KEGG   PATHWAY: fca04062
Entry
fca04062                    Pathway                                
Name
Chemokine signaling pathway - Felis catus (domestic cat)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
fca04062  Chemokine signaling pathway
fca04062

Other DBs
GO: 0070098
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100049057  CCR2; C-C chemokine receptor type 2 [KO:K04177]
100127112  MCP-1; C-C motif chemokine 2 [KO:K14624]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100191004  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100191005  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100302540  [KO:K05408]
100302541  [KO:K12964]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101080369  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
101080496  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101080675  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
101080922  PXN; paxillin isoform X2 [KO:K05760]
101081091  [KO:K05408]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081548  FOXO3; forkhead box protein O3 [KO:K09408]
101081599  [KO:K05507]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101081809  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101081928  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
101082104  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101082354  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101082454  [KO:K04393]
101082811  PREX1; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
101083247  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101083489  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
101083494  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101083781  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101084151  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101084327  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101084346  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101084561  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101084670  CX3CL1; fractalkine isoform X1 [KO:K05508]
101084799  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101084908  CRKL; crk-like protein isoform X1 [KO:K04438]
101085396  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101085650  [KO:K04175]
101086016  CCL14; C-C motif chemokine 14 [KO:K21092]
101086100  CRK; adapter molecule crk isoform X1 [KO:K04438]
101086226  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
101086264  VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730]
101086275  CCL24; C-C motif chemokine 24 [KO:K21097]
101086511  CCL27; C-C motif chemokine 27 [KO:K16598]
101086516  [KO:K05511]
101086525  CCL26; C-C motif chemokine 26 [KO:K21096]
101086526  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101086580  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101087015  CCL19; C-C motif chemokine 19 [KO:K05512]
101087171  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101087275  CCL21; C-C motif chemokine 21 [KO:K16062]
101087379  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101087417  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101087555  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087716  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101087851  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087962  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101088157  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101088219  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101088476  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101088915  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101088959  JAK2; tyrosine-protein kinase JAK2 isoform X3 [KO:K04447] [EC:2.7.10.2]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101089032  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
101089047  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
101089290  GRK7; rhodopsin kinase GRK7 isoform X1 [KO:K00909] [EC:2.7.11.14]
101089378  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101089679  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090393  GRK3; beta-adrenergic receptor kinase 2 isoform X4 [KO:K00910] [EC:2.7.11.15]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101090622  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101090663  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101090817  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101091211  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101091326  CCL22; C-C motif chemokine 22 [KO:K21095]
101091560  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101091691  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
101091759  CCL28; C-C motif chemokine 28 [KO:K05513]
101091855  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092327  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101092339  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101092409  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101092459  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101092552  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101092837  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101092911  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101093286  [KO:K02649]
101093310  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101093317  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101093558  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093854  [KO:K10030]
101094096  [KO:K05407]
101094148  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101094327  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101094344  [KO:K10029]
101094450  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101094501  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
101094530  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101094573  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101094593  [KO:K05506]
101094708  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101095698  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101095721  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101095865  SHC3; SHC-transforming protein 3 [KO:K17448]
101095942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101095952  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096184  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101096215  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101096604  RELA; transcription factor p65 [KO:K04735]
101096625  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
101096633  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101096888  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101096931  [KO:K05509]
101097189  CCL8; C-C motif chemokine 8 [KO:K16596]
101097212  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097491  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101097544  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
101097735  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101098840  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101099050  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101099224  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101099259  NFKBIB; LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta [KO:K02581]
101099650  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101099760  [KO:K16595]
101099880  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101099898  CX3CR1; CX3C chemokine receptor 1 isoform X3 [KO:K04192]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101100011  CCL1; C-C motif chemokine 1 [KO:K05514]
101100131  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101100223  PARD3; partitioning defective 3 homolog isoform X8 [KO:K04237]
101100307  CCR6; C-C chemokine receptor type 6 isoform X2 [KO:K04181]
101100320  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101100388  CXCL9; C-X-C motif chemokine 9 isoform X1 [KO:K05416]
101100749  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101100785  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
101101078  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
101101082  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
101101207  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101375  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102899861  CCL25; C-C motif chemokine 25 isoform X2 [KO:K13072]
102900629  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102901432  [KO:K05505]
102902542  CCL16; C-C motif chemokine 16 isoform X1 [KO:K21093]
109493846  [KO:K16598]
111557526  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111558429  XCR1; chemokine XC receptor 1 [KO:K04193]
111560177  [KO:K05505]
111560178  [KO:K05505]
111561761  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123380358  [KO:K04540]
493676  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
493689  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
493769  CCR5; C-C chemokine receptor type 5 [KO:K04180]
493806  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
493832  CCL17; C-C motif chemokine 17 precursor [KO:K21083]
493836  CXCL8; interleukin-8 precursor [KO:K10030]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
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Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
fca04010  MAPK signaling pathway
fca04060  Cytokine-cytokine receptor interaction
fca04120  Ubiquitin mediated proteolysis
fca04630  JAK-STAT signaling pathway
fca04670  Leukocyte transendothelial migration
fca04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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