KEGG   PATHWAY: fca05022
Entry
fca05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Felis catus (domestic cat)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
fca05022  Pathways of neurodegeneration - multiple diseases
fca05022

Organism
Felis catus (domestic cat) [GN:fca]
Gene
100126581  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100135767  CASP12; inactive caspase-12 [KO:K04741] [EC:3.4.22.-]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100142684  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100144608  UBA52; ubiquitin-60S ribosomal protein L40 precursor [KO:K02927]
100188929  TUBB1; tubulin beta-1 chain [KO:K07375]
100502578  BID; BH3-interacting domain death agonist [KO:K04726]
101080288  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
101080392  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
101080547  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101080579  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101080607  WNT3A; protein Wnt-3a [KO:K00312]
101080694  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101080736  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101080739  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
101080844  WNT9B; protein Wnt-9b [KO:K01064]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101080904  WNT2B; protein Wnt-2b [KO:K00182]
101080950  DNAH12; dynein axonemal heavy chain 12 isoform X1 [KO:K10408]
101080975  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101080991  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
101081009  PSMB7; proteasome subunit beta type-7 isoform X2 [KO:K02739] [EC:3.4.25.1]
101081039  NEFL; neurofilament light polypeptide [KO:K04572]
101081169  FZD10; frizzled-10 [KO:K02842]
101081291  NEFM; neurofilament medium polypeptide [KO:K04573]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081442  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
101081479  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
101081534  CALM2; calmodulin-2 [KO:K02183]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101081685  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
101081693  PSEN2; presenilin-2 isoform X2 [KO:K04522] [EC:3.4.23.-]
101081808  [KO:K02264]
101081819  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101081833  ACTR1A; alpha-centractin [KO:K16575]
101081984  [KO:K10435]
101081992  [KO:K07374]
101082021  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101082048  DNAH1; LOW QUALITY PROTEIN: dynein axonemal heavy chain 1 [KO:K10408]
101082082  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101082167  DNAL4; dynein axonemal light chain 4 [KO:K10412]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101082211  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
101082246  LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
101082247  PRPH; peripherin isoform X1 [KO:K07607]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101082343  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
101082357  DNAH17; dynein axonemal heavy chain 17 isoform X1 [KO:K10408]
101082389  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101082635  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101082681  DNAH7; dynein axonemal heavy chain 7 isoform X1 [KO:K10408]
101082735  FZD1; frizzled-1 [KO:K02432]
101082779  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101083042  DNAI1; dynein axonemal intermediate chain 1 isoform X1 [KO:K10409]
101083231  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
101083455  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101083475  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101083481  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
101083630  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:5.6.1.10]
101083664  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
101083751  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
101083819  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial isoform X2 [KO:K02270]
101083978  DCTN3; dynactin subunit 3 isoform X6 [KO:K10425]
101083981  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101084148  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101084186  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101084209  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101084245  KLC3; kinesin light chain 3 [KO:K10407]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101084324  TUBB4B; tubulin beta-4B chain [KO:K07375]
101084342  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101084481  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101084482  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101084530  PDYN; proenkephalin-B [KO:K15840]
101084533  DCTN1; dynactin subunit 1 isoform X10 [KO:K04648]
101084743  DNAH10; dynein axonemal heavy chain 10 isoform X1 [KO:K10408]
101084763  DNAH14; dynein axonemal heavy chain 14 isoform X1 [KO:K10408]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084782  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
101084817  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101084876  TUBB2B; tubulin beta-2B chain [KO:K07375]
101084912  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
101084949  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101084963  KLC4; kinesin light chain 4 [KO:K10407]
101084967  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101085106  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101085200  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
101085253  FZD2; frizzled-2 [KO:K02235]
101085348  [KO:K03945]
101085431  SQSTM1; sequestosome-1 isoform X2 [KO:K14381]
101085528  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101085531  [KO:K02271]
101085564  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
101085602  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
101085609  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101085618  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101085809  WNT5B; protein Wnt-5b [KO:K00444]
101085859  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101086110  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101086188  DNAH9; dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
101086207  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101086215  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101086294  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101086349  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
101086376  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086476  HTT; LOW QUALITY PROTEIN: huntingtin [KO:K04533]
101086493  [KO:K10881]
101086572  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
101086664  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
101086703  [KO:K00420]
101086780  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101086911  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101086953  TUBB4A; tubulin beta-4A chain [KO:K07375]
101087003  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101087018  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X3 [KO:K10575] [EC:2.3.2.23]
101087020  NOS2; nitric oxide synthase, inducible isoform X2 [KO:K13241] [EC:1.14.13.39]
101087197  GPX8; probable glutathione peroxidase 8 isoform X2 [KO:K00432] [EC:1.11.1.9]
101087239  PSEN1; presenilin-1 isoform X2 [KO:K04505] [EC:3.4.23.-]
101087245  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101087255  FZD7; frizzled-7 [KO:K02432]
101087259  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101087272  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
101087282  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101087310  PRNP; major prion protein [KO:K05634]
101087312  RAB1A; ras-related protein Rab-1A [KO:K07874]
101087318  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101087414  OPTN; optineurin isoform X1 [KO:K19946]
101087577  GPX6; glutathione peroxidase 6 isoform X1 [KO:K00432] [EC:1.11.1.9]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087664  CSNK2B; casein kinase II subunit beta [KO:K03115]
101087686  FRAT1; proto-oncogene FRAT1 [KO:K03069]
101087691  DNAI2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
101087697  FZD9; frizzled-9 [KO:K02842]
101087808  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2 [KO:K00236]
101087870  CCS; copper chaperone for superoxide dismutase [KO:K04569]
101087871  FADD; FAS-associated death domain protein [KO:K02373]
101087919  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087993  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101088019  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
101088122  [KO:K08738]
101088226  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101088234  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
101088251  DNAL1; dynein axonemal light chain 1 [KO:K10411]
101088298  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101088339  [KO:K08738]
101088378  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101088533  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101088613  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101088631  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
101088804  AXIN1; LOW QUALITY PROTEIN: axin-1 [KO:K02157]
101088821  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
101088901  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101088976  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X2 [KO:K11518]
101089019  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
101089045  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X2 [KO:K23932]
101089087  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
101089135  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101089141  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101089240  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
101089258  [KO:K04565] [EC:1.15.1.1]
101089265  DAXX; death domain-associated protein 6 [KO:K02308]
101089345  DNAH6; dynein axonemal heavy chain 6 isoform X1 [KO:K10408]
101089348  DCTN6; dynactin subunit 6 isoform X3 [KO:K10428]
101089489  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
101089499  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
101089557  MAPT; microtubule-associated protein tau isoform X15 [KO:K04380]
101089731  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101089839  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101089891  NOX4; NADPH oxidase 4 isoform X3 [KO:K21423] [EC:1.6.3.-]
101089914  [KO:K02263]
101089925  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090100  DKK2; dickkopf-related protein 2 [KO:K02165]
101090177  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
101090190  RYR3; ryanodine receptor 3 [KO:K04963]
101090224  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101090252  WNT16; protein Wnt-16 [KO:K01558]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X4 [KO:K06268]
101090365  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101090508  ACTR1B; beta-centractin [KO:K16575]
101090535  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
101090548  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
101090556  [KO:K07374]
101090590  [KO:K00417]
101090672  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101090761  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090948  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
101091063  CALM3; calmodulin-3 [KO:K02183]
101091174  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X3 [KO:K03951]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091319  UBB; polyubiquitin-B [KO:K08770]
101091411  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
101091412  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101091455  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101091492  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091642  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
101091655  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
101091665  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101091693  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101091694  SNCA; alpha-synuclein [KO:K04528]
101091711  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101091740  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101091804  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101091823  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101091850  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101091893  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
101091895  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101091918  HIP1; huntingtin-interacting protein 1 isoform X2 [KO:K04559]
101091923  DNAH5; LOW QUALITY PROTEIN: dynein axonemal heavy chain 5 [KO:K10408]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101091994  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101092150  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101092172  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X2 [KO:K10707]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092268  ATXN1; ataxin-1 [KO:K23616]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101092350  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
101092368  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101092455  WNT10A; protein Wnt-10a [KO:K01357]
101092508  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101092668  RAB8A; ras-related protein Rab-8A [KO:K07901]
101092693  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
101092726  DNAH3; dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
101092793  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101092860  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101092862  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101092868  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101092929  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101093033  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
101093051  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101093061  AXIN2; axin-2 isoform X1 [KO:K04385]
101093065  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101093140  [KO:K10428]
101093248  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
101093382  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X3 [KO:K03959]
101093395  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101093435  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101093604  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
101093608  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
101093612  [KO:K03948]
101093631  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X4 [KO:K03954]
101093640  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
101093692  SPG11; spatacsin isoform X1 [KO:K19026]
101093710  FZD4; frizzled-4 isoform X1 [KO:K02354]
101093741  [KO:K02135]
101093801  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101093860  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
101093891  CAT; catalase [KO:K03781] [EC:1.11.1.6]
101093902  DLG4; disks large homolog 4 isoform X10 [KO:K11828]
101093917  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101093948  WNT10B; protein Wnt-10b [KO:K01357]
101093950  DCTN2; dynactin subunit 2 isoform X3 [KO:K10424]
101094025  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101094104  GRM1; metabotropic glutamate receptor 1 isoform X2 [KO:K04603]
101094190  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101094224  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
101094239  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
101094305  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X3 [KO:K03033]
101094311  [KO:K00411] [EC:7.1.1.8]
101094314  ATXN2L; ataxin-2-like protein isoform X13 [KO:K23625]
101094318  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101094356  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101094385  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
101094451  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
101094546  CD4H9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
101094563  BECN2; beclin-2 [KO:K08334]
101094679  CALM1; calmodulin-1 [KO:K02183]
101094708  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101094768  KIF5A; kinesin heavy chain isoform X2 [KO:K10396] [EC:5.6.1.3]
101094867  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101094869  ALS2; alsin isoform X3 [KO:K04575]
101094890  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
101094940  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101094974  TRAP1; heat shock protein 75 kDa, mitochondrial isoform X1 [KO:K09488]
101094997  DNAH11; dynein axonemal heavy chain 11 isoform X1 [KO:K10408]
101095032  [KO:K00416]
101095061  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
101095118  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101095185  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
101095190  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101095250  FZD3; frizzled-3 isoform X1 [KO:K02329]
101095258  DNAH8; dynein axonemal heavy chain 8 isoform X1 [KO:K10408]
101095277  TUBA4A; tubulin alpha-4A chain isoform X2 [KO:K07374]
101095280  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101095300  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
101095435  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101095457  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101095592  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
101095657  TUBB; tubulin beta chain [KO:K07375]
101095675  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
101095705  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101095773  [KO:K02266]
101095941  [KO:K05863]
101095973  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101095987  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096138  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
101096157  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
101096309  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101096357  WNT8B; protein Wnt-8b [KO:K00714]
101096363  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101096376  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101096402  [KO:K07374]
101096420  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
101096448  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101096603  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101096604  RELA; transcription factor p65 [KO:K04735]
101096614  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
101096643  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2 [KO:K02263]
101096738  ATXN3; ataxin-3 isoform X7 [KO:K11863] [EC:3.4.22.-]
101096871  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
101096876  [KO:K02268]
101096892  AGER; advanced glycosylation end product-specific receptor isoform X6 [KO:K19722]
101096902  TUBA1A; tubulin alpha-1A chain [KO:K07374]
101096914  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101096916  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101096969  GPR37; prosaposin receptor GPR37 [KO:K04243]
101097006  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101097054  RAB39B; ras-related protein Rab-39B [KO:K07925]
101097080  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101097110  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101097114  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
101097118  STX1A; syntaxin-1A isoform X1 [KO:K04560]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101097173  DKK1; dickkopf-related protein 1 [KO:K02165]
101097211  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
101097226  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
101097227  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101097246  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101097257  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101097360  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
101097403  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101097436  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101097508  FZD5; frizzled-5 [KO:K02375]
101097621  GRIA1; glutamate receptor 1 isoform X2 [KO:K05197]
101097623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101097703  [KO:K02183]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101098090  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
101098213  [KO:K08738]
101098221  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101098228  PRKN; E3 ubiquitin-protein ligase parkin isoform X3 [KO:K04556] [EC:2.3.2.31]
101098308  ATG101; autophagy-related protein 101 [KO:K19730]
101098515  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101098564  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101098615  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
101098629  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101098658  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101098762  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
101098780  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101098797  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
101098808  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101098883  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
101098912  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101099010  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101099117  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101099130  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
101099249  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101099268  [KO:K07374]
101099307  [KO:K02183]
101099338  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
101099392  WNT6; protein Wnt-6 [KO:K00445]
101099491  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101099547  DKK4; dickkopf-related protein 4 [KO:K02165]
101099589  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X4 [KO:K09565] [EC:5.2.1.8]
101099660  UBC; polyubiquitin-C [KO:K08770]
101099742  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101099759  DNAH2; LOW QUALITY PROTEIN: dynein axonemal heavy chain 2 [KO:K10408]
101099952  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101099992  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101099995  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101100080  WNT11; protein Wnt-11 [KO:K01384]
101100189  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101100214  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101100266  [KO:K02267]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101100342  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101100445  DERL1; derlin-1 isoform X1 [KO:K11519]
101100487  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101100747  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101100851  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101100868  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101100919  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101100947  [KO:K08738]
101101015  BECN1; beclin-1 isoform X2 [KO:K08334]
101101060  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101101068  MFN2; mitofusin-2 isoform X2 [KO:K06030] [EC:3.6.5.-]
101101091  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
101101113  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101229  FZD8; frizzled-8 [KO:K02375]
101101230  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101101276  ATXN1L; ataxin-1-like [KO:K23616]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101321  [KO:K08960] [EC:2.7.11.1]
101101360  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
101101418  ATXN2; ataxin-2 isoform X5 [KO:K23625]
101101443  FZD6; frizzled-6 [KO:K02376]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101101591  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
101101618  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
101101628  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X2 [KO:K04554] [EC:2.3.2.23]
101101674  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101101678  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101101684  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102899183  [KO:K02272]
102899304  [KO:K05862]
102899476  [KO:K02265]
102900799  [KO:K00420]
102901624  [KO:K02128]
102902352  [KO:K15041]
102902667  [KO:K02183]
105260036  [KO:K04557]
105260413  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105261037  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105261050  UQCR10; uncharacterized protein UQCR10 isoform X1 [KO:K00419]
105261211  [KO:K02267]
105261306  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
109496610  [KO:K02267]
109499596  TUBB2A; tubulin beta-2A chain [KO:K07375]
109502991  [KO:K02128]
109503558  [KO:K08738]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111559153  [KO:K02267]
111560436  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
111560594  [KO:K10881]
123378935  SEPTIN5; septin-5 isoform X1 [KO:K04557]
123380058  [KO:K03957]
123381617  [KO:K02128]
123384428  [KO:K02128]
123386183  [KO:K02264]
493672  WNT2; protein Wnt-2 precursor [KO:K00182]
493687  IL6; interleukin-6 precursor [KO:K05405]
493690  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
493691  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
493701  BCL2L1; bcl-2-like protein 1 [KO:K04570]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493837  BAX; apoptosis regulator BAX [KO:K02159]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
493944  IL1A; interleukin-1 alpha precursor [KO:K04383]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
751113  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
751617  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
751619  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
768257  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
768259  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
768262  CASP7; caspase-7 isoform X2 [KO:K04397] [EC:3.4.22.60]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
768274  IL1B; interleukin-1 beta [KO:K04519]
807928  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807929  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807930  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
807931  CYTB; cytochrome b [KO:K00412]
807932  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
807933  COX3; cytochrome c oxidase subunit III [KO:K02262]
807934  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807935  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807936  COX2; cytochrome c oxidase subunit II [KO:K02261]
807937  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807938  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807939  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807940  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
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Related
pathway
fca00190  Oxidative phosphorylation
fca03050  Proteasome
fca04020  Calcium signaling pathway
fca04120  Ubiquitin mediated proteolysis
fca04137  Mitophagy - animal
fca04140  Autophagy - animal
fca04141  Protein processing in endoplasmic reticulum
fca04142  Lysosome biogenesis
fca04210  Apoptosis
fca04310  Wnt signaling pathway
fca04724  Glutamatergic synapse
fca04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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