KEGG   PATHWAY: rno05171
Entry
rno05171                    Pathway                                
Name
Coronavirus disease - COVID-19 - Rattus norvegicus (rat)
Description
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by  interleukin-6 (IL-6) production. SARS-CoV-2 also activates the innate immune system; macrophage stimulation triggers the overproduction of pro-inflammatory cytokines, including IL-6, and the "cytokine storm", which results in systemic inflammatory response syndrome and multiple organ failure. The combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05171  Coronavirus disease - COVID-19
rno05171

Disease
H02398  COVID-19
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359505  [KO:K02971]
100359563  Rps20l4; small ribosomal subunit protein uS10-like [KO:K02969]
100359613  [KO:K02870]
100359616  Rpl36l6; large ribosomal subunit protein eL36-like [KO:K02920]
100359922  [KO:K02873]
100360252  Rpl31l2; ribosomal protein L31-like 2 [KO:K02910]
100360439  Rpl36l5; large ribosomal subunit protein eL36-like [KO:K02920]
100360491  [KO:K02873]
100360522  [KO:K02942]
100360558  Rps12l2; ribosomal protein S12-like 2 [KO:K02951]
100360573  [KO:K02951]
100360642  Rps12l3; ribosomal protein S12-like 3 [KO:K02951]
100360679  Rps18l1; small ribosomal subunit protein uS13 [KO:K02964]
100360843  Rps19l3; small ribosomal subunit protein eS19-like [KO:K02966]
100361060  Rpl36l3; large ribosomal subunit protein eL36-like [KO:K02920]
100361079  Rpl36l2; large ribosomal subunit protein eL36-like [KO:K02920]
100361143  Rpl30l3; large ribosomal subunit protein eL30-like [KO:K02908]
100361180  [KO:K02962]
100361240  Rps10l6; small ribosomal subunit protein eS10-like [KO:K02947]
100361259  [KO:K02873]
100361294  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100361715  Rps15al4; small ribosomal subunit protein uS8 [KO:K02957]
100361756  Rps26l6; small ribosomal subunit protein eS26-like [KO:K02976]
100361933  Rps12l8; small ribosomal subunit protein eS12-like [KO:K02951]
100361974  Rpl31l15; large ribosomal subunit protein eL31-like [KO:K02910]
100362027  Rpl30l2; ribosomal protein L30-like [KO:K02908]
100362069  [KO:K02903]
100362139  Rps15al2; small ribosomal subunit protein uS8-like [KO:K02957]
100362185  Rpl27-ps4; large ribosomal subunit protein eL27-like [KO:K02901]
100362298  Rps18l5; small ribosomal subunit protein uS13-like [KO:K02964]
100362339  Rps19l4; small ribosomal subunit protein eS19-like [KO:K02966]
100362366  [KO:K02962]
100362400  [KO:K02873]
100362479  Rpl15l3; large ribosomal subunit protein eL15-like [KO:K02877]
100362640  Rps4x; small ribosomal subunit protein eS4 [KO:K02987]
100362751  Rplp2l3; large ribosomal subunit protein P2-like [KO:K02943]
100362987  Rps27l3; small ribosomal subunit protein eS27-like [KO:K02978]
100363452  Rps8-ps17; small ribosomal subunit protein eS8-like [KO:K02995]
100363469  Rps24-ps15; small ribosomal subunit protein eS24-like [KO:K02974]
100363869  Rpl32l5; large ribosomal subunit protein eL32-like [KO:K02912]
100364427  [KO:K02951]
100364561  [KO:K02978]
100365839  [KO:K02984]
100909433  Rpl12-ps2; large ribosomal subunit protein uL11-like [KO:K02870]
100909911  [KO:K02969]
100910017  [KO:K02910]
100910180  [KO:K02929]
100910888  [KO:K02920]
100911018  Rpl6-ps6; large ribosomal subunit protein eL6-like [KO:K02934]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100911728  [KO:K02978]
100912027  [KO:K02901]
100912032  Rps27a; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
100912314  [KO:K05414]
100912356  [KO:K05414]
100912756  [KO:K02910]
102546803  Rpl19-ps10; large ribosomal subunit protein eL19-like [KO:K02885]
102547034  [KO:K02973]
102547604  [KO:K02900]
102548369  [KO:K02960]
102548794  [KO:K02978]
102548890  [KO:K02983]
102550534  [KO:K02983]
102550668  [KO:K02889]
102550734  [KO:K02910]
102553078  [KO:K02983]
102554672  [KO:K02978]
102555307  [KO:K02951]
102555453  [KO:K02870]
102557182  [KO:K02910]
103689992  Rps9; small ribosomal subunit protein uS4 [KO:K02997]
103690331  Rpl13l1; large ribosomal subunit protein eL13-like [KO:K02873]
103690495  Rpl27al9; large ribosomal subunit protein uL15-like [KO:K02900]
103690796  [KO:K02940]
103690851  Rpl35al4; large ribosomal subunit protein eL33-like [KO:K02917]
103690888  [KO:K02865]
103690889  Rpl39l2; large ribosomal subunit protein eL39-like [KO:K02924]
103690996  Rpl35al1; large ribosomal subunit protein eL33 [KO:K02917]
103691294  Rpl27al8; uncharacterized protein Rpl27al8 [KO:K02900]
103691423  Rpl36l7; large ribosomal subunit protein eL36-like [KO:K02920]
103691460  Rpl39l5; putative ribosomal protein eL39-like 5 [KO:K02924]
103691519  [KO:K02940]
103691563  Rpl31l11; large ribosomal subunit protein eL31-like [KO:K02910]
103692210  Rps12l11; small ribosomal subunit protein eS12-like [KO:K02951]
103692519  [KO:K02940]
103692829  [KO:K02940]
103693101  Rps15al7; small ribosomal subunit protein uS8-like [KO:K02957]
103693459  Rpl22l4; ribosomal protein eL22-like 1 [KO:K02891]
103693494  [KO:K02929]
103693700  [KO:K02929]
103693978  [KO:K02940]
103694419  Rpl39l4; large ribosomal subunit protein eL39-like [KO:K02924]
103695152  Rpl39l3; large ribosomal subunit protein eL39-like [KO:K02924]
103695246  [KO:K02924]
108348409  Rpl21l3; large ribosomal subunit protein eL21-like [KO:K02889]
108348509  Rpl35al5; large ribosomal subunit protein eL33-like [KO:K02917]
108348781  Rpl31l16; large ribosomal subunit protein eL31-like [KO:K02910]
108348813  Rpl37al4; large ribosomal subunit protein eL43-like [KO:K02921]
108348937  Rpl29l3; large ribosomal subunit protein eL29-like [KO:K02905]
108348969  Rpl21l5; large ribosomal subunit protein eL21-like [KO:K02889]
108348980  Rps29l5; small ribosomal subunit protein uS14-like [KO:K02980]
108349446  Rpl35al7; large ribosomal subunit protein eL33-like [KO:K02917]
108349465  Rpl35al10; large ribosomal subunit protein eL33-like [KO:K02917]
108349831  Rps29-ps21; small ribosomal subunit protein uS14-like [KO:K02980]
108349835  [KO:K02917]
108349932  Rpl21l6; large ribosomal subunit protein eL21-like [KO:K02889]
108350082  [KO:K02889]
108350287  Rpl21l2; large ribosomal subunit protein eL21-like [KO:K02889]
108350290  Rpl21l1; large ribosomal subunit protein eL21-like [KO:K02889]
108350355  Rps29-ps18; small ribosomal subunit protein uS14-like [KO:K02980]
108350427  Rpl35al6; large ribosomal subunit protein eL33-like [KO:K02917]
108350542  Rpl34l2; large ribosomal subunit protein eL34-like [KO:K02915]
108350588  [KO:K02894]
108350671  Rpl31l14; large ribosomal subunit protein eL31-like [KO:K02910]
108350852  Rps29-ps20; large ribosomal subunit protein eL29-like [KO:K02905]
108351255  Rpl35al8; large ribosomal subunit protein eL33-like [KO:K02917]
108351377  Rpl35al2; large ribosomal subunit protein eL33-like [KO:K02917]
108351519  Rps35al1; large ribosomal subunit protein eL33-like [KO:K02917]
108351691  Rpl35al11; large ribosomal subunit protein eL33-like [KO:K02917]
108351703  [KO:K02900]
108351811  [KO:K02978]
108351931  Rpl31l12; large ribosomal subunit protein eL31-like [KO:K02910]
108351936  [KO:K02908]
108352001  Rpl21l4; large ribosomal subunit protein eL21-like [KO:K02889]
108352027  [KO:K02979]
108352176  Rpl35al9; large ribosomal subunit protein eL33-like [KO:K02917]
108352207  Rpl35al3; large ribosomal subunit protein eL33-like [KO:K02917]
108352551  Rpl23al9; large ribosomal subunit protein uL23-like [KO:K02893]
108352780  Rps17l4; small ribosomal subunit protein eS17-like [KO:K02962]
108352809  Rps12l10; small ribosomal subunit protein eS12-like [KO:K02951]
108352861  Rps28-ps5; small ribosomal subunit protein eS28-like [KO:K02979]
108353033  Rps29-ps19; small ribosomal subunit protein uS14-like [KO:K02980]
108353424  Rps28-ps4; small ribosomal subunit protein eS28-like [KO:K02979]
108353425  [KO:K02978]
113959  C5ar1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116562  Il2; interleukin-2 precursor [KO:K05429]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116630  Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
116669  Vwf; von Willebrand factor precursor [KO:K03900]
117042  Rpl6; large ribosomal subunit protein eL6 [KO:K02934]
117053  Rps15a; small ribosomal subunit protein uS8 [KO:K02957]
117512  C9; complement component C9 [KO:K04000]
117517  C7; complement component C7 isoform X1 [KO:K03996]
120093056  Rpl37; large ribosomal subunit protein eL37 [KO:K02922]
120093118  [KO:K02960]
120093119  [KO:K02922]
120093186  [KO:K02865]
120093238  [KO:K02918]
120093247  [KO:K02905]
120093557  [KO:K02910]
120094652  [KO:K02905]
120094789  [KO:K02980]
120095009  [KO:K02910]
120095270  [KO:K02870]
120095889  [KO:K02905]
120096286  [KO:K02922]
120096659  [KO:K02920]
120096991  [KO:K02910]
120097043  [KO:K02980]
120097492  [KO:K02997]
120097744  [KO:K02922]
120097785  [KO:K02901]
120098252  [KO:K02942]
120098309  [KO:K02893]
120098629  [KO:K02905]
120098771  [KO:K02969]
120099957  [KO:K02920]
120099964  [KO:K02889]
120100003  [KO:K02951]
120100542  [KO:K02880]
120100578  [KO:K02971]
120100647  [KO:K02880]
120101650  [KO:K02955]
120101775  [KO:K02873]
120102444  [KO:K02893]
120102453  [KO:K02880]
120103001  [KO:K02969]
120103572  [KO:K02889]
122772  Rps20; small ribosomal subunit protein uS10 [KO:K02969]
122799  Rps25; small ribosomal subunit protein eS25 [KO:K02975]
124323  Rps23; small ribosomal subunit protein uS12 [KO:K02973]
124440  Rpl41; small ribosomal subunit protein eS32 [KO:K02928]
134478821  [KO:K02976]
134478854  [KO:K02918]
134478972  [KO:K02905]
134479620  [KO:K02917]
134480154  [KO:K02889]
134480185  [KO:K02889]
134480273  [KO:K02889]
134480302  [KO:K02889]
134480573  [KO:K02894]
134480579  [KO:K02889]
134480843  [KO:K02889]
134481478  [KO:K02889]
134481532  [KO:K06472]
134483817  [KO:K02936]
134484045  [KO:K02889]
134484054  [KO:K02889]
134484062  [KO:K02889]
134484088  [KO:K02905]
134484121  [KO:K00922] [EC:2.7.1.153]
134485591  [KO:K02889]
134485594  [KO:K02889]
134485599  [KO:K02889]
134485939  [KO:K02889]
134486107  [KO:K02936]
134486414  [KO:K02889]
134486536  [KO:K02880]
134486654  [KO:K02889]
134486984  [KO:K02917]
134487046  [KO:K02978]
134487075  [KO:K05414]
134487077  [KO:K05414]
140654  Rps3; small ribosomal subunit protein uS3 [KO:K02985]
140655  Rps16; small ribosomal subunit protein uS9 [KO:K02960]
140661  Rplp1; large ribosomal subunit protein P1 [KO:K02942]
140662  Rplp2; large ribosomal subunit protein P2 [KO:K02943]
156435  Tmprss2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
161477  Rps13; small ribosomal subunit protein uS15 [KO:K02953]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
171045  Mmp3; stromelysin-1 preproprotein [KO:K01394] [EC:3.4.24.17]
192262  C1s; complement C1s subcomponent precursor [KO:K01331] [EC:3.4.21.42]
192281  Oas1a; 2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
24180  Agtr1a; type-1 angiotensin II receptor A [KO:K04166]
24231  C2; complement C2 precursor [KO:K01332] [EC:3.4.21.43]
24232  C3; complement C3 precursor [KO:K03990]
24233  C4a; complement C4 precursor [KO:K03989]
24237  C6; complement component C6 precursor [KO:K03995]
24310  Ace; angiotensin-converting enzyme precursor [KO:K01283] [EC:3.4.15.1]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24366  Fgb; fibrinogen beta chain precursor [KO:K03904]
24367  Fgg; fibrinogen gamma chain precursor [KO:K03905]
24481  Ifnb1; interferon beta precursor [KO:K05415]
24494  Il1b; interleukin-1 beta [KO:K04519]
24498  Il6; interleukin-6 precursor [KO:K05405]
24499  Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055]
24516  Jun; transcription factor Jun [KO:K04448]
24548  Mbl1; mannose-binding protein A precursor [KO:K03991]
24575  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
245920  Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671]
245981  Rpl15; large ribosomal subunit protein eL15 [KO:K02877]
246268  Oas1b; inactive 2'-5'-oligoadenylate synthase 1B [KO:K14216] [EC:2.7.7.84]
246331  Nrp1; neuropilin-1 precursor [KO:K06724]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24770  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
24835  Tnf; tumor necrosis factor [KO:K03156]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
25153  Mas1; proto-oncogene Mas [KO:K04303]
25155  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
25166  Casp1; caspase-1 [KO:K01370] [EC:3.4.22.36]
25205  Il6st; interleukin-6 receptor subunit beta precursor [KO:K05060]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
25347  Rpl39; large ribosomal subunit protein eL39 [KO:K02924]
25348  Rps29; small ribosomal subunit protein uS14 [KO:K02980]
25433  Hbegf; proheparin-binding EGF-like growth factor precursor [KO:K08523]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25538  Rps5; small ribosomal subunit protein uS7 isoform 1 [KO:K02989]
25610  Csf3; granulocyte colony-stimulating factor precursor [KO:K05423]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
25651  Selp; P-selectin precursor [KO:K06496]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
26962  Rpl8; large ribosomal subunit protein uL2 [KO:K02938]
27139  Rps26; small ribosomal subunit protein eS26 [KO:K02976]
28298  Rpl32; large ribosomal subunit protein eL32 [KO:K02912]
286918  Mx2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
287122  Rpl3l; 60S ribosomal protein L3-like [KO:K02925]
287362  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
287417  Rpl26; large ribosomal subunit protein uL24 [KO:K02898]
287518  Rpl29l6; large ribosomal subunit protein eL29-like [KO:K02905]
287562  Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
289055  F13b; coagulation factor XIII B chain precursor [KO:K03906]
289384  Rpl37l2; large ribosomal subunit protein eL37-like [KO:K02922]
289401  Rpl31l9; large ribosomal subunit protein eL31-like [KO:K02910]
289656  Rpl23al5; large ribosomal subunit protein uL23-like [KO:K02893]
289932  Rps7l1; small ribosomal subunit protein eS7-like [KO:K02993]
290641  Rpl18a; large ribosomal subunit protein eL20 [KO:K02882]
290678  Rps10l2; small ribosomal subunit protein eS10-like [KO:K02947]
290820  Rpl13a-ps8; large ribosomal subunit protein uL13-like [KO:K02872]
290916  Rpl23al2; large ribosomal subunit protein uL23-like [KO:K02893]
291353  Rps8l1; small ribosomal subunit protein eS8-like [KO:K02995]
291434  Rpl17; large ribosomal subunit protein uL22 [KO:K02880]
291561  Rpl31l7; large ribosomal subunit protein eL31-like [KO:K02910]
29236  Rpsa; small ribosomal subunit protein uS2 [KO:K02998]
292474  Rpl27al2; large ribosomal subunit protein uL15-like [KO:K02900]
29251  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
29257  Rpl9; large ribosomal subunit protein uL6 [KO:K02940]
29258  Rps7; small ribosomal subunit protein eS7 [KO:K02993]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
29282  Rpl23; large ribosomal subunit protein uL14 [KO:K02894]
29283  Rpl29; large ribosomal subunit protein eL29 [KO:K02905]
29284  Rps14; small ribosomal subunit protein uS11 [KO:K02955]
29285  Rps15; small ribosomal subunit protein uS19 [KO:K02958]
29286  Rps17; small ribosomal subunit protein eS17 [KO:K02962]
29287  Rps19; small ribosomal subunit protein eS19 [KO:K02966]
29288  Rps3a; small ribosomal subunit protein eS1 [KO:K02984]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
292964  Rpl36a; large ribosomal subunit protein eL42 [KO:K02929]
29304  Rps6; small ribosomal subunit protein eS6 [KO:K02991]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
293418  Rpl27a; large ribosomal subunit protein uL15 [KO:K02900]
293846  RGD1565183; large ribosomal subunit protein eL28-like [KO:K02903]
294077  Rps12l6; small ribosomal subunit protein eS12-like [KO:K02951]
294257  Cfb; complement factor B precursor [KO:K01335] [EC:3.4.21.47]
294282  Rps18; small ribosomal subunit protein uS13 [KO:K02964]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
295340  Rplp0l1; large ribosomal subunit protein uL10-like [KO:K02941]
296545  C8g; complement component C8 gamma chain isoform 1 precursor [KO:K03999]
296596  Rpl7a; large ribosomal subunit protein eL8 [KO:K02936]
296709  Rpl35; large ribosomal subunit protein uL29 [KO:K02918]
29687  C1qb; complement C1q subcomponent subunit B precursor [KO:K03987]
296870  Rpl34l1; ribosomal protein L34-like1 [KO:K02915]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
29752  Fau; 40S ribosomal protein S30 precursor [KO:K02983]
297755  Rpl7; large ribosomal subunit protein uL30 [KO:K02937]
297989  Rig1; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
298126  Rpl31-ps11; large ribosomal subunit protein eL31-like [KO:K02910]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298288  C8a; complement component C8 alpha chain precursor [KO:K03997]
298566  C1qa; complement C1q subcomponent subunit A precursor [KO:K03986]
298693  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
299041  Rplp1l2; large ribosomal subunit protein P1-like [KO:K02942]
299106  Rpl10l1; 60S ribosomal protein L10-like [KO:K02866]
299190  Rpl23al8; large ribosomal subunit protein uL23-like [KO:K02893]
299713  Rps12l4; uncharacterized protein LOC299713 [KO:K02951]
299823  Rps10-ps22; small ribosomal subunit protein eS10-like [KO:K02947]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
299848  Rps26l1; small ribosomal subunit protein eS26-like [KO:K02976]
300001  Rpl36l1; large ribosomal subunit protein eL36-like [KO:K02920]
300079  Rpl3; large ribosomal subunit protein uL3 [KO:K02925]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
300278  Rps9l1; small ribosomal subunit protein uS4-like [KO:K02997]
300338  Mmp1b; interstitial collagenase B [KO:K01388] [EC:3.4.24.7]
300339  Mmp1; interstitial collagenase precursor [KO:K01388] [EC:3.4.24.7]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
301725  Rpl35l4; large ribosomal subunit protein uL29-like [KO:K02918]
302497  Rpl10al2; large ribosomal subunit protein uL1-like [KO:K02865]
302668  Ace2; angiotensin-converting enzyme 2 precursor [KO:K09708] [EC:3.4.17.23]
302961  Rps2-ps17; small ribosomal subunit protein uS5-like [KO:K02981]
303815  Rpl12l2; large ribosomal subunit protein uL11-like [KO:K02870]
303862  Rps26-ps13; small ribosomal subunit protein eS26-like [KO:K02976]
304507  Oas1i; 2 ' -5 ' oligoadenylate synthetase 1I [KO:K14216] [EC:2.7.7.84]
305275  RGD1565048; large ribosomal subunit protein uL6-like [KO:K02940]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
306259  Rps24l3; small ribosomal subunit protein eS24-like [KO:K02974]
307049  Rpl27al1; large ribosomal subunit protein uL15-like [KO:K02900]
307665  Rps18l2; small ribosomal subunit protein uS13-like [KO:K02964]
308267  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
308353  Rpl36Al2; large ribosomal subunit protein eL42-like [KO:K02929]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
311120  Rpl15l2; large ribosomal subunit protein eL15-like [KO:K02877]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311430  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
312705  C1r; complement C1r subcomponent precursor [KO:K01330] [EC:3.4.21.41]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
313283  Rps12l5; similar to ribosomal protein S12 [KO:K02951]
313421  C8b; complement component C8 beta chain precursor [KO:K03998]
314248  Rps17l1; small ribosomal subunit protein eS17-like [KO:K02962]
314322  Fos; protein c-Fos [KO:K04379]
314556  Rps18l3; small ribosomal subunit protein uS13-like [KO:K02964]
314652  Rplp1l1; large ribosomal subunit protein P1-like [KO:K02942]
315035  Rps24-ps17; small ribosomal subunit protein eS24-like [KO:K02974]
315051  Rpl29l5; large ribosomal subunit protein eL29-like [KO:K02905]
315521  Rpl32l1; large ribosomal subunit protein eL32-like [KO:K02912]
316158  Rps26-ps12; small ribosomal subunit protein eS26-like [KO:K02976]
317468  Tlr7; toll-like receptor 7 [KO:K05404]
317646  Rpl13a; large ribosomal subunit protein uL13 [KO:K02872]
360572  Rpl23a; large ribosomal subunit protein uL23 [KO:K02893]
361456  Rbs10l2; small ribosomal subunit protein eS10-like [KO:K02947]
361923  Rpl22l1; 60S ribosomal protein L22-like 1 [KO:K02891]
361969  Fga; fibrinogen alpha chain isoform 1 precursor [KO:K03903]
362041  Rpl34; large ribosomal subunit protein eL34 [KO:K02915]
362119  C5; complement C5 precursor [KO:K03994]
362631  Rpl11; large ribosomal subunit protein uL5 [KO:K02868]
362634  C1qc; complement C1q subcomponent subunit C precursor [KO:K03988]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
363099  Rsl24d1; probable ribosome biogenesis protein RLP24 [KO:K02896]
363248  Rpl37a; large ribosomal subunit protein eL43 [KO:K02921]
363520  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
363650  Faul2; ubiquitin-like FUBI-ribosomal protein eS30 fusion protein [KO:K02983]
363817  Rpl27al7; large ribosomal subunit protein uL15-like [KO:K02900]
363918  Rpl27l5; large ribosomal subunit protein eL27-like [KO:K02901]
363938  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
364023  Rps17l3; small ribosomal subunit protein eS17-like [KO:K02962]
364060  Rpl30l1; large ribosomal subunit protein eL30-like [KO:K02908]
364068  Uba52-ps19; ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
364129  Rpl30-ps7; large ribosomal subunit protein eL30-like [KO:K02908]
364594  Tlr3; toll-like receptor 3 precursor [KO:K05401]
365357  Rps18l4; small ribosomal subunit protein uS13-like [KO:K02964]
366030  Rps16l1; small ribosomal subunit protein uS9-like [KO:K02960]
366191  Rpl31l6; large ribosomal subunit protein eL31-like [KO:K02910]
366411  Rps24-ps18; small ribosomal subunit protein eS24-like [KO:K02974]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
366605  Rps25l2; small ribosomal subunit protein eS25-like [KO:K02975]
366656  Rpl10al1; similar to ribosomal protein L10a [KO:K02865]
367050  Rpl35l2; large ribosomal subunit protein uL29-like [KO:K02918]
367175  Rpl29l4; large ribosomal subunit protein eL29-like [KO:K02905]
367324  Rps17l2; small ribosomal subunit protein eS17-like [KO:K02962]
367865  Rpl24l1; large ribosomal subunit protein eL24-like [KO:K02896]
406161  C4b; complement component 4, gene 2 precursor [KO:K03989]
494202  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
497860  Rpl39l1; ribosomal protein L39-like [KO:K02924]
497882  Rps10-ps20; small ribosomal subunit protein eS10-like [KO:K02947]
498012  Ace3; angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 precursor [KO:K01283] [EC:3.4.15.1]
498085  Rpl27l7; large ribosomal subunit protein eL27-like [KO:K02901]
498143  Rpl15l1; large ribosomal subunit protein eL15-like [KO:K02877]
498276  Fcgr2al1; Fc gamma receptor 2A like 1 [KO:K06472]
498360  Rps23l1; small ribosomal subunit protein uS12-like [KO:K02973]
498523  Rpl23al4; large ribosomal subunit protein uL23-like [KO:K02893]
498555  Rplp2l2; large ribosomal subunit protein P2-like [KO:K02943]
498828  Rpl10-ps14; large ribosomal subunit protein uL16-like [KO:K02866]
498840  Sting1; stimulator of interferon genes protein [KO:K12654]
499057  Rpl18al1; large ribosomal subunit protein eL20-like [KO:K02882]
499133  Rpl27al3; large ribosomal subunit protein uL15-like [KO:K02900]
499374  Rpl8l1; large ribosomal subunit protein uL2-like [KO:K02938]
499522  Rpl17l3; large ribosomal subunit protein uL22-like [KO:K02880]
499523  Rpl23al1; large ribosomal subunit protein uL23-like [KO:K02893]
499599  Rpl23al3; large ribosomal subunit protein uL23-like [KO:K02893]
499782  Rpl12; large ribosomal subunit protein uL11 [KO:K02870]
499801  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
499803  Rps3l1; small ribosomal subunit protein uS3-like [KO:K02985]
500044  Rpl7al1; large ribosomal subunit protein eL8-like [KO:K02936]
500123  Rpl27al5; large ribosomal subunit protein uL15-like [KO:K02900]
500451  Rps20l1; similar to 40S ribosomal protein S20 [KO:K02969]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
500817  Rps20l2; small ribosomal subunit protein uS10-like [KO:K02969]
501027  Rpl32l4; large ribosomal subunit protein eL32-like [KO:K02912]
501058  Rps23-ps11; small ribosomal subunit protein uS12-like [KO:K02973]
501206  Rpl5l1; large ribosomal subunit protein uL18-like [KO:K02932]
502654  Rpl38l2; large ribosomal subunit protein eL38-like [KO:K02923]
502741  Rpl38l1; large ribosomal subunit protein eL38-like [KO:K02923]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
503183  Rps24-ps16; small ribosomal subunit protein eS24-like [KO:K02974]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54249  Cfd; complement factor D precursor [KO:K01334] [EC:3.4.21.46]
54287  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
57027  Adam17; disintegrin and metalloproteinase domain-containing protein 17 precursor [KO:K06059] [EC:3.4.24.86]
57809  Rpl35a; large ribosomal subunit protein eL33 [KO:K02917]
58927  Rpl36; large ribosomal subunit protein eL36 [KO:K02920]
60327  F13a1; coagulation factor XIII A chain [KO:K03917] [EC:2.3.2.13]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64023  Masp1; mannan-binding lectin serine protease 1 precursor [KO:K03992] [EC:3.4.21.-]
64156  Uba52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
64205  Rplp0; large ribosomal subunit protein uL10 [KO:K02941]
64298  Rpl31; large ribosomal subunit protein eL31 [KO:K02910]
64302  Rpl4; large ribosomal subunit protein uL4 [KO:K02930]
64306  Rpl27; large ribosomal subunit protein eL27 [KO:K02901]
64307  Rpl24; large ribosomal subunit protein eL24 [KO:K02896]
64459  Masp2; mannan-binding lectin serine protease 2 precursor [KO:K03993] [EC:3.4.21.104]
64546  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
64638  Rpl28; large ribosomal subunit protein eL28 [KO:K02903]
64640  Rpl30; large ribosomal subunit protein eL30 [KO:K02908]
64668  Mbl2; mannose-binding protein C precursor [KO:K03991]
65043  Rpl14; large ribosomal subunit protein eL14 [KO:K02875]
65136  Rps8; small ribosomal subunit protein eS8 [KO:K02995]
65139  Rps12; small ribosomal subunit protein eS12 [KO:K02951]
66021  Cybb; cytochrome b-245 beta chain [KO:K21421] [EC:1.-.-.-]
679899  Rps20l3; small ribosomal subunit protein uS10-like [KO:K02969]
680353  Rpl38l3; large ribosomal subunit protein eL38-like [KO:K02923]
680441  Rpl23al6; large ribosomal subunit protein uL23-like [KO:K02893]
680512  Rpl38l4; large ribosomal subunit protein eL38-like [KO:K02923]
680575  Rpl22l2; ribosomal protein L22-like 2 [KO:K02891]
680579  Rpl14l2; large ribosomal subunit protein eL14-like [KO:K02875]
680585  Rps28l1; small ribosomal subunit protein eS28-like [KO:K02979]
680700  Rpl10al3; large ribosomal subunit protein uL1-like isoform X2 [KO:K02865]
680959  Rpl32l2; large ribosomal subunit protein eL32-like [KO:K02912]
680960  Rpl27l3; large ribosomal subunit protein eL27-like [KO:K02901]
681429  Rps27l; small ribosomal subunit protein eS27-like [KO:K02978]
682147  Cgas; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
683961  Rps13l1; small ribosomal subunit protein uS15-like [KO:K02953]
684440  Tlr8; toll-like receptor 8 precursor [KO:K10170]
685085  Rps25l3; small ribosomal subunit protein eS25-like [KO:K02975]
686066  Rpl38l5; large ribosomal subunit protein eL38-like [KO:K02923]
686074  Rpl35l1; large ribosomal subunit protein uL29-like [KO:K02918]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
687780  Faul1; ubiquitin-like FUBI-ribosomal protein eS30 fusion protein [KO:K02983]
688416  Rpl31l1; large ribosomal subunit protein eL31-like [KO:K02910]
688470  Rpl24l2; large ribosomal subunit protein eL24-like [KO:K02896]
688684  Rpl32l3; large ribosomal subunit protein eL32-like [KO:K02912]
688712  Rpl22l3; ribosomal protein eL22-like 1 [KO:K02891]
688784  Rpl27l1; ribosomal protein L27-like 1 [KO:K02901]
688948  Rps26l4; small ribosomal subunit protein eS26-like [KO:K02976]
689284  Rpl38; large ribosomal subunit protein eL38 [KO:K02923]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
689346  Rpl37al3; large ribosomal subunit protein eL43-like [KO:K02921]
689481  [KO:K02951]
689965  Rpl27l8; large ribosomal subunit protein eL27-like [KO:K02901]
690096  Rpl28l3; large ribosomal subunit protein eL28-like [KO:K02903]
690335  Rpl23al7; large ribosomal subunit protein uL23-like [KO:K02893]
690384  Rpl31l10; large ribosomal subunit protein eL31-like [KO:K02910]
690475  Rps24-ps19; small ribosomal subunit protein eS24-like [KO:K02974]
690495  Rps15al1; small ribosomal subunit protein uS8-like [KO:K02957]
690597  Rpl38l6; large ribosomal subunit protein eL38-like [KO:K02923]
690718  Rps20l6; small ribosomal subunit protein uS10-like [KO:K02969]
690840  Rpl37l4; large ribosomal subunit protein eL37-like [KO:K02922]
690845  Rps4y2; ribosomal protein S4, Y-linked 2 [KO:K02987]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
691392  Rpl17l5; large ribosomal subunit protein uL22-like [KO:K02880]
691531  Rps28; small ribosomal subunit protein eS28 [KO:K02979]
691532  Rps25-ps11; small ribosomal subunit protein eS25-like [KO:K02975]
79449  Rpl21; large ribosomal subunit protein eL21 [KO:K02889]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
81635  Adar; double-stranded RNA-specific adenosine deaminase [KO:K12968] [EC:3.5.4.37]
81638  Agtr1b; type-1 angiotensin II receptor B [KO:K04166]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
81729  Rpl10a; large ribosomal subunit protein uL1 [KO:K02865]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81763  Rpl5; large ribosomal subunit protein uL18 [KO:K02932]
81764  Rpl10; large ribosomal subunit protein uL16 [KO:K02866]
81765  Rpl13; large ribosomal subunit protein eL13 [KO:K02873]
81766  Rpl18; large ribosomal subunit protein eL18 [KO:K02883]
81767  Rpl19; large ribosomal subunit protein eL19 [KO:K02885]
81768  Rpl22; large ribosomal subunit protein eL22 [KO:K02891]
81769  Rpl36al1; large ribosomal subunit protein eL42 [KO:K02929]
81770  Rpl37l1; 60S ribosomal protein L37 [KO:K02922]
81773  Rps10; small ribosomal subunit protein eS10 [KO:K02947]
81774  Rps11; small ribosomal subunit protein uS17 [KO:K02949]
81775  Rps21; small ribosomal subunit protein eS21 [KO:K02971]
81776  Rps24; small ribosomal subunit protein eS24 [KO:K02974]
83789  Rps2; small ribosomal subunit protein uS5 [KO:K02981]
84007  C3ar1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84405  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
94266  Rps27; small ribosomal subunit protein eS27 [KO:K02978]
Compound
C00027  Hydrogen peroxide
C00046  RNA
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00704  Superoxide
C00873  Angiotensin I
C02135  Angiotensin II
C15850  Angiotensin (1-7)
C20640  Cyclic GMP-AMP
Reference
PMID:33132005
  Authors
Harrison AG, Lin T, Wang P
  Title
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.
  Journal
Trends Immunol S1471-4906(20)30233-7 (2020)
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PMID:33077917
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Perico L, Benigni A, Casiraghi F, Ng LFP, Renia L, Remuzzi G
  Title
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19.
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Nat Rev Nephrol 10.1038/s41581-020-00357-4 (2020)
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Battagello DS, Dragunas G, Klein MO, Ayub ALP, Velloso FJ, Correa RG
  Title
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission.
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Clin Sci (Lond) 134:2137-2160 (2020)
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Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
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COVID-19: Immunology and treatment options.
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Clin Immunol 215:108448 (2020)
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Inflamm Regen 40:37 (2020)
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PMID:32544563
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Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S, Nabipour I
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COVID-19 cytokine storm: The anger of inflammation.
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Cytokine 133:155151 (2020)
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PMID:32635353
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  Title
Treatment of Severe COVID-19 with Tocilizumab Mitigates Cytokine Storm and Averts Mechanical Ventilation During Acute Respiratory Distress: A Case Report and Literature Review.
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Trop Med Infect Dis 5:E112 (2020)
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Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions.
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Autoimmun Rev 19:102567 (2020)
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Reference
PMID:32722596
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Kiselevskiy M, Shubina I, Chikileva I, Sitdikova S, Samoylenko I, Anisimova N, Kirgizov K, Suleimanova A, Gorbunova T, Varfolomeeva S
  Title
Immune Pathogenesis of COVID-19 Intoxication: Storm or Silence?
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Pharmaceuticals (Basel) 13:E166 (2020)
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Reference
PMID:32922297
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Curran CS, Rivera DR, Kopp JB
  Title
COVID-19 Usurps Host Regulatory Networks.
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Front Pharmacol 11:1278 (2020)
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Reference
PMID:33055229
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Quan C, Li C, Ma H, Li Y, Zhang H
  Title
Immunopathogenesis of Coronavirus-Induced Acute Respiratory Distress Syndrome (ARDS): Potential Infection-Associated Hemophagocytic Lymphohistiocytosis.
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Clin Microbiol Rev 34:e00074-20 (2020)
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PMID:32973803
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Ahmed-Hassan H, Sisson B, Shukla RK, Wijewantha Y, Funderburg NT, Li Z, Hayes D Jr, Demberg T, Liyanage NPM
  Title
Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.
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Front Immunol 11:1979 (2020)
DOI:10.3389/fimmu.2020.01979
Reference
PMID:32346093
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Tay MZ, Poh CM, Renia L, MacAry PA, Ng LFP
  Title
The trinity of COVID-19: immunity, inflammation and intervention.
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Nat Rev Immunol 20:363-374 (2020)
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PMID:32979938
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Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY
  Title
Evasion of Type I Interferon by SARS-CoV-2.
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Cell Rep 33:108234 (2020)
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The molecular virology of coronaviruses.
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J Biol Chem 295:12910-12934 (2020)
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  Title
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  Title
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  Title
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  Journal
Nat Rev Immunol 20:355-362 (2020)
DOI:10.1038/s41577-020-0331-4
Reference
PMID:32246101
  Authors
South AM, Tomlinson L, Edmonston D, Hiremath S, Sparks MA
  Title
Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic.
  Journal
Nat Rev Nephrol 16:305-307 (2020)
DOI:10.1038/s41581-020-0279-4
Reference
PMID:32433641
  Authors
Furuhashi M, Moniwa N, Takizawa H, Ura N, Shimamoto K
  Title
Potential differential effects of renin-angiotensin system inhibitors on SARS-CoV-2 infection and lung injury in COVID-19.
  Journal
Hypertens Res 43:837-840 (2020)
DOI:10.1038/s41440-020-0478-1
Reference
PMID:32423094
  Authors
Gemmati D, Bramanti B, Serino ML, Secchiero P, Zauli G, Tisato V
  Title
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?
  Journal
Int J Mol Sci 21:E3474 (2020)
DOI:10.3390/ijms21103474
Reference
PMID:33184193
  Authors
Kielian M
  Title
Enhancing host cell infection by SARS-CoV-2.
  Journal
Science 370:765-766 (2020)
DOI:10.1126/science.abf0732
Reference
PMID:32327719
  Authors
Risitano AM, Mastellos DC, Huber-Lang M, Yancopoulou D, Garlanda C, Ciceri F, Lambris JD
  Title
Complement as a target in COVID-19?
  Journal
Nat Rev Immunol 20:343-344 (2020)
DOI:10.1038/s41577-020-0320-7
Reference
PMID:32461141
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
PMID:32559343
  Authors
Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, Klavinskis LS, Sacks S
  Title
Rationale for targeting complement in COVID-19.
  Journal
EMBO Mol Med 12:e12642 (2020)
DOI:10.15252/emmm.202012642
Reference
PMID:32439870
  Authors
Teuwen LA, Geldhof V, Pasut A, Carmeliet P
  Title
COVID-19: the vasculature unleashed.
  Journal
Nat Rev Immunol 20:389-391 (2020)
DOI:10.1038/s41577-020-0343-0
Reference
PMID:32643798
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol 178:2832-2848 (2021)
DOI:10.1111/bph.15187
Reference
PMID:32608159
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost 18:2110-2117 (2020)
DOI:10.1111/jth.14981
Reference
PMID:32558620
  Authors
Colling ME, Kanthi Y
  Title
COVID-19-associated coagulopathy: An exploration of mechanisms.
  Journal
Vasc Med 25:471-478 (2020)
DOI:10.1177/1358863X20932640
Reference
PMID:32586214
  Authors
McFadyen JD, Stevens H, Peter K
  Title
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
  Journal
Circ Res 127:571-587 (2020)
DOI:10.1161/CIRCRESAHA.120.317447
Reference
PMID:32995777
  Authors
Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H
  Title
SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
  Journal
bioRxiv 2020.09.18.302901 (2020)
DOI:10.1101/2020.09.18.302901
Reference
PMID:32693241
  Authors
Paniri A, Akhavan-Niaki H
  Title
Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation.
  Journal
Life Sci 257:118114 (2020)
DOI:10.1016/j.lfs.2020.118114
Reference
PMID:32405269
  Authors
Omarjee L, Janin A, Perrot F, Laviolle B, Meilhac O, Mahe G
  Title
Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.
  Journal
Clin Immunol 216:108464 (2020)
DOI:10.1016/j.clim.2020.108464
Reference
PMID:32337664
  Authors
Zhang S, Li L, Shen A, Chen Y, Qi Z
  Title
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia.
  Journal
Clin Drug Investig 40:511-518 (2020)
DOI:10.1007/s40261-020-00917-3
Related
pathway
rno03015  mRNA surveillance pathway
rno04144  Endocytosis
rno04270  Vascular smooth muscle contraction
rno04610  Complement and coagulation cascades
rno04611  Platelet activation
rno04613  Neutrophil extracellular trap formation
rno04614  Renin-angiotensin system
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04630  JAK-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04666  Fc gamma R-mediated phagocytosis
rno04668  TNF signaling pathway
rno04670  Leukocyte transendothelial migration
KO pathway
ko05171   

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