KEGG   PATHWAY: cpep03040
Entry
cpep03040                   Pathway                                
Name
Spliceosome - Cucurbita pepo subsp. pepo (vegetable marrow)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
cpep03040  Spliceosome
cpep03040

Other DBs
GO: 0005681
Organism
Cucurbita pepo subsp. pepo (vegetable marrow) [GN:cpep]
Gene
111780756  U1 spliceosomal RNA [KO:K14276]
111802786  U1 spliceosomal RNA [KO:K14276]
111777908  U1 spliceosomal RNA [KO:K14276]
111801226  U1 spliceosomal RNA [KO:K14276]
111782834  U1 spliceosomal RNA [KO:K14276]
111794179  U1 spliceosomal RNA [KO:K14276]
111784349  U1 spliceosomal RNA [KO:K14276]
111777944  U1 spliceosomal RNA [KO:K14276]
111810975  U2 spliceosomal RNA [KO:K14277]
111779418  U2 spliceosomal RNA [KO:K14277]
111802766  U2 spliceosomal RNA [KO:K14277]
111809485  U2 spliceosomal RNA [KO:K14277]
111783748  U2 spliceosomal RNA [KO:K14277]
111785271  U2 spliceosomal RNA [KO:K14277]
111776541  U2 spliceosomal RNA [KO:K14277]
111787202  U2 spliceosomal RNA [KO:K14277]
111806216  U4 spliceosomal RNA [KO:K14278]
111782863  U4 spliceosomal RNA [KO:K14278]
111776542  U4 spliceosomal RNA [KO:K14278]
111791940  U4 spliceosomal RNA [KO:K14278]
111794150  U4 spliceosomal RNA [KO:K14278]
111779432  U5 spliceosomal RNA [KO:K14279]
111794152  U5 spliceosomal RNA [KO:K14279]
111807841  U5 spliceosomal RNA [KO:K14279]
111782879  U5 spliceosomal RNA [KO:K14279]
111782889  U5 spliceosomal RNA [KO:K14279]
111797760  U6 spliceosomal RNA [KO:K14280]
111783726  U6 spliceosomal RNA [KO:K14280]
111783725  U6 spliceosomal RNA [KO:K14280]
111783728  U6 spliceosomal RNA [KO:K14280]
111779187  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
111798845  DEAD-box ATP-dependent RNA helicase 56-like isoform X1 [KO:K12812] [EC:5.6.2.7]
111805229  DEAD-box ATP-dependent RNA helicase 56 [KO:K12812] [EC:5.6.2.7]
111792337  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 isoform X1 [KO:K12813] [EC:5.6.2.6]
111806717  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
111801889  pre-mRNA-processing factor 17-like isoform X1 [KO:K12816]
111806849  pre-mRNA-processing factor 17-like [KO:K12816]
111778936  pre-mRNA-splicing factor 18-like [KO:K12817]
111807616  pre-mRNA-splicing factor 18-like [KO:K12817]
111785815  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
111783818  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
111798826  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
111793583  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
111806019  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 isoform X1 [KO:K12818] [EC:5.6.2.6]
111805820  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
111799751  pre-mRNA-splicing factor SLU7 [KO:K12819]
111790178  pre-mRNA-splicing factor SLU7-like [KO:K12819]
111779338  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
111806837  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
111781406  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
111804110  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
111811104  small nuclear ribonucleoprotein SmD1b-like [KO:K11087]
111794343  small nuclear ribonucleoprotein SmD1b-like [KO:K11087]
111795674  small nuclear ribonucleoprotein SmD1b [KO:K11087]
111787968  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
111809716  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
111786321  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
111796460  small nuclear ribonucleoprotein SmD3b-like isoform X1 [KO:K11088]
111784400  small nuclear ribonucleoprotein E-like [KO:K11097]
111780137  small nuclear ribonucleoprotein E-like [KO:K11097]
111792255  small nuclear ribonucleoprotein E-like [KO:K11097]
111799164  probable small nuclear ribonucleoprotein F [KO:K11098]
111805833  probable small nuclear ribonucleoprotein F [KO:K11098]
111781083  probable small nuclear ribonucleoprotein G [KO:K11099]
111804297  probable small nuclear ribonucleoprotein G [KO:K11099]
111781292  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
111803577  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
111788401  U1 small nuclear ribonucleoprotein A [KO:K11091]
111791605  U1 small nuclear ribonucleoprotein A-like [KO:K11091]
111779178  U1 small nuclear ribonucleoprotein C [KO:K11095]
111807131  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
111788103  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
111797953  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
111796840  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
111793812  RNA-binding protein 25-like isoform X1 [KO:K12822]
111801667  RNA-binding protein 25-like isoform X1 [KO:K12822]
111780707  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
111791150  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
111793068  DEAD-box ATP-dependent RNA helicase 14 [KO:K12823] [EC:5.6.2.7]
111790994  DEAD-box ATP-dependent RNA helicase 46-like [KO:K12823] [EC:5.6.2.7]
111799961  DEAD-box ATP-dependent RNA helicase 40-like [KO:K12823] [EC:5.6.2.7]
111790432  DEAD-box ATP-dependent RNA helicase 40-like [KO:K12823] [EC:5.6.2.7]
111789291  DEAD-box ATP-dependent RNA helicase 20 isoform X1 [KO:K12823] [EC:5.6.2.7]
111806510  pre-mRNA-processing protein 40C [KO:K12824]
111783053  transcription initiation factor TFIID subunit 15b [KO:K13098]
111787083  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
111778573  U2 small nuclear ribonucleoprotein A' [KO:K11092]
111782827  U2 small nuclear ribonucleoprotein B'' 2-like [KO:K11094]
111789235  U2 small nuclear ribonucleoprotein B'' 2-like isoform X1 [KO:K11094]
111777189  probable splicing factor 3A subunit 1 [KO:K12825]
111801187  splicing factor 3A subunit 2 [KO:K12826]
111801630  splicing factor SF3a60 homolog [KO:K12827]
111809929  splicing factor 3B subunit 1-like [KO:K12828]
111794039  splicing factor 3B subunit 1-like [KO:K12828]
111805714  splicing factor 3B subunit 2-like [KO:K12829]
111798310  splicing factor 3B subunit 2-like [KO:K12829]
111790079  splicing factor 3B subunit 3 [KO:K12830]
111806163  spliceosome-associated protein 130 A [KO:K12830]
111802475  spliceosome-associated protein 130 A-like [KO:K12830]
111787967  RNA-binding protein 7-like isoform X1 [KO:K12831]
111801076  splicing factor 3B subunit 4 [KO:K12831]
111796936  splicing factor 3B subunit 4-like isoform X1 [KO:K12831]
111785016  uncharacterized protein At4g14342 [KO:K12832]
111803105  uncharacterized protein At4g14342 [KO:K12832]
111799874  uncharacterized protein At4g14342 [KO:K12832]
111791302  uncharacterized protein At4g14342-like [KO:K12832]
111795383  splicing factor 3B subunit 6-like protein [KO:K12833]
111782700  PHD finger-like domain-containing protein 5B [KO:K12834]
111789422  PHD finger-like domain-containing protein 5B [KO:K12834]
111787521  DEAD-box ATP-dependent RNA helicase 24 isoform X1 [KO:K12835] [EC:5.6.2.7]
111788961  splicing factor U2af small subunit B-like [KO:K12836]
111781637  splicing factor U2af small subunit B-like [KO:K12836]
111784736  splicing factor U2af small subunit B-like [KO:K12836]
111783022  splicing factor U2af small subunit B-like [KO:K12836]
111803563  splicing factor U2af small subunit B-like [KO:K12836]
111778470  splicing factor U2af large subunit A [KO:K12837]
111778343  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
111807705  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
111806869  splicing factor U2af large subunit B-like [KO:K12837]
111793056  survival of motor neuron-related-splicing factor 30 [KO:K12839]
111781775  DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840]
111803587  DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840]
111805382  protein RRC1-like isoform X1 [KO:K12842]
111798763  protein RRC1-like [KO:K12842]
111795197  sm-like protein LSM2 [KO:K12621]
111811200  sm-like protein LSM2 [KO:K12621]
111806813  sm-like protein LSM3A [KO:K12622]
111809241  sm-like protein LSM3A [KO:K12622]
111787556  sm-like protein LSM4 isoform X1 [KO:K12623]
111797034  sm-like protein LSM4 [KO:K12623]
111794701  sm-like protein LSM5 [KO:K12624]
111811380  sm-like protein LSM5 [KO:K12624]
111778180  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
111800438  uncharacterized protein LOC111800438 [KO:K12625]
111789260  sm-like protein LSM7 [KO:K12626]
111790011  sm-like protein LSM7 [KO:K12626]
111801466  sm-like protein LSM8 [KO:K12627]
111798612  protein RDM16-like isoform X1 [KO:K12843]
111807989  protein RDM16-like isoform X1 [KO:K12843]
111788895  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
111801321  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
111801872  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
111790053  U4/U6 small nuclear ribonucleoprotein Prp31 homolog isoform X1 [KO:K12844]
111785654  NHP2-like protein 1 [KO:K12845]
111785309  NHP2-like protein 1 [KO:K12845]
111780250  NHP2-like protein 1 [KO:K12845]
111792357  NHP2-like protein 1 [KO:K12845]
111798153  NHP2-like protein 1 [KO:K12845]
111805974  NHP2-like protein 1 [KO:K12845]
111793028  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
111782891  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
111796123  SART-1 family protein DOT2 [KO:K11984]
111798012  zinc finger matrin-type protein 2 [KO:K12848]
111798580  pre-mRNA-splicing factor 38-like [KO:K12849]
111804740  pre-mRNA-splicing factor 38-like [KO:K12849]
111808526  pre-mRNA splicing factor SR-like 1 [KO:K12850]
111807167  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
111805313  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
111789162  DExH-box ATP-dependent RNA helicase DExH12-like isoform X1 [KO:K12854] [EC:5.6.2.6]
111794979  protein STABILIZED1 [KO:K12855]
111806951  pre-mRNA-processing-splicing factor 8A [KO:K12856]
111802267  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
111790957  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
111777647  thioredoxin-like protein YLS8 isoform X1 [KO:K12859]
111803176  thioredoxin-like protein YLS8 [KO:K12859]
111794805  thioredoxin-like protein YLS8 [KO:K12859]
111800120  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
111790519  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
111795264  cell division cycle 5-like protein isoform X1 [KO:K12860]
111792713  cell division cycle 5-like protein isoform X1 [KO:K12860]
111782465  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
111806497  protein pleiotropic regulatory locus 1 [KO:K12862]
111800859  protein CWC15 homolog isoform X1 [KO:K12863]
111810812  protein CWC15 homolog [KO:K12863]
111808871  beta-catenin-like protein 1 [KO:K12864]
111778555  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
111781472  heat shock cognate 70 kDa protein 2-like [KO:K03283]
111779793  heat shock 70 kDa protein [KO:K03283]
111808166  heat shock cognate 70 kDa protein 2-like [KO:K03283]
111794831  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
111797033  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
111808827  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
111803465  heat shock cognate 70 kDa protein 2 [KO:K03283]
111808387  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
111793900  heat shock cognate 70 kDa protein 2-like [KO:K03283]
111791012  uncharacterized protein LOC111791012 [KO:K12865]
111805255  SNW/SKI-interacting protein A-like [KO:K06063]
111805256  SNW/SKI-interacting protein A-like [KO:K06063]
111798645  SNW/SKI-interacting protein-like [KO:K06063]
111805842  SNW/SKI-interacting protein A-like [KO:K06063]
111803503  pre-mRNA-splicing factor SYF1 [KO:K12867]
111777630  pre-mRNA-splicing factor syf2-like [KO:K12868]
111795142  pre-mRNA-splicing factor syf2-like [KO:K12868]
111794741  pre-mRNA-splicing factor syf2-like [KO:K12868]
111794742  pre-mRNA-splicing factor syf2-like [KO:K12868]
111784365  crooked neck-like protein 1 [KO:K12869]
111782993  crooked neck-like protein 1 [KO:K12869]
111779020  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
111799698  peptidyl-prolyl cis-trans isomerase CYP18-2-like [KO:K12733] [EC:5.2.1.8]
111789955  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
111783558  coiled-coil domain-containing protein 12-like [KO:K12871]
111802202  coiled-coil domain-containing protein 12-like [KO:K12871]
111788754  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
111783627  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
111781474  protein BUD31 homolog 2 [KO:K12873]
111783141  protein BUD31 homolog 1-like [KO:K12873]
111803557  protein BUD31 homolog 1 [KO:K12873]
111778577  intron-binding protein aquarius-like [KO:K12874]
111801622  intron-binding protein aquarius-like [KO:K12874]
111794288  histone acetyltransferase KAT6A-like [KO:K12875]
111809860  histone acetyltransferase KAT6A-like isoform X1 [KO:K12875]
111789191  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
111791589  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
111780252  RNA-binding protein Y14-like [KO:K12876]
111792109  RNA-binding protein Y14-like [KO:K12876]
111793994  protein mago nashi homolog [KO:K12877]
111801140  protein mago nashi homolog [KO:K12877]
111802273  THO complex subunit 1 [KO:K12878]
111809366  THO complex subunit 2-like isoform X1 [KO:K12879]
111808014  THO complex subunit 2-like isoform X1 [KO:K12879]
111800847  THO complex subunit 3 [KO:K12880]
111787440  THO complex subunit 4A-like isoform X1 [KO:K12881]
111785396  THO complex subunit 4A-like [KO:K12881]
111783402  THO complex subunit 4A-like [KO:K12881]
111794484  THO complex subunit 4A-like [KO:K12881]
111790458  THO complex subunit 4D [KO:K12881]
111780082  nuclear cap-binding protein subunit 1-like [KO:K12882]
111793337  nuclear cap-binding protein subunit 1-like [KO:K12882]
111795908  nuclear cap-binding protein subunit 2-like [KO:K12883]
111788872  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
111785439  UBP1-associated protein 2B-like [KO:K12741]
111785440  UBP1-associated protein 2B-like [KO:K12741]
111779021  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
111780026  glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741]
111788538  UBP1-associated protein 2C-like [KO:K12741]
111776714  UBP1-associated protein 2A-like [KO:K12741]
111793271  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
111792988  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
111795236  UBP1-associated protein 2A-like [KO:K12741]
111797417  RNA-binding protein 3-like [KO:K12741]
111789831  UBP1-associated protein 2C-like [KO:K12741]
111809859  UBP1-associated protein 2B-like isoform X1 [KO:K12741]
111810865  UBP1-associated protein 2C-like [KO:K12741]
111799147  UBP1-associated protein 2C-like [KO:K12741]
111797065  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
111805812  UBP1-associated protein 2B-like isoform X1 [KO:K12741]
111801579  glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741]
111778444  serine/arginine-rich-splicing factor SR34-like isoform X1 [KO:K12890]
111792879  serine/arginine-rich splicing factor SR30-like [KO:K12890]
111806774  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
111795368  serine/arginine-rich splicing factor SR34A-like isoform X1 [KO:K12890]
111808790  serine/arginine-rich splicing factor SR34A [KO:K12890]
111799014  serine/arginine-rich splicing factor SC35-like isoform X1 [KO:K12891]
111792624  serine/arginine-rich splicing factor SC35-like [KO:K12891]
111806018  serine/arginine-rich splicing factor SC35-like isoform X1 [KO:K12891]
111811552  serine/arginine-rich splicing factor SC35-like isoform X1 [KO:K12891]
111784426  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
111810796  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
111810801  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
111800455  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
111790621  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
111788299  serine/arginine-rich splicing factor RSZ22-like [KO:K12896]
111788322  serine/arginine-rich splicing factor RSZ22-like [KO:K12896]
111790074  serine/arginine-rich splicing factor RSZ21-like [KO:K12896]
111802188  serine/arginine-rich splicing factor RSZ21-like [KO:K12896]
111801893  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
111800490  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
111797163  serine/arginine-rich splicing factor RSZ22A [KO:K12896]
111782082  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
111803616  serine/arginine-rich splicing factor SR45a [KO:K12897]
111779655  serine/arginine-rich SC35-like splicing factor SCL30 isoform X1 [KO:K12900]
111780356  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
111799851  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
111790713  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
111807799  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
111800458  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
111793736  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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