KEGG   ORTHOLOGY: K03099Help
Entry
K03099                      KO                                     

Name
SOS
Definition
son of sevenless
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04714  Thermogenesis
ko04722  Neurotrophin signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04926  Relaxin signaling pathway
ko05034  Alcoholism
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05231  Choline metabolism in cancer
Disease
H00523  Noonan syndrome and related disorders
H01250  Hereditary gingival fibromatosis
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K03099  SOS; son of sevenless
   04010 MAPK signaling pathway
    K03099  SOS; son of sevenless
   04013 MAPK signaling pathway - fly
    K03099  SOS; son of sevenless
   04012 ErbB signaling pathway
    K03099  SOS; son of sevenless
   04630 Jak-STAT signaling pathway
    K03099  SOS; son of sevenless
   04068 FoxO signaling pathway
    K03099  SOS; son of sevenless
   04072 Phospholipase D signaling pathway
    K03099  SOS; son of sevenless
   04151 PI3K-Akt signaling pathway
    K03099  SOS; son of sevenless
   04150 mTOR signaling pathway
    K03099  SOS; son of sevenless
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K03099  SOS; son of sevenless
   04540 Gap junction
    K03099  SOS; son of sevenless
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K03099  SOS; son of sevenless
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K03099  SOS; son of sevenless
   04660 T cell receptor signaling pathway
    K03099  SOS; son of sevenless
   04662 B cell receptor signaling pathway
    K03099  SOS; son of sevenless
   04664 Fc epsilon RI signaling pathway
    K03099  SOS; son of sevenless
   04062 Chemokine signaling pathway
    K03099  SOS; son of sevenless
  09152 Endocrine system
   04910 Insulin signaling pathway
    K03099  SOS; son of sevenless
   04912 GnRH signaling pathway
    K03099  SOS; son of sevenless
   04915 Estrogen signaling pathway
    K03099  SOS; son of sevenless
   04917 Prolactin signaling pathway
    K03099  SOS; son of sevenless
   04926 Relaxin signaling pathway
    K03099  SOS; son of sevenless
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03099  SOS; son of sevenless
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K03099  SOS; son of sevenless
  09159 Environmental adaptation
   04714 Thermogenesis
    K03099  SOS; son of sevenless
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03099  SOS; son of sevenless
   05206 MicroRNAs in cancer
    K03099  SOS; son of sevenless
   05205 Proteoglycans in cancer
    K03099  SOS; son of sevenless
   05231 Choline metabolism in cancer
    K03099  SOS; son of sevenless
  09162 Cancer: specific types
   05210 Colorectal cancer
    K03099  SOS; son of sevenless
   05225 Hepatocellular carcinoma
    K03099  SOS; son of sevenless
   05226 Gastric cancer
    K03099  SOS; son of sevenless
   05214 Glioma
    K03099  SOS; son of sevenless
   05221 Acute myeloid leukemia
    K03099  SOS; son of sevenless
   05220 Chronic myeloid leukemia
    K03099  SOS; son of sevenless
   05211 Renal cell carcinoma
    K03099  SOS; son of sevenless
   05215 Prostate cancer
    K03099  SOS; son of sevenless
   05213 Endometrial cancer
    K03099  SOS; son of sevenless
   05224 Breast cancer
    K03099  SOS; son of sevenless
   05223 Non-small cell lung cancer
    K03099  SOS; son of sevenless
  09165 Substance dependence
   05034 Alcoholism
    K03099  SOS; son of sevenless
  09172 Infectious disease: viral
   05161 Hepatitis B
    K03099  SOS; son of sevenless
   05160 Hepatitis C
    K03099  SOS; son of sevenless
   05163 Human cytomegalovirus infection
    K03099  SOS; son of sevenless
   05165 Human papillomavirus infection
    K03099  SOS; son of sevenless
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K03099  SOS; son of sevenless
   01522 Endocrine resistance
    K03099  SOS; son of sevenless
BRITE hierarchy
Genes
HSA: 6654(SOS1) 6655(SOS2)
PTR: 452897(SOS2) 459171(SOS1)
PPS: 100972953(SOS1) 100980038(SOS2)
GGO: 101130824(SOS1) 101137539(SOS2)
PON: 100434331(SOS2) 100458733(SOS1)
NLE: 100590165(SOS1) 100600495(SOS2)
MCC: 705601(SOS2) 713777(SOS1)
MCF: 102135079(SOS1) 102138313(SOS2)
CSAB: 103220440(SOS1) 103228953(SOS2)
RRO: 104663024(SOS1) 104682751(SOS2)
RBB: 108513636(SOS2) 108520869(SOS1)
CJC: 100410124(SOS2) 100414931(SOS1)
SBQ: 101036943(SOS1) 101046427(SOS2)
MMU: 20662(Sos1) 20663(Sos2)
MCAL: 110306968(Sos2) 110312423(Sos1)
MPAH: 110324314(Sos2) 110335780(Sos1)
RNO: 313845(Sos1) 85384(Sos2)
MUN: 110547073(Sos1) 110556913(Sos2)
CGE: 100757521(Sos1) 100769325(Sos2)
NGI: 103731514(Sos2) 103743944(Sos1)
HGL: 101701753(Sos2) 101707893(Sos1)
OCU: 100346391(SOS2) 100356615(SOS1)
TUP: 102477222(SOS2) 102494629(SOS1)
CFA: 483042(SOS1) 490682(SOS2)
VVP: 112921310(SOS2) 112935267(SOS1)
AML: 100474396(SOS2) 100482526(SOS1)
UMR: 103665409(SOS2) 103671891(SOS1)
UAH: 113241630(SOS1) 113266205(SOS2)
ORO: 101369947(SOS1) 101385114(SOS2)
FCA: 101088847(SOS2) 101098862(SOS1)
PTG: 102949403(SOS1) 102950748(SOS2)
AJU: 106978987(SOS1) 106989073(SOS2)
BTA: 100138040(SOS2) 537682(SOS1)
BOM: 102277585(SOS2) 102286943(SOS1)
BIU: 109564346(SOS2) 109566002(SOS1)
BBUB: 102392913(SOS1) 102412823(SOS2)
PHD: 102328967(SOS2) 102337448(SOS1)
CHX: 102184154(SOS2) 102185660(SOS1)
OAS: 101102732(SOS2) 101118865(SOS1)
SSC: 100156602(SOS2) 100520187(SOS1)
CFR: 102507247(SOS1) 102517014(SOS2)
CDK: 105091467(SOS2) 105103654(SOS1)
BACU: 102999196(SOS1) 103019365(SOS2)
LVE: 103079242(SOS1) 103081084(SOS2)
OOR: 101284580(SOS2) 101286587(SOS1) 105748221
DLE: 111173177(SOS2) 111174855(SOS1)
PCAD: 102978925(SOS2) 102981677 102991639(SOS1)
ECB: 100053889(SOS1) 100066282(SOS2)
EPZ: 103553088(SOS1) 103556123(SOS2) 103559175
EAI: 106825844(SOS1) 106839506(SOS2)
MYB: 102252301(SOS1) 102259408(SOS2)
MYD: 102763262(SOS2) 102768105(SOS1)
MNA: 107525851(SOS2) 107541780(SOS1)
HAI: 109375221(SOS2) 109385471(SOS1)
RSS: 109444341(SOS2) 109452993(SOS1)
DRO: 112297971(SOS1) 112310995(SOS2)
PALE: 102882462(SOS1) 102889597(SOS2)
RAY: 107511436(SOS2) 107519446(SOS1)
LAV: 100656200(SOS2) 100657379(SOS1)
MDO: 100029256(SOS2) 100618058(SOS1)
SHR: 100931009(SOS1) 100932999(SOS2)
PCW: 110201388(SOS1) 110211774(SOS2)
OAA: 100078989(SOS1) 100084645(SOS2)
GGA: 423572(SOS2) 431192(SOS1)
MGP: 100540230(SOS2) 100542624(SOS1)
CJO: 107310899(SOS1) 107315513(SOS2)
NMEL: 110397177(SOS1) 110401960(SOS2)
APLA: 101802245(SOS1) 101804628(SOS2)
ACYG: 106045585(SOS1) 106049938
TGU: 100230917(SOS1) 100232589(SOS2)
LSR: 110473496(SOS2) 110474839(SOS1)
SCAN: 103821384(SOS1) 103826824(SOS2) 108964250
GFR: 102033314(SOS2) 102038427(SOS1)
FAB: 101809111(SOS1) 101818186(SOS2)
PHI: 102102138(SOS1) 102114309(SOS2)
PMAJ: 107201824(SOS1) 107206011(SOS2)
CCAE: 111926571(SOS1) 111929515(SOS2)
CCW: 104695922(SOS2) 104696641(SOS1)
ETL: 114060067(SOS1) 114070305(SOS2)
FPG: 101910509(SOS1) 101913074(SOS2)
FCH: 102052422(SOS1) 102056424(SOS2)
CLV: 102089495(SOS2) 102095838(SOS1)
EGZ: 104127966(SOS1) 104135007(SOS2)
NNI: 104019491(SOS2) 104022133(SOS1)
ACUN: 113477828(SOS1) 113480382(SOS2)
PADL: 103914918(SOS2) 103925086(SOS1)
AAM: 106495130(SOS2) 106497440 106499697(SOS1)
ASN: 102382733(SOS1) 102387180(SOS2)
AMJ: 102572638(SOS2) 102576889(SOS1)
PSS: 102453319(SOS1) 102458741(SOS2)
CMY: 102929489(SOS2) 102942399(SOS1)
CPIC: 101932674(SOS2) 101939889(SOS1)
ACS: 100559237(sos1) 100563366(sos2)
PVT: 110079544(SOS1) 110089155(SOS2)
PBI: 103059323(SOS2) 103066310(SOS1)
PMUR: 107291909(SOS1) 107296218(SOS2)
GJA: 107116186(SOS1) 107122628
XLA: 108698752(sos2.L) 108699793(sos2.S) 108716660(sos1.L) 108717808(sos1.S)
XTR: 100489960(sos1) 100497015(sos2)
NPR: 108788949(SOS1) 108795074(SOS2)
DRE: 556286(sos1) 561670(sos2)
IPU: 108263000(sos2) 108270875(sos1)
PHYP: 113536776(sos1)
AMEX: 103028577(sos1) 103037386(sos2)
EEE: 113577720 113578009(sos1)
TRU: 101061547(sos2) 101070228(sos1)
LCO: 104935443(sos1) 104935981(sos2)
MZE: 101471030(sos2) 101471853(sos1) 112434380
OLA: 101166461(sos1) 101168334(sos2)
XMA: 102232244(sos1) 102234002(sos2)
XCO: 114134500(sos2) 114145177(sos1)
PRET: 103458478(sos2) 103461060 103471606(sos1)
NFU: 107391733(sos2) 107395003(sos1)
AOCE: 111563950(sos1) 111579378(sos2)
CSEM: 103380955(sos2) 103383302(sos1)
LCF: 108882268(sos1) 108886692(sos2)
SDU: 111225570(sos2) 111237578(sos1)
BPEC: 110163236(sos2)
MALB: 109971796(sos1) 109973380(sos2)
ELS: 105025539(sos2) 105026828
LCM: 102347108(SOS1) 102348404(SOS2)
CMK: 103175274(sos2) 103179222(sos1)
CIN: 100179302
SPU: 576982(SOS2)
APLC: 110987135
SKO: 100376216(SOS1) 100376972
DME: Dmel_CG7793(Sos)
DER: 6542322
DSI: Dsimw501_GD23927(Dsim_Sos)
DPE: 6598044
DWI: 6644072
DAZ: 108611531
DNV: 108649955
DHE: 111594674
LCQ: 111679121
AAG: 5568816
AME: 552718
BIM: 100740163
BTER: 100643983
SOC: 105199730
MPHA: 105836700
AEC: 105146854
ACEP: 105618963
PBAR: 105423636
VEM: 105563721
HST: 105181318
DQU: 106745217
LHU: 105671413
PGC: 109858468
OBO: 105282921
PCF: 106784021
NVI: 100121433
MDL: 103577406
TCA: 662194
DPA: 109537782
NVL: 108565246
BMOR: 101736570
HAW: 110378489
TNL: 113502709
AGS: 114123880
BTAB: 109044537
CLEC: 106669246
ZNE: 110832971
FCD: 110859192
TUT: 107371185
DPTE: 113794124
CEL: CELE_T28F12.3(sos-1)
CBR: CBG24573(Cbr-sos-1)
BMY: Bm1_52610
TSP: Tsp_08277
PCAN: 112571367
CRG: 105347925
MYI: 110447714
OBI: 106875192
LAK: 106161320
EPA: 110238840
ADF: 107331175
PDAM: 113673576
SPIS: 111341510
HMG: 100196975(sos2)
QSU: 112021608
SCE: YLR310C(CDC25)
KMX: KLMA_20701(CDC25)
NCS: NCAS_0A05970(NCAS0A05970) NCAS_0C05710(NCAS0C05710)
NDI: NDAI_0D02940(NDAI0D02940) NDAI_0H00410(NDAI0H00410)
TPF: TPHA_0F00380(TPHA0F00380) TPHA_0K02000(TPHA0K02000)
TBL: TBLA_0B09980(TBLA0B09980) TBLA_0E01560(TBLA0E01560)
TDL: TDEL_0E05520(TDEL0E05520)
KAF: KAFR_0I01330(KAFR0I01330)
CAL: CAALFM_C303890WA(CSC25)
CDU: CD36_83870(CDC25)
SLB: AWJ20_2121 AWJ20_2122(CDC25)
NCR: NCU06500
NTE: NEUTE1DRAFT129474(NEUTE1DRAFT_129474)
SMP: SMAC_05336(putative cdc25)
MGR: MGG_00371
SSCK: SPSK_02953
MAW: MAC_06489
MAJ: MAA_03615
CMT: CCM_05772
ELA: UCREL1_28
MBE: MBM_02121
ANI: AN2130.2
ANG: ANI_1_1032034(An03g01230) ANI_1_898134(An15g06650)
ABE: ARB_03209
TVE: TRV_06862
PTE: PTT_11781
SPO: SPBC336.03(efc25)
CNE: CNN01840
CNB: CNBN1800
ABP: AGABI1DRAFT124307(AGABI1DRAFT_124307) AGABI1DRAFT74259(AGABI1DRAFT_74259)
ABV: AGABI2DRAFT207084(AGABI2DRAFT_207084) AGABI2DRAFT214033(AGABI2DRAFT_214033)
MGL: MGL_2133
DDI: DDB_G0276019(gefY) DDB_G0276963(gefH)
DFA: DFA_03677(gefY) DFA_05530(gefAA) DFA_05909(gefH) DFA_06786 DFA_09696(gefN) DFA_11219
EHI: EHI_148500(1.t00104)
EHX: EMIHUDRAFT_521924(RasGEF)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8493579
  Authors
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
  Title
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
  Journal
Science 260:1338-43 (1993)
DOI:10.1126/science.8493579
  Sequence
[hsa:6654]
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