KEGG   PATHWAY: ncar04010
Entry
ncar04010                   Pathway                                
Name
MAPK signaling pathway - Sciurus carolinensis (gray squirrel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ncar04010  MAPK signaling pathway
ncar04010

Other DBs
GO: 0000165
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124969155  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
124964767  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
124982084  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
124968359  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
124961627  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
124971751  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
124979221  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
124970247  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
124982472  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
124961645  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
124990321  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
124992864  voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
124969140  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
124982731  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
124980591  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
124961976  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
124982456  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3-like [KO:K04864]
124979835  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
124980463  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
124982217  voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
124970546  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
124981165  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
124980471  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
124966274  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
124966037  voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
124967101  voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124979014  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124970211  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
124967611  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124970276  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
124993726  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
124969192  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
124994051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124984768  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124982403  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124963548  calcineurin subunit B type 1 [KO:K06268]
124963939  calcineurin subunit B type 2 [KO:K06268]
124978031  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
124987550  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
124976078  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
124958788  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
124963581  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
124967269  RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
124994402  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
124959202  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
124979705  neurofibromin isoform X1 [KO:K08052]
124987003  ras GTPase-activating protein 1 [KO:K04352]
124992970  ras GTPase-activating protein 2 isoform X1 [KO:K08053]
124978224  ras-related protein Rap-1A [KO:K04353]
124982482  ras-related protein Rap-1b [KO:K07836]
124994951  pro-epidermal growth factor-like isoform X1 [KO:K04357]
124962678  protransforming growth factor alpha [KO:K08774]
124994080  proepiregulin-like [KO:K09784]
124994712  amphiregulin-like [KO:K09782]
124987262  fibroblast growth factor 1 isoform X1 [KO:K18496]
124958424  fibroblast growth factor 3-like [KO:K04358]
124987059  fibroblast growth factor 10 [KO:K04358]
124987153  fibroblast growth factor 18 [KO:K04358]
124994943  fibroblast growth factor 5 [KO:K04358]
124984357  fibroblast growth factor 9 [KO:K04358]
124985265  fibroblast growth factor 8 isoform X1 [KO:K04358]
124960728  fibroblast growth factor 4 [KO:K04358]
124972107  fibroblast growth factor 16 [KO:K04358]
124975376  fibroblast growth factor 22-like isoform X1 [KO:K04358]
124975960  LOW QUALITY PROTEIN: fibroblast growth factor 7-like [KO:K04358]
124983367  fibroblast growth factor 6 [KO:K04358]
124983497  fibroblast growth factor 20 [KO:K04358]
124983717  fibroblast growth factor 17 isoform X1 [KO:K04358]
124958169  fibroblast growth factor 19-like [KO:K22603]
124966645  fibroblast growth factor 21 [KO:K22429]
124983480  fibroblast growth factor 23 [KO:K22428]
124958523  beta-nerve growth factor [KO:K02582]
124983315  neurotrophin-3 isoform X1 [KO:K04356]
124967426  neurotrophin-4 [KO:K12457]
124960685  insulin [KO:K04526]
124983128  insulin-like growth factor I isoform X1 [KO:K05459]
124960684  insulin-like growth factor II isoform X1 [KO:K13769]
124970285  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
124982576  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
124994986  platelet-derived growth factor C isoform X1 [KO:K05450]
124960701  platelet-derived growth factor D isoform X1 [KO:K05450]
124969224  macrophage colony-stimulating factor 1-like isoform X1 [KO:K05453]
124983679  kit ligand isoform X1 [KO:K05461]
124966775  fms-related tyrosine kinase 3 ligand-like isoform X1 [KO:K05454]
124988567  vascular endothelial growth factor A [KO:K05448]
124960505  vascular endothelial growth factor B isoform X1 [KO:K16858]
124977223  placenta growth factor-like isoform X1 [KO:K16859]
124971938  vascular endothelial growth factor D isoform X1 [KO:K05449]
124983115  vascular endothelial growth factor C [KO:K05449]
124991665  hepatocyte growth factor isoform X1 [KO:K05460]
124964588  angiopoietin-1 isoform X1 [KO:K05465]
124982506  angiopoietin-2 [KO:K05466]
124977499  angiopoietin-4-like isoform X1 [KO:K05467]
124992767  ephrin-A3 isoform X1 [KO:K05462]
124992967  ephrin-A4 [KO:K05462]
124987247  ephrin-A5 isoform X1 [KO:K05462]
124990608  ephrin-A1-like [KO:K05462]
124969343  ephrin-A2 isoform X1 [KO:K05462]
124966421  ephrin-A1-like [KO:K05462]
124987151  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
124969250  neurturin isoform X1 [KO:K25414]
124990774  LOW QUALITY PROTEIN: artemin-like [KO:K25415]
124969500  persephin-like [KO:K25416]
124990601  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
124979806  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
124983061  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
124979980  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
124983698  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
124984495  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
124995087  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
124986677  LOW QUALITY PROTEIN: fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
124980147  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
124985938  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
124964245  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
124968393  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
124978062  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
124995024  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
124986803  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
124986612  macrophage colony-stimulating factor 1 receptor-like isoform X1 [KO:K05090] [EC:2.7.10.1]
124994841  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
124984996  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
124985904  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
124987325  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
124994570  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
124990426  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
124964747  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
124980445  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
124985472  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
124980188  growth factor receptor-bound protein 2 [KO:K04364]
124977045  son of sevenless homolog 2 [KO:K03099]
124963384  son of sevenless homolog 1 isoform X1 [KO:K03099]
124974041  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124967072  ras-related protein R-Ras [KO:K07829]
124958716  ras-related protein R-Ras2 [KO:K07830]
124966277  ras-related protein R-Ras2-like [KO:K07830]
124993317  ras-related protein M-Ras [KO:K07831]
124971762  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969568  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
124994024  ragulator complex protein LAMTOR3 [KO:K04370]
124984015  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR3-like [KO:K04370]
124979533  ragulator complex protein LAMTOR3-like [KO:K04370]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124960739  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
124969203  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
124988357  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
124985017  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
124971903  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
124972555  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
124984025  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124971802  ETS domain-containing protein Elk-1 [KO:K04375]
124961726  ETS domain-containing protein Elk-4 [KO:K04376]
124965808  myc proto-oncogene protein [KO:K04377]
124989492  LOW QUALITY PROTEIN: serum response factor-like [KO:K04378]
124977967  protein c-Fos [KO:K04379]
124980973  microtubule-associated protein tau isoform X1 [KO:K04380]
124961569  stathmin [KO:K04381]
124976716  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
124976990  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
124978216  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
124978217  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
124962073  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
124974890  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
124988890  tumor necrosis factor [KO:K03156]
124963656  interleukin-1 alpha-like [KO:K04383]
124967085  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
124962328  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
124977343  transforming growth factor beta-3 proprotein [KO:K13377]
124984003  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
124962993  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
124992826  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
124964432  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
124968435  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
124962014  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
124984583  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
124986944  monocyte differentiation antigen CD14-like [KO:K04391]
124970154  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
124971456  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124982630  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
124980331  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
124993558  cell division control protein 42 homolog [KO:K04393]
124990642  cell division control protein 42 homolog [KO:K04393]
124980858  cell division control protein 42 homolog isoform X1 [KO:K04393]
124966312  tumor necrosis factor receptor type 1-associated DEATH domain protein-like isoform X1 [KO:K03171]
124972492  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
124983898  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124964641  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
124988670  death domain-associated protein 6 [KO:K02308]
124968831  myeloid differentiation primary response protein MyD88 [KO:K04729]
124972468  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
124983710  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
124959952  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
124987492  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
124968653  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
124965544  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
124983359  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
124988761  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
124968333  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like isoform X1 [KO:K04405]
124963665  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
124963037  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
124966811  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
124958584  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
124992680  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
124992782  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124993680  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124993681  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124977469  serine/threonine-protein kinase 4 [KO:K04411]
124992491  LOW QUALITY PROTEIN: serine/threonine-protein kinase 3-like [KO:K04412]
124958685  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
124961556  mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
124986862  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
124960176  mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
124979813  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
124979643  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
124977280  mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
124967089  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
124962401  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K17534] [EC:2.7.11.25]
124982140  mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
124992671  mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
124979089  mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
124963253  mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
124988565  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
124988810  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
124988149  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
124990626  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
124979415  LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
124970249  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
124980435  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
124968601  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
124980599  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
124981341  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
124958394  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
124983647  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
124970516  LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436]
124972332  filamin-A isoform X1 [KO:K04437]
124991190  crk-like protein [KO:K04438]
124980118  adapter molecule crk isoform X1 [KO:K04438]
124958432  beta-arrestin-1 isoform X1 [KO:K04439]
124979615  beta-arrestin-2 isoform X1 [KO:K04439]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124988515  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
124989076  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124978202  mitogen-activated protein kinase 14-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124982485  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
124982486  LOW QUALITY PROTEIN: mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124990359  MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
124962236  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
124993289  MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
124977339  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
124960469  ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
124975972  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
124965416  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
124966545  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
124991717  transcription factor Jun [KO:K04448]
124963740  LOW QUALITY PROTEIN: transcription factor Jun-like [KO:K04448]
124968509  transcription factor JunD [KO:K04449]
124979831  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
124980281  cellular tumor antigen p53 [KO:K04451]
124983170  LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein-like [KO:K04452]
124978146  protein max isoform X1 [KO:K04453]
124986526  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
124970339  heat shock protein beta-1 [KO:K04455]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124975241  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
124983994  receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
124959485  tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
124961844  tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
124987585  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
124985491  dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124993540  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124983955  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124960103  dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124977798  LOW QUALITY PROTEIN: dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124963191  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124982318  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124983900  dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
124972394  dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
124962270  LOW QUALITY PROTEIN: dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
124980727  dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
124967531  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
124963003  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
124993125  heat shock 70 kDa protein 6 [KO:K03283]
124993503  heat shock cognate 71 kDa protein-like [KO:K03283]
124988136  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
124988137  heat shock 70 kDa protein 1 [KO:K03283]
124988335  heat shock 70 kDa protein 1 [KO:K03283]
124988964  heat shock cognate 71 kDa protein [KO:K03283]
124959781  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
124992923  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
124973399  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
124980909  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
124982326  nuclear receptor subfamily 4 group A member 1 [KO:K04465]
124980247  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
124985256  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
124983354  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
124971778  NF-kappa-B essential modulator isoform X1 [KO:K07210]
124980470  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
124994613  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124985379  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
124960546  transcription factor p65 [KO:K04735]
124966996  transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ncar04070  Phosphatidylinositol signaling system
ncar04110  Cell cycle
ncar04115  p53 signaling pathway
ncar04210  Apoptosis
ncar04310  Wnt signaling pathway
ncar04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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