KEGG   PATHWAY: otw04140
Entry
otw04140                    Pathway                                
Name
Autophagy - animal - Oncorhynchus tshawytscha (Chinook salmon)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
otw04140  Autophagy - animal
otw04140

Other DBs
GO: 0006914
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112255913  insulin-like [KO:K04526]
112259393  insulin [KO:K04526]
112234673  insulin-like [KO:K04526]
112218557  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112252377  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112224871  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112229124  insulin receptor substrate 1-B-like [KO:K16172]
112257780  insulin receptor substrate 1-B-like [KO:K16172]
112216688  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
112259956  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
112233838  LOW QUALITY PROTEIN: insulin receptor substrate 1-B [KO:K16172]
112230587  insulin receptor substrate 2-B-like [KO:K07187]
112214510  insulin receptor substrate 2-B [KO:K07187]
112266609  LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
112225416  insulin receptor substrate 2 [KO:K07187]
112220193  insulin receptor substrate 2-like [KO:K07187]
112241326  insulin receptor substrate 2 [KO:K07187]
112236594  LOW QUALITY PROTEIN: insulin receptor substrate 2-B [KO:K07187]
112267269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112216060  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112260202  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112227144  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112251044  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112265788  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112266167  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
112260699  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112250738  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112260309  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112244626  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
112252131  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112226747  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112248937  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112230790  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
112234933  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112250872  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112220315  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112224117  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
112223683  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112250387  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112256640  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112225150  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112261841  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112230362  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265711  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112224566  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265172  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112217662  RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
112231417  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
112267273  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112253032  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112254533  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112224277  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112223442  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112252501  GTPase HRas [KO:K02833]
112218668  GTPase HRas [KO:K02833]
112252543  GTPase KRas isoform X1 [KO:K07827]
112226270  zgc:55558 [KO:K07827]
112218714  kras; GTPase KRas isoform X1 [KO:K07827]
112253803  ras-related protein M-Ras [KO:K07831]
112225639  mrasa; ras-related protein M-Ras [KO:K07831]
112246677  ras-related protein M-Ras-like [KO:K07831]
112266533  ras-related protein M-Ras-like [KO:K07831]
112249307  rras2; ras-related protein R-Ras2 [KO:K07830]
112261637  rras; ras-related protein R-Ras [KO:K07830]
112261648  ras-related protein R-Ras [KO:K07830]
112263826  ras-related protein R-Ras2 isoform X1 [KO:K07830]
112215764  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
112222214  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
112262497  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112250875  map2k2a; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112231367  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112237794  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
112262493  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251950  mapk3; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251959  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112237408  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112242516  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112231158  hif1al2; hypoxia inducible factor 1 subunit alpha, like 2 [KO:K08268]
112256768  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
112261708  hypoxia-inducible factor 1-alpha [KO:K08268]
112265295  hif1al; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
112266879  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
112253218  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
112247192  DNA damage-inducible transcript 4 protein-like isoform X1 [KO:K08270]
112242265  LOW QUALITY PROTEIN: tuberin [KO:K07207]
112219359  tsc1b; LOW QUALITY PROTEIN: hamartin [KO:K07206]
112248911  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
112230526  hamartin-like [KO:K07206]
112257438  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
112253054  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
112214475  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
112236301  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
112254607  GTP-binding protein Rheb [KO:K07208]
112217539  GTP-binding protein Rheb [KO:K07208]
112247671  GTP-binding protein Rheb isoform X1 [KO:K07208]
112215328  GTP-binding protein Rheb isoform X1 [KO:K07208]
112227773  GTP-binding protein Rheb isoform X1 [KO:K07208]
112241353  GTP-binding protein Rheb-like [KO:K07208]
121843888  GTP-binding protein Rheb-like [KO:K07208]
112230310  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
112245614  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR-like [KO:K07204]
112254376  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
112239764  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
112215922  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112258995  akt1s1; LOW QUALITY PROTEIN: uncharacterized protein akt1s1 [KO:K16184]
112224435  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
112246925  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112234433  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112257848  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112267151  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
112265573  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112231729  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
112250255  immunoglobulin-binding protein 1-like isoform X1 [KO:K17606]
112257664  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
112255883  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112258092  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
112247251  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112248938  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112246744  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112221252  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
112228204  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
112220375  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
112230934  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
112262995  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
112265630  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
112267200  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
112232254  autophagy-related protein 13 isoform X1 [KO:K08331]
112249018  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
112257834  autophagy-related protein 101 [KO:K19730]
112233384  autophagy-related protein 101 [KO:K19730]
112260618  RB1-inducible coiled-coil protein 1-like isoform X1 [KO:K17589]
112226804  rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
112256710  autophagy-related protein 2 homolog B [KO:K17906]
112221170  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
112255918  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
112259126  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
112224474  WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
112240620  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
121838807  LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
121842428  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
121845626  wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
112223373  WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
112230837  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
112233667  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
112247030  autophagy-related protein 9A-like [KO:K17907]
112253685  autophagy-related protein 9A [KO:K17907]
112260633  autophagy-related protein 9A [KO:K17907]
112226797  autophagy-related protein 9A [KO:K17907]
112238391  transcription factor SPT20 homolog isoform X1 [KO:K21245]
112255712  supt20; LOW QUALITY PROTEIN: transcription factor SPT20 homolog [KO:K21245]
112242362  LOW QUALITY PROTEIN: guanine nucleotide exchange protein smcr8a [KO:K23611]
112242395  guanine nucleotide exchange protein smcr8a isoform X1 [KO:K23611]
112220286  wdr41; WD repeat-containing protein 41 [KO:K23610]
112246784  guanine nucleotide exchange C9orf72-like isoform X1 [KO:K23609]
112250803  ras-related protein Rab-8A [KO:K07901]
112260902  ras-related protein Rab-8A isoform X1 [KO:K07901]
112252202  ras-related protein Rab-8A [KO:K07901]
112228959  ras-related protein Rab-39B [KO:K07925]
112234206  rab42b; ras-related protein Rab-42b [KO:K07925]
112264619  ras-related protein Rab-39B [KO:K07925]
112230590  ras-related protein Rab-39B-like [KO:K07925]
112229260  ras-related protein Rab-39B-like [KO:K07925]
121847414  ras-related protein Rab-39B-like [KO:K07925]
112214501  ras-related protein Rab-39B-like [KO:K07925]
112221034  sequestosome-1 [KO:K14381]
112256318  sqstm1; sequestosome-1 [KO:K14381]
112240934  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
112242097  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
112225188  LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
112236024  TRAF family member-associated NF-kappa-B activator [KO:K12650]
112265147  zgc:171927; ras-related protein Rab-1A [KO:K07874]
112231161  ras-related protein Rab-1A [KO:K07874]
112252931  ras-related protein ORAB-1 [KO:K07874]
112228962  ras-related protein Rab-1B [KO:K07874]
112230377  ras-related protein ORAB-1 [KO:K07874]
112265328  ras-related protein ORAB-1 isoform X1 [KO:K07874]
112267365  ras-related protein Rab-1A-like [KO:K07874]
112253790  rab1ab; RAB1A, member RAS oncogene family b [KO:K07874]
112257690  rraga; ras-related GTP-binding protein A [KO:K16185]
112245040  ras-related GTP-binding protein C [KO:K16186]
112261565  rragd; ras-related GTP-binding protein D [KO:K16186]
112223065  ras-related GTP-binding protein C [KO:K16186]
112229553  ras-related GTP-binding protein C [KO:K16186]
112250849  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112260836  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112226590  LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112251091  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112230882  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
112220217  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
112260362  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112226218  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
112260598  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112217412  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
112223316  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
112227364  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
112217414  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
112219327  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
112254618  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
112254422  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
112252764  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112220751  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112252352  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112224208  mitogen-activated protein kinase 8-like isoform X3 [KO:K04440] [EC:2.7.11.24]
112231415  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
112219617  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112257338  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
112223506  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112227752  apoptosis regulator Bcl-2 [KO:K02161]
112260550  apoptosis regulator Bcl-2 [KO:K02161]
112232698  apoptosis regulator Bcl-2-like [KO:K02161]
112226859  apoptosis regulator Bcl-2 [KO:K02161]
112254374  bcl-2-like protein 1 [KO:K04570]
112215997  bcl-2-like protein 1 isoform X1 [KO:K04570]
112219887  bcl-2-like protein 1 [KO:K04570]
112222374  bcl-2-like protein 1 isoform X1 [KO:K04570]
112228809  bada; bcl2-associated agonist of cell death [KO:K02158]
112237949  badb; BCL2 associated agonist of cell death b [KO:K02158]
112223767  becn1; beclin-1 isoform X1 [KO:K08334]
112240487  nrbf2b; nuclear receptor-binding factor 2b isoform X1 [KO:K21246]
112222485  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
112214613  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
112261585  atg14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
112256861  beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
112218296  ambra1b; activating molecule in BECN1-regulated autophagy protein 1b [KO:K17985]
112249007  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
112263501  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
112247822  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112222323  tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
112249070  si:ch211-260e23.9; si:ch211-260e23.9 isoform X1 [KO:K21247]
112263557  tumor protein p53-inducible nuclear protein 2-like [KO:K21247]
112228585  vacuole membrane protein 1 isoform X1 [KO:K21248]
112267154  vacuole membrane protein 1 isoform X1 [KO:K21248]
112265575  vmp1; vacuole membrane protein 1 [KO:K21248]
112222692  syntaxin-17 [KO:K08491]
121846133  stx17; syntaxin-17 [KO:K08491]
112257826  UV radiation resistance-associated gene protein [KO:K21249]
112233378  UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
112215522  sh3glb1a; endophilin-B1a [KO:K11248]
112238210  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
112236744  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
112230923  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
112219945  calcium/calmodulin-dependent protein kinase kinase 2-like [KO:K07359] [EC:2.7.11.17]
112261976  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
112217513  mitogen-activated protein kinase kinase kinase 7-like isoform X2 [KO:K04427] [EC:2.7.11.25]
112256531  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
112250048  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112239288  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121844289  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
112254359  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112262812  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112220132  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
112255286  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
112226580  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
112228771  death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
112264672  death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
112229689  death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
112222863  death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
112259659  death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
112239103  dapk1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
112255692  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
112218050  death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
112231450  hmgb1a; high mobility group protein B1a isoform X1 [KO:K10802]
112216705  high mobility group-T protein [KO:K10802]
112238325  high mobility group-T protein [KO:K10802]
112265013  high mobility group protein B1 [KO:K10802]
112236837  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112261826  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
112255754  LOW QUALITY PROTEIN: eIF-2-alpha kinase GCN2-like [KO:K16196] [EC:2.7.11.1]
112250468  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112261564  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112256881  eif2s1a; eukaryotic translation initiation factor 2 subunit 1a [KO:K03237]
112258344  myotubularin-related protein 4 isoform X3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
112248360  myotubularin-related protein 3-like isoform X2 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
112239701  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
112263041  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
112267540  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
112246236  myotubularin-related protein 14-like isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
112265265  zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
112247580  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
112266853  zinc finger FYVE domain-containing protein 1 [KO:K17603]
112261804  zinc finger FYVE domain-containing protein 1-like isoform X1 [KO:K17603]
112240763  ubiquitin-like protein ATG12 [KO:K08336]
112247686  ubiquitin-like protein ATG12 [KO:K08336]
112222912  autophagy protein 5 [KO:K08339]
112222925  autophagy protein 5 [KO:K08339]
112265003  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
112239650  LOW QUALITY PROTEIN: protein Atg16l2 [KO:K20868]
112248143  atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
112230841  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
112266314  atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
112224883  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
112239519  ras-related protein Rab-33B isoform X1 [KO:K07920]
112256231  ras-related protein Rab-33B [KO:K07920]
112220931  ras-related protein Rab-33B [KO:K07920]
121843634  ras-related protein Rab-33B-like isoform X1 [KO:K07920]
112214258  prkcq; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
112217182  protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
112253764  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112214757  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
112252285  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112229012  gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
112225868  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112238146  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112260042  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
112252256  microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
112254127  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
112230156  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112265571  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112218432  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
112221163  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112258864  cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
112226318  cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
112231145  cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
112251367  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
112241463  LOW QUALITY PROTEIN: cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
112229057  cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
112236275  cysteine protease ATG4B-like [KO:K08342] [EC:3.4.22.-]
112241462  cysteine protease ATG4D-like isoform X1 [KO:K08342] [EC:3.4.22.-]
112245924  atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
112226106  next to BRCA1 gene 1 protein [KO:K17987]
112258782  nbr1b; next to BRCA1 gene 1 protein [KO:K17987]
112224172  next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
112223542  next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
112214267  optn; optineurin isoform X1 [KO:K19946]
112216928  optineurin isoform X1 [KO:K19946]
112223600  calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
112234311  tax1-binding protein 1 homolog A [KO:K21347]
112264409  tax1-binding protein 1 homolog A [KO:K21347]
112238257  tax1bp1b; tax1-binding protein 1 homolog B [KO:K21347]
112263890  wdfy3; WD repeat and FYVE domain-containing protein 3 [KO:K22262]
112250729  ubiquitin-60S ribosomal protein L40 [KO:K02927]
112260320  ubiquitin-60S ribosomal protein L40 [KO:K02927]
112244610  ubiquitin-60S ribosomal protein L40 [KO:K02927]
112252118  ubiquitin-60S ribosomal protein L40 [KO:K02927]
112253134  ubiquitin-40S ribosomal protein S27a [KO:K02977]
112255483  ubiquitin-40S ribosomal protein S27a [KO:K02977]
112257863  ubb; LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
112215747  snap29; synaptosomal-associated protein 29 [KO:K08509]
112257459  si:ch73-234b20.5; vesicle-associated membrane protein 8 [KO:K08512]
112248664  vamp8; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
112262674  vesicle-associated membrane protein 8-like [KO:K08512]
112219866  vesicle-associated membrane protein 7 isoform X1 [KO:K08512]
112220223  synaptobrevin homolog YKT6-like isoform X1 [KO:K08516]
112262624  synaptobrevin homolog YKT6 [KO:K08516]
112248785  synaptobrevin homolog YKT6 [KO:K08516]
112250112  syntaxin-7 [KO:K08488]
112217552  syntaxin-7 [KO:K08488]
112248564  epg5; ectopic P granules protein 5 homolog [KO:K23883]
112223638  pleckstrin homology domain-containing family M member 1 [KO:K23282]
112224091  pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
112258008  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
112266302  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
112217959  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
112249876  vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
112245911  vacuolar protein sorting-associated protein 33A [KO:K20182]
112262888  vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
112255822  vam6/Vps39-like protein [KO:K20183]
112240218  vam6/Vps39-like protein isoform X1 [KO:K20183]
112215679  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
112227951  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
112252964  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
112254114  baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
112237037  gorasp1b; Golgi reassembly-stacking protein 1 [KO:K26797]
112259676  Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797]
112225230  Golgi reassembly-stacking protein 2 [KO:K26797]
112236484  Golgi reassembly-stacking protein 2 [KO:K26797]
112260815  gorasp2; Golgi reassembly-stacking protein 2 [KO:K26797]
112254414  ras-related protein rab7 [KO:K07897]
112220246  ras-related protein rab7 [KO:K07897]
112254627  ras-related protein rab7 [KO:K07897]
112219400  rab7a; ras-related protein rab7 [KO:K07897]
112262932  rab7b; ras-related protein Rab-7a isoform X1 [KO:K07897]
112217354  ras-related protein rab7 [KO:K07897]
112230838  ras-related protein rab7 [KO:K07897]
112225348  lamp1b; lysosome-associated membrane glycoprotein 1 [KO:K06528]
112221087  lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
112256373  lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
112224657  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
121845189  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
112258482  cathepsin D [KO:K01379] [EC:3.4.23.5]
112222204  cathepsin D [KO:K01379] [EC:3.4.23.5]
112225886  cathepsin D [KO:K01379] [EC:3.4.23.5]
112224690  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
112246235  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
112265668  procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
112214478  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
112246217  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
112257425  procathepsin L [KO:K01365] [EC:3.4.22.15]
112255725  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
112262069  procathepsin L [KO:K01365] [EC:3.4.22.15]
112244697  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
112261490  cathepsin B [KO:K01363] [EC:3.4.22.1]
112217696  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
112260913  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
otw04010  MAPK signaling pathway
otw04141  Protein processing in endoplasmic reticulum
otw04142  Lysosome
otw04150  mTOR signaling pathway
otw04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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