KEGG   PATHWAY: xhe04010
Entry
xhe04010                    Pathway                                
Name
MAPK signaling pathway - Xiphophorus hellerii (green swordtail)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
xhe04010  MAPK signaling pathway
xhe04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Xiphophorus hellerii (green swordtail) [GN:xhe]
Gene
116707486  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
116707507  [KO:K04439]
116707510  [KO:K13375]
116707686  rasa2; ras GTPase-activating protein 2 [KO:K08053]
116707763  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
116707764  [KO:K04429] [EC:2.7.11.1]
116707876  [KO:K04457] [EC:3.1.3.16]
116707984  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
116707997  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116707998  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116708098  [KO:K05461]
116708172  nf1; neurofibromin isoform X1 [KO:K08052]
116708226  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116708280  [KO:K03283]
116708331  [KO:K09253]
116708647  [KO:K22428]
116708651  [KO:K04358]
116708658  [KO:K04410] [EC:2.7.11.1]
116708747  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
116708807  [KO:K04853]
116708833  [KO:K04402]
116708847  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116708872  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116708917  [KO:K05462]
116708930  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116709012  [KO:K04445] [EC:2.7.11.1]
116709016  [KO:K17333]
116709027  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
116709106  [KO:K04427] [EC:2.7.11.25]
116709110  [KO:K04373] [EC:2.7.11.1]
116709123  [KO:K04379]
116709334  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
116709344  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116709476  [KO:K04453]
116709506  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116709536  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
116709624  [KO:K16859]
116709631  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
116709708  [KO:K02582]
116709713  [KO:K08774]
116710018  [KO:K04444] [EC:2.7.11.1]
116710092  [KO:K04423] [EC:2.7.11.25]
116710208  [KO:K04465]
116710236  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116710265  [KO:K04851]
116710286  [KO:K04393]
116710358  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116710401  [KO:K04377]
116710497  [KO:K04441] [EC:2.7.11.24]
116710623  [KO:K04411]
116710744  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116710769  [KO:K04411]
116710773  rap1a; ras-related protein Rap-1A [KO:K04353]
116710947  [KO:K05103] [EC:2.7.10.1]
116710979  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116711087  [KO:K05465]
116711094  [KO:K04376]
116711104  [KO:K04860]
116711129  [KO:K04377]
116711131  [KO:K04444] [EC:2.7.11.1]
116711210  [KO:K04861]
116711224  cacna2d2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
116711403  [KO:K04434]
116711620  [KO:K05092] [EC:2.7.10.1]
116711622  [KO:K05092] [EC:2.7.10.1]
116711743  hgf; hepatocyte growth factor [KO:K05460]
116711766  [KO:K04421] [EC:2.7.11.25]
116711854  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116711908  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
116711941  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
116712032  [KO:K04674] [EC:2.7.11.30]
116712093  [KO:K04361] [EC:2.7.10.1]
116712103  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
116712138  [KO:K04353]
116712209  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
116712350  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
116712543  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
116712731  [KO:K04456] [EC:2.7.11.1]
116712736  [KO:K04440] [EC:2.7.11.24]
116712874  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116712898  [KO:K04469]
116713079  [KO:K04390]
116713097  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
116713100  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
116713137  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
116713293  [KO:K17534] [EC:2.7.11.25]
116713350  [KO:K04469]
116713354  [KO:K04467] [EC:2.7.11.10]
116713421  srf; serum response factor isoform X1 [KO:K04378]
116713566  [KO:K05093] [EC:2.7.10.1]
116713630  angpt2; angiopoietin-2 [KO:K05466]
116713771  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116713784  [KO:K04358]
116713909  fgf16; fibroblast growth factor 16 [KO:K04358]
116713917  rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
116713960  pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116713961  [KO:K05090] [EC:2.7.10.1]
116713970  [KO:K04407] [EC:2.7.11.1]
116714009  [KO:K18496]
116714046  [KO:K04389]
116714078  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
116714079  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116714246  fgf18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116714284  [KO:K04358]
116714401  [KO:K04348] [EC:3.1.3.16]
116714406  [KO:K04440] [EC:2.7.11.24]
116714445  [KO:K04440] [EC:2.7.11.24]
116714458  [KO:K05096] [EC:2.7.10.1]
116714467  egf; pro-epidermal growth factor [KO:K04357]
116714539  vegfb; vascular endothelial growth factor B [KO:K05448]
116714572  [KO:K04358]
116714586  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
116714658  pdgfc; platelet-derived growth factor C [KO:K05450]
116714723  [KO:K02187] [EC:3.4.22.56]
116714813  fgf2; fibroblast growth factor 2 [KO:K18497]
116714851  [KO:K04465]
116714921  [KO:K04526]
116714923  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116714966  [KO:K13376]
116715785  [KO:K04407] [EC:2.7.11.1]
116715804  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
116716039  [KO:K04865]
116716059  [KO:K19663] [EC:2.7.11.13]
116716070  [KO:K04873]
116716076  [KO:K04872]
116716082  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
116716242  [KO:K05449]
116716437  [KO:K04446]
116716954  [KO:K03176] [EC:2.7.10.1]
116717097  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116717242  [KO:K04426] [EC:2.7.11.25]
116717249  [KO:K02583]
116717275  [KO:K03283]
116717329  [KO:K05462]
116717388  efna1; ephrin-A1 [KO:K05462]
116717484  [KO:K05462]
116717534  [KO:K04388] [EC:2.7.11.30]
116717718  [KO:K04393]
116717735  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
116717747  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116717933  [KO:K04381]
116718041  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116718296  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116718342  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116718477  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116718493  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
116718570  [KO:K05087] [EC:2.7.10.1]
116718607  [KO:K04349]
116718809  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
116718813  rras2; ras-related protein R-Ras2 [KO:K07830]
116718814  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
116718992  [KO:K04373] [EC:2.7.11.1]
116719097  fgf3; fibroblast growth factor 3 [KO:K04358]
116719100  fgf19; fibroblast growth factor 19 [KO:K22603]
116719103  fgf4; fibroblast growth factor 4 [KO:K04358]
116719109  fgf7; fibroblast growth factor 7 [KO:K04358]
116719186  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116719310  vegfc; vascular endothelial growth factor C [KO:K05449]
116719420  [KO:K04867]
116719427  [KO:K04358]
116719433  [KO:K19662] [EC:2.7.11.13]
116719536  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116719537  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
116719583  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
116719625  [KO:K04456] [EC:2.7.11.1]
116719795  [KO:K05091] [EC:2.7.10.1]
116719804  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116719884  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116719889  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116720012  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
116720110  [KO:K04378]
116720180  fgf8; fibroblast growth factor 8 [KO:K04358]
116720213  [KO:K07860]
116720292  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
116720298  [KO:K04856]
116720406  [KO:K17386]
116720481  [KO:K04441] [EC:2.7.11.24]
116720542  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116720596  [KO:K04359]
116720597  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
116720602  [KO:K04374]
116720647  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
116720725  [KO:K25416]
116720735  [KO:K04868]
116720770  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
116720798  [KO:K02187] [EC:3.4.22.56]
116720812  [KO:K04437]
116720896  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116721002  [KO:K04377]
116721147  jun; transcription factor AP-1 [KO:K04448]
116721171  insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
116721459  [KO:K05459]
116721673  [KO:K04852]
116721778  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116721954  [KO:K04347]
116722050  [KO:K02582]
116722090  [KO:K04449]
116722242  [KO:K04424] [EC:2.7.11.25]
116722331  [KO:K25415]
116722334  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116722341  [KO:K25414]
116722696  [KO:K04853]
116722833  [KO:K04451]
116722873  [KO:K04730] [EC:2.7.11.1]
116722974  [KO:K04375]
116722992  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
116723009  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
116723020  [KO:K04407] [EC:2.7.11.1]
116723202  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
116723227  [KO:K05085] [EC:2.7.10.1]
116723299  mras; ras-related protein M-Ras [KO:K07831]
116723514  map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
116723605  [KO:K04386]
116723814  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
116723818  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116723857  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116723858  [KO:K04455]
116723863  [KO:K03173] [EC:2.3.2.27]
116724071  [KO:K04448]
116724142  [KO:K04348] [EC:3.1.3.16]
116724170  [KO:K04360] [EC:2.7.10.1]
116724200  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116724269  [KO:K12326]
116724304  crkl; crk-like protein [KO:K04438]
116724360  [KO:K04441] [EC:2.7.11.24]
116724430  [KO:K04849]
116724585  [KO:K05462]
116724590  [KO:K04402]
116724598  [KO:K04402]
116724713  epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116724736  [KO:K04362] [EC:2.7.10.1]
116724744  [KO:K04454]
116724880  [KO:K04429] [EC:2.7.11.1]
116724978  [KO:K03173] [EC:2.3.2.27]
116725092  [KO:K04358]
116725097  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
116725172  [KO:K04389]
116725221  [KO:K04358]
116725281  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
116725365  [KO:K04527] [EC:2.7.10.1]
116725485  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116725606  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116725703  [KO:K03158]
116725965  [KO:K04448]
116725984  jund; transcription factor jun-D [KO:K04449]
116726010  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
116726146  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116726148  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116726166  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116726174  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116726200  [KO:K04347]
116726310  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
116726329  [KO:K03283]
116726343  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116726414  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116726429  [KO:K05462]
116726444  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116726481  [KO:K05462]
116726572  [KO:K04441] [EC:2.7.11.24]
116726663  [KO:K04430] [EC:2.7.12.2]
116726678  [KO:K04466] [EC:2.7.11.25]
116726742  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116726757  [KO:K04854]
116726859  [KO:K04864]
116726869  [KO:K04429] [EC:2.7.11.1]
116726919  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116726974  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116727014  [KO:K04461] [EC:3.1.3.16]
116727080  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116727097  [KO:K04380]
116727133  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
116727210  [KO:K04467] [EC:2.7.11.10]
116727319  [KO:K02583]
116727336  [KO:K05084] [EC:2.7.10.1]
116727357  [KO:K04433] [EC:2.7.12.2]
116727538  [KO:K04423] [EC:2.7.11.25]
116727627  [KO:K04392]
116727628  [KO:K04392]
116727629  [KO:K04392]
116727630  [KO:K04392]
116727681  [KO:K22429]
116727748  [KO:K07861]
116727805  [KO:K05095] [EC:2.7.10.1]
116727826  [KO:K04860]
116727897  [KO:K04345] [EC:2.7.11.11]
116727938  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
116728043  [KO:K18496]
116728047  ins; insulin isoform X1 [KO:K04526]
116728076  [KO:K16510] [EC:2.7.11.1]
116728107  [KO:K04429] [EC:2.7.11.1]
116728165  hspb1; heat shock protein beta-1 [KO:K04455]
116728444  [KO:K05089] [EC:2.7.10.1]
116728446  [KO:K05090] [EC:2.7.10.1]
116728498  [KO:K04438]
116728589  [KO:K04348] [EC:3.1.3.16]
116728746  [KO:K03283]
116728885  [KO:K04457] [EC:3.1.3.16]
116729102  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116729244  [KO:K05452]
116729276  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116729278  fgf10; fibroblast growth factor 10 [KO:K04358]
116729300  fgf5; fibroblast growth factor 5 [KO:K04358]
116729302  efna5; ephrin-A5 isoform X1 [KO:K05462]
116729319  fgf17; fibroblast growth factor 17 [KO:K04358]
116729328  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
116729383  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116729435  [KO:K04348] [EC:3.1.3.16]
116729539  [KO:K08845] [EC:2.7.11.1]
116729606  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
116729785  rasa1; ras GTPase-activating protein 1 [KO:K04352]
116729844  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116729945  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
116730282  [KO:K03173] [EC:2.3.2.27]
116730398  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116730402  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116730453  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
116730467  [KO:K04519]
116730468  [KO:K04519]
116730482  [KO:K09784]
116730492  [KO:K04849]
116730623  [KO:K05465]
116730740  [KO:K05466]
116730770  [KO:K04358]
116730815  [KO:K04873]
116730816  [KO:K04872]
116731340  [KO:K04393]
116731415  stk3; serine/threonine-protein kinase 3 [KO:K04412]
116731462  [KO:K05462]
116731491  [KO:K04388] [EC:2.7.11.30]
116731546  [KO:K02308]
116731712  [KO:K04381]
116731788  [KO:K05462]
116731887  [KO:K03156]
116731938  [KO:K04871]
116732205  [KO:K04348] [EC:3.1.3.16]
116732253  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116732465  [KO:K04419] [EC:2.7.11.25]
116732473  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116732698  [KO:K04735]
116732775  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
116732837  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
116732855  [KO:K04349]
116732888  [KO:K05087] [EC:2.7.10.1]
116732898  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116733478  mapk8ip2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
116733613  [KO:K16859]
116733629  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116733761  kras; GTPase KRas isoform X1 [KO:K07827]
116733855  [KO:K04393]
116733997  [KO:K04453]
116734003  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116734025  hras; GTPase HRas [KO:K02833]
116734034  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
116734169  igf2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
116734198  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116734207  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
116734333  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
116734396  [KO:K04379]
116734514  [KO:K13377]
116734543  [KO:K04441] [EC:2.7.11.24]
116734627  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116734702  [KO:K04379]
116734805  [KO:K04393]
116734831  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116734852  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
116734867  [KO:K04866]
116734943  [KO:K03283]
116734944  [KO:K03283]
116734947  [KO:K04468] [EC:2.7.11.24]
116734971  [KO:K04429] [EC:2.7.11.1]
116735087  [KO:K02583]
116735102  [KO:K04374]
116735267  [KO:K04855]
116735303  [KO:K02677] [EC:2.7.11.13]
116735307  [KO:K04870]
116735310  [KO:K04392]
116735320  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
116735417  [KO:K04380]
116735519  pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
116735593  [KO:K07827]
116735597  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116735644  grb2; growth factor receptor-bound protein 2 [KO:K04364]
116735682  [KO:K04371] [EC:2.7.11.24]
116735792  [KO:K04856]
116735806  [KO:K04466] [EC:2.7.11.25]
116735865  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
116735892  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
116735966  [KO:K04344]
116735977  [KO:K04433] [EC:2.7.12.2]
116735978  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116735979  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
116736154  [KO:K04347]
116736165  [KO:K04867]
116736192  [KO:K04869]
116736206  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
116736238  [KO:K07830]
116736298  [KO:K04345] [EC:2.7.11.11]
116736373  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
116736395  [KO:K04441] [EC:2.7.11.24]
116736409  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116736419  [KO:K05461]
116736679  [KO:K04861]
116736692  [KO:K04858]
116736693  rap1b; ras-related protein Rap-1b [KO:K07836]
116736817  ntf3; neurotrophin-3 [KO:K04356]
116736851  [KO:K04850]
116736857  [KO:K04441] [EC:2.7.11.24]
116736895  [KO:K22428]
116736897  [KO:K04358]
116736929  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
116736982  [KO:K05460]
116737032  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116737136  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116737332  crk; adapter molecule crk [KO:K04438]
116737512  [KO:K05093] [EC:2.7.10.1]
116737531  [KO:K04456] [EC:2.7.11.1]
116737563  [KO:K04468] [EC:2.7.11.24]
116737673  [KO:K04350]
116737685  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
116737695  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
xhe04070  Phosphatidylinositol signaling system
xhe04110  Cell cycle
xhe04115  p53 signaling pathway
xhe04210  Apoptosis
xhe04310  Wnt signaling pathway
KO pathway
ko04010   

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