Entry Name Herpes simplex virus 1 infection - Oryctolagus cuniculus (rabbit)
Description Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map ocu05168 Herpes simplex virus 1 infection
Disease H00365 Herpes simplex virus infection
Organism Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene 100008609 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
100009318 EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754 ]
100009393 EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
100009560 EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680 ]
100328929 RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752 ]
100349135 STING1; stimulator of interferon genes protein isoform X1 [KO:K12654 ]
100350656 RLA-DRB1; HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752 ]
100352415 RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like precursor [KO:K06752 ]
100355948 RLA-DMB; histocompatibility antigen DM heterodimer light chain-like precursor [KO:K06752 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Granger SW, Rickert S
Title LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal Reference Authors Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal Reference Authors MacLeod IJ, Minson T
Title Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal Reference Authors Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal Reference Authors Gianni T, Campadelli-Fiume G
Title The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal Reference Authors Spear PG
Title Herpes simplex virus: receptors and ligands for cell entry.
Journal Reference Authors Boutell C, Everett RD
Title The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal Reference Authors Ma Y, He B
Title Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal Reference Authors Su C, Zhan G, Zheng C
Title Evasion of host antiviral innate immunity by HSV-1, an update.
Journal Reference Authors Melchjorsen J, Matikainen S, Paludan SR
Title Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal Reference Authors Morrison LA
Title The Toll of herpes simplex virus infection.
Journal Reference Authors Zheng C
Title Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal Reference Authors Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal Reference Authors Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal Reference Authors Sanchez R, Mohr I
Title Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal Reference Authors Wysocka J, Herr W
Title The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal Reference Authors Fleming SB
Title Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal Reference Authors Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal Reference Authors Gu H, Zheng Y, Roizman B
Title Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal Reference Authors Tavalai N, Stamminger T
Title Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal Reference Authors Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal Reference Authors Neumann J, Eis-Hubinger AM, Koch N
Title Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal Reference Authors Liu X, Cohen JI
Title The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal Reference Authors Vink EI, Smiley JR, Mohr I
Title Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal Reference Authors Sandri-Goldin RM
Title The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal Reference Authors Sandri-Goldin RM
Title Viral regulation of mRNA export.
Journal Reference Authors Yu X, He S
Title The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal Related ocu04610 Complement and coagulation cascades
ocu04612 Antigen processing and presentation
ocu04620 Toll-like receptor signaling pathway
ocu04622 RIG-I-like receptor signaling pathway
KO pathway
