KEGG   PATHWAY: llv05022
Entry
llv05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Lutra lutra (Eurasian river otter)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
llv05022  Pathways of neurodegeneration - multiple diseases
llv05022

Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125095266  LOW QUALITY PROTEIN: amyloid-beta precursor protein-like [KO:K04520]
125086936  microtubule-associated protein tau isoform X1 [KO:K04380]
125093175  alpha-synuclein [KO:K04528]
125097952  TAR DNA-binding protein 43 isoform X1 [KO:K23600]
125090619  RNA-binding protein FUS isoform X1 [KO:K13098]
125095124  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
125090786  ataxin-2-like protein isoform X1 [KO:K23625]
125082113  ataxin-2 isoform X1 [KO:K23625]
125093489  LOW QUALITY PROTEIN: huntingtin-like [KO:K04533]
125103281  ataxin-1 [KO:K23616]
125089239  ataxin-1-like [KO:K23616]
125105182  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
125105342  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
125109125  major prion protein [KO:K05634]
125079089  muscarinic acetylcholine receptor M1 [KO:K04129]
125085095  muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
125105102  muscarinic acetylcholine receptor M5 [KO:K04133]
125078449  spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
125103220  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
125078918  metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
125083151  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125102349  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
125108695  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
125108926  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125110237  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
125105190  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125109927  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
125087644  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125090366  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
125089171  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125093345  short transient receptor potential channel 3 isoform X1 [KO:K04966]
125083427  sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
125109360  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125107116  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
125103123  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125089926  ryanodine receptor 1 isoform X1 [KO:K04961]
125084581  ryanodine receptor 2 isoform X1 [KO:K04962]
125104347  ryanodine receptor 3 [KO:K04963]
125108751  proenkephalin-B-like isoform X1 [KO:K15840]
125087807  disks large homolog 4 isoform X1 [KO:K11828]
125083753  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
125090978  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
125107946  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
125088031  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
125089770  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
125100568  glutamate receptor 1 isoform X1 [KO:K05197]
125093104  glutamate receptor 2 isoform X1 [KO:K05198]
125092047  glutamate receptor 3 isoform X1 [KO:K05199]
125078340  glutamate receptor 4 isoform X1 [KO:K05200]
125083483  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
125107204  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125078710  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
125091668  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
125086002  voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
125090532  syntaxin-1A [KO:K04560]
125105622  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
125086958  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
125082008  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
125090153  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
125107381  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like [KO:K05853] [EC:7.2.2.10]
125103933  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
125085890  presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
125096914  derlin-1 [KO:K11519]
125083303  transitional endoplasmic reticulum ATPase [KO:K13525]
125100166  ubiquitin-like [KO:K02927]
125108923  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
125102899  LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40-like [KO:K02927]
125081993  ubiquitin-60S ribosomal protein L40 [KO:K02927]
125108777  ubiquitin-40S ribosomal protein S27a [KO:K02977]
125084841  ubiquitin-40S ribosomal protein S27a [KO:K02977]
125087415  polyubiquitin-B isoform X1 [KO:K04551]
125099136  polyubiquitin [KO:K04551]
125082105  polyubiquitin-C [KO:K08770]
125104146  proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
125109995  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
125080624  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
125108598  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
125082245  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
125097859  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
125100126  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
125079111  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
125103789  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
125104069  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
125088052  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
125083212  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
125086953  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
125098622  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
125105071  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
125103078  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
125097141  proteasome subunit beta type-4 isoform X1 [KO:K02736] [EC:3.4.25.1]
125096092  26S proteasome regulatory subunit 7 [KO:K03061]
125081460  26S proteasome regulatory subunit 7 [KO:K03061]
125104108  26S proteasome regulatory subunit 4 [KO:K03062]
125089639  26S proteasome regulatory subunit 6B [KO:K03063]
125099654  26S proteasome regulatory subunit 10B-like [KO:K03064]
125103928  26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
125078966  26S proteasome regulatory subunit 6A [KO:K03065]
125087452  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
125101380  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
125095187  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
125087556  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
125082300  26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
125087622  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
125087268  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
125110307  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
125089556  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
125079296  26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
125097439  26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
125095471  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
125089490  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
125108403  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
125100241  26S proteasome complex subunit SEM1-like [KO:K10881]
125080895  26S proteasome complex subunit SEM1 [KO:K10881]
125093667  ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
125080796  ubiquitin carboxyl-terminal hydrolase isozyme L1-like [KO:K05611] [EC:3.4.19.12]
125091384  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
125079965  ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
125083455  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
125083471  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
125095313  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
125082080  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
125079476  ubiquitin/ISG15-conjugating enzyme E2 L6-like isoform X1 [KO:K04553] [EC:2.3.2.23]
125085597  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
125097710  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
125102495  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
125093348  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
125086725  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
125095663  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
125081324  prosaposin receptor GPR37 [KO:K04243]
125082444  septin-5 isoform X1 [KO:K04557]
125100737  synphilin-1 isoform X1 [KO:K04558]
125083228  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
125108458  vesicle-associated membrane protein-associated protein B isoform X1 [KO:K10707]
125085601  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
125106097  DNA damage-inducible transcript 3 protein [KO:K04452]
125081642  LOW QUALITY PROTEIN: uncharacterized protein LOC125081642 [KO:K09027]
125086988  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
125083298  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125103005  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125085818  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125099732  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125084526  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125093137  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125078536  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
125089071  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
125108962  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
125105209  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
125106338  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125100023  sodium-dependent dopamine transporter isoform X1 [KO:K05036]
125097148  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
71922402  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
71922406  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
71922421  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
71922424  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
71922423  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
71922428  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
71922429  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
125079144  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
125107912  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
125081923  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
125093717  nucleolar and coiled-body phosphoprotein 1-like isoform X1 [KO:K03944]
125091362  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
125108496  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
125100354  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
125094229  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
125088848  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like isoform X1 [KO:K03947]
125081117  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
125107352  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
125091808  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
125094078  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
125080931  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
125106375  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
125085932  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
125083711  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
125088846  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
125106590  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
125095304  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
125090987  acyl carrier protein, mitochondrial [KO:K03955]
125088449  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
125106370  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
125081657  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
125091537  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
125085582  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
125080587  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
125094996  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
125097907  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
125100711  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
125083630  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
125083554  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
125085175  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
125096953  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
125104059  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-like [KO:K03966]
125090506  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
125091408  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
125095035  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
125085766  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
125078280  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
125096286  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
125100031  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
125097856  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
125100336  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
125089153  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
125078801  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
125104453  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
125093405  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
125107051  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
125078368  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
125100859  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
125097891  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
125085786  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
125110335  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
125089498  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
71922431  CYTB; cytochrome b [KO:K00412]
125097461  cytochrome c1, heme protein, mitochondrial [KO:K00413]
125080688  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
125095337  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
125090285  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
125097897  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
125099302  cytochrome b-c1 complex subunit 7-like [KO:K00417]
125088620  cytochrome b-c1 complex subunit 7-like [KO:K00417]
125098858  cytochrome b-c1 complex subunit 7 [KO:K00417]
125100787  cytochrome b-c1 complex subunit 8 [KO:K00418]
125084995  cytochrome b-c1 complex subunit 9-like [KO:K00419]
125082667  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
125094379  cytochrome b-c1 complex subunit 10 [KO:K00420]
125089233  cytochrome b-c1 complex subunit 10 [KO:K00420]
71922419  COX3; cytochrome c oxidase subunit III [KO:K02262]
71922412  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
71922415  COX2; cytochrome c oxidase subunit II [KO:K02261]
125085010  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
125109679  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like isoform X1 [KO:K02263]
125089146  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
125084063  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
125105228  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
125109731  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
125078878  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
125081662  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
125090669  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
125102537  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
125088465  cytochrome c oxidase subunit 6B1 [KO:K02267]
125089137  cytochrome c oxidase subunit 6B2 [KO:K02267]
125097548  cytochrome c oxidase subunit 6B1-like [KO:K02267]
125091830  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
125108724  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
125101862  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
125088454  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
125106771  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
125091810  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
125078870  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
125094364  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
125097679  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
125100628  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
125091285  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
125078677  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
125103906  cytochrome c oxidase subunit 8C, mitochondrial-like [KO:K02273]
125082374  ATP synthase subunit alpha, mitochondrial [KO:K02132]
125106433  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
125106361  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
125089163  ATP synthase subunit delta, mitochondrial [KO:K02134]
125108884  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
125101556  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
125103329  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
71922418  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
125097179  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
125084568  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
125093193  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
125102334  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125095139  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125095210  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125095763  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
125087945  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
125096423  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125080864  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125081272  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125106031  ATP synthase F(0) complex subunit C2, mitochondrial-like isoform X1 [KO:K02128]
125082594  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
125099178  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125101037  ATP synthase subunit d, mitochondrial [KO:K02138]
125078149  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125093488  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125087224  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125104881  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125080785  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125089234  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125084993  LOW QUALITY PROTEIN: ATP synthase subunit O, mitochondrial-like [KO:K02137]
125094993  ATP synthase subunit O, mitochondrial [KO:K02137]
125095301  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
125081686  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
125100315  voltage-dependent anion-selective channel protein 1 [KO:K05862]
125081242  voltage-dependent anion-selective channel protein 1 [KO:K05862]
125086141  mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
125088674  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
125084524  calcium uniporter protein, mitochondrial [KO:K20858]
125099896  calmodulin-1-like [KO:K02183]
125107709  calmodulin-like protein 3 [KO:K02183]
125092830  calmodulin-1 [KO:K02183]
125109105  calmodulin-1 [KO:K02183]
125104272  calmodulin-like protein 4 isoform X1 [KO:K02183]
125104293  calmodulin-1 [KO:K02183]
125097034  calmodulin-like protein 6 [KO:K02183]
125097532  calmodulin-1-like [KO:K02183]
125089454  calmodulin-1 [KO:K02183]
125084662  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like [KO:K04348] [EC:3.1.3.16]
125092859  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125093220  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125083501  calcineurin subunit B type 2 [KO:K06268]
125079150  bcl2-associated agonist of cell death-like isoform X1 [KO:K02158]
125086282  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125084890  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
125079328  FAS-associated death domain protein-like [KO:K02373]
125094998  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125106056  BH3-interacting domain death agonist-like [KO:K04726]
125086017  apoptosis regulator BAX-like [KO:K02159]
125089829  apoptosis regulator BAX [KO:K02159]
125102734  bcl-2 homologous antagonist/killer [KO:K14021]
125106618  LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2-like [KO:K08844] [EC:2.7.11.1]
125108306  serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
125091009  heat shock protein 75 kDa, mitochondrial [KO:K09488]
125084591  voltage-dependent anion-selective channel protein 2 [KO:K15040]
125092799  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
125107880  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
125091556  ADP/ATP translocase 1 [KO:K05863]
125091941  ADP/ATP translocase 3 [KO:K05863]
125092137  ADP/ATP translocase 2 [KO:K05863]
125093372  ADP/ATP translocase 4 [KO:K05863]
125094113  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
125085020  peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
125109865  LOW QUALITY PROTEIN: cytochrome c homolog [KO:K08738]
125080891  cytochrome c [KO:K08738]
125082666  cytochrome c-like [KO:K08738]
125106261  apoptotic protease-activating factor 1 [KO:K02084]
125098709  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
125091274  caspase-3 [KO:K02187] [EC:3.4.22.56]
125090796  huntingtin-interacting protein 1 isoform X1 [KO:K04559]
125096807  intraflagellar transport protein 57 homolog isoform X1 [KO:K04638]
125092362  3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
125093092  peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
125097941  Parkinson disease protein 7 homolog [KO:K05687] [EC:3.5.1.124]
125108270  bcl-2-like protein 1 [KO:K04570]
125100641  mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
125098037  mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
125106642  optineurin isoform X1 [KO:K19946]
125100227  sequestosome-1 [KO:K14381]
125109681  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
125086434  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
125079924  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
125089822  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
125106807  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
125095469  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
125100124  WD repeat-containing protein 41 isoform X1 [KO:K23610]
125087935  guanine nucleotide exchange protein SMCR8 [KO:K23611]
125084054  guanine nucleotide exchange factor C9orf72 isoform X1 [KO:K23609]
125095697  ras-related protein Rab-8A-like [KO:K07901]
125083046  ras-related protein Rab-8A [KO:K07901]
125092263  ras-related protein Rab-39B [KO:K07925]
125108878  ras-related protein Rab-1A [KO:K07874]
125097001  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125081694  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
125086710  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
125087326  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
125107508  autophagy-related protein 101 [KO:K19730]
125079466  autophagy-related protein 13 isoform X1 [KO:K08331]
125097109  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
125079465  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
125086239  beclin-2-like [KO:K08334]
125086868  beclin-1 isoform X1 [KO:K08334]
125104614  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
125103993  beclin 1-associated autophagy-related key regulator [KO:K17889]
125084349  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
125082224  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
125078893  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
125105615  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
125087891  WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
125090587  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
125103962  zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
125095122  alsin isoform X1 [KO:K04575]
125104900  ras-related protein Rab-5A [KO:K07887]
125090900  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125101158  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125095756  charged multivesicular body protein 2b isoform X1 [KO:K12192]
125102707  polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
125103837  spatacsin-like isoform X1 [KO:K19026]
125103142  tumor necrosis factor isoform X1 [KO:K03156]
125107758  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
125098107  tumor necrosis factor receptor superfamily member 1B-like isoform X1 [KO:K05141]
125102313  death domain-associated protein 6 isoform X1 [KO:K02308]
125087473  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125087142  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
125101777  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125103018  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125096321  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
125106184  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
125106185  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
125082424  LOW QUALITY PROTEIN: nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
125078983  copper chaperone for superoxide dismutase [KO:K04569]
125099901  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
125100890  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
125103265  epididymal secretory glutathione peroxidase-like isoform X1 [KO:K00432] [EC:1.11.1.9]
125103266  glutathione peroxidase 6-like [KO:K00432] [EC:1.11.1.9]
125103718  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
125080187  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
125098847  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
125078629  catalase [KO:K03781] [EC:1.11.1.6]
125107950  peripherin [KO:K07607]
125085586  peripherin-like [KO:K07607]
125092887  neurofilament light polypeptide [KO:K04572]
125092886  neurofilament medium polypeptide [KO:K04573]
125082446  neurofilament heavy polypeptide-like isoform X1 [KO:K04574]
125095859  kinesin heavy chain [KO:K10396]
125106653  kinesin-1 heavy chain [KO:K10396]
125107354  kinesin heavy chain [KO:K10396]
125078492  kinesin light chain 2 [KO:K10407]
125102372  kinesin light chain 4 isoform X1 [KO:K10407]
125104608  kinesin light chain 1 isoform X1 [KO:K10407]
125089545  kinesin light chain 3 isoform X1 [KO:K10407]
125085593  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
125086043  tubulin alpha-8 chain-like [KO:K07374]
125094690  tubulin alpha-1C chain-like [KO:K07374]
125095116  tubulin alpha-4A chain-like [KO:K07374]
125095140  tubulin alpha-4A chain [KO:K07374]
125096476  tubulin alpha-1C chain-like [KO:K07374]
125088530  tubulin alpha chain-like [KO:K07374]
125097294  tubulin alpha-8 chain-like [KO:K07374]
125106192  tubulin alpha-1A chain [KO:K07374]
125106193  tubulin alpha-1C chain [KO:K07374]
125081884  tubulin alpha-3 chain [KO:K07374]
125081976  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
125106546  LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
125106792  tubulin alpha-8 chain isoform X1 [KO:K07374]
125107228  tubulin alpha-1B chain [KO:K07374]
125108883  tubulin beta-1 chain-like isoform X1 [KO:K07375]
125101802  tubulin beta chain [KO:K07375]
125101908  tubulin beta-2A chain [KO:K07375]
125102491  tubulin beta-2B chain [KO:K07375]
125086294  tubulin beta-4A chain [KO:K07375]
125094678  tubulin beta chain-like [KO:K07375]
125082337  tubulin beta-5 chain isoform X1 [KO:K07375]
125082867  tubulin beta-4B chain [KO:K07375]
125089483  uncharacterized protein LOC125089483 [KO:K07375]
125097853  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125108552  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
125089115  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
125101757  casein kinase II subunit beta isoform X1 [KO:K03115]
125079596  brain-derived neurotrophic factor isoform X1 [KO:K04355]
125108489  dynactin subunit 1 isoform X1 [KO:K04648]
125095161  dynactin subunit 2-like [KO:K10424]
125106096  dynactin subunit 2 isoform X1 [KO:K10424]
125083428  dynactin subunit 3 isoform X1 [KO:K10425]
125100231  dynactin subunit 4 [KO:K10426]
125090175  dynactin subunit 5 [KO:K10427]
125091698  dynactin subunit 6 [KO:K10428]
125084868  alpha-centractin [KO:K16575]
125109318  beta-centractin isoform X1 [KO:K16575]
125105145  actin-related protein 10 [KO:K16576]
125087546  LOW QUALITY PROTEIN: huntingtin-associated protein 1-like [KO:K04647]
125091021  dynein axonemal heavy chain 3-like isoform X1 [KO:K10408]
125100371  dynein axonemal heavy chain 5 isoform X1 [KO:K10408]
125108936  dynein axonemal heavy chain 6 isoform X1 [KO:K10408]
125078535  dynein axonemal heavy chain 12-like isoform X1 [KO:K10408]
125086178  dynein axonemal heavy chain 14-like [KO:K10408]
125079098  dynein axonemal heavy chain 1 isoform X1 [KO:K10408]
125086876  dynein axonemal heavy chain 17 isoform X1 [KO:K10408]
125094962  dynein axonemal heavy chain 7 isoform X1 [KO:K10408]
125103028  dynein axonemal heavy chain 8-like isoform X1 [KO:K10408]
125087110  dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
125087139  LOW QUALITY PROTEIN: dynein axonemal heavy chain 9-like [KO:K10408]
125080843  dynein axonemal heavy chain 11 [KO:K10408]
125082071  dynein axonemal heavy chain 10 isoform X1 [KO:K10408]
125096860  axonemal dynein light intermediate polypeptide 1 [KO:K10410]
125083962  LOW QUALITY PROTEIN: dynein axonemal intermediate chain 1-like [KO:K10409]
125082978  dynein axonemal intermediate chain 1-like [KO:K10409]
125088103  dynein axonemal intermediate chain 2 [KO:K11143]
125103707  dynein axonemal light chain 1 isoform X1 [KO:K10411]
125107603  dynein axonemal light chain 4 [KO:K10412]
125100120  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125084354  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125093303  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
125080735  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
125083453  LOW QUALITY PROTEIN: calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
125078527  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
125085781  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
125087895  cyclin-dependent kinase 5 activator 1 [KO:K11716]
125081339  cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
125084583  caspase-7 [KO:K04397] [EC:3.4.22.60]
125092800  dickkopf-related protein 4-like [KO:K02165]
125085265  dickkopf-related protein 1 [KO:K02165]
125093255  dickkopf-related protein 2 [KO:K02165]
125107370  proto-oncogene Wnt-1 [KO:K03209]
125081085  protein Wnt-2 [KO:K00182]
125098175  protein Wnt-2b isoform X1 [KO:K00182]
125101036  protein Wnt-3a [KO:K00312]
125088073  proto-oncogene Wnt-3 isoform X1 [KO:K00312]
125098580  protein Wnt-4 isoform X1 [KO:K00408]
125078671  protein Wnt-5a isoform X1 [KO:K00444]
125107157  protein Wnt-5b isoform X1 [KO:K00444]
125095143  protein Wnt-6 [KO:K00445]
125107901  protein Wnt-7b isoform X1 [KO:K00572]
125108174  protein Wnt-7a [KO:K00572]
125100301  protein Wnt-8a [KO:K00714]
125085171  protein Wnt-8b [KO:K00714]
125100593  protein Wnt-9a isoform X1 [KO:K01064]
125088110  protein Wnt-9b [KO:K01064]
125107986  protein Wnt-10b [KO:K01357]
125096183  protein Wnt-10a isoform X1 [KO:K01357]
125079445  LOW QUALITY PROTEIN: protein Wnt-11-like [KO:K01384]
125080356  protein Wnt-16 [KO:K01558]
125095704  frizzled-7-like isoform X1 [KO:K02432]
125080933  frizzled-1 [KO:K02432]
125087982  frizzled-2 [KO:K02235]
125092957  frizzled-3 [KO:K02329]
125078464  frizzled-4 [KO:K02354]
125095037  frizzled-5 [KO:K02375]
125107368  LOW QUALITY PROTEIN: frizzled-8-like [KO:K02375]
125098261  frizzled-6 isoform X1 [KO:K02376]
125090242  frizzled-9 [KO:K02842]
125082700  frizzled-10 [KO:K02842]
125078425  low-density lipoprotein receptor-related protein 5 [KO:K03068]
125106478  low-density lipoprotein receptor-related protein 6 [KO:K03068]
125106630  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
125101157  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
125087806  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
125097045  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
125085157  proto-oncogene FRAT1-like [KO:K03069]
125085133  GSK-3-binding protein FRAT2-like [KO:K03096]
125090605  axin-1 isoform X1 [KO:K02157]
125087597  axin-2 isoform X1 [KO:K04385]
125100483  adenomatous polyposis coli protein isoform X1 [KO:K02085]
125088522  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
125106092  catenin beta-1 [KO:K02105]
125099793  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
125096218  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
125102493  advanced glycosylation end product-specific receptor-like isoform X1 [KO:K19722]
125078621  GTPase HRas isoform X1 [KO:K02833]
125106241  GTPase KRas isoform X1 [KO:K07827]
125098043  GTPase NRas [KO:K07828]
125091395  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125080584  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125108469  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125105594  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
125086704  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125081690  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125090203  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125091852  NADPH oxidase 1-like isoform X1 [KO:K08008]
125091990  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
125079264  NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
125078405  transcription factor p65 isoform X1 [KO:K04735]
125093224  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125087863  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
125086360  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
125081177  interleukin-6 [KO:K05405]
125109147  interleukin-1 alpha [KO:K04383]
125109148  interleukin-1 beta [KO:K04519]
125098134  macrophage colony-stimulating factor 1-like isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
  Authors
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
  Title
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
  Journal
Int J Mol Sci 21:E2108 (2020)
DOI:10.3390/ijms21062108
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
llv00190  Oxidative phosphorylation
llv03050  Proteasome
llv04020  Calcium signaling pathway
llv04120  Ubiquitin mediated proteolysis
llv04137  Mitophagy - animal
llv04140  Autophagy - animal
llv04141  Protein processing in endoplasmic reticulum
llv04142  Lysosome
llv04210  Apoptosis
llv04310  Wnt signaling pathway
llv04724  Glutamatergic synapse
llv04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

DBGET integrated database retrieval system