KEGG   PATHWAY: bta04151
Entry
bta04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Bos taurus (cow)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
bta04151  PI3K-Akt signaling pathway
bta04151

Other DBs
GO: 0043491
Organism
Bos taurus (cow) [GN:bta]
Gene
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
540388  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100295476  EREG; proepiregulin isoform X1 [KO:K09784]
538751  AREG; amphiregulin precursor [KO:K09782]
281160  FGF1; fibroblast growth factor 1 [KO:K18496]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
521475  FGF19; fibroblast growth factor 19 [KO:K22603]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
530239  FGF23; fibroblast growth factor 23 [KO:K22428]
281350  NGF; beta-nerve growth factor precursor [KO:K02582]
617701  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
532393  NTF3; neurotrophin-3 precursor [KO:K04356]
506660  NTF4; neurotrophin-4 precursor [KO:K12457]
280829  INS; insulin preproprotein [KO:K04526]
281239  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
281240  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
281094  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
281885  KITLG; kit ligand precursor [KO:K05461]
282233  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
282121  VEGFB; vascular endothelial growth factor B precursor [KO:K16858]
280894  PGF; placenta growth factor precursor [KO:K16859]
286799  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
282122  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
282140  ANGPT1; angiopoietin-1 precursor [KO:K05465]
282141  ANGPT2; angiopoietin-2 precursor [KO:K05466]
617915  ANGPT4; angiopoietin-4 precursor [KO:K05467]
615879  EFNA4; ephrin-A4 precursor [KO:K05462]
616742  EFNA5; ephrin-A5 precursor [KO:K05462]
507319  EFNA1; ephrin-A1 precursor [KO:K05462]
614453  EFNA2; ephrin-A2 precursor [KO:K05462]
540776  EFNA3; ephrin-A3 precursor [KO:K05462]
386587  GDNF; glial cell line-derived neurotrophic factor precursor [KO:K05452]
525562  NRTN; neurturin [KO:K25414]
530812  ARTN; artemin [KO:K25415]
518266  PSPN; persephin [KO:K25416]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
785655  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
522419  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
404193  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
281769  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
317696  FGFR4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
353110  NGFR; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
353111  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
505824  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
408017  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
281848  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
509418  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
280832  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
512700  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
503620  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
338031  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
407170  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
280939  TEK; angiopoietin-1 receptor precursor [KO:K05121] [EC:2.7.10.1]
512798  EPHA2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
515924  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100847184  GTPase HRas-like [KO:K02833]
541140  KRAS; GTPase KRas [KO:K07827]
506322  NRAS; GTPase NRas [KO:K07828]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
538598  IRS1; insulin receptor substrate 1 [KO:K16172]
281534  TLR2; toll-like receptor 2 precursor [KO:K10159]
281536  TLR4; toll-like receptor 4 precursor [KO:K10160]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
524810  IgM precursor [KO:K06856]
100300716  immunoglobulin heavy variable 4-38-2 [KO:K06856]
100300806  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
104968484  immunoglobulin heavy variable 4-59 [KO:K06856]
515515  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
517359  CD19; B-lymphocyte antigen CD19 precursor [KO:K06465]
100138311  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
280804  GH1; somatotropin precursor [KO:K05438]
280901  PRL; prolactin precursor [KO:K05439]
100298767  chorionic somatomammotropin hormone 2 precursor [KO:K05439]
281097  CSH2; chorionic somatomammotropin hormone 2 isoform 2 [KO:K05439]
281429  PRP1; placental prolactin-related protein 1 precursor [KO:K05439]
281430  PRP3; placental prolactin-related protein 3 precursor [KO:K05439]
282007  PRP14; prolactin-related protein 14 precursor [KO:K05439]
404081  PRP6; prolactin-related protein VI precursor [KO:K05439]
406200  PRP4; placental prolactin-related protein 4 precursor [KO:K05439]
497206  PRP-VII; prolactin-related protein VII precursor [KO:K05439]
519859  PRP9; prolactin-related protein IX precursor [KO:K05439]
613971  PRP8; prolactin-related protein VIII precursor [KO:K05439]
790470  PRP2; placental prolactin-related protein 2 precursor [KO:K05439]
319086  OSM; oncostatin-M precursor [KO:K05418]
280822  IL2; interleukin-2 precursor [KO:K05429]
280823  IL3; interleukin-3 precursor [KO:K04736]
280826  IL6; interleukin-6 precursor [KO:K05405]
280824  IL4; interleukin-4 precursor [KO:K05430]
280827  IL7; interleukin-7 precursor [KO:K05431]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
510726  IFNA16; interferon alpha-H [KO:K05414]
523244  interferon alpha-B-like [KO:K05414]
517108  interferon alpha-2 [KO:K05414]
618947  interferon alpha-B-like [KO:K05414]
787343  interferon alpha-2 [KO:K05414]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100335490  interferon alpha-G-like [KO:K05414]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
783912  interferon alpha-H [KO:K05414]
617556  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
132345931  interferon alpha-H-like [KO:K05414]
281845  IFNB1; interferon beta precursor [KO:K05415]
525550  interferon beta-2 [KO:K05415]
517016  interferon beta-2 precursor [KO:K05415]
784525  interferon beta-2 [KO:K05415]
618946  IFNB3; interferon beta-3 precursor [KO:K05415]
100848709  interferon beta-3 [KO:K05415]
616977  interferon beta-2 [KO:K05415]
112441480  interferon beta-3 [KO:K05415]
112447877  interferon beta-3 [KO:K05415]
112447878  interferon beta-3 [KO:K05415]
112447879  interferon beta-3 [KO:K05415]
112447880  interferon beta-3 [KO:K05415]
112441471  interferon beta [KO:K05415]
280784  EPO; erythropoietin precursor [KO:K05437]
281096  CSF3; granulocyte colony-stimulating factor precursor [KO:K05423]
280805  GHR; growth hormone receptor precursor [KO:K05080]
281422  PRLR; prolactin receptor long isoform precursor [KO:K05081]
514720  OSMR; oncostatin-M-specific receptor subunit beta precursor [KO:K05057]
281861  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
510185  interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
104968644  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
281862  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
100299249  IL3RA; interleukin-3 receptor subunit alpha isoform X3 [KO:K04737]
132342083  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
507359  IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055]
404154  IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071]
521554  IL7R; interleukin-7 receptor subunit alpha precursor [KO:K05072]
282257  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
282258  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
281144  EPOR; erythropoietin receptor precursor [KO:K05079]
132344945  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
537201  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
525246  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
538276  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
282188  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
282187  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
407142  COL2A1; collagen alpha-1(II) chain isoform 1 preproprotein [KO:K19719]
282191  COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237]
508632  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
523526  COL4A6; collagen alpha-6(IV) chain isoform X3 [KO:K06237]
511602  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
407107  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
317711  COL4A3; collagen alpha-3(IV) chain precursor [KO:K06237]
530657  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
282194  COL6A2; collagen alpha-2(VI) chain precursor [KO:K06238]
511422  COL6A1; collagen alpha-1(VI) chain precursor [KO:K06238]
530102  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
785805  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
282195  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
505942  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
789493  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
506387  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
100138434  LAMA2; laminin subunit alpha-2 [KO:K05637]
506751  LAMA5; laminin subunit alpha-5 [KO:K06240]
100336873  LAMA3; laminin subunit alpha-3 isoform X4 [KO:K06240]
529670  LAMA4; laminin subunit alpha-4 precursor [KO:K06241]
520030  LAMB1; laminin subunit beta-1 precursor [KO:K05636]
530599  laminin subunit beta-2 isoform X1 [KO:K06243]
520167  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
529939  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
532572  LAMC1; laminin subunit gamma-1 precursor [KO:K05635]
511043  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
518914  LAMC3; laminin subunit gamma-3 [KO:K06247]
281069  CHAD; chondroadherin precursor [KO:K06248]
281450  RELN; reelin precursor [KO:K06249] [EC:3.4.21.-]
281530  THBS1; thrombospondin-1 precursor [KO:K16857]
338092  THBS2; thrombospondin-2 precursor [KO:K04659]
281088  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
504323  THBS3; thrombospondin-3 precursor [KO:K04659]
541281  THBS4; thrombospondin-4 precursor [KO:K04659]
280794  FN1; fibronectin precursor [KO:K05717]
281499  SPP1; osteopontin precursor [KO:K06250]
507525  VTN; vitronectin precursor [KO:K06251]
282654  TNXB; tenascin-X precursor [KO:K06252]
540664  TNC; tenascin precursor [KO:K06252]
526409  TNR; tenascin-R precursor [KO:K06252]
517433  TNN; tenascin-N precursor [KO:K06252]
280958  VWF; von Willebrand factor precursor [KO:K03900]
281233  IBSP; bone sialoprotein 2 precursor [KO:K06253]
535951  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
281872  ITGA2; integrin alpha-2 precursor [KO:K06481]
515011  ITGA2B; integrin alpha-IIb [KO:K06476]
508490  ITGA3; integrin alpha-3 precursor [KO:K06482]
282882  ITGA4; integrin alpha-4 precursor [KO:K06483]
281873  ITGA5; integrin alpha-5 [KO:K06484]
535043  ITGA6; integrin alpha-6 precursor [KO:K06485]
506953  ITGA7; integrin alpha-7 [KO:K06583]
511976  ITGA8; integrin alpha-8 [KO:K06584]
532127  ITGA9; integrin alpha-9 precursor [KO:K06585]
506526  ITGA10; integrin alpha-10 precursor [KO:K06586]
523755  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
281875  ITGAV; integrin alpha-V precursor [KO:K06487]
281876  ITGB1; integrin beta-1 precursor [KO:K05719]
282642  ITGB3; integrin beta-3 precursor [KO:K06493]
506995  ITGB4; integrin beta-4 precursor [KO:K06525]
282564  ITGB5; integrin beta-5 precursor [KO:K06588]
282644  ITGB6; integrin beta-6 precursor [KO:K06589]
514031  ITGB7; integrin beta-7 precursor [KO:K06590]
536286  ITGB8; integrin beta-8 precursor [KO:K06591]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
526585  F2R; proteinase-activated receptor 1 precursor [KO:K03914]
281684  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
522170  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
281136  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
509748  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
532829  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
539738  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
507598  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
782518  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104968964  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
530001  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
614838  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
515621  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100138102  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100337329  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
538954  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
540404  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
529235  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
533440  TSC1; hamartin isoform X1 [KO:K07206]
504985  TSC2; tuberin isoform X9 [KO:K07207]
528204  RHEB; GTP-binding protein Rheb [KO:K07208]
535236  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
507056  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
509613  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
281751  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
519920  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform 1 [KO:K03259]
614570  EIF4E1B; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 1B [KO:K03259]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
505850  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
787914  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
784521  small ribosomal subunit protein eS6-like [KO:K02991]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
509080  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
519754  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
505353  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
515854  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
517909  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
504480  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
783484  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23 [KO:K05631]
100298336  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
540786  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
787270  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
282320  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
524361  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
616695  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
535321  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100138150  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
132344360  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
508045  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
509290  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
782110  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
533147  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
100298789  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
787607  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
132342097  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
505915  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
505757  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
533617  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
533788  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100134966  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
767874  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
281832  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
282646  HSP90B1; endoplasmin precursor [KO:K09487]
520883  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
540959  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
615982  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1 [KO:K16340] [EC:3.1.3.16]
533130  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
506540  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100848382  TCL1B; uncharacterized protein TCL1B [KO:K16836]
784937  MTCP1; protein p13 MTCP-1 [KO:K16837]
287024  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
353120  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
786335  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
537451  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
282855  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
282856  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
538710  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
505012  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
369023  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
511077  MYC; myc proto-oncogene protein [KO:K04377]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
513497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
512613  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
519217  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
510618  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
511754  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
615414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
533526  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
538436  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
535530  FOXO3; forkhead box protein O3 [KO:K09408]
533294  RBL2; retinoblastoma-like protein 2 [KO:K16332]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
507390  BCL2L11; bcl-2-like protein 11 [KO:K16341]
287022  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
286863  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
768311  YWHAQ; 14-3-3 protein theta [KO:K16197]
282125  YWHAE; 14-3-3 protein epsilon [KO:K06630]
282126  YWHAH; 14-3-3 protein eta [KO:K16198]
286862  YWHAG; 14-3-3 protein gamma [KO:K16198]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
282152  BCL2L1; bcl-2-like protein 1 [KO:K04570]
281020  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100140945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
509827  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
509107  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
281715  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
513105  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
513010  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
529566  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X5 [KO:K09048]
785086  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
534129  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
513928  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
788087  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
507554  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
528390  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
508233  RELA; transcription factor p65 [KO:K04735]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
317776  MYB; transcriptional activator Myb [KO:K09420]
540378  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
bta00010  Glycolysis / Gluconeogenesis
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04062  Chemokine signaling pathway
bta04064  NF-kappa B signaling pathway
bta04068  FoxO signaling pathway
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04150  mTOR signaling pathway
bta04210  Apoptosis
bta04370  VEGF signaling pathway
bta04510  Focal adhesion
bta04620  Toll-like receptor signaling pathway
bta04630  JAK-STAT signaling pathway
bta04662  B cell receptor signaling pathway
bta04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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