:K20217] [EC:]
103350360  UBE2E2; ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:]
100348202  UBE2F; ubiquitin conjugating enzyme E2 F (putative) [KO:K10687] [EC:]
100345408  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:]
100353960  UBE2G1; ubiquitin conjugating enzyme E2 G1 [KO:K10575] [EC:]
100343272  UBE2G2; ubiquitin conjugating enzyme E2 G2 [KO:K04555] [EC:]
100350643  UBE2H; ubiquitin conjugating enzyme E2 H [KO:K10576] [EC:]
100358924  UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
100341530  UBE2J1; ubiquitin conjugating enzyme E2 J1 [KO:K10578] [EC:]
100350316  UBE2J2; ubiquitin conjugating enzyme E2 J2 [KO:K04554] [EC:]
100345190  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:]
100346312  UBE2L3; ubiquitin conjugating enzyme E2 L3 [KO:K04552] [EC:]
100349814  UBE2L6; ubiquitin conjugating enzyme E2 L6 [KO:K04553] [EC:]
100341057  UBE2M; ubiquitin conjugating enzyme E2 M [KO:K10579] [EC:]
100339349  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:]
100343655  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:]
100353764  UBE2N; ubiquitin conjugating enzyme E2 N [KO:K10580] [EC:]
100341684  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:]
100355504  UBE2O; ubiquitin conjugating enzyme E2 O [KO:K10581] [EC:]
103345224  UBE2QL1; ubiquitin conjugating enzyme E2 Q family like 1 [KO:K10582] [EC:]
100009425  UBE2Q2; ubiquitin conjugating enzyme E2 Q2 [KO:K10582] [EC:]
100347500  UBE2Q1; ubiquitin conjugating enzyme E2 Q1 [KO:K10582] [EC:]
100338008  CDC34; cell division cycle 34 [KO:K02207] [EC:]
100009436  UBE2R2; ubiquitin conjugating enzyme E2 R2 [KO:K02207] [EC:]
100348547  UBE2S; ubiquitin conjugating enzyme E2 S [KO:K10583] [EC:]
100356820  UBE2U; ubiquitin conjugating enzyme E2 U (putative) [KO:K10584] [EC:]
103347952  ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:]
100340823  UBE2W; ubiquitin conjugating enzyme E2 W [KO:K10688] [EC:]
100350589  UBE2Z; ubiquitin conjugating enzyme E2 Z [KO:K10585] [EC:]
100355519  UBE2K; ubiquitin conjugating enzyme E2 K [KO:K04649] [EC:]
100342432  BIRC6; baculoviral IAP repeat containing 6 [KO:K10586] [EC:]
100342825  UBE3A; ubiquitin protein ligase E3A [KO:K10587] [EC:]
100338868  UBE3B; ubiquitin protein ligase E3B [KO:K10588] [EC:]
100352014  UBE3C; ubiquitin protein ligase E3C [KO:K10589] [EC:]
100353573  SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:]
100358121  SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:]
100356696  ITCH; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:]
100350478  WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:]
100344222  WWP2; WW domain containing E3 ubiquitin protein ligase 2 [KO:K05630] [EC:]
100341427  TRIP12; thyroid hormone receptor interactor 12 [KO:K10590] [EC:]
100009418  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:]
100353099  NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:]
100342658  HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase [KO:K10592] [EC:]
100338221  UBR5; ubiquitin protein ligase E3 component n-recognin 5 [KO:K10593] [EC:]
100344755  HERC1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [KO:K10594] [EC:]
100340267  E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:]
100344750  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:]
100348847  HERC4; HECT and RLD domain containing E3 ubiquitin protein ligase 4 [KO:K10615] [EC:]
100353223  UBE4A; ubiquitination factor E4A [KO:K10596] [EC:]
100356207  UBE4B; ubiquitination factor E4B [KO:K10597] [EC:]
100344510  PPIL2; peptidylprolyl isomerase like 2 [KO:K10598] [EC:]
100358501  PRPF19; pre-mRNA processing factor 19 [KO:K10599] [EC:]
100340389  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:]
100342595  CBL; Cbl proto-oncogene [KO:K04707] [EC:]
100355469  CBLB; Cbl proto-oncogene B [KO:K22517] [EC:]
100357032  CBLC; Cbl proto-oncogene C [KO:K22518] [EC:]
100358886  PARK2; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:]
100355829  SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:]
100351382  PML; promyelocytic leukemia [KO:K10054] [EC:2.3.2.-]
100343190  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:]
100348484  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:]
100356568  RFWD2; ring finger and WD repeat domain 2 [KO:K10143] [EC:]
100342142  RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:]
100340120  BIRC3; baculoviral IAP repeat containing 3 [KO:K16060]
100338118  BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
100328700  XIAP; X-linked inhibitor of apoptosis [KO:K04725] [EC:]
100339627  BIRC7; baculoviral IAP repeat containing 7 [KO:K16061]
100339509  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
100357839  PIAS2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-]
100341019  PIAS3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-]
100354913  SYVN1; synoviolin 1 [KO:K10601] [EC:]
100341052  NHLRC1; NHL repeat containing E3 ubiquitin protein ligase 1 [KO:K10602] [EC:]
100342669  MGRN1; mahogunin ring finger 1 [KO:K10604] [EC:]
100347269  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:]
100344973  FANCL; Fanconi anemia complementation group L [KO:K10606] [EC:]
103350019  E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:]
100341307  TRIM32; tripartite motif containing 32 [KO:K10607] [EC:]
100353301  TRIM37; tripartite motif containing 37 [KO:K10608] [EC:]
103352470  RBX1; ring-box 1 [KO:K03868] [EC:]
100345752  CUL1; cullin 1 [KO:K03347]
100339463  SKP1; S-phase kinase associated protein 1 [KO:K03094]
100340737  FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
100350519  BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
100342452  SKP2; S-phase kinase associated protein 2 [KO:K03875]
100356214  FBXW7; F-box and WD repeat domain containing 7 [KO:K10260]
100357072  FBXO4; F-box protein 4 [KO:K10291]
100343513  CUL2; cullin 2 [KO:K03870]
100341083  ELOC; elongin C [KO:K03872]
100355441  transcription elongation factor B polypeptide 1-like [KO:K03872]
100340879  ELOB; elongin B [KO:K03873]
100350053  VHL; von Hippel-Lindau tumor suppressor [KO:K03871]
100338738  CUL3; cullin 3 [KO:K03869]
100346935  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
100349700  KLHL13; kelch like family member 13 [KO:K10447]
100342168  KLHL9; kelch like family member 9 [KO:K10447]
100345646  RHOBTB2; Rho related BTB domain containing 2 [KO:K07868]
100352605  RHOBTB1; Rho related BTB domain containing 1 [KO:K07868]
100354247  CUL4A; cullin 4A [KO:K10609]
100351102  CUL4B; cullin 4B [KO:K10609]
100354475  DDB1; damage specific DNA binding protein 1 [KO:K10610]
100352386  DDB2; damage specific DNA binding protein 2 [KO:K10140]
100352258  ERCC8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit [KO:K10570]
100343868  DET1; de-etiolated homolog 1 (Arabidopsis) [KO:K10571]
103350405  RNF7; ring finger protein 7 [KO:K10611]
100009207  CUL5; cullin 5 [KO:K10612]
100339386  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100345084  CUL7; cullin 7 [KO:K10613]
100345880  FBXW8; F-box and WD repeat domain containing 8 [KO:K10264]
100343351  ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
100357094  anaphase-promoting complex subunit 11 [KO:K03358]
100354874  CDC20; cell division cycle 20 [KO:K03363]
100357502  FZR1; fizzy-related protein homolog [KO:K03364]
100348299  ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
100345196  CDC27; cell division cycle 27 [KO:K03350]
100350229  ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
100350286  ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
100359101  CDC16; cell division cycle 16 [KO:K03353]
100357348  ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
100345665  CDC23; cell division cycle 23 [KO:K03355]
100342311  ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
100358835  CDC26; cell division cycle 26 [KO:K03359]
100352519  ANAPC13; anaphase promoting complex subunit 13 [KO:K12456]
100342681  ANAPC15; anaphase promoting complex subunit 15 [KO:K25228]
100342147  ANAPC16; anaphase promoting complex subunit 16 [KO:K25229]
Kamura T.
[Cullin-based E3 family]
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Matsuda N.
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Tokunaga F.
[E2 ubiquitin-conjugating enzymes: structures and functions]
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Nalepa G, Rolfe M, Harper JW.
Drug discovery in the ubiquitin-proteasome system.
Nat Rev Drug Discov 5:596-613 (2006)
Hsu YJ, Goodman SR.
Spectrin and ubiquitination: a review.
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Hatakeyama S, Nakayama KI.
Ubiquitylation as a quality control system for intracellular proteins.
J Biochem 134:1-8 (2003)
Lee J, Zhou P.
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Mol Cell 26:775-80 (2007)
ocu03050  Proteasome
KO pathway

DBGET integrated database retrieval system