KEGG   PATHWAY: mmu05163
Entry
mmu05163                    Pathway                                
Name
Human cytomegalovirus infection - Mus musculus (house mouse)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmu05163  Human cytomegalovirus infection
mmu05163

Disease
H00368  Cytomegalovirus infection
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100043318  Gng5c; G protein subunit gamma 5C [KO:K04542]
100503710  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100529082  H2-T27; predicted gene 11127 precursor [KO:K06751]
102633809  Gm3785; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104110  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase type 3 isoform 1 [KO:K08043] [EC:4.6.1.1]
108802  Calr4; calreticulin 4 isoform b precursor [KO:K08057]
110157  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform 1 [KO:K04366] [EC:2.7.11.1]
110557  H2-Q6; histocompatibility 2, Q region locus 6 isoform a precursor [KO:K06751]
110558  H2-Q9; H-2 class I histocompatibility antigen, Q9 alpha chain isoform 1 precursor [KO:K06751]
110696  H2-M10.3; histocompatibility 2, M region locus 10.3 precursor [KO:K06751]
11512  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase type 8 isoform 1 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase type 9 isoform 1 [KO:K08049] [EC:4.6.1.1]
11651  Akt1; RAC-alpha serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
11848  Rhoa; transforming protein RhoA precursor [KO:K04513]
11909  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform 1 [KO:K04450]
11911  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
12010  B2m; beta-2-microglobulin precursor [KO:K08055]
12018  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
12028  Bax; apoptosis regulator BAX isoform 1 [KO:K02159]
12122  Bid; BH3-interacting domain death agonist [KO:K04726]
12313  Calm1; calmodulin-1 isoform 2 [KO:K02183]
12314  Calm2; calmodulin-2 isoform 1 [KO:K02183]
12315  Calm3; calmodulin-3 [KO:K02183]
12317  Calr; calreticulin precursor [KO:K08057]
12367  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
12370  Casp8; caspase-8 isoform 1 [KO:K04398] [EC:3.4.22.61]
12371  Casp9; caspase-9 isoform 1 precursor [KO:K04399] [EC:3.4.22.62]
12387  Ctnnb1; catenin beta-1 [KO:K02105]
12443  Ccnd1; G1/S-specific cyclin-D1 isoform 2 [KO:K04503]
12567  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
12571  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
12575  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
12578  Cdkn2a; cyclin-dependent kinase inhibitor 2A isoform p19ARF [KO:K06621]
12675  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2 [KO:K04467] [EC:2.7.11.10]
12765  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
12767  Cxcr4; C-X-C chemokine receptor type 4 isoform 2 [KO:K04189]
12768  Ccr1; C-C chemokine receptor type 1 [KO:K04176]
12770  Ccr1l1; C-C chemokine receptor 1-like protein 1 [KO:K04176]
12771  Ccr3; probable C-C chemokine receptor type 3 [KO:K04178]
12774  Ccr5; C-C chemokine receptor type 5 [KO:K04180]
12912  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
12913  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
12915  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
12927  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform B [KO:K05726]
12928  Crk; adapter molecule crk isoform 2 [KO:K04438]
12929  Crkl; crk-like protein isoform 1 [KO:K04438]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis-specific [KO:K08738]
13555  E2f1; transcription factor E2F1 isoform a [KO:K17454]
13557  E2f3; transcription factor E2F3 isoform E2f3a [KO:K06620]
13649  Egfr; epidermal growth factor receptor isoform 1 precursor [KO:K04361] [EC:2.7.10.1]
13685  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
13712  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
14082  Fadd; FAS-associated death domain protein [KO:K02373]
14083  Ptk2; focal adhesion kinase 1 isoform 1 [KO:K05725] [EC:2.7.10.2]
14102  Fas; tumor necrosis factor receptor superfamily member 6 isoform 1 precursor [KO:K04390]
14103  Fasl; tumor necrosis factor ligand superfamily member 6 isoform 1 [KO:K04389]
14672  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
14673  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
14674  Gna13; guanine nucleotide-binding protein subunit alpha-13 isoform 1 [KO:K04639]
14677  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
14678  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
14679  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
14681  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform B [KO:K04534]
14682  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
14683  Gnas; protein GNAS isoform XLas [KO:K04632]
14688  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
14693  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
14695  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
14696  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform 1 [KO:K04538]
14697  Gnb5; guanine nucleotide-binding protein subunit beta-5 isoform 1 [KO:K04539]
14699  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
14700  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
14701  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
14702  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
14704  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
14706  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor [KO:K04541]
14707  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
14708  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
14709  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
14710  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
14784  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
14827  Pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
14963  H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  H2-D1; H-2 class I histocompatibility antigen, D-B alpha chain precursor [KO:K06751]
14972  H2-K1; H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 1 precursor [KO:K06751]
14985  H2-M10.1; histocompatibility 2, M region locus 10.1 isoform 2 precursor [KO:K06751]
14990  H2-M2; histocompatibility 2, M region locus 2 precursor [KO:K06751]
14991  H2-M3; histocompatibility 2, M region locus 3 precursor [KO:K06751]
14997  H2-M9; histocompatibility 2, M region locus 9 isoform 1 precursor [KO:K06751]
15006  H2-Q1; histocompatibility 2, Q region locus 1 isoform 2 precursor [KO:K06751]
15007  H2-Q10; H-2 class I histocompatibility antigen, Q10 alpha chain precursor [KO:K06751]
15013  H2-Q2; histocompatibility 2, Q region locus 2 isoform 2 precursor [KO:K06751]
15015  H2-Q4; histocompatibility 2, Q region locus 4 precursor [KO:K06751]
15018  H2-Q7; H-2 class I histocompatibility antigen, Q7 alpha chain isoform 1 precursor [KO:K06751]
15024  H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
15039  H2-T22; histocompatibility 2, T region locus 22 isoform 2 precursor [KO:K06751]
15040  H2-T23; H-2 class I histocompatibility antigen, D-37 alpha chain precursor [KO:K06751]
15042  H2-T24; histocompatibility 2, T region locus 24 precursor [KO:K06751]
15043  H2-T3; H-2 class I histocompatibility antigen, TLA(B) alpha chain precursor [KO:K06751]
15461  Hras; GTPase HRas isoform 1 [KO:K02833]
15962  Ifna1; interferon alpha-1 precursor [KO:K05414]
15964  Ifna11; interferon alpha-11 precursor [KO:K05414]
15965  Ifna2; interferon alpha-2 precursor [KO:K05414]
15967  Ifna4; interferon alpha-4 precursor [KO:K05414]
15968  Ifna5; interferon alpha-5 precursor [KO:K05414]
15969  Ifna6; interferon alpha-6 precursor [KO:K05414]
15970  Ifna7; interferon alpha-7 precursor [KO:K05414]
15972  Ifna9; interferon alpha-9 precursor [KO:K05414]
15974  Ifnab; interferon alpha family, gene B precursor [KO:K05414]
15977  Ifnb1; interferon beta precursor [KO:K05415]
16150  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; NF-kappa-B essential modulator isoform 1 [KO:K07210]
16154  Il10ra; interleukin-10 receptor subunit alpha isoform 1 precursor [KO:K05134]
16155  Il10rb; interleukin-10 receptor subunit beta isoform 2 [KO:K05135]
16176  Il1b; interleukin-1 beta [KO:K04519]
16177  Il1r1; interleukin-1 receptor type 1 isoform 1 precursor [KO:K04386]
16193  Il6; interleukin-6 isoform 1 precursor [KO:K05405]
16194  Il6ra; interleukin-6 receptor subunit alpha isoform 1 precursor [KO:K05055]
16410  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
16416  Itgb3; integrin beta-3 precursor [KO:K06493]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform 1 [KO:K04959]
16440  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
16451  Jak1; tyrosine-protein kinase JAK1 isoform 2 [KO:K11217] [EC:2.7.10.2]
16653  Kras; GTPase KRas isoform 2 [KO:K07827]
16801  Arhgef1; rho guanine nucleotide exchange factor 1 isoform c [KO:K12330]
170758  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
17246  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform 1 [KO:K06643] [EC:2.3.2.27]
17869  Myc; myc proto-oncogene protein isoform a [KO:K04377]
18018  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 3 [KO:K04446]
18019  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform a [KO:K17332]
18021  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform 2 [KO:K17333]
18033  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 1 [KO:K02580]
18035  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
18176  Nras; GTPase NRas [KO:K07828]
18595  Pdgfra; platelet-derived growth factor receptor alpha isoform 1 precursor [KO:K04363] [EC:2.7.10.1]
18706  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 [KO:K02649]
18709  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform 1 [KO:K02649]
18710  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 [KO:K02649]
18747  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform 1 [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform 1 [KO:K04345] [EC:2.7.11.11]
18750  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C gamma type isoform 1 [KO:K19663] [EC:2.7.11.13]
18795  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform a [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a [KO:K05858] [EC:3.1.4.11]
19055  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform 1 [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 1 [KO:K04348] [EC:3.1.3.16]
19057  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2 [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
19059  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
19216  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
19217  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
19218  Ptger3; prostaglandin E2 receptor EP3 subtype isoform 1 [KO:K04260]
19219  Ptger4; prostaglandin E2 receptor EP4 subtype isoform 2 [KO:K04261]
19225  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
19229  Ptk2b; protein-tyrosine kinase 2-beta isoform 1 [KO:K05871] [EC:2.7.10.2]
19303  Pxn; paxillin isoform 3 [KO:K05760]
19353  Rac1; ras-related C3 botulinum toxin substrate 1 isoform 2 [KO:K04392]
19354  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
19645  Rb1; retinoblastoma-associated protein [KO:K06618]
19697  Rela; transcription factor p65 isoform 1 [KO:K04735]
19744  Rheb; GTP-binding protein Rheb [KO:K07208]
19766  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
19877  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
19878  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
20293  Ccl12; C-C motif chemokine 12 precursor [KO:K14624]
20296  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
20302  Ccl3; C-C motif chemokine 3 precursor [KO:K05408]
20303  Ccl4; C-C motif chemokine 4 precursor [KO:K12964]
20304  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
20312  Cx3cl1; fractalkine precursor [KO:K05508]
20315  Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031]
20662  Sos1; son of sevenless homolog 1 [KO:K03099]
20663  Sos2; son of sevenless homolog 2 [KO:K03099]
20683  Sp1; transcription factor Sp1 [KO:K04684]
20779  Src; proto-oncogene tyrosine-protein kinase Src isoform 2 [KO:K05704] [EC:2.7.10.2]
20848  Stat3; signal transducer and activator of transcription 3 isoform 1 [KO:K04692]
208647  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
208677  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
210044  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
213233  Tapbpl; tapasin-related protein precursor [KO:K28445]
213498  Arhgef11; rho guanine nucleotide exchange factor 11 isoform 1 [KO:K12331]
21354  Tap1; antigen peptide transporter 1 isoform 1 [KO:K05653] [EC:7.4.2.14]
21355  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
21356  Tapbp; tapasin isoform 2 precursor [KO:K08058]
214763  Cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
21926  Tnf; tumor necrosis factor isoform 1 [KO:K03156]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
22030  Traf2; TNF receptor-associated factor 2 isoform b [KO:K03173] [EC:2.3.2.27]
22033  Traf5; TNF receptor-associated factor 5 [KO:K09849]
22059  Trp53; cellular tumor antigen p53 isoform a [KO:K04451]
22084  Tsc2; tuberin isoform 2 [KO:K07207]
22339  Vegfa; vascular endothelial growth factor A, long form isoform 1 [KO:K05448]
224129  Adcy5; adenylate cyclase type 5 isoform 1 [KO:K08045] [EC:4.6.1.1]
224753  H2-M10.4; histocompatibility 2, M region locus 10.4 precursor [KO:K06751]
224754  H2-M11; histocompatibility 2, M region locus 11 precursor [KO:K06751]
224756  H2-M1; histocompatibility 2, M region locus 1 precursor [KO:K06751]
224761  H2-M10.5; histocompatibility 2, M region locus 10.5 precursor [KO:K06751]
230396  Ifna13; interferon alpha-13 precursor [KO:K05414]
230398  Ifna16; interferon alpha 16 precursor [KO:K05414]
231991  Creb5; cyclic AMP-responsive element-binding protein 5 isoform 1 [KO:K09047]
23797  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
240095  H2-M5; histocompatibility 2, M region locus 5 precursor [KO:K06751]
242517  Ifna15; interferon alpha 15 precursor [KO:K05414]
242519  Ifna12; interferon alpha-12 precursor [KO:K05414]
242705  E2f2; transcription factor E2F2 isoform 1 [KO:K09389]
26395  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1 [KO:K04369] [EC:2.7.12.2]
26399  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform 1 [KO:K04433] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 isoform 1 [KO:K04441] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26427  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
29857  Mapk12; mitogen-activated protein kinase 12 isoform 1 [KO:K04441] [EC:2.7.11.24]
333715  H2-M10.2; histocompatibility 2, M region locus 10.2 precursor [KO:K06751]
399549  H2-M10.6; histocompatibility 2, M region locus 10.6 precursor [KO:K06751]
404549  Ifna14; interferon alpha 14 precursor [KO:K05414]
432530  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
494124  Calm5; calmodulin 5 [KO:K02183]
54131  Irf3; interferon regulatory factor 3 [KO:K05411]
56480  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
56637  Gsk3b; glycogen synthase kinase-3 beta isoform 1 [KO:K03083] [EC:2.7.11.26]
56717  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
58988  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
630294  H2-T25; uncharacterized protein LOC630294 precursor [KO:K06751]
64337  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
64930  Tsc1; hamartin isoform 1 [KO:K07206]
66066  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
667977  H2-T26; uncharacterized protein LOC667977 precursor [KO:K06751]
67653  4930544G11Rik; ras homolog gene family, member A-like [KO:K04513]
69632  Arhgef12; rho guanine nucleotide exchange factor 12 isoform 2 [KO:K07532]
69717  Gm10499; gene 10499 isoform 1 precursor [KO:K06751]
70405  Calml3; calmodulin-like protein 3 [KO:K02183]
71609  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
72508  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform 1 [KO:K04688] [EC:2.7.11.1]
72512  Sting1; stimulator of interferon genes protein isoform 1 [KO:K12654]
73181  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform 1 [KO:K17334]
74769  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
75547  Akap13; A-kinase anchor protein 13 [KO:K16529]
75600  Calml4; calmodulin-like protein 4 isoform a [KO:K02183]
78284  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
80796  Calm4; calmodulin-4 [KO:K02183]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
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Related
pathway
mmu00590  Arachidonic acid metabolism
mmu03050  Proteasome
mmu04010  MAPK signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04110  Cell cycle
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04210  Apoptosis
mmu04612  Antigen processing and presentation
mmu04623  Cytosolic DNA-sensing pathway
mmu04630  JAK-STAT signaling pathway
mmu04668  TNF signaling pathway
mmu04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

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